Abstract：
:Brains from human fetuses of 13 to 27 weeks gestation have been examined immunohistologically for the presence of macrophages using the marker alpha-1-anti-chymotrypsin. A preliminary study demonstrated this to be a satisfactory marker of brain macrophages, although macrophages were also weakly positive for the more specific marker MAC-387. Macrophages were widely present within the cerebral hemispheres following their rapid accumulation between 14 and 16 weeks of gestation. They were identified in characteristic locations which, in the earliest gestation brains examined at 13 weeks, included the mid-line of the corpus callosum, around the optic tract and at the junction of the external and internal capsules near the apex of the putamen. Subsequently, macrophages were identified in abundance in the internal and external capsules and, by 22 weeks gestation, in the periventricular tissues. Their consistent presence and distribution indicate that at least the majority of these macrophages are a normal feature of the developing brain possibly related to remodelling processes.
journal_name
Neuropathol Appl Neurobioljournal_title
Neuropathology and applied neurobiologyauthors
Gould SJ,Howard Sdoi
10.1111/j.1365-2990.1991.tb00738.xsubject
Has Abstractpub_date
1991-10-01 00:00:00pages
383-90issue
5eissn
0305-1846issn
1365-2990journal_volume
17pub_type
杂志文章abstract：:The causes of most neurological disorders are not fully understood. Inflammation and blood-brain barrier dysfunction appear to play major roles in the pathology of these diseases. Inflammatory insults that occur during brain development may have widespread effects later in life for a spectrum of neurological disorders...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2990.2008.01005.x
更新日期：2009-04-01 00:00:00
abstract：:An elderly man suffering from dementia associated with hypertension developed right-sided parkinsonism marked by rigidity and flexion. At autopsy the brain showed generalized vascular changes chiefly in the white matter, diffuse plaque and neurofibrillary tangle formation in the temporal cortex, and a discrete gliotic...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1978.tb00548.x
更新日期：1978-07-01 00:00:00
abstract：:Dysfunction of the ubiquitin-dependent proteolytic pathway contributes to progressive accumulation of ubiquitinated protein inclusions in neurodegenerative disorders, such as Parkinson's disease (PD). Ubiquitin C-terminal hydrolase-L1 (UCH-L1), alternatively designated protein gene product 9.5 (PGP9.5), is a neural de...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1046/j.1365-2990.2001.00313.x
更新日期：2001-04-01 00:00:00
abstract：:Accumulating evidence indicates an important pathophysiological role of brain inflammation in epilepsy. In this review, we will provide an update of specific inflammatory pathways that have been proposed to be crucial in the underlying molecular mechanisms of epilepsy, including the interleukin-1 receptor/toll-like re...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1111/nan.12444
更新日期：2018-02-01 00:00:00
abstract：:Immunohistochemistry using antibodies to dystrophin is the pathological basis for the diagnosis of Duchenne and Becker muscular dystrophy (DMD and BMD). While the sarcolemma of DMD muscle is negative, BMD muscle generally shows variable labelling because of the translation of a partially functional dystrophin that is ...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2004.00561.x
更新日期：2004-10-01 00:00:00
abstract：:During an electron microscopic study of the white matter in multiple sclerosis (MS), spheroidal reticular particles were found both in MS and in control brains. These particles have previously been described in the brain in MS and in brain-derived cell cultures in subacute sclerosing panencephalitis. In both cases the...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1978.tb01347.x
更新日期：1978-09-01 00:00:00
abstract：AIMS:Wnt activation in medulloblastomas is associated with good outcome. Upfront testing and risk-adapted stratification of patients will be done in future clinical studies. In a cohort of 186 paediatric medulloblastomas our aim was to identify the optimal methods in standard clinical practice to detect this subgroup. ...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12161
更新日期：2015-02-01 00:00:00
abstract：AIMS:Frontotemporal lobar degeneration (FTLD) and motor neurone disease are linked by the possession of a hexanucleotide repeat expansion in C9ORF72, and both show neuronal cytoplasmic inclusions within cerebellar and hippocampal neurones which are TDP-43 negative but immunoreactive for p62 and dipeptide repeat protein...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12178
更新日期：2015-08-01 00:00:00
abstract：:The curiously consistent localization of cerebellar cortical damage in chronic alcoholism is re-evaluated in the light of selective damage, with a similar topography in the cerebellar vermal region, in superficial siderosis in man and in experimental animals exposed to certain toxic substances. Attention is drawn to t...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：
更新日期：1997-10-01 00:00:00
abstract：:Human fetal dorsal root ganglia aged from 8 to 12 weeks post-menstrual were grown in vitro for up to 20 days. Outgrowth of Schwann cells, axons and fibroblasts occurred after 4 h. By the 7th day in vitro Schwann cells enclosed bundles of axons and after 10 days some Schwann cells were seen to enclose individual axons....
