Developmental profile of plasma proteins in human fetal cerebrospinal fluid and blood.

abstract：:The tight junction protein occludin 'glues' normal, adjacent brain microvessel endothelial cells together. Malignant brain tumours cause cerebral oedema because they have leaky endothelial tight junctions, which allow plasma fluid to enter the brain from the microvessel lumen. In order to identify molecular abnormalit...

journal_title：Neuropathology and applied neurobiology

authors： Papadopoulos MC,Saadoun S,Woodrow CJ,Davies DC,Costa-Martins P,Moss RF,Krishna S,Bell BA

更新日期：2001-10-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is characterized by the deposition of granular osmiophilic material in association with vascular smooth muscle cells in many different organs. However, the cause of the subsequent destruction of smooth muscle cells tha...

journal_title：Neuropathology and applied neurobiology

authors： Ruchoux MM,Maurage CA

更新日期：1998-02-01 00:00:00

abstract：:A few nanograms of tetanus toxin injected into a rat hippocampus causes a chronic epileptic syndrome characterized by brief seizures that recur intermittently for about 6 weeks. Cognitive and other behavioural impairments persist after the seizures and other epileptic electrographic activity have remitted, and may be ...

journal_title：Neuropathology and applied neurobiology

authors： Jefferys JG,Evans BJ,Hughes SA,Williams SF

更新日期：1992-02-01 00:00:00

abstract：:Serial sections of the brains of two cases with Alzheimer's disease were stained with the standard Bodian, modified Bielschowsky (reformed Gros-Schultze's modification) and thioflavin S methods. The numbers of demonstrated Alzheimer's neurofibrillary tangles (NFTs) were different between the two silver stains: from 15...

journal_title：Neuropathology and applied neurobiology

authors： Yamamoto T,Hirano A

更新日期：1986-01-01 00:00:00

abstract：:The mechanism of the neuroprotective effect of hyperbaric oxygenation remains unclear although its clinical benefits have been well recognized for human ischaemic neuronal disease. The preventive effect of hyperbaric oxygenation against delayed neuronal death was investigated in the gerbil following transient forebrai...

journal_title：Neuropathology and applied neurobiology

authors： Konda A,Baba S,Iwaki T,Harai H,Koga H,Kimura T,Takamatsu J

更新日期：1996-08-01 00:00:00

abstract：:Human fetal dorsal root ganglia aged from 8 to 12 weeks post-menstrual were grown in vitro for up to 20 days. Outgrowth of Schwann cells, axons and fibroblasts occurred after 4 h. By the 7th day in vitro Schwann cells enclosed bundles of axons and after 10 days some Schwann cells were seen to enclose individual axons....

journal_title：Neuropathology and applied neurobiology

authors： Crawford K,Armati-Gulson P

更新日期：1982-11-01 00:00:00

abstract：:Over the past few years, the traditional view of brain tumorigenesis has been revolutionized by advances in genomic medicine, molecular biology, stem cell biology and genetically engineered small-animal modelling. We now appreciate that paediatric brain tumours arise following specific genetic mutations in specialized...

journal_title：Neuropathology and applied neurobiology

authors： Thangarajh M,Gutmann DH

更新日期：2012-06-01 00:00:00

abstract：:The causes of most neurological disorders are not fully understood. Inflammation and blood-brain barrier dysfunction appear to play major roles in the pathology of these diseases. Inflammatory insults that occur during brain development may have widespread effects later in life for a spectrum of neurological disorders...

journal_title：Neuropathology and applied neurobiology

authors： Stolp HB,Dziegielewska KM

更新日期：2009-04-01 00:00:00

abstract：:A 50-year-old female patient died of an untreatable glioma apoplecticum. At autopsy a strongly vascularized glial tumour was found. The criteria for malignancy according to the WHO classification were only partially fulfilled by this tumour which displayed morphological features of an astrocytoma but could not be furt...

journal_title：Neuropathology and applied neurobiology

authors： Radner H,Kleinert R,Vennigerholz F,Denk H

更新日期：1990-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has recently been implicated in several neurological disorders. Apart from its prominent role in angiogenesis, VEGF has been shown to have direct effects on neuronal and glial cells through activation of different VEGF receptor (VEGFR) types. In the present study the expressio...

journal_title：Neuropathology and applied neurobiology

authors： Spliet WG,Aronica E,Ramkema M,Witmer AN,Schlingemann RO,de Jong JM,Troost D

更新日期：2004-08-01 00:00:00

abstract：:Prolonged neurotoxicity of the recreational drug, MDMA (3,4-methylenedioxymethamphetamine) on serotoninergic axon terminals has been suggested. The effect of a single (15 mg/kg) dose of intraperitoneally administered MDMA on serotoninergic fibre density, defined by tryptophan hydroxylase (TpH) and serotonin transporte...

