当前位置： SCI文献检索 > NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY期刊下所有文献 > Growth-associated protein 43 in lesions and cerebrospinal fluid in multiple sclerosis.

Growth-associated protein 43 in lesions and cerebrospinal fluid in multiple sclerosis.

Abstract：

:Axonal damage in multiple sclerosis (MS) is correlated to disease progression. Early axonal damage may be compensated for by regenerative processes. Growth-associated protein 43 (GAP-43) is a marker for axonal growth and synaptogenesis in various neurodegenerative diseases. We investigated the expression of GAP-43 in 48 MS grey and white matter lesions of different stages. Decreased GAP-43 expression was found in 74% of the white matter lesions, independent of the lesion stage. In 19 out of 35 white matter lesions, areas of increased GAP-43 expression were present immediately adjacent to the lesions. Increased or unaltered expression was observed in remyelinated lesions. GAP-43 was expressed in neurofilament-positive structures. GAP-43 expression appeared unchanged in grey matter lesions. Macrophages were present in the areas of changed GAP-43 expression. cerebrospinal fluid GAP-43 levels were negatively correlated with magnetic resonance imaging measures of whole-brain atrophy (r = -0.30). In conclusion, these results indicate that decreased GAP-43 immunopositivity reflects axonal damage in MS lesions, which may again be reflected in decreased cerebrospinal fluid levels. The increased levels of GAP-43 in remyelinated or nondemyelinated white matter close to MS lesions may reflect regenerative attempts by damaged axons.

journal_name

Neuropathol Appl Neurobiol

journal_title

Neuropathology and applied neurobiology

authors

Teunissen CE,Dijkstra CD,Jasperse B,Barkhof F,Vanderstichele H,Vanmechelen E,Polman CH,Bö L

doi

10.1111/j.1365-2990.2006.00730.x

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

318-31

issue

3

eissn

0305-1846

issn

1365-2990

pii

NAN730

journal_volume

32

pub_type

杂志文章

相关文献

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY文献大全
  • Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles.

    abstract：AIMS:Granulovacuolar degeneration involves the accumulation of large, double membrane-bound bodies within certain neurones during the course of Alzheimer's disease (AD) and other adult-onset dementias. Because of the two-layer membrane morphology, it has been proposed that the bodies are related to autophagic organelle...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2010.01135.x

    authors： Funk KE,Mrak RE,Kuret J

    更新日期：2011-04-01 00:00:00

  • Molecular characterization of disseminated pilocytic astrocytomas.

    abstract：AIM:Pilocytic astrocytomas represent the most common paediatric tumours of the central nervous system. Dissemination through the ventricular system occurs rarely in patients with pilocytic astrocytomas; however, it is more common in infants with diencephalic tumours, and is associated with a poor outcome. Despite histo...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12256

    authors： Gessi M,Engels AC,Lambert S,Rothämel T,von Hornstein S,Collins VP,Denkhaus D,Gnekow A,Pietsch T

    更新日期：2016-04-01 00:00:00

  • Heterozygous APOE Christchurch in familial Alzheimer's disease without mutations in other Mendelian genes.

    abstract：:We present the clinical and neuropathological findings of a patient with early onset Alzheimer's dementia (AD), heterozygous carrier of the rare Apolipoprotein E Christchurch (APOEch) variant. The patient did not harbor any pathogenic mutation in known Mendelian genes related to AD or other neurodegenerative disorders...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12670

    authors： Hernandez I,Gelpi E,Molina-Porcel L,Bernal S,Rodríguez-Santiago B,Dols-Icardo O,Ruiz A,Alcolea D,Boada M,Lleó A,Clarimón J

    更新日期：2020-10-23 00:00:00

  • Regional pattern of microgliosis in sporadic Creutzfeldt-Jakob disease in relation to phenotypic variants and disease progression.

    abstract：AIMS:The aim of this study was to describe the regional profiles of microglial activation in sporadic Creutzfeldt-Jakob disease (sCJD) subtypes and analyse the influence of prion strain, disease duration and codon 129 genotype. METHODS:We studied the amount/severity and distribution of activated microglia, protease-re...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12461

    authors： Franceschini A,Strammiello R,Capellari S,Giese A,Parchi P

    更新日期：2018-10-01 00:00:00

  • Single dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord.

    abstract：:Prolonged neurotoxicity of the recreational drug, MDMA (3,4-methylenedioxymethamphetamine) on serotoninergic axon terminals has been suggested. The effect of a single (15 mg/kg) dose of intraperitoneally administered MDMA on serotoninergic fibre density, defined by tryptophan hydroxylase (TpH) and serotonin transporte...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2006.00790.x

    authors： Kovács GG,Andó RD,Adori C,Kirilly E,Benedek A,Palkovits M,Bagdy G

    更新日期：2007-04-01 00:00:00

  • Brain mural cell loss in the parietal cortex in Alzheimer's disease correlates with cognitive decline and TDP-43 pathology.