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1982.tb00315.x
更新日期：1982-11-01 00:00:00
abstract：:Dementia with Lewy bodies (DLB) is characterized by the widespread presence of Lewy bodies (LBs) in the brain. alpha-Synuclein, the main component of LBs, is expressed as two main isoforms (112 and 140), but little is known about their differential expression in the brain. We compared alpha-synuclein 112 and alpha-syn...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2004.00572.x
更新日期：2004-12-01 00:00:00
abstract：:The nature of the glial and inflammatory cell responses to infection in scrapie-affected brains was studied in terminally-affected mice of five scrapie models. There were marked astrocytic and microglial responses. Microglia showed increased staining of the surface antigens F4/80, leucocyte-common antigen, type 3 comp...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1994.tb00956.x
更新日期：1994-02-01 00:00:00
abstract：:We present the clinical and neuropathological findings of a patient with early onset Alzheimer's dementia (AD), heterozygous carrier of the rare Apolipoprotein E Christchurch (APOEch) variant. The patient did not harbor any pathogenic mutation in known Mendelian genes related to AD or other neurodegenerative disorders...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12670
更新日期：2020-10-23 00:00:00
abstract：AIMS:Apolipoprotein A-I (apoA-I), the principal apolipoprotein associated with high-density lipoproteins in the periphery, is also found at high concentrations in the cerebrospinal fluid. Previous studies have reported either no impact or vascular-specific effects of apoA-I knockout (KO) on β-amyloid (Aβ) pathology. Ho...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12556
更新日期：2019-12-01 00:00:00
abstract：:Neural tissue grafting presently stands as one of the more intriguing experimental strategies being applied to the problem of spinal cord regeneration. The following annotation presents an overview of recent investigations which have shown: that peripheral nerve grafts can stimulate axonal outgrowth in many descending...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2990.1985.tb00007.x
更新日期：1985-03-01 00:00:00
abstract：AIM:Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the contribution of peroxisomes in lipid alterations of area 8 of the frontal cortex in the spectrum of TD...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12681
更新日期：2020-12-17 00:00:00
abstract：:Flow through the vasculature of an experimental rat glioma has been investigated during in situ perfusion of the brain, via the ascending aorta, with a simple saline solution. Using such a system, it has been shown previously that the blood-brain barrier will remain intact with an adequate cerebral perfusate flow rate...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1994.tb00995.x
更新日期：1994-10-01 00:00:00
abstract：:Neuronal loss is often quoted as an element of the pathology of the transmissible spongiform encephalopathies, but few data are published. To determine whether neuronal loss is a salient feature of murine scrapie, and whether there is a relationship with the other hallmark lesions of scrapie we compared the numbers of...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1995.tb01027.x
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND:Juvenile neuronal ceroid lipofuscinoses (JNCL) or juvenile Batten disease is a recessively inherited childhood neurodegenerative disorder resulting from a mutation in CLN3, which encodes a putative lysosomal protein of unknown function. AIM:Recent evidence suggests that a disruption in CLN3 function results...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2008.00984.x
更新日期：2009-04-01 00:00:00
abstract：:The critical role of the neurofibromatosis 1 (NF1) gene as a tumour suppressor has been clearly demonstrated for malignancies arising in NF1 patients. However, little is known about the more common benign tumours, such as the pilocytic astrocytoma. Most NF1-associated astrocytomas are benign and clinically non-progres...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1046/j.1365-2990.2000.00258.x
更新日期：2000-08-01 00:00:00
abstract：:The expression of two heat shock proteins, HSP72 and p57, in addition to ubiquitin, has been studied immunocytochemically in nine amyotrophic lateral sclerosis (ALS) cases and 10 age-matched controls. HSP72 and p57 antibodies did not identify the characteristic ubiquitin-immunoreactive inclusions present in anterior h...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1991.tb00692.x
更新日期：1991-02-01 00:00:00
abstract：:Focal cortical dysplasia (FCD), which is often associated with intractable epilepsy, is a form of abnormal structure of the cerebral cortex caused by a disorder of normal neocortical development. In such cerebral lesions obtained from four patients (two male, two female; average age 32.3 years at operation), the immun...
