Regional neurone damage after cerebral ischaemia in the normo- and hypoglycaemic rat.

abstract：:There is a great deal of evidence suggesting an important role for systemic inflammation in the pathogenesis of Alzheimer's disease. The role of systemic inflammation, and indeed inflammation in general, is still largely considered to be as a contributor to the disease process rather than of aetiological importance al...

journal_title：Neuropathology and applied neurobiology

authors： Holmes C

更新日期：2013-02-01 00:00:00

abstract：AIMS:Transition metals, oxidative stress and neuroinflammation have been proposed as part of a vicious cycle in central nervous system neurodegeneration. Our aim was to study the anti-inflammatory effect of pioglitazone, a peroxisome proliferative activated receptor-γ agonist, on iron-induced oxidative injury in rat br...

journal_title：Neuropathology and applied neurobiology

authors： Yu HC,Feng SF,Chao PL,Lin AM

更新日期：2010-12-01 00:00:00

abstract：AIMS:Much evidence demonstrates that Toll-like receptor-4 (TLR4)-mediated microglial activation is an important contributor to the inflammatory injury in intracerebral haemorrhage (ICH). However, the exact mechanism of TLR4-mediated microglial activation induced by ICH is not clear. In addition, microglial autophagy is...

journal_title：Neuropathology and applied neurobiology

authors： Yang Z,Liu B,Zhong L,Shen H,Lin C,Lin L,Zhang N,Yuan B

更新日期：2015-06-01 00:00:00

abstract：:In this study we describe the effects of trapidil, a putative platelet-derived growth factor-antagonist, on spontaneously occurring remyelination in rat spinal cord. Demyelination was created in the dorsal funiculus of 6- and 11-week-old female rats by the direct injection of 1.0 microliter of 1% lysolecithin. The ani...

journal_title：Neuropathology and applied neurobiology

authors： McKay JS,Blakemore WF,Franklin RJ

更新日期：1997-02-01 00:00:00

abstract：AIMS:Brain oedema is a major contributing factor to the morbidity and mortality of a variety of brain disorders. Although there has been considerable progress in our understanding of pathophysiological and molecular mechanisms associated with brain oedema so far, more effective treatment is required and is still awaite...

journal_title：Neuropathology and applied neurobiology

authors： Karmacharya MB,Kim KH,Kim SY,Chung J,Min BH,Park SR,Choi BH

更新日期：2015-06-01 00:00:00

abstract：AIMS:Glioblastomas are highly aggressive and treatment resistant. Increasing evidence suggests that tumour-associated macrophages/microglia (TAMs) facilitate tumour progression by acquiring a M2-like phenotype. Our objective was to investigate the prognostic value of TAMs in gliomas using automated quantitative double ...

journal_title：Neuropathology and applied neurobiology

authors： Sørensen MD,Dahlrot RH,Boldt HB,Hansen S,Kristensen BW

更新日期：2018-02-01 00:00:00

abstract：AIMS:To explore alterations in the expression of genes encoding enzymes involved in purine metabolism in Parkinson's disease (PD) brains as purines are the core of the DNA, RNA, nucleosides and nucleotides which participate in a wide variety of crucial metabolic pathways. METHODS:Analysis of mRNA using real-time quant...

journal_title：Neuropathology and applied neurobiology

authors： Garcia-Esparcia P,Hernández-Ortega K,Ansoleaga B,Carmona M,Ferrer I

更新日期：2015-12-01 00:00:00

abstract：:This report deals with a comparative study on the expression of alpha B crystallin, ubiquitin, stress-response protein 27 (srp 27), srp 72 and phosphorylated neurofilament protein (pNFP) by ballooned neurons in Pick's disease, Creutzfeldt-Jakob disease (CJD), amyotrophic lateral sclerosis (ALS), leptomeningeal carcino...

journal_title：Neuropathology and applied neurobiology

authors： Kato S,Hirano A,Umahara T,Kato M,Herz F,Ohama E

更新日期：1992-08-01 00:00:00

abstract：:Brains from human fetuses of 13 to 27 weeks gestation have been examined immunohistologically for the presence of macrophages using the marker alpha-1-anti-chymotrypsin. A preliminary study demonstrated this to be a satisfactory marker of brain macrophages, although macrophages were also weakly positive for the more s...

journal_title：Neuropathology and applied neurobiology

authors： Gould SJ,Howard S

更新日期：1991-10-01 00:00:00

abstract：:Creutzfeldt-Jakob disease (CJD) is characterized by a loss of neurons accompanied by astrogliosis and spongiform changes in the neuropil. It has been recognized that reactive microglia occur in CJD but little is known about the regional distribution and extent of the microglial activation. We have, therefore, examined...

