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Review: autophagy and neurodegeneration: survival at a cost?

Abstract：

:Protein aggregation, mitochondrial impairment and oxidative stress are common to multiple neurodegenerative diseases. Homeostasis is regulated by a balanced set of anabolic and catabolic responses, which govern removal and repair of damaged proteins and organelles. Macroautophagy is an evolutionarily conserved pathway for the degradation of long-lived proteins, effete organelles and protein aggregates. Aberrations in macroautophagy have been observed in Alzheimer, Huntington, Parkinson, motor neuron and prion diseases. In this review, we will discuss the divergent roles of macroautophagy in neurodegenerative diseases and suggest a potential regulatory mechanism that could determine cell death or survival outcomes. We also highlight emerging data on neurite morphology and synaptic remodelling that indicate the possibility of detrimental functional trade-offs in the face of neuronal cell survival, particularly if the need for elevated macroautophagy is sustained.

journal_name

Neuropathol Appl Neurobiol

journal_title

Neuropathology and applied neurobiology

authors

Cherra SJ 3rd,Dagda RK,Chu CT

doi

10.1111/j.1365-2990.2010.01062.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

125-32

issue

2

eissn

0305-1846

issn

1365-2990

pii

NAN1062

journal_volume

36

pub_type

杂志文章,评审

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