Role of axon-deprived Schwann cells in perineurial regeneration in the rat sciatic nerve.

abstract：:A disorder of the gracile axonal dystrophy (GAD) mutant mouse is characterized by a neuromuscular disease with sensory ataxia (detectable 30 days after birth) and paresis of the hindlimbs (detectable at 80 days). In the sensory ataxia stage, histological study of the primary sensory system shows that, in addition to t...

journal_title：Neuropathology and applied neurobiology

authors： Oda K,Yamazaki K,Miura H,Shibasaki H,Kikuchi T

更新日期：1992-06-01 00:00:00

abstract：:Diabetic neuropathy is probably the most common and one of the most disabling complications of diabetes mellitus. Although several possible pathogenetic mechanisms for this complication have been suggested, they cannot easily be tested in man. Therefore animal models with induced or spontaneous onset of diabetes melli...

journal_title：Neuropathology and applied neurobiology

authors： Sima AA

更新日期：1985-07-01 00:00:00

abstract：:Creutzfeldt-Jakob disease (CJD) is characterized by a loss of neurons accompanied by astrogliosis and spongiform changes in the neuropil. It has been recognized that reactive microglia occur in CJD but little is known about the regional distribution and extent of the microglial activation. We have, therefore, examined...

journal_title：Neuropathology and applied neurobiology

authors： Mühleisen H,Gehrmann J,Meyermann R

更新日期：1995-12-01 00:00:00

abstract：:There is a great deal of evidence suggesting an important role for systemic inflammation in the pathogenesis of Alzheimer's disease. The role of systemic inflammation, and indeed inflammation in general, is still largely considered to be as a contributor to the disease process rather than of aetiological importance al...

journal_title：Neuropathology and applied neurobiology

authors： Holmes C

更新日期：2013-02-01 00:00:00

abstract：:Inflammatory cells from the meninges of guinea-pigs with acute EAE have been isolated and quantitated. A mean of 7.5 x 10(6) cells were recovered from the brains of animals showing clinical signs of disease in contrast to only 1.5 x 10(6) cells in the controls. The immunological specificity of the meningeal inflammato...

journal_title：Neuropathology and applied neurobiology

authors： Allsopp G,Parker D,Hinrichs DJ,Turk JL

更新日期：1981-03-01 00:00:00

abstract：AIMS:Apolipoprotein A-I (apoA-I), the principal apolipoprotein associated with high-density lipoproteins in the periphery, is also found at high concentrations in the cerebrospinal fluid. Previous studies have reported either no impact or vascular-specific effects of apoA-I knockout (KO) on β-amyloid (Aβ) pathology. Ho...

journal_title：Neuropathology and applied neurobiology

authors： Contu L,Carare RO,Hawkes CA

更新日期：2019-12-01 00:00:00

abstract：:Ten minutes of total cerebral ischaemia was produced in normo- and hypoglycaemic rats. The most conspicuous findings were loss of hippocampal (CA-1) pyramidal cells and Purkinje cells, which were most pronounced in the normoglycaemic rats. While pre-ischaemic hypoglycaemia to some extent protected these cells, it led ...

journal_title：Neuropathology and applied neurobiology

authors： Diemer NH,Siemkowicz E

更新日期：1981-05-01 00:00:00

abstract：:Two cases of Aspergillus infection of the nervous system are reported. In the first case it occurred in a healthy individual and presented as a space occupying lesion mimicking a tuberculous granuloma. In the second case it was an opportunistic infection in a patient with predisposing conditions and manifested as chro...

journal_title：Neuropathology and applied neurobiology

authors： Diengdoh JV,Barnard RO,Thomas DG

更新日期：1983-11-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme complex that synthesizes telomere DNA. It is detected in 85-90% of malignant tumours in humans, but not in most somatic cells. Because telomerase plays a critical role in cell immortality, it represents an important target for anticancer therapies. We have previously shown that...

