The ethics of reusing archived tissue for research.

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal devastating neurodegenerative disorder which predominantly affects the motor neurons in the brain and spinal cord. The death of the motor neurons in ALS causes subsequent muscle atrophy, paralysis and eventual death. Clinical and biological evidence now demonstrates that ...

journal_title：Neuropathology and applied neurobiology

authors： Smethurst P,Sidle KC,Hardy J

更新日期：2015-08-01 00:00:00

abstract：:Brains from human fetuses of 13 to 27 weeks gestation have been examined immunohistologically for the presence of macrophages using the marker alpha-1-anti-chymotrypsin. A preliminary study demonstrated this to be a satisfactory marker of brain macrophages, although macrophages were also weakly positive for the more s...

journal_title：Neuropathology and applied neurobiology

authors： Gould SJ,Howard S

更新日期：1991-10-01 00:00:00

abstract：:The brain is vulnerable to a number of acute insults, with traumatic brain injury being among the commonest. Neuroinflammation is a common response to acute injury and microglial activation is a key component of the inflammatory response. In the acute and subacute phase it is likely that this response is protective an...

journal_title：Neuropathology and applied neurobiology

authors： Smith C

更新日期：2013-02-01 00:00:00

abstract：:A 19-year-old male intravenous drug abuser, was admitted to hospital with a one-week history of lower limb weakness and urinary retention. He was known to have been HIV-seropositive for 3 years and had been treated for cerebral toxoplasmosis. Neurological examination confirmed flaccid paraparesis with weak ankle jerks...

journal_title：Neuropathology and applied neurobiology

authors： Geny C,Gherardi R,Boudes P,Lionnet F,Cesaro P,Gray F

更新日期：1991-04-01 00:00:00

abstract：:The relative amounts of amyloid beta-protein (A beta) in cerebral blood vessels and parenchyma vary considerably amongst patients with Alzheimer's disease (AD). Although several mechanisms have been proposed to explain this variability, the underlying genetic and environmental determinants are still unclear, as are th...

journal_title：Neuropathology and applied neurobiology

authors： Chalmers K,Wilcock GK,Love S

更新日期：2003-06-01 00:00:00

abstract：:Dementia with Lewy bodies (DLB) is characterized by the widespread presence of Lewy bodies (LBs) in the brain. alpha-Synuclein, the main component of LBs, is expressed as two main isoforms (112 and 140), but little is known about their differential expression in the brain. We compared alpha-synuclein 112 and alpha-syn...

journal_title：Neuropathology and applied neurobiology

authors： Beyer K,Lao JI,Carrato C,Mate JL,López D,Ferrer I,Ariza A

更新日期：2004-12-01 00:00:00

abstract：AIMS:Previous neuroimaging reports described morphological and functional abnormalities in anterior cingulate cortex (ACC) in schizophrenia and mood disorders. In earlier neuropathological studies, microvascular changes that could affect brain perfusion in these disorders have rarely been studied. Here, we analysed mor...

journal_title：Neuropathology and applied neurobiology

authors： Sinka L,Kovari E,Santos M,Herrmann FR,Gold G,Hof PR,Bouras C,Giannakopoulos P

更新日期：2012-12-01 00:00:00

abstract：AIMS:To explore alterations in the expression of genes encoding enzymes involved in purine metabolism in Parkinson's disease (PD) brains as purines are the core of the DNA, RNA, nucleosides and nucleotides which participate in a wide variety of crucial metabolic pathways. METHODS:Analysis of mRNA using real-time quant...

journal_title：Neuropathology and applied neurobiology

authors： Garcia-Esparcia P,Hernández-Ortega K,Ansoleaga B,Carmona M,Ferrer I

更新日期：2015-12-01 00:00:00

abstract：:Monolayer cultures of rat glial cells derived from 12 to 14 day fetal spinal cords and rat C6 glioma cells were examined for immunofluorescent reactivity with human or rabbit autoantibodies to intermediate filaments and with rabbit antibody to GFAP. The embryonic glial cells and C6 glima cells reacted identically with...

journal_title：Neuropathology and applied neurobiology

authors： Sotelo J,Toh BH,Lolait SJ,Yildiz A,Osung O,Holborow EJ

更新日期：1980-07-01 00:00:00

abstract：:The human chromosome 22 displays an unusual concentration of medically relevant genes, especially gene(s) involved in malignancies of the central nervous system. A full genomic and transcriptional characterization of this autosome will no doubt make a strong impact on the understanding of some of the processes which l...

journal_title：Neuropathology and applied neurobiology

authors： Dumanski JP

更新日期：1996-10-01 00:00:00

abstract：:Prolonged neurotoxicity of the recreational drug, MDMA (3,4-methylenedioxymethamphetamine) on serotoninergic axon terminals has been suggested. The effect of a single (15 mg/kg) dose of intraperitoneally administered MDMA on serotoninergic fibre density, defined by tryptophan hydroxylase (TpH) and serotonin transporte...

