Abstract:
:Apoptotic bodies are frequently found in oligodendrogliomas, particularly in the anaplastic subtype. A range of proteins, such as those of the Bcl family, are implicated in the control of apoptosis. The ratio of antagonists of apoptosis, such as Bcl-2, to agonists, such as Bax, is thought to determine the outcome for a particular cell. This study aimed to determine the expression of Bcl-2 and Bax proteins in a series of oligodendrogliomas and to relate the expression of these to measures of apoptosis. Immunohistochemistry was used to detect the expression of Bcl-2 and Bax in an archival series of 32 oligodendrogliomas. The results were scored semiquantitatively for the extent and intensity of tumour staining. Apoptosis indices were determined by counting apoptotic bodies on haematoxylin and eosin staining and the percentage of cells showing a positive reaction with the TdT-mediated dUTP-biotin nick end-labelling technique (TUNEL). Granular cytoplasmic staining for Bcl-2 was seen in tumour cells in 81% of cases. Cases with a strong intensity (but not extent) of staining showed a lower TUNEL index (P=0.038). Bcl-2 expression was identified in the walls of intratumoural blood vessels in 55% of cases and in peri-tumoural neurones (where present) in 87%. Bax expression was detected in tumour cells in 69% of cases but no relationship to TI was detected. Bax positivity was seen in blood vessels in 44% of cases and peri-tumoural neurones in 60%. Bcl-2 and Bax were concluded to be expressed in a high proportion of oligodendrogliomas, suggesting that they may exert a regulatory role in cell death in these tumours.
journal_name
Neuropathol Appl Neurobioljournal_title
Neuropathology and applied neurobiologyauthors
Delgado MB,Anderson JR,Whittle IR,Wharton SBdoi
10.1046/j.1365-2990.1999.00199.xkeywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
400-7issue
5eissn
0305-1846issn
1365-2990pii
nan199journal_volume
25pub_type
杂志文章abstract::Neural tissue grafting presently stands as one of the more intriguing experimental strategies being applied to the problem of spinal cord regeneration. The following annotation presents an overview of recent investigations which have shown: that peripheral nerve grafts can stimulate axonal outgrowth in many descending...
journal_title:Neuropathology and applied neurobiology
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doi:10.1111/j.1365-2990.1985.tb00007.x
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journal_title:Neuropathology and applied neurobiology
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doi:10.1111/j.1365-2990.1989.tb01145.x
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journal_title:Neuropathology and applied neurobiology
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journal_title:Neuropathology and applied neurobiology
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journal_title:Neuropathology and applied neurobiology
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doi:10.1046/j.0305-1846.2000.00289.x
更新日期:2000-12-01 00:00:00
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更新日期:2013-02-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
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更新日期:2016-12-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1046/j.1365-2990.2003.00457.x
更新日期:2003-06-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
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doi:10.1111/j.1365-2990.1993.tb00445.x
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journal_title:Neuropathology and applied neurobiology
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pub_type: 杂志文章,评审
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journal_title:Neuropathology and applied neurobiology
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更新日期:1991-04-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
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更新日期:2015-06-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/j.1365-2990.1982.tb00315.x
更新日期:1982-11-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
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更新日期:2011-04-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
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journal_title:Neuropathology and applied neurobiology
pub_type: 临床试验,杂志文章
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更新日期:1999-08-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/nan.12328
更新日期:2017-02-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/j.1365-2990.1979.tb00619.x
更新日期:1979-05-01 00:00:00
abstract:AIMS:Apolipoprotein A-I (apoA-I), the principal apolipoprotein associated with high-density lipoproteins in the periphery, is also found at high concentrations in the cerebrospinal fluid. Previous studies have reported either no impact or vascular-specific effects of apoA-I knockout (KO) on β-amyloid (Aβ) pathology. Ho...
journal_title:Neuropathology and applied neurobiology
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更新日期:2019-12-01 00:00:00