    abstract：AIMS:Brain mural cells (BMC), smooth muscle cells and pericytes, interact closely with endothelial cells and modulate numerous cerebrovascular functions. A loss of BMC function is suspected to play a role in the pathophysiology of Alzheimer's Disease (AD). METHODS:BMC markers, namely smooth muscle alpha actin (α-SMA) ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12599

    authors： Bourassa P,Tremblay C,Schneider JA,Bennett DA,Calon F

    更新日期：2020-08-01 00:00:00

  • Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress.

    abstract：:Dysfunction of the ubiquitin-dependent proteolytic pathway contributes to progressive accumulation of ubiquitinated protein inclusions in neurodegenerative disorders, such as Parkinson's disease (PD). Ubiquitin C-terminal hydrolase-L1 (UCH-L1), alternatively designated protein gene product 9.5 (PGP9.5), is a neural de...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2001.00313.x

    authors： Satoh JI,Kuroda Y

    更新日期：2001-04-01 00:00:00

  • Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy.

    abstract：:In a stereological study of the human substantia nigra (SN), the total number of melanin-positive and melanin-negative neurones from 28 male subjects aged 19-92 years was estimated using a uniform sampling design and optical disectors. There was a significant decrease in the total number of melanin-positive neurones a...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2002.00393.x

    authors： Cabello CR,Thune JJ,Pakkenberg H,Pakkenberg B

    更新日期：2002-08-01 00:00:00

  • Transcription factors c-Jun/activator protein-1 and nuclear factor-kappa B in oxidative stress response in mitochondrial diseases.

    abstract：:Mitochondrial dysfunction leads to oxygen free radical (ROS) generation with consequent oxidative stress and cellular damage. Recently, activation of the cellular antioxidant system and apoptosis were demonstrated in skeletal muscle fibres from patients with mitochondrial diseases, but the underlying mechanisms remain...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2003.00411.x

    authors： Filosto M,Tonin P,Vattemi G,Savio C,Rizzuto N,Tomelleri G

    更新日期：2003-02-01 00:00:00

  • Region-specific regulation of the serotonin 2A receptor expression in development and ageing in post mortem human brain.

    abstract：AIMS:The serotonin 2A receptor (HTR2A) is widely expressed in the brain and involved in the modulation of fear, mood, anxiety and other symptoms. HTR2A and HTR2A gene variations are implicated in depression, schizophrenia, anxiety and obsessive-compulsive disorder. To understand HTR2A signalling changes in psychiatric ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12167

    authors： Marinova Z,Monoranu CM,Fetz S,Walitza S,Grünblatt E

    更新日期：2015-06-01 00:00:00

  • Role of axon-deprived Schwann cells in perineurial regeneration in the rat sciatic nerve.

    abstract：:The role of Schwann cells (SC) in perineurial regeneration after nerve injury has not yet been resolved. It was hypothesized that SC alone are able to induce at least partial morphological restoration of the destroyed orthotopic perineureum (PN). To test the hypothesis, a permanently denervated segment of the rat scia...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2000.00238.x

    authors： Popović M,Bresjanac M,Sketelj J

    更新日期：2000-06-01 00:00:00

  • Microvascular changes in late-life schizophrenia and mood disorders: stereological assessment of capillary diameters in anterior cingulate cortex.

    abstract：AIMS:Previous neuroimaging reports described morphological and functional abnormalities in anterior cingulate cortex (ACC) in schizophrenia and mood disorders. In earlier neuropathological studies, microvascular changes that could affect brain perfusion in these disorders have rarely been studied. Here, we analysed mor...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2012.01263.x

    authors： Sinka L,Kovari E,Santos M,Herrmann FR,Gold G,Hof PR,Bouras C,Giannakopoulos P

    更新日期：2012-12-01 00:00:00

  • Myopathology in congenital myopathies.

    abstract：:Congenital myopathies are clinically and genetically a heterogeneous group of early onset neuromuscular disorders, characterized by hypotonia and muscle weakness. Clinical severity and age of onset are variable. Many patients are severely affected at birth while others have a milder, moderately progressive or nonprogr...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/nan.12369

    authors： Sewry CA,Wallgren-Pettersson C

    更新日期：2017-02-01 00:00:00

  • Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease.