journal_title：Neuropathology and applied neurobiology

authors： Kovács GG,Andó RD,Adori C,Kirilly E,Benedek A,Palkovits M,Bagdy G

更新日期：2007-04-01 00:00:00

abstract：:Ultrastructural studies of spongiform encephalopathy (SE) reveal no very early pathological changes in kuru where membrane lamellation has been reported. This observation is challenged. In the later stages of SE, two main theories are examined--the spiroplasma theory and the prion (6 nm filament) theory. Neither are s...

journal_title：Neuropathology and applied neurobiology

authors： Gray EG

更新日期：1986-03-01 00:00:00

abstract：:Multiple system atrophy (MSA) is an unrelenting, sporadic, adult-onset, neurodegenerative disease of unknown aetiology. Its clinically progressive course is characterized by a variable combination of parkinsonism, cerebellar ataxia and/or autonomic dysfunction. Neuropathological examination often reveals gross abnorma...

journal_title：Neuropathology and applied neurobiology

authors： Ahmed Z,Asi YT,Sailer A,Lees AJ,Houlden H,Revesz T,Holton JL

更新日期：2012-02-01 00:00:00

abstract：AIMS:Little is known about the immune response of the brain to invasive meningiomas. The present study was based upon the hypothesis that the microglial/macrophagic response towards brain-invasive meningiomas is dependent on the intactness of the pial-glial basement membrane. METHODS:We immunostained sections from 40 ...

journal_title：Neuropathology and applied neurobiology

authors： Grund S,Schittenhelm J,Roser F,Tatagiba M,Mawrin C,Kim YJ,Bornemann A

更新日期：2009-02-01 00:00:00

abstract：:Protein aggregation, mitochondrial impairment and oxidative stress are common to multiple neurodegenerative diseases. Homeostasis is regulated by a balanced set of anabolic and catabolic responses, which govern removal and repair of damaged proteins and organelles. Macroautophagy is an evolutionarily conserved pathway...

journal_title：Neuropathology and applied neurobiology

authors： Cherra SJ 3rd,Dagda RK,Chu CT

更新日期：2010-04-01 00:00:00

abstract：:Semliki Forest virus infections in mice produce an encephalitis with demyelination. If before giving the virus the mice are treated with muramyl dipeptide in Freund's incomplete adjuvant, there is a significant increase in demyelination. If ovalbumin is added to the above and then followed after an interval by a secon...

journal_title：Neuropathology and applied neurobiology

authors： Illavia SJ,Webb HE,Colover J

更新日期：1988-11-01 00:00:00

abstract：:Although intrinsic tumours of the brain seldom metastasize to distant sites, their diffuse, infiltrative-invasive growth within the brain generally precludes successful surgical and adjuvant therapy. Hence, attention has now focused on novel therapeutic approaches to combat brain tumours that include the use of anti-i...

journal_title：Neuropathology and applied neurobiology

authors： Rooprai HK,Kandanearatchi A,Maidment SL,Christidou M,Trillo-Pazos G,Dexter DT,Rucklidge GJ,Widmer W,Pilkington GJ

更新日期：2001-02-01 00:00:00

abstract：:CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a type of small-artery stroke and vascular dementia-inducing pathology of the brain. In order to explain the molecular mechanisms behind the alterations to the blood vessels in CADASIL subjects, we scrutinized the e...

journal_title：Neuropathology and applied neurobiology

authors： Brulin-Fardoux P,Godfrain C,Maurage CA,De Reuck J,Hauw JJ,Kaltner H,Bovin NV,Gabius HJ,Ruchoux MM,Kiss R,Camby I

更新日期：2003-08-01 00:00:00

abstract：:The curiously consistent localization of cerebellar cortical damage in chronic alcoholism is re-evaluated in the light of selective damage, with a similar topography in the cerebellar vermal region, in superficial siderosis in man and in experimental animals exposed to certain toxic substances. Attention is drawn to t...

journal_title：Neuropathology and applied neurobiology

authors： Cavanagh JB,Holton JL,Nolan CC

更新日期：1997-10-01 00:00:00

abstract：:To confirm the intracellular accumulation of amyloid beta-protein (Abeta), we carefully performed immunohistochemistry using brains of cynomolgus monkeys of various ages. Cortical neurones and their large neurites were immunostained with antibodies against Abeta in young monkey brains. In aged monkey brains, intracell...

journal_title：Neuropathology and applied neurobiology

authors： Kimura N,Yanagisawa K,Terao K,Ono F,Sakakibara I,Ishii Y,Kyuwa S,Yoshikawa Y