journal_title：Neuropathology and applied neurobiology

authors： Long S,Argyle DJ,Nixon C,Nicholson I,Botteron C,Olby N,Platt S,Smith K,Rutteman GR,Grinwis GC,Nasir L

更新日期：2006-12-01 00:00:00

abstract：:Medulloblastomas (MBs) are malignant primitive neuroectodermal tumours (PNETs) of the cerebellum occurring predominantly in childhood. The association of monosomy of chromosome 22 with MB is controversial. Atypical teratoid/rhabdoid tumours (AT/RTs) of the brain share clinical and histological features with MBs and su...

journal_title：Neuropathology and applied neurobiology

authors： Kraus JA,Oster C,Sörensen N,Berthold F,Schlegel U,Tonn JC,Wiestler OD,Pietsch T

更新日期：2002-04-01 00:00:00

abstract：AIMS:Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for some of the cognitive impairment not fully explained by Alzheimer-type pathology. METHODS:Fr...

journal_title：Neuropathology and applied neurobiology

authors： Simpson JE,Ince PG,Minett T,Matthews FE,Heath PR,Shaw PJ,Goodall E,Garwood CJ,Ratcliffe LE,Brayne C,Rattray M,Wharton SB,MRC Cognitive Function and Ageing Neuropathology Study Group.

更新日期：2016-02-01 00:00:00

abstract：:Patients infected with the malaria parasite Plasmodium falciparum may develop a diffuse reversible encephalopathy, termed cerebral malaria. It is unclear how the intraerythrocytic parasite, which sequesters in the cerebral microvasculature but does not enter the brain parenchyma, induces this neurological syndrome. Ad...

journal_title：Neuropathology and applied neurobiology

authors： Brown H,Hien TT,Day N,Mai NT,Chuong LV,Chau TT,Loc PP,Phu NH,Bethell D,Farrar J,Gatter K,White N,Turner G

更新日期：1999-08-01 00:00:00

abstract：:Mutation of the LRRK2 gene has been associated with autosomal dominant parkinsonism. An R1441C pathogenic substitution was identified in Family D, a large Western Nebraskan kindred, with four members demonstrating pleomorphic pathology at autopsy. One member of this family displayed tau pathology suggestive of progres...

journal_title：Neuropathology and applied neurobiology

authors： Ross OA,Whittle AJ,Cobb SA,Hulihan MM,Lincoln SJ,Toft M,Farrer MJ,Dickson DW

更新日期：2006-02-01 00:00:00

abstract：AIMS:Frontotemporal lobar degeneration (FTLD) and motor neurone disease are linked by the possession of a hexanucleotide repeat expansion in C9ORF72, and both show neuronal cytoplasmic inclusions within cerebellar and hippocampal neurones which are TDP-43 negative but immunoreactive for p62 and dipeptide repeat protein...

journal_title：Neuropathology and applied neurobiology

authors： Baborie A,Griffiths TD,Jaros E,Perry R,McKeith IG,Burn DJ,Masuda-Suzukake M,Hasegawa M,Rollinson S,Pickering-Brown S,Robinson AC,Davidson YS,Mann DM

更新日期：2015-08-01 00:00:00

abstract：:Damage to the frontal cortex and to the hippocampus, both in terms of cell loss and neuronal dysfunction, is thought to underlie many of the neurological and behavioural consequences of traumatic brain injury (TBI). Several studies have indicated that the hippocampus is particularly susceptible to central nervous syst...

journal_title：Neuropathology and applied neurobiology

authors： Rall JM,Matzilevich DA,Dash PK

更新日期：2003-04-01 00:00:00

abstract：AIMS:Neurogenesis in adult humans occurs in at least two areas of the brain, the subventricular zone of the telencephalon and the subgranular layer of the dentate gyrus in the hippocampal formation. We studied dentate gyrus subgranular layer neurogenesis in patients subjected to tailored antero-mesial temporal resectio...

