The Dorothy Russell Memorial Lecture. The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms.

abstract：:Using a combined biochemical and histological approach certain conclusions can be drawn as to the origin of the increase in lysosomal enzymes in white matter from MS brains. Firstly, there is a gradient of lysosomal enzyme activity, plaque greater than periplaque greater than macroscopically normal white matter, which...

journal_title：Neuropathology and applied neurobiology

authors： McKeown SR,Allen IV

更新日期：1978-11-01 00:00:00

abstract：:Adhalin and alpha-dystroglycan are two components of a complex of proteins that, in conjunction with dystrophin, provide a link between the subsarcolemmal cytoskeleton and the basal lamina of the extracellular matrix of skeletal muscle. In the absence of dystrophin, in Duchenne muscular dystrophy (DMD) and the mdx mou...

journal_title：Neuropathology and applied neurobiology

authors： Cullen MJ,Walsh J,Roberds SL,Campbell KP

更新日期：1996-02-01 00:00:00

abstract：AIMS:Wnt activation in medulloblastomas is associated with good outcome. Upfront testing and risk-adapted stratification of patients will be done in future clinical studies. In a cohort of 186 paediatric medulloblastomas our aim was to identify the optimal methods in standard clinical practice to detect this subgroup. ...

journal_title：Neuropathology and applied neurobiology

authors： Goschzik T,Zur Mühlen A,Kristiansen G,Haberler C,Stefanits H,Friedrich C,von Hoff K,Rutkowski S,Pfister SM,Pietsch T

更新日期：2015-02-01 00:00:00

abstract：:Dystrophic (D) and normal (N) chicken pectoral muscle was analysed for histopathological differences from the embryo (day 20) through to the mature adult stage. A variety of indices of structural changes were used, to express the progression quantitatively. At the embryonic stage, fibroblast numbers (but not satellite...

journal_title：Neuropathology and applied neurobiology

authors： Pizzey JA,Barnard EA

更新日期：1983-03-01 00:00:00

abstract：AIMS:Although modifications of the survival motor neurone gene are responsible for most spinal muscular atrophy (SMA) cases, the molecular pathophysiology and the muscular target proteins involved are still unknown. The aim of this study was to compare the expression of contractile and regulatory protein isoforms in qu...

journal_title：Neuropathology and applied neurobiology

authors： Stevens L,Bastide B,Maurage CA,Dupont E,Montel V,Cieniewski-Bernard C,Cuisset JM,Vallée L,Mounier Y

更新日期：2008-12-01 00:00:00

abstract：:Irradiation of a rat hind limb at 15 days of age caused marked shortening of the limb, with a consequent reduction in nerve length. The tibial nerves of the irradiated limbs were examined qualitatively and quantitatively, and compared with the unirradiated nerve. There was no evidence of fibre degeneration and only ve...

journal_title：Neuropathology and applied neurobiology

authors： Jacobs JM,Myers R

更新日期：1993-02-01 00:00:00

abstract：AIMS:Normal neurovascular coupling, mediated by the fine interplay and communication of cells within the neurovascular unit, is critical for maintaining normal brain activity and cognitive function. This study investigated whether, with advancing age there is disruption of neurovascular coupling and specific cellular c...

journal_title：Neuropathology and applied neurobiology

authors： Duncombe J,Lennen RJ,Jansen MA,Marshall I,Wardlaw JM,Horsburgh K

更新日期：2017-10-01 00:00:00

abstract：:Cell death in gliomas may occur either by apoptosis, or, in the case of high grade tumours, by necrosis, but questions remain as to the pathogenesis and relationship between these processes. The development of cell death was investigated in multicellular glioma spheroid cultures. Spheroids model the development of cel...

journal_title：Neuropathology and applied neurobiology

authors： Bell HS,Whittle IR,Walker M,Leaver HA,Wharton SB

更新日期：2001-08-01 00:00:00

abstract：:Brains from human fetuses of 13 to 27 weeks gestation have been examined immunohistologically for the presence of macrophages using the marker alpha-1-anti-chymotrypsin. A preliminary study demonstrated this to be a satisfactory marker of brain macrophages, although macrophages were also weakly positive for the more s...

journal_title：Neuropathology and applied neurobiology

authors： Gould SJ,Howard S

更新日期：1991-10-01 00:00:00

abstract：:We have previously demonstrated that amyloid beta (Abeta) peptide is acutely toxic to retinal neurones in vivo and that this toxicity is mediated by an indirect mechanism. We have now extended these studies to look at the chronic effect of intravitreal injection of Abeta peptides on retinal ganglion cells (RGC), the p...