journal_title：Neuropathology and applied neurobiology

authors： Kovács GG,Andó RD,Adori C,Kirilly E,Benedek A,Palkovits M,Bagdy G

更新日期：2007-04-01 00:00:00

abstract：:An unusual inherited progressive distal myopathy of early childhood onset is described in two sisters from a consanguineous Asian family. Motor milestones were normal but gait deteriorated slowly thereafter with development of generalized hypotonia and muscle weakness particularly in the wrist extensors and hand muscl...

journal_title：Neuropathology and applied neurobiology

authors： Mahon M,Kristmundsdottir F,Cumming WJ,Noronha MJ

更新日期：1989-01-01 00:00:00

abstract：:Creutzfeldt-Jakob disease (CJD) is characterized by a loss of neurons accompanied by astrogliosis and spongiform changes in the neuropil. It has been recognized that reactive microglia occur in CJD but little is known about the regional distribution and extent of the microglial activation. We have, therefore, examined...

journal_title：Neuropathology and applied neurobiology

authors： Mühleisen H,Gehrmann J,Meyermann R

更新日期：1995-12-01 00:00:00

abstract：:Dementia with Lewy bodies (DLB) is characterized by the widespread presence of Lewy bodies (LBs) in the brain. alpha-Synuclein, the main component of LBs, is expressed as two main isoforms (112 and 140), but little is known about their differential expression in the brain. We compared alpha-synuclein 112 and alpha-syn...

journal_title：Neuropathology and applied neurobiology

authors： Beyer K,Lao JI,Carrato C,Mate JL,López D,Ferrer I,Ariza A

更新日期：2004-12-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme complex that synthesizes telomere DNA. It is detected in 85-90% of malignant tumours in humans, but not in most somatic cells. Because telomerase plays a critical role in cell immortality, it represents an important target for anticancer therapies. We have previously shown that...

journal_title：Neuropathology and applied neurobiology

authors： Long S,Argyle DJ,Nixon C,Nicholson I,Botteron C,Olby N,Platt S,Smith K,Rutteman GR,Grinwis GC,Nasir L

更新日期：2006-12-01 00:00:00

abstract：:Toxicity associated with abnormal protein folding and protein aggregation are major hypotheses for neurodegeneration. This article comparatively reviews the experimental and human tissue-based evidence for the involvement of such mechanisms in neuronal death associated with the motor system disorders of X-linked spino...

journal_title：Neuropathology and applied neurobiology

authors： Wood JD,Beaujeux TP,Shaw PJ

更新日期：2003-12-01 00:00:00

abstract：:Two cases are described, one with a multifocal cranial and limb neuropathy of adult onset associated with optic neuropathy, and the other with a diffuse demyelinating neuropathy characterized by congenital cataract, mental retardation and progressive lower limb paresis with an onset in childhood. Extensive investigati...

journal_title：Neuropathology and applied neurobiology

authors： Thomas PK,King RH,Workman JM,Schröder JM

更新日期：2000-12-01 00:00:00

abstract：:This paper continues the historical review on the concept of a sensorimotor cortex into the twentieth century. Paul Flechsig was probably the first to accept this concept after the turn of the century. Like Munk, he believed in an almost reflex-like unity between cortical sensory and motor function. With the help of h...

journal_title：Neuropathology and applied neurobiology

authors： Meyer A

更新日期：1982-03-01 00:00:00

abstract：:Sandhoff disease is a heritable lysosomal storage disease resulting from impaired degradation of GM2 ganglioside and related substrates. A mouse model of Sandhoff disease created by gene targeting displays progressive neurological manifestations, similar to patients with the disease. In the present in vivo and in vitr...

journal_title：Neuropathology and applied neurobiology

authors： Sango K,Yamanaka S,Ajiki K,Tokashiki A,Watabe K

更新日期：2002-02-01 00:00:00

abstract：:Fibre type differentiation was carried out on 20 biopsies from Duchenne Muscular Dystrophy (DMD) sufferers using the acid-preincubated reaction for myofibrillar ATPase. Fibres, classified as either type 1, type 2 or 2C, were counted and their minimum diameters (least fibre axis) measured. Particular attention was paid...

journal_title：Neuropathology and applied neurobiology

authors： Watkins SC,Cullen MJ

更新日期：1985-11-01 00:00:00

abstract：:A demyelinating perivascular condition has been observed in the optic nerves of three cats, the lesions of which included the following features: thinly myelinated and demyelinated axons, few normal oligodendrocytes, astroglial scar tissue, lymphocytes, plasma cells, mononuclear phagocytic cells and lipid-laden cells....