journal_title：Neuropathology and applied neurobiology

authors： Mühleisen H,Gehrmann J,Meyermann R

更新日期：1995-12-01 00:00:00

abstract：:Mutation of the LRRK2 gene has been associated with autosomal dominant parkinsonism. An R1441C pathogenic substitution was identified in Family D, a large Western Nebraskan kindred, with four members demonstrating pleomorphic pathology at autopsy. One member of this family displayed tau pathology suggestive of progres...

journal_title：Neuropathology and applied neurobiology

authors： Ross OA,Whittle AJ,Cobb SA,Hulihan MM,Lincoln SJ,Toft M,Farrer MJ,Dickson DW

更新日期：2006-02-01 00:00:00

abstract：AIM:Borna disease virus (BDV) induces a persistent infection in the central nervous system (CNS) accompanied by a non-purulent meningoencephalitis. BDV-infection of Lewis rats provides an important model to investigate basic principles of neurotropism, viral persistence and resulting dysfunctions. To date, the in vivo ...

journal_title：Neuropathology and applied neurobiology

authors： Werner-Keiss N,Garten W,Richt JA,Porombka D,Algermissen D,Herzog S,Baumgärtner W,Herden C

更新日期：2008-12-01 00:00:00

abstract：:Toxicity associated with abnormal protein folding and protein aggregation are major hypotheses for neurodegeneration. This article comparatively reviews the experimental and human tissue-based evidence for the involvement of such mechanisms in neuronal death associated with the motor system disorders of X-linked spino...

journal_title：Neuropathology and applied neurobiology

authors： Wood JD,Beaujeux TP,Shaw PJ

更新日期：2003-12-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) was taken from strain 13 guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis, the spinal cords removed for histological examination and meningeal stretch preparations made. CSF cells were counted and characterized by morphological studies, anti-IgG and a...

journal_title：Neuropathology and applied neurobiology

authors： Suckling AJ,Wilson NR,Kirby JA,Rumsby MG

更新日期：1983-05-01 00:00:00

abstract：:Recent studies have described silver- and tau-positive glia and threads in the degenerating lesions of progressive supranuclear palsy. In this study, Gallyas-Braak silver impregnation and several immunohistochemical techniques were employed to examine the distribution of tangles, abnormal glia and threads in the cereb...

journal_title：Neuropathology and applied neurobiology

authors： Hanihara T,Amano N,Takahashi T,Nagatomo H,Yagashita S

更新日期：1995-08-01 00:00:00

abstract：:Tubular vesicular and net-like dissolution of myelin sheaths associated with complete demyelination and preservation of axons, is described in the brain, obtained within 4 h of death, from a patient who died with acute multiple sclerosis (MS). It was rare, being found in only three out of twenty-three blocks examined,...

journal_title：Neuropathology and applied neurobiology

authors： Kirk J

更新日期：1979-08-01 00:00:00

abstract：:The tight junction protein occludin 'glues' normal, adjacent brain microvessel endothelial cells together. Malignant brain tumours cause cerebral oedema because they have leaky endothelial tight junctions, which allow plasma fluid to enter the brain from the microvessel lumen. In order to identify molecular abnormalit...

journal_title：Neuropathology and applied neurobiology

authors： Papadopoulos MC,Saadoun S,Woodrow CJ,Davies DC,Costa-Martins P,Moss RF,Krishna S,Bell BA

更新日期：2001-10-01 00:00:00

abstract：:Damage to the frontal cortex and to the hippocampus, both in terms of cell loss and neuronal dysfunction, is thought to underlie many of the neurological and behavioural consequences of traumatic brain injury (TBI). Several studies have indicated that the hippocampus is particularly susceptible to central nervous syst...

journal_title：Neuropathology and applied neurobiology

authors： Rall JM,Matzilevich DA,Dash PK

更新日期：2003-04-01 00:00:00

abstract：:The topography and cellular events in the experimental lesions caused by chlorosugars, 6-aminonicotinamide, dinitrobenzene and tribromoimidazole in animals are considered in relation to those features in human acute thiamine deficiency (Wernicke's) encephalopathy and for comparison in Leigh's disease. The topography a...

journal_title：Neuropathology and applied neurobiology

authors： Cavanagh JB

更新日期：1993-12-01 00:00:00

abstract：:Paediatric diffuse high-grade gliomas (pHGG) are rare, but deadly tumours. The discovery of recurrent mutations in the tail of histone H3, changing lysine 27 to methionine, or glycine 34 to arginine or valine, has illuminated a critical role for epigenetic dysregulation in the aetiology of childhood gliomas and opened...

journal_title：Neuropathology and applied neurobiology

authors： Kasper LH,Baker SJ

更新日期：2020-02-01 00:00:00

abstract：:To confirm the intracellular accumulation of amyloid beta-protein (Abeta), we carefully performed immunohistochemistry using brains of cynomolgus monkeys of various ages. Cortical neurones and their large neurites were immunostained with antibodies against Abeta in young monkey brains. In aged monkey brains, intracell...