journal_title：Neuropathology and applied neurobiology

authors： Walsh DT,Bresciani L,Saunders D,Manca MF,Jen A,Gentleman SM,Jen LS

更新日期：2005-10-01 00:00:00

abstract：:Ubiquitin targets proteins for attack by certain proteolytic enzymes, but the ubiquitinated cytoplasmic inclusions seen in some chronic neurodegenerative diseases may indicate the occurrence of reparative rather than destructive metabolic events. We have examined the production of ubiquitin in motor neurons of the rat...

journal_title：Neuropathology and applied neurobiology

authors： Savedia S,Kiernan JA

更新日期：1994-12-01 00:00:00

abstract：:Existing techniques have been adapted and it has been possible to demonstrate acid phosphatase (APP) and myelin, lipid or astrocytic fibres in the same histological section. In normal controls APP was demonstrated in neurons, astrocytes, ependyma including choroid plexus epithelium and in pericytes, but not in oligode...

journal_title：Neuropathology and applied neurobiology

authors： Allen IV,Glover G,McKeown SR,McCormick D

更新日期：1979-05-01 00:00:00

abstract：:Protein aggregation, mitochondrial impairment and oxidative stress are common to multiple neurodegenerative diseases. Homeostasis is regulated by a balanced set of anabolic and catabolic responses, which govern removal and repair of damaged proteins and organelles. Macroautophagy is an evolutionarily conserved pathway...

journal_title：Neuropathology and applied neurobiology

authors： Cherra SJ 3rd,Dagda RK,Chu CT

更新日期：2010-04-01 00:00:00

abstract：AIM:Borna disease virus (BDV) induces a persistent infection in the central nervous system (CNS) accompanied by a non-purulent meningoencephalitis. BDV-infection of Lewis rats provides an important model to investigate basic principles of neurotropism, viral persistence and resulting dysfunctions. To date, the in vivo ...

journal_title：Neuropathology and applied neurobiology

authors： Werner-Keiss N,Garten W,Richt JA,Porombka D,Algermissen D,Herzog S,Baumgärtner W,Herden C

更新日期：2008-12-01 00:00:00

abstract：AIM:Pilocytic astrocytomas represent the most common paediatric tumours of the central nervous system. Dissemination through the ventricular system occurs rarely in patients with pilocytic astrocytomas; however, it is more common in infants with diencephalic tumours, and is associated with a poor outcome. Despite histo...

journal_title：Neuropathology and applied neurobiology

authors： Gessi M,Engels AC,Lambert S,Rothämel T,von Hornstein S,Collins VP,Denkhaus D,Gnekow A,Pietsch T

更新日期：2016-04-01 00:00:00

abstract：AIMS:The secondary dystroglycanopathies represent a heterogeneous group of congenital muscular dystrophies characterized by the defective glycosylation of alpha dystroglycan. These disorders are associated with mutations in at least 17 genes, including Fukutin-related protein (FKRP). At the severe end of the clinical s...

journal_title：Neuropathology and applied neurobiology

authors： Booler HS,Pagalday-Vergara V,Williams JL,Hopkinson M,Brown SC

更新日期：2017-06-01 00:00:00

abstract：AIM:To understand the progression of CLN1 disease and develop effective therapies we need to characterize early sites of pathology. Therefore, we performed a comprehensive evaluation of the nature and timing of early CLN1 disease pathology in the spinal cord, which appears especially vulnerable, and how this may affect...

journal_title：Neuropathology and applied neurobiology

authors： Nelvagal HR,Dearborn JT,Ostergaard JR,Sands MS,Cooper JD

更新日期：2020-08-25 00:00:00

abstract：:The effects of exposure to a cytotoxic agent, methylazoxymethanol acetate (MAM Ac), on the distribution, density and quantitative morphology of microglia in the rat forebrain have been examined with the aid of a peroxidase-conjugated lectin derived from Griffonia simplicifolia. Following exposure to MAM Ac (25 mg/kg m...

journal_title：Neuropathology and applied neurobiology

authors： Ashwell KW

更新日期：1992-12-01 00:00:00

abstract：:The anatomical arrangement of the pia mater suggests that it may act as a regulatory interface between cerebrospinal fluid and the surface of the brain and between arterioles within the brain and the surrounding neural tissue. However, the functional aspects of such a barrier are difficult to evaluate in vivo. In the ...

journal_title：Neuropathology and applied neurobiology

authors： Feurer DJ,Weller RO

更新日期：1991-10-01 00:00:00

abstract：AIMS:This study explores the neuroprotective effects and mechanisms of N-acetyl-L-cysteine (NAC) in mice exposed to cadmium (Cd). METHODS:NAC (150 mg/kg) was intraperitoneally administered to mice exposed to Cd (10-50 mg/L) in drinking water for 6 weeks. The changes of cell damage and death, reactive oxygen species (R...

journal_title：Neuropathology and applied neurobiology

authors： Chen S,Ren Q,Zhang J,Ye Y,Zhang Z,Xu Y,Guo M,Ji H,Xu C,Gu C,Gao W,Huang S,Chen L