更新日期：2005-04-01 00:00:00

abstract：AIMS:Alzheimer's disease (AD) is characterized by degeneration of cholinergic basal forebrain (CBF) neurons in the nucleus basalis of Meynert (nbM), which provides the major cholinergic input to the cortical mantle and is related to cognitive decline in patients with AD. Cortical histone deacetylase (HDAC) dysregulatio...

journal_title：Neuropathology and applied neurobiology

authors： Mahady L,Nadeem M,Malek-Ahmadi M,Chen K,Perez SE,Mufson EJ

更新日期：2019-06-01 00:00:00

abstract：:A demyelinating perivascular condition has been observed in the optic nerves of three cats, the lesions of which included the following features: thinly myelinated and demyelinated axons, few normal oligodendrocytes, astroglial scar tissue, lymphocytes, plasma cells, mononuclear phagocytic cells and lipid-laden cells....

journal_title：Neuropathology and applied neurobiology

authors： Cook RD

更新日期：1979-09-01 00:00:00

abstract：:Immunohistochemical staining of Thy-1 antigen was studied in rat peripheral nerves shortly after a complete crush lesion and after an epineural depot injection of lysophosphatidylcholine-palmitate (lysoPC). The Thy-1 antigen was expressed in endoneurial capillaries after 20-30 h and was visible previous to alterations...

journal_title：Neuropathology and applied neurobiology

authors： Beuche W

更新日期：1988-01-01 00:00:00

abstract：:Diabetic neuropathy is probably the most common and one of the most disabling complications of diabetes mellitus. Although several possible pathogenetic mechanisms for this complication have been suggested, they cannot easily be tested in man. Therefore animal models with induced or spontaneous onset of diabetes melli...

journal_title：Neuropathology and applied neurobiology

authors： Sima AA

更新日期：1985-07-01 00:00:00

abstract：AIMS:Rodents exposed to 3,3'-iminodipropionitrile (IDPN) develop an axonopathy similar to that observed in amyotrophic lateral sclerosis motor neurones, in which neurofilaments accumulate in swollen proximal axon segments. This study addressed the hypotheses that this proximal axonopathy is associated with loss of neur...

journal_title：Neuropathology and applied neurobiology

authors： Soler-Martín C,Vilardosa U,Saldaña-Ruíz S,Garcia N,Llorens J

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:To perform a systematic review and meta-analysis on the prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults. METHODS:We systematically reviewed and performed a meta-analysis on the prevalence of TDP-43 proteinopathy in older adults with normal c...

journal_title：Neuropathology and applied neurobiology

authors： Nascimento C,Di Lorenzo Alho AT,Bazan Conceição Amaral C,Leite REP,Nitrini R,Jacob-Filho W,Pasqualucci CA,Hokkanen SRK,Hunter S,Keage H,Kovacs GG,Grinberg LT,Suemoto CK

更新日期：2018-04-01 00:00:00

abstract：AIMS:Plectin, a universally expressed multi-functional cytolinker protein, is crucial for intermediate filament networking, including crosstalk with actomyosin and microtubules. In addition to its involvement in a number of diseases affecting skin, skeletal muscle, heart, and other stress-exposed tissues, indications f...

journal_title：Neuropathology and applied neurobiology

authors： Valencia RG,Mihailovska E,Winter L,Bauer K,Fischer I,Walko G,Jorgacevski J,Potokar M,Zorec R,Wiche G

更新日期：2021-02-01 00:00:00

abstract：:Herpes simplex virus was injected into the vitreous of suckling and adult rabbits. In the suckling rabbits the infection caused an arrested myelination of the strip. Further, the infected strips showed degenerative changes with splitting and distension of myelin sheaths which then disintegrated. Ultrastructurally, her...

journal_title：Neuropathology and applied neurobiology

authors： Kristensson K,Wiśniewski HM

更新日期：1978-01-01 00:00:00

abstract：:Cell death in gliomas may occur either by apoptosis, or, in the case of high grade tumours, by necrosis, but questions remain as to the pathogenesis and relationship between these processes. The development of cell death was investigated in multicellular glioma spheroid cultures. Spheroids model the development of cel...

journal_title：Neuropathology and applied neurobiology

authors： Bell HS,Whittle IR,Walker M,Leaver HA,Wharton SB

更新日期：2001-08-01 00:00:00

abstract：AIMS:Brain oedema is a major contributing factor to the morbidity and mortality of a variety of brain disorders. Although there has been considerable progress in our understanding of pathophysiological and molecular mechanisms associated with brain oedema so far, more effective treatment is required and is still awaite...

journal_title：Neuropathology and applied neurobiology

authors： Karmacharya MB,Kim KH,Kim SY,Chung J,Min BH,Park SR,Choi BH

更新日期：2015-06-01 00:00:00