Cocaine induces cell death within the primate fetal cerebral wall.

abstract：INTRODUCTION:Cerebral ischaemia is the defining pathophysiological abnormality in most forms of vascular dementia (VAD), but the pathogenesis of the dementia remains poorly understood. In Alzheimer's disease (AD), there is early loss of synaptic proteins, but these have been little studied in VAD. MATERIALS AND METHOD...

journal_title：Neuropathology and applied neurobiology

authors： Sinclair LI,Tayler HM,Love S

更新日期：2015-06-01 00:00:00

abstract：:The relationships between the degree of cortical prion protein (PrP) deposition, tissue vacuolation and astrocytosis were studied in the frontal cortex of 27 cases of human spongiform encephalopathy, encompassing 13 cases of sporadic Creutzfeldt-Jakob disease (sCJD), four cases of familial CJD (fCJD) (one owing to E20...

journal_title：Neuropathology and applied neurobiology

authors： Fraser E,McDonagh AM,Head M,Bishop M,Ironside JW,Mann DM

更新日期：2003-10-01 00:00:00

abstract：:Obstructive hydrocephalus was induced in 12-day-old rats by the infusion of kaolin into the cisterna magna. After 7 days, cortical and ependymal lesions were made with thin wire in non-hydrocephalic brains and in hydrocephalic brains. The wounds were allowed to heal for times ranging from 1 day to 10 days post-lesion,...

journal_title：Neuropathology and applied neurobiology

authors： Collins P,Goulding DA

更新日期：1992-08-01 00:00:00

abstract：:Cyclins are important regulators of the cell cycle; there is increasing evidence that some cyclins are positively involved in carcinogenesis. Amplification and translocation of the cyclin genes and overexpression of their mRNAs and proteins have been observed in a variety of tumours. We studied cyclin A protein in ast...

journal_title：Neuropathology and applied neurobiology

authors： Chakrabarty A,Bridges LR

更新日期：1998-06-01 00:00:00

abstract：AIMS:The secondary dystroglycanopathies represent a heterogeneous group of congenital muscular dystrophies characterized by the defective glycosylation of alpha dystroglycan. These disorders are associated with mutations in at least 17 genes, including Fukutin-related protein (FKRP). At the severe end of the clinical s...

journal_title：Neuropathology and applied neurobiology

authors： Booler HS,Pagalday-Vergara V,Williams JL,Hopkinson M,Brown SC

更新日期：2017-06-01 00:00:00

abstract：:Professional boxers and other contact sport athletes are exposed to repetitive brain trauma that may affect motor functions, cognitive performance, emotional regulation and social awareness. The term of chronic traumatic encephalopathy (CTE) was recently introduced to regroup a wide spectrum of symptoms such as cerebe...

journal_title：Neuropathology and applied neurobiology

authors： Costanza A,Weber K,Gandy S,Bouras C,Hof PR,Giannakopoulos P,Canuto A

更新日期：2011-10-01 00:00:00

abstract：:In babies of low birth weight dying in the first week of life, bilirubin encephalopathy involving the thalamus only or the thalamus and one or two other areas occurred in nineteen of 376 cases examined over a 10 year period. Although coexistent germinal layer haemorrhage was present in sixteen, this was not thought to...

journal_title：Neuropathology and applied neurobiology

authors： Sherwood AJ,Smith JF

更新日期：1983-07-01 00:00:00

abstract：:Fibre type differentiation was carried out on 20 biopsies from Duchenne Muscular Dystrophy (DMD) sufferers using the acid-preincubated reaction for myofibrillar ATPase. Fibres, classified as either type 1, type 2 or 2C, were counted and their minimum diameters (least fibre axis) measured. Particular attention was paid...

journal_title：Neuropathology and applied neurobiology

authors： Watkins SC,Cullen MJ

更新日期：1985-11-01 00:00:00

abstract：AIMS:EphB2 is a member of receptor tyrosine kinases (RTKs) family that is essential for the cell adhesion, neural crest migration, axon guidance and synaptogenesis in the nervous system. Recent studies show that preservation of EphB2 in a transgenic mouse model of Alzheimer's disease (AD) rescues the cognitive deficit,...

journal_title：Neuropathology and applied neurobiology

authors： Qu M,Jiang J,Liu XP,Tian Q,Chen LM,Yin G,Liu D,Wang JZ,Zhu LQ

更新日期：2013-10-01 00:00:00

abstract：:To characterize the distribution of apoptotic neurons and their relationships with the stage of disease, a history of HIV-dementia, and the degree of productive HIV infection, microglial activation and axonal damage, we examined the brains of 40 patients. Samples of frontal and temporal cortex, basal ganglia and brain...

journal_title：Neuropathology and applied neurobiology

authors： Adle-Biassette H,Chrétien F,Wingertsmann L,Héry C,Ereau T,Scaravilli F,Tardieu M,Gray F

更新日期：1999-04-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) is a protooncogene that is frequently observed with alterations in late stage gliomas, suggesting an important role of this gene in glial tumorigenesis and progression. In this study we evaluated an antisense EGFR approach as an alternative therapeutic modality for glioblast...