更新日期：2014-10-01 00:00:00

abstract：AIMS:post-haemorrhagic ventricular dilatation (PHVD) is a significant problem in neonatal care, with sequelae extending beyond childhood. Its management is important in determining outcome. Although rodent hydrocephalus models have been developed, PHVD, as a specific entity with a distinct pathophysiology, has not been...

journal_title：Neuropathology and applied neurobiology

authors： Aquilina K,Chakkarapani E,Love S,Thoresen M

更新日期：2011-02-01 00:00:00

abstract：:The brain is frequently affected by the spread of lung cancer, and haematogenous metastasis is a common route to brain metastasis. We therefore developed an isogenic brain metastasis model of lung cancer to use the Lewis lung carcinoma cell line and analysed dynamics of neoplastic cells after extravasation. Histologic...

journal_title：Neuropathology and applied neurobiology

authors： Saito N,Hatori T,Murata N,Zhang ZA,Ishikawa F,Nonaka H,Iwabuchi S,Samejima H

更新日期：2007-06-01 00:00:00

abstract：:Sandhoff disease is a heritable lysosomal storage disease resulting from impaired degradation of GM2 ganglioside and related substrates. A mouse model of Sandhoff disease created by gene targeting displays progressive neurological manifestations, similar to patients with the disease. In the present in vivo and in vitr...

journal_title：Neuropathology and applied neurobiology

authors： Sango K,Yamanaka S,Ajiki K,Tokashiki A,Watabe K

更新日期：2002-02-01 00:00:00

abstract：:We have examined the influence that axons may have on the expression of proteolipid protein (PLP), the major myelin protein of the CNS. Partial transections were made of the optic nerve of adult rats to produce approximately a 50% loss of axons. Twenty-eight days after lesioning, sections of the distal nerves were imm...

journal_title：Neuropathology and applied neurobiology

authors： McPhilemy K,Griffiths IR,Mitchell LS,Kennedy PG

更新日期：1991-08-01 00:00:00

abstract：:Apoptotic bodies are frequently found in oligodendrogliomas, particularly in the anaplastic subtype. A range of proteins, such as those of the Bcl family, are implicated in the control of apoptosis. The ratio of antagonists of apoptosis, such as Bcl-2, to agonists, such as Bax, is thought to determine the outcome for ...

journal_title：Neuropathology and applied neurobiology

authors： Delgado MB,Anderson JR,Whittle IR,Wharton SB

更新日期：1999-10-01 00:00:00

abstract：AIMS:14,15-Epoxyeicosatrienoic acid (14,15-EET) is abundantly expressed in brain and exerts protective effects against ischaemia. 14,15-EET is hydrolysed by soluble epoxide hydrolase (sEH). sEH-/- mice show a higher level of 14,15-EET in the brain. Astrocytes play a pivotal role in neuronal survival under ischaemic con...

journal_title：Neuropathology and applied neurobiology

authors： Yuan L,Liu J,Dong R,Zhu J,Tao C,Zheng R,Zhu S

更新日期：2016-12-01 00:00:00

abstract：UNLABELLED:It is well known that glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for motoneurons. We have previously shown that it greatly enhanced motoneuron survival and axon regeneration after implantation of peripheral nerve graft following spinal root avulsion. AIMS:In the curre...

journal_title：Neuropathology and applied neurobiology

authors： Chu TH,Wang L,Guo A,Chan VW,Wong CW,Wu W

更新日期：2012-12-01 00:00:00

abstract：:Creutzfeldt-Jakob disease (CJD) is characterized by a loss of neurons accompanied by astrogliosis and spongiform changes in the neuropil. It has been recognized that reactive microglia occur in CJD but little is known about the regional distribution and extent of the microglial activation. We have, therefore, examined...

journal_title：Neuropathology and applied neurobiology

authors： Mühleisen H,Gehrmann J,Meyermann R

更新日期：1995-12-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) may be implicated in the pathogenetic mechanisms of hepatic encephalopathy. We tested this hypothesis by treating confluent primary cultures of rat astroglial cells with ammonium chloride for various periods and analysing the effect of ammonia on the signalling pathway that regulates...

journal_title：Neuropathology and applied neurobiology

authors： Bodega G,Suárez I,Almonacid L,Ciordia S,Beloso A,López-Fernández LA,Zaballos A,Fernández B

更新日期：2007-08-01 00:00:00

abstract：:Corpora amylacea (CAm) are regarded as a hallmark of brain ageing, but little is known about their role in normal and pathological circumstances. CAm contain, in addition to glucose polymers, ageing-, stress- and proinflammatory proteins. In view of their almost universal occurrence and their cumulation with time, for...

journal_title：Neuropathology and applied neurobiology

authors： Botez G,Rami A

更新日期：2001-12-01 00:00:00