journal_title：Neuropathology and applied neurobiology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2990.1999.00180.x
更新日期：1999-06-01 00:00:00
abstract：:Cyclins are important regulators of the cell cycle; there is increasing evidence that some cyclins are positively involved in carcinogenesis. Amplification and translocation of the cyclin genes and overexpression of their mRNAs and proteins have been observed in a variety of tumours. We studied cyclin A protein in ast...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1046/j.1365-2990.1998.00114.x
更新日期：1998-06-01 00:00:00
abstract：:The tight junction protein occludin 'glues' normal, adjacent brain microvessel endothelial cells together. Malignant brain tumours cause cerebral oedema because they have leaky endothelial tight junctions, which allow plasma fluid to enter the brain from the microvessel lumen. In order to identify molecular abnormalit...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1046/j.0305-1846.2001.00341.x
更新日期：2001-10-01 00:00:00
abstract：AIMS:In Alzheimer's disease (AD), microglial activation prompted by the presence of amyloid has been proposed as an important contributor to the neurodegenerative process. Conversely following Aβ immunization, phagocytic microglia have been implicated in plaque removal, potentially a beneficial effect. We have investig...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2010.01156.x
更新日期：2011-08-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) has recently been implicated in several neurological disorders. Apart from its prominent role in angiogenesis, VEGF has been shown to have direct effects on neuronal and glial cells through activation of different VEGF receptor (VEGFR) types. In the present study the expressio...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2003.00543.x
更新日期：2004-08-01 00:00:00
abstract：AIMS:The serotonin 2A receptor (HTR2A) is widely expressed in the brain and involved in the modulation of fear, mood, anxiety and other symptoms. HTR2A and HTR2A gene variations are implicated in depression, schizophrenia, anxiety and obsessive-compulsive disorder. To understand HTR2A signalling changes in psychiatric ...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12167
更新日期：2015-06-01 00:00:00
abstract：AIMS:Infection of the mouse central nervous system with wild type (WT) and vaccine strains of measles virus (MV) results in lack of clinical signs and limited antigen detection. It is considered that cell entry receptors for these viruses are not present on murine neural cells and infection is restricted at cell entry....
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2009.01023.x
更新日期：2009-10-01 00:00:00
abstract：:Toxicity associated with abnormal protein folding and protein aggregation are major hypotheses for neurodegeneration. This article comparatively reviews the experimental and human tissue-based evidence for the involvement of such mechanisms in neuronal death associated with the motor system disorders of X-linked spino...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1046/j.0305-1846.2003.00518.x
更新日期：2003-12-01 00:00:00
abstract：:Changes of 5'-nucleotidase (5'-N) activity during subcultivation of C6 clonal rat glioma cells were studied histochemically, cytochemically and biochemically. Two different cell populations were seeded with high or low cell density respectively. 5'-N activity in cultured cells increased continuously in both population...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1985.tb00014.x
更新日期：1985-05-01 00:00:00