    abstract：:Studies in vitro have shown that phosphorylated translation initiation factor 2 alpha (TIF 2 alpha) may have several functions, including regulation of protein synthesis, control of cell death and procurement of resistance to oxidative stress in nerve cells. These properties may have implications in certain human neur...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2002.t01-1-00410.x

    authors： Ferrer I

    更新日期：2002-12-01 00:00:00

  • Enhancement of demyelination in the central nervous system of Semliki Forest virus infected mice after pretreatment with muramyl dipeptide.

    abstract：:Semliki Forest virus infections in mice produce an encephalitis with demyelination. If before giving the virus the mice are treated with muramyl dipeptide in Freund's incomplete adjuvant, there is a significant increase in demyelination. If ovalbumin is added to the above and then followed after an interval by a secon...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1988.tb01339.x

    authors： Illavia SJ,Webb HE,Colover J

    更新日期：1988-11-01 00:00:00

  • A double three-step theory of brain metastasis in mice: the role of the pia mater and matrix metalloproteinases.

    abstract：:The brain is frequently affected by the spread of lung cancer, and haematogenous metastasis is a common route to brain metastasis. We therefore developed an isogenic brain metastasis model of lung cancer to use the Lewis lung carcinoma cell line and analysed dynamics of neoplastic cells after extravasation. Histologic...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2007.00799.x

    authors： Saito N,Hatori T,Murata N,Zhang ZA,Ishikawa F,Nonaka H,Iwabuchi S,Samejima H

    更新日期：2007-06-01 00:00:00

  • Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease.

    abstract：:The pathological findings in Alzheimer's disease (AD) are partly attributed to alterations in calcium-binding protein (CBP) functions. We showed previously that immunoreactivity of secretagogin, a recently cloned CBP, in the human hippocampus is restricted to pyramidal neurones and that the amount of immunoreactive ne...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2007.00854.x

    authors： Attems J,Preusser M,Grosinger-Quass M,Wagner L,Lintner F,Jellinger K

    更新日期：2008-02-01 00:00:00

  • Comparative immunohistochemical study on the expression of alpha B crystallin, ubiquitin and stress-response protein 27 in ballooned neurons in various disorders.

    abstract：:This report deals with a comparative study on the expression of alpha B crystallin, ubiquitin, stress-response protein 27 (srp 27), srp 72 and phosphorylated neurofilament protein (pNFP) by ballooned neurons in Pick's disease, Creutzfeldt-Jakob disease (CJD), amyotrophic lateral sclerosis (ALS), leptomeningeal carcino...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1992.tb00795.x

    authors： Kato S,Hirano A,Umahara T,Kato M,Herz F,Ohama E

    更新日期：1992-08-01 00:00:00

  • Antisense epidermal growth factor receptor RNA transfection in human malignant glioma cells leads to inhibition of proliferation and induction of differentiation.

    abstract：:The epidermal growth factor receptor (EGFR) is a protooncogene that is frequently observed with alterations in late stage gliomas, suggesting an important role of this gene in glial tumorigenesis and progression. In this study we evaluated an antisense EGFR approach as an alternative therapeutic modality for glioblast...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.1998.00128.x

    authors： Tian XX,Lam PY,Chen J,Pang JC,To SS,Di-Tomaso E,Ng HK

    更新日期：1998-10-01 00:00:00

  • Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis.

    abstract：AIMS:Clusterin is a topologically dynamic chaperone protein with the ability to participate in both intra- and extacellular proteostasis. Clusterin has been shown to be upregulated in the spinal cord of patients with amyotrophic lateral sclerosis (ALS) and has been shown to protect against TDP-43 protein misfolding in ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12575

    authors： Gregory JM,Elliott E,McDade K,Bak T,Pal S,Chandran S,Abrahams S,Smith C

    更新日期：2020-04-01 00:00:00

  • Altered arginine metabolism in the central nervous system (CNS) of the Cln3-/- mouse model of juvenile Batten disease.

    abstract：BACKGROUND:Juvenile neuronal ceroid lipofuscinoses (JNCL) or juvenile Batten disease is a recessively inherited childhood neurodegenerative disorder resulting from a mutation in CLN3, which encodes a putative lysosomal protein of unknown function. AIM:Recent evidence suggests that a disruption in CLN3 function results...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2008.00984.x

    authors： Chan CH,Ramirez-Montealegre D,Pearce DA

    更新日期：2009-04-01 00:00:00

  • Experimental traction injuries of ventral spinal nerve roots. A scanning electron microscopic study.

    abstract：:The aims of this experimental scanning electron microscopic study were to identify the levels at which cervical ventral nerve roots, or the rootlets by which they are attached to the spinal cord, rupture under traction and to document the resulting damage. This information would provide the basis of a rationale for re...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1989.tb01254.x

    authors： Bristol DC,Fraher JP

    更新日期：1989-11-01 00:00:00

  • The fine structure of the CNS in multiple sclerosis. I. Interpretation of cytoplasmic papovavirus-like and paramyxovirus-like inclusions.