journal_title：Neuropathology and applied neurobiology

authors： Paradisi M,Fernández M,Del Vecchio G,Lizzo G,Marucci G,Giulioni M,Pozzati E,Antonelli T,Lanzoni G,Bagnara GP,Giardino L,Calzà L

更新日期：2010-10-01 00:00:00

abstract：:A 50-year-old female patient died of an untreatable glioma apoplecticum. At autopsy a strongly vascularized glial tumour was found. The criteria for malignancy according to the WHO classification were only partially fulfilled by this tumour which displayed morphological features of an astrocytoma but could not be furt...

journal_title：Neuropathology and applied neurobiology

authors： Radner H,Kleinert R,Vennigerholz F,Denk H

更新日期：1990-04-01 00:00:00

abstract：:Clinicopathological observations suggest there is considerable overlap between vascular dementia (VaD) and Alzheimer's disease (AD). We used immunochemical methods to compare quantities of amyloid-beta (Abeta) peptides in post mortem brain samples from VaD, AD subjects and nondemented ageing controls. Total Abeta pept...

journal_title：Neuropathology and applied neurobiology

authors： Lewis H,Beher D,Cookson N,Oakley A,Piggott M,Morris CM,Jaros E,Perry R,Ince P,Kenny RA,Ballard CG,Shearman MS,Kalaria RN

更新日期：2006-04-01 00:00:00

abstract：AIMS:This study explores the neuroprotective effects and mechanisms of N-acetyl-L-cysteine (NAC) in mice exposed to cadmium (Cd). METHODS:NAC (150 mg/kg) was intraperitoneally administered to mice exposed to Cd (10-50 mg/L) in drinking water for 6 weeks. The changes of cell damage and death, reactive oxygen species (R...

journal_title：Neuropathology and applied neurobiology

authors： Chen S,Ren Q,Zhang J,Ye Y,Zhang Z,Xu Y,Guo M,Ji H,Xu C,Gu C,Gao W,Huang S,Chen L

更新日期：2014-10-01 00:00:00

abstract：:Over the last decade, there has been increasing evidence that hyperactivation of the mechanistic target of rapamycin (mTOR) pathway is a hallmark of malformations of cortical development such as focal cortical dysplasia (FCD) or hemimegalencephaly. The mTOR pathway governs protein and lipid synthesis, cell growth and ...

journal_title：Neuropathology and applied neurobiology

authors： Marsan E,Baulac S

更新日期：2018-02-01 00:00:00

abstract：AIMS:Little is known about the immune response of the brain to invasive meningiomas. The present study was based upon the hypothesis that the microglial/macrophagic response towards brain-invasive meningiomas is dependent on the intactness of the pial-glial basement membrane. METHODS:We immunostained sections from 40 ...

journal_title：Neuropathology and applied neurobiology

authors： Grund S,Schittenhelm J,Roser F,Tatagiba M,Mawrin C,Kim YJ,Bornemann A

更新日期：2009-02-01 00:00:00

abstract：:Oligodendrocyte progenitors, originating in the ventral ventricular zone of the embryonic rodent spinal cord, migrate and differentiate into the oligodendrocytes myelinating the future white matter. Transcripts for the dm-20 isoform of the proteolipid protein (plp) gene are detectable initially in cells of the ventral...

journal_title：Neuropathology and applied neurobiology

authors： Dickinson PJ,Fanarraga ML,Griffiths IR,Barrie JM,Kyriakides E,Montague P

更新日期：1996-06-01 00:00:00

abstract：:The causes of most neurological disorders are not fully understood. Inflammation and blood-brain barrier dysfunction appear to play major roles in the pathology of these diseases. Inflammatory insults that occur during brain development may have widespread effects later in life for a spectrum of neurological disorders...