journal_title：Neuropathology and applied neurobiology

authors： Kimura N,Yanagisawa K,Terao K,Ono F,Sakakibara I,Ishii Y,Kyuwa S,Yoshikawa Y

更新日期：2005-04-01 00:00:00

abstract：AIMS:Insufficient oligodendroglial differentiation of oligodendroglial progenitor cells (OPCs) is suggested to be responsible for remyelination failure and astroglial scar formation in Theiler's murine encephalomyelitis (TME). The aim of the present study is to identify molecular key regulators of OPC differentiation i...

journal_title：Neuropathology and applied neurobiology

authors： Sun Y,Lehmbecker A,Kalkuhl A,Deschl U,Sun W,Rohn K,Tzvetanova ID,Nave KA,Baumgärtner W,Ulrich R

更新日期：2015-04-01 00:00:00

abstract：AIMS:Clusterin is a topologically dynamic chaperone protein with the ability to participate in both intra- and extacellular proteostasis. Clusterin has been shown to be upregulated in the spinal cord of patients with amyotrophic lateral sclerosis (ALS) and has been shown to protect against TDP-43 protein misfolding in ...

journal_title：Neuropathology and applied neurobiology

authors： Gregory JM,Elliott E,McDade K,Bak T,Pal S,Chandran S,Abrahams S,Smith C

更新日期：2020-04-01 00:00:00

abstract：:The critical role of the neurofibromatosis 1 (NF1) gene as a tumour suppressor has been clearly demonstrated for malignancies arising in NF1 patients. However, little is known about the more common benign tumours, such as the pilocytic astrocytoma. Most NF1-associated astrocytomas are benign and clinically non-progres...

journal_title：Neuropathology and applied neurobiology

authors： Gutmann DH,Donahoe J,Brown T,James CD,Perry A

更新日期：2000-08-01 00:00:00

abstract：AIMS:Although modifications of the survival motor neurone gene are responsible for most spinal muscular atrophy (SMA) cases, the molecular pathophysiology and the muscular target proteins involved are still unknown. The aim of this study was to compare the expression of contractile and regulatory protein isoforms in qu...

journal_title：Neuropathology and applied neurobiology

authors： Stevens L,Bastide B,Maurage CA,Dupont E,Montel V,Cieniewski-Bernard C,Cuisset JM,Vallée L,Mounier Y

更新日期：2008-12-01 00:00:00

abstract：AIMS:Increasing evidences suggest a similarity in the pathophysiological mechanisms of neuronal cell death in amyotrophic lateral sclerosis (ALS) and myofibre degeneration in sporadic inclusion body myositis (sIBM). The aim of this study is to elucidate the involvement of ALS-causing proteins in the pathophysiological ...

journal_title：Neuropathology and applied neurobiology

authors： Yamashita S,Kimura E,Tawara N,Sakaguchi H,Nakama T,Maeda Y,Hirano T,Uchino M,Ando Y

更新日期：2013-06-01 00:00:00

abstract：:Neural tissue grafting presently stands as one of the more intriguing experimental strategies being applied to the problem of spinal cord regeneration. The following annotation presents an overview of recent investigations which have shown: that peripheral nerve grafts can stimulate axonal outgrowth in many descending...

journal_title：Neuropathology and applied neurobiology

authors： Reier PJ

更新日期：1985-03-01 00:00:00

abstract：:Pathologists have been establishing archives of human organs and tissue for research use for many years now. Controversy has arisen recently over these collections, particularly with regard to the right of patients or relatives to consent to removal and retention of tissue, genetic research using stored tissue samples...

journal_title：Neuropathology and applied neurobiology

authors： Ashcroft R

更新日期：2000-10-01 00:00:00

abstract：:Oestrogen receptors and progesterone receptors were measured by an isoelectric focussing technique in cytosols from cryostat sections of eight human pituitary adenomas. Cryostat sections adjacent to the assayed sample were stained for anterior pituitary hormones using the peroxidase-antiperoxidase technique, and the c...

journal_title：Neuropathology and applied neurobiology

authors： Ironside JW,Dangerfield VJ,Timperley WR,Underwood JC

更新日期：1986-11-01 00:00:00

abstract：AIMS:Neurogenesis in adult humans occurs in at least two areas of the brain, the subventricular zone of the telencephalon and the subgranular layer of the dentate gyrus in the hippocampal formation. We studied dentate gyrus subgranular layer neurogenesis in patients subjected to tailored antero-mesial temporal resectio...

journal_title：Neuropathology and applied neurobiology

authors： Paradisi M,Fernández M,Del Vecchio G,Lizzo G,Marucci G,Giulioni M,Pozzati E,Antonelli T,Lanzoni G,Bagnara GP,Giardino L,Calzà L

更新日期：2010-10-01 00:00:00