    abstract：:During an electron microscopic study of the white matter in multiple sclerosis (MS), spheroidal reticular particles were found both in MS and in control brains. These particles have previously been described in the brain in MS and in brain-derived cell cultures in subacute sclerosing panencephalitis. In both cases the...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1978.tb01347.x

    authors： Kirk J,Hutchinson WM

    更新日期：1978-09-01 00:00:00

  • Immunohistochemical analysis of cyclin A in astrocytic tumours.

    abstract：:Cyclins are important regulators of the cell cycle; there is increasing evidence that some cyclins are positively involved in carcinogenesis. Amplification and translocation of the cyclin genes and overexpression of their mRNAs and proteins have been observed in a variety of tumours. We studied cyclin A protein in ast...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.1998.00114.x

    authors： Chakrabarty A,Bridges LR

    更新日期：1998-06-01 00:00:00

  • Selective vulnerability in acute energy deprivation syndromes.

    abstract：:The topography and cellular events in the experimental lesions caused by chlorosugars, 6-aminonicotinamide, dinitrobenzene and tribromoimidazole in animals are considered in relation to those features in human acute thiamine deficiency (Wernicke's) encephalopathy and for comparison in Leigh's disease. The topography a...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2990.1993.tb00474.x

    authors： Cavanagh JB

    更新日期：1993-12-01 00:00:00

  • Hypoxia-inducible factor 1alpha/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis.

    abstract：:Hypoxia-inducible factor (HIF)-1alpha is a transcription factor that promotes ischaemia-driven angiogenesis. The aim of this study was to determine the relation of HIF-1alpha to vascular endothelial growth factor (VEGF; an important angiogenic molecule in brain tumours), p53 expression, angiogenesis, proliferative pot...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2003.00535.x

    authors： Korkolopoulou P,Patsouris E,Konstantinidou AE,Pavlopoulos PM,Kavantzas N,Boviatsis E,Thymara I,Perdiki M,Thomas-Tsagli E,Angelidakis D,Rologis D,Sakkas D

    更新日期：2004-06-01 00:00:00

  • The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling.

    abstract：AIMS:Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease recurrence. Our aim was to shed light on the biology of pLGG...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12479

    authors： Catanzaro G,Besharat ZM,Miele E,Chiacchiarini M,Po A,Carai A,Marras CE,Antonelli M,Badiali M,Raso A,Mascelli S,Schrimpf D,Stichel D,Tartaglia M,Capper D,von Deimling A,Giangaspero F,Mastronuzzi A,Locatelli F,Ferrett

    更新日期：2018-12-01 00:00:00

  • Optineurin is potentially associated with TDP-43 and involved in the pathogenesis of inclusion body myositis.

    abstract：AIMS:Increasing evidences suggest a similarity in the pathophysiological mechanisms of neuronal cell death in amyotrophic lateral sclerosis (ALS) and myofibre degeneration in sporadic inclusion body myositis (sIBM). The aim of this study is to elucidate the involvement of ALS-causing proteins in the pathophysiological ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2012.01297.x

    authors： Yamashita S,Kimura E,Tawara N,Sakaguchi H,Nakama T,Maeda Y,Hirano T,Uchino M,Ando Y

    更新日期：2013-06-01 00:00:00

  • The neuropathology, pathophysiology and genetics of multiple system atrophy.

    abstract：:Multiple system atrophy (MSA) is an unrelenting, sporadic, adult-onset, neurodegenerative disease of unknown aetiology. Its clinically progressive course is characterized by a variable combination of parkinsonism, cerebellar ataxia and/or autonomic dysfunction. Neuropathological examination often reveals gross abnorma...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2990.2011.01234.x

    authors： Ahmed Z,Asi YT,Sailer A,Lees AJ,Houlden H,Revesz T,Holton JL

    更新日期：2012-02-01 00:00:00

  • Spinal cord pathology and viral burden in homosexuals and drug users with AIDS.

    abstract：:Unless treated with effective antiretroviral therapy many AIDS patients develop a characteristic vacuolar myelopathy of the spinal cord associated with moderate clinical disability. Opinion is divided as to whether vacuolar myelopathy is causally linked to HIV myelitis. To investigate this further, spinal cord patholo...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2990.1999.00152.x

    authors： Shepherd EJ,Brettle RP,Liberski PP,Aguzzi A,Ironside JW,Simmonds P,Bell JE

    更新日期：1999-02-01 00:00:00