journal_title：Neuropathology and applied neurobiology

authors： Cook RD

更新日期：1979-09-01 00:00:00

abstract：:Cyclins are important regulators of the cell cycle; there is increasing evidence that some cyclins are positively involved in carcinogenesis. Amplification and translocation of the cyclin genes and overexpression of their mRNAs and proteins have been observed in a variety of tumours. We studied cyclin A protein in ast...

journal_title：Neuropathology and applied neurobiology

authors： Chakrabarty A,Bridges LR

更新日期：1998-06-01 00:00:00

abstract：AIMS:post-haemorrhagic ventricular dilatation (PHVD) is a significant problem in neonatal care, with sequelae extending beyond childhood. Its management is important in determining outcome. Although rodent hydrocephalus models have been developed, PHVD, as a specific entity with a distinct pathophysiology, has not been...

journal_title：Neuropathology and applied neurobiology

authors： Aquilina K,Chakkarapani E,Love S,Thoresen M

更新日期：2011-02-01 00:00:00

abstract：:The role of Schwann cells (SC) in perineurial regeneration after nerve injury has not yet been resolved. It was hypothesized that SC alone are able to induce at least partial morphological restoration of the destroyed orthotopic perineureum (PN). To test the hypothesis, a permanently denervated segment of the rat scia...

journal_title：Neuropathology and applied neurobiology

authors： Popović M,Bresjanac M,Sketelj J

更新日期：2000-06-01 00:00:00

abstract：AIMS:This study explores the neuroprotective effects and mechanisms of N-acetyl-L-cysteine (NAC) in mice exposed to cadmium (Cd). METHODS:NAC (150 mg/kg) was intraperitoneally administered to mice exposed to Cd (10-50 mg/L) in drinking water for 6 weeks. The changes of cell damage and death, reactive oxygen species (R...

journal_title：Neuropathology and applied neurobiology

authors： Chen S,Ren Q,Zhang J,Ye Y,Zhang Z,Xu Y,Guo M,Ji H,Xu C,Gu C,Gao W,Huang S,Chen L

更新日期：2014-10-01 00:00:00

abstract：:Viliuisk encephalomyelitis (VE) is an unique neurological disease occurring in the Iakut (Sakha) people of Siberia. Evolution of the disease follows one of three broad clinical forms: subacute, slowly progressive or chronic. Death occurs within 3 to 6 months in subacute cases and within 6 years in the slowly progressi...

journal_title：Neuropathology and applied neurobiology

authors： McLean CA,Masters CL,Vladimirtsev VA,Prokhorova IA,Goldfarb LG,Asher DM,Vladimirtsev AI,Alekseev VP,Gajdusek DC

更新日期：1997-06-01 00:00:00

abstract：AIMS:Much evidence demonstrates that Toll-like receptor-4 (TLR4)-mediated microglial activation is an important contributor to the inflammatory injury in intracerebral haemorrhage (ICH). However, the exact mechanism of TLR4-mediated microglial activation induced by ICH is not clear. In addition, microglial autophagy is...

journal_title：Neuropathology and applied neurobiology

authors： Yang Z,Liu B,Zhong L,Shen H,Lin C,Lin L,Zhang N,Yuan B

更新日期：2015-06-01 00:00:00

abstract：AIMS:EphB2 is a member of receptor tyrosine kinases (RTKs) family that is essential for the cell adhesion, neural crest migration, axon guidance and synaptogenesis in the nervous system. Recent studies show that preservation of EphB2 in a transgenic mouse model of Alzheimer's disease (AD) rescues the cognitive deficit,...

journal_title：Neuropathology and applied neurobiology

authors： Qu M,Jiang J,Liu XP,Tian Q,Chen LM,Yin G,Liu D,Wang JZ,Zhu LQ

更新日期：2013-10-01 00:00:00

abstract：:Minute amounts of tetanus toxin injected into the hippocampus of rats results in an epileptiform syndrome. When the toxin injection is made unilaterally or bilaterally into the ventral hippocampus, about one-third of animals with seizures show bilateral neuronal loss in dorsal CA1 of the hippocampus after 1 week. In a...

journal_title：Neuropathology and applied neurobiology

authors： Shaw JA,Perry VH,Mellanby J

更新日期：1994-08-01 00:00:00

abstract：:Rats were given 2,5-hexanediol in their water for more than 5 weeks. The changes in the optic pathways were studied both qualitatively and quantitatively. Increase in 10-nm filaments within axons was noticeable from 10 days onwards in the superior colliculus and in the brachium of the superior colliculus. From then on...

journal_title：Neuropathology and applied neurobiology

authors： Jones HB,Cavanagh JB

更新日期：1982-07-01 00:00:00