Abstract:
:The critical role of the neurofibromatosis 1 (NF1) gene as a tumour suppressor has been clearly demonstrated for malignancies arising in NF1 patients. However, little is known about the more common benign tumours, such as the pilocytic astrocytoma. Most NF1-associated astrocytomas are benign and clinically non-progressive, though aggressive tumours are occasionally encountered. In this study, eight pilocytic astrocytomas from six individuals affected with NF1 were analysed for NF1 expression. All eight tumours demonstrated loss of neurofibromin expression by immunohistochemistry, which was confirmed in one case using Western blot analysis. Microsatellite analysis showed loss of a single NF1 allele (LOH) in two of four NF1-associated tumours. These results demonstrate that, in contrast to sporadic astrocytomas, loss of NF1 expression is an important primary genetic event in the pathogenesis of NF1-associated pilocytic astrocytomas.
journal_name
Neuropathol Appl Neurobioljournal_title
Neuropathology and applied neurobiologyauthors
Gutmann DH,Donahoe J,Brown T,James CD,Perry Adoi
10.1046/j.1365-2990.2000.00258.xkeywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
361-7issue
4eissn
0305-1846issn
1365-2990pii
nan258journal_volume
26pub_type
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journal_title:Neuropathology and applied neurobiology
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更新日期:1995-08-01 00:00:00
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