journal_title：Neuropathology and applied neurobiology

authors： Tian XX,Lam PY,Chen J,Pang JC,To SS,Di-Tomaso E,Ng HK

更新日期：1998-10-01 00:00:00

abstract：AIMS:Normal neurovascular coupling, mediated by the fine interplay and communication of cells within the neurovascular unit, is critical for maintaining normal brain activity and cognitive function. This study investigated whether, with advancing age there is disruption of neurovascular coupling and specific cellular c...

journal_title：Neuropathology and applied neurobiology

authors： Duncombe J,Lennen RJ,Jansen MA,Marshall I,Wardlaw JM,Horsburgh K

更新日期：2017-10-01 00:00:00

abstract：:The pattern of cell loss and neuronal degeneration resulting from multiple microinjections of N-methyl-D-aspartate (NMDA), ibotenate (IBO), quisqualate (QUIS), and kainate (KA) into hippocampus was studied, together with the protection provided by the NMDA antagonist 3-(+/-)-2-carboxypiperazin-4-yl-propyl-1-phosphonat...

journal_title：Neuropathology and applied neurobiology

authors： Jarrard LE,Meldrum BS

更新日期：1993-10-01 00:00:00

abstract：AIMS:Population-based studies have shown that approximately 20% of the ageing population (aged 65 years and over) with dementia have little or no classical Alzheimer-type neuropathology. Cumulative DNA damage and a reduced capacity of DNA repair may result in neuronal dysfunction and contribute to cognitive impairment ...

journal_title：Neuropathology and applied neurobiology

authors： Simpson JE,Ince PG,Matthews FE,Shaw PJ,Heath PR,Brayne C,Garwood C,Higginbottom A,Wharton SB,MRC Cognitive Function and Ageing Neuropathology Study Group.

更新日期：2015-06-01 00:00:00

abstract：:The effects of exposure to a cytotoxic agent, methylazoxymethanol acetate (MAM Ac), on the distribution, density and quantitative morphology of microglia in the rat forebrain have been examined with the aid of a peroxidase-conjugated lectin derived from Griffonia simplicifolia. Following exposure to MAM Ac (25 mg/kg m...

journal_title：Neuropathology and applied neurobiology

authors： Ashwell KW

更新日期：1992-12-01 00:00:00

abstract：:Two HIV-positive male patients presented with a variety of symptoms including hemiparesis, unsteadiness, progressive loss of vision and poor memory. There were multiple non-enhancing lesions shown by CT scan in the white matter of the cerebral hemispheres. Specimens obtained by burr-hole biopsy showed the features of ...

journal_title：Neuropathology and applied neurobiology

authors： Scaravilli F,Ellis DS,Tovey G,Harcourt-Webster JN,Guiloff RJ,Sinclair E

更新日期：1989-09-01 00:00:00

abstract：:The cellular distribution of the lysosomal proteinase cathepsin D was studied in a series of 76 neoplasms and 18 non-neoplastic tissues from the human central nervous system, using a well-characterized polyclonal antibody in a peroxidase-antiperoxidase technique. In the normal and developing brain, cathepsin D is conf...

journal_title：Neuropathology and applied neurobiology

authors： Robson DK,Ironside JW,Reid WA,Bogue PR

更新日期：1990-02-01 00:00:00

abstract：AIMS:Resident and peripherally derived glioma associated microglia/macrophages (GAMM) play a key role in driving tumour progression, angiogenesis, invasion and attenuating host immune responses. Differentiating these cells' origins is challenging and current preclinical models such as irradiation-based adoptive transfe...

journal_title：Neuropathology and applied neurobiology

authors： Yu K,Youshani AS,Wilkinson FL,O'Leary C,Cook P,Laaniste L,Liao A,Mosses D,Waugh C,Shorrock H,Pathmanaban O,Macdonald A,Kamaly-Asl I,Roncaroli F,Bigger BW

更新日期：2019-02-01 00:00:00

abstract：AIMS:Limb-girdle muscular dystrophy R9 (LGMDR9) is an autosomal recessive disorder caused by mutations in the fukutin-related protein gene (FKRP), encoding a glycosyltransferase involved in α-dystroglycan modification. Muscle atrophy, a significant feature of LGMDR9, occurs by a change in the normal balance between pro...

journal_title：Neuropathology and applied neurobiology

authors： Franekova V,Storjord HI,Leivseth G,Nilssen Ø

更新日期：2020-12-18 00:00:00

abstract：AIMS:Microglial cells have been originally identified as a target for the CXC chemokine, SDF-1, by their expression of CXCR4. More recently, it has been recognized that SDF-1 additionally binds to CXCR7, which depending on the cell type acts as either a nonclassical, a classical or a scavenger chemokine receptor. Here,...