journal_title：Neuropathology and applied neurobiology

authors： Stolp HB,Dziegielewska KM

更新日期：2009-04-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF)-1alpha is a transcription factor that promotes ischaemia-driven angiogenesis. The aim of this study was to determine the relation of HIF-1alpha to vascular endothelial growth factor (VEGF; an important angiogenic molecule in brain tumours), p53 expression, angiogenesis, proliferative pot...

journal_title：Neuropathology and applied neurobiology

authors： Korkolopoulou P,Patsouris E,Konstantinidou AE,Pavlopoulos PM,Kavantzas N,Boviatsis E,Thymara I,Perdiki M,Thomas-Tsagli E,Angelidakis D,Rologis D,Sakkas D

更新日期：2004-06-01 00:00:00

abstract：:The four GPI-anchored cell adhesion molecules that exemplify the IgLON family are most highly expressed in the nervous system and associate to form up to six different heterodimeric 'Diglons' that can modify cell adhesion and inhibit axon migration. Recently, two members, OPCML and LSAMP, were identified as putative t...

journal_title：Neuropathology and applied neurobiology

authors： Reed JE,Dunn JR,du Plessis DG,Shaw EJ,Reeves P,Gee AL,Warnke PC,Sellar GC,Moss DJ,Walker C

更新日期：2007-02-01 00:00:00

abstract：AIMS:Cytoplasmic accumulation of the nuclear protein transactive response DNA-binding protein 43 (TDP-43) is an early determinant of motor neuron degeneration in most amyotrophic lateral sclerosis (ALS) cases. We previously disclosed this accumulation in circulating lymphomonocytes (CLM) of ALS patients with mutant TAR...

journal_title：Neuropathology and applied neurobiology

authors： De Marco G,Lomartire A,Calvo A,Risso A,De Luca E,Mostert M,Mandrioli J,Caponnetto C,Borghero G,Manera U,Canosa A,Moglia C,Restagno G,Fini N,Tarella C,Giordana MT,Rinaudo MT,Chiò A

更新日期：2017-02-01 00:00:00

abstract：:It has previously been suggested that the pathological abnormalities seen in muscle biopsies from patients with motor neuron disease (MND) are of predictive value in relation to the rate of progression of the disease. In this study, quadriceps muscle biopsies from 19 patients with MND and 20 age matched controls were ...

journal_title：Neuropathology and applied neurobiology

authors： Froes MM,Kristmundsdottir F,Mahon M,Cumming WJ

更新日期：1987-11-01 00:00:00

abstract：:Oestrogen receptors and progesterone receptors were measured by an isoelectric focussing technique in cytosols from cryostat sections of eight human pituitary adenomas. Cryostat sections adjacent to the assayed sample were stained for anterior pituitary hormones using the peroxidase-antiperoxidase technique, and the c...

journal_title：Neuropathology and applied neurobiology

authors： Ironside JW,Dangerfield VJ,Timperley WR,Underwood JC

更新日期：1986-11-01 00:00:00

abstract：:Corpora amylacea (CAm) are regarded as a hallmark of brain ageing, but little is known about their role in normal and pathological circumstances. CAm contain, in addition to glucose polymers, ageing-, stress- and proinflammatory proteins. In view of their almost universal occurrence and their cumulation with time, for...

journal_title：Neuropathology and applied neurobiology

authors： Botez G,Rami A

更新日期：2001-12-01 00:00:00

abstract：AIMS:Plectin, a universally expressed multi-functional cytolinker protein, is crucial for intermediate filament networking, including crosstalk with actomyosin and microtubules. In addition to its involvement in a number of diseases affecting skin, skeletal muscle, heart, and other stress-exposed tissues, indications f...

journal_title：Neuropathology and applied neurobiology

authors： Valencia RG,Mihailovska E,Winter L,Bauer K,Fischer I,Walko G,Jorgacevski J,Potokar M,Zorec R,Wiche G

更新日期：2021-02-01 00:00:00