journal_title：Neuropathology and applied neurobiology

authors： Lipfert J,Ödemis V,Wagner DC,Boltze J,Engele J

更新日期：2013-10-01 00:00:00

abstract：:Tubular vesicular and net-like dissolution of myelin sheaths associated with complete demyelination and preservation of axons, is described in the brain, obtained within 4 h of death, from a patient who died with acute multiple sclerosis (MS). It was rare, being found in only three out of twenty-three blocks examined,...

journal_title：Neuropathology and applied neurobiology

authors： Kirk J

更新日期：1979-08-01 00:00:00

abstract：AIMS:Transition metals, oxidative stress and neuroinflammation have been proposed as part of a vicious cycle in central nervous system neurodegeneration. Our aim was to study the anti-inflammatory effect of pioglitazone, a peroxisome proliferative activated receptor-γ agonist, on iron-induced oxidative injury in rat br...

journal_title：Neuropathology and applied neurobiology

authors： Yu HC,Feng SF,Chao PL,Lin AM

更新日期：2010-12-01 00:00:00

abstract：:The brain is frequently affected by the spread of lung cancer, and haematogenous metastasis is a common route to brain metastasis. We therefore developed an isogenic brain metastasis model of lung cancer to use the Lewis lung carcinoma cell line and analysed dynamics of neoplastic cells after extravasation. Histologic...

journal_title：Neuropathology and applied neurobiology

authors： Saito N,Hatori T,Murata N,Zhang ZA,Ishikawa F,Nonaka H,Iwabuchi S,Samejima H

更新日期：2007-06-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF)-1alpha is a transcription factor that promotes ischaemia-driven angiogenesis. The aim of this study was to determine the relation of HIF-1alpha to vascular endothelial growth factor (VEGF; an important angiogenic molecule in brain tumours), p53 expression, angiogenesis, proliferative pot...

journal_title：Neuropathology and applied neurobiology

authors： Korkolopoulou P,Patsouris E,Konstantinidou AE,Pavlopoulos PM,Kavantzas N,Boviatsis E,Thymara I,Perdiki M,Thomas-Tsagli E,Angelidakis D,Rologis D,Sakkas D

更新日期：2004-06-01 00:00:00

abstract：AIMS:We observed a microvascular structure in the cerebral cortex that has not, to our knowledge, been previously described. We have termed the structure a 'raspberry', referring to its appearance under a bright-field microscope. We hypothesized that raspberries form through angiogenesis due to some form of brain ischa...

journal_title：Neuropathology and applied neurobiology

authors： Ek Olofsson H,Englund E

更新日期：2019-10-01 00:00:00

abstract：:Accumulating evidence indicates an important pathophysiological role of brain inflammation in epilepsy. In this review, we will provide an update of specific inflammatory pathways that have been proposed to be crucial in the underlying molecular mechanisms of epilepsy, including the interleukin-1 receptor/toll-like re...

journal_title：Neuropathology and applied neurobiology

authors： van Vliet EA,Aronica E,Vezzani A,Ravizza T

更新日期：2018-02-01 00:00:00

abstract：:Sandhoff disease is a heritable lysosomal storage disease resulting from impaired degradation of GM2 ganglioside and related substrates. A mouse model of Sandhoff disease created by gene targeting displays progressive neurological manifestations, similar to patients with the disease. In the present in vivo and in vitr...

journal_title：Neuropathology and applied neurobiology

authors： Sango K,Yamanaka S,Ajiki K,Tokashiki A,Watabe K

更新日期：2002-02-01 00:00:00

abstract：AIMS:Frontotemporal lobar degeneration (FTLD) and motor neurone disease are linked by the possession of a hexanucleotide repeat expansion in C9ORF72, and both show neuronal cytoplasmic inclusions within cerebellar and hippocampal neurones which are TDP-43 negative but immunoreactive for p62 and dipeptide repeat protein...

journal_title：Neuropathology and applied neurobiology

authors： Baborie A,Griffiths TD,Jaros E,Perry R,McKeith IG,Burn DJ,Masuda-Suzukake M,Hasegawa M,Rollinson S,Pickering-Brown S,Robinson AC,Davidson YS,Mann DM

更新日期：2015-08-01 00:00:00

abstract：AIMS:The serotonin 2A receptor (HTR2A) is widely expressed in the brain and involved in the modulation of fear, mood, anxiety and other symptoms. HTR2A and HTR2A gene variations are implicated in depression, schizophrenia, anxiety and obsessive-compulsive disorder. To understand HTR2A signalling changes in psychiatric ...

journal_title：Neuropathology and applied neurobiology

authors： Marinova Z,Monoranu CM,Fetz S,Walitza S,Grünblatt E

更新日期：2015-06-01 00:00:00

abstract：:Corpora amylacea (CAm) are regarded as a hallmark of brain ageing, but little is known about their role in normal and pathological circumstances. CAm contain, in addition to glucose polymers, ageing-, stress- and proinflammatory proteins. In view of their almost universal occurrence and their cumulation with time, for...

journal_title：Neuropathology and applied neurobiology

authors： Botez G,Rami A

更新日期：2001-12-01 00:00:00