A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort.

abstract：AIMS:In Alzheimer's disease (AD), microglial activation prompted by the presence of amyloid has been proposed as an important contributor to the neurodegenerative process. Conversely following Aβ immunization, phagocytic microglia have been implicated in plaque removal, potentially a beneficial effect. We have investig...

journal_title：Neuropathology and applied neurobiology

authors： Zotova E,Holmes C,Johnston D,Neal JW,Nicoll JA,Boche D

更新日期：2011-08-01 00:00:00

abstract：:Obstructive hydrocephalus was induced in 12-day-old rats by the infusion of kaolin into the cisterna magna. After 7 days, cortical and ependymal lesions were made with thin wire in non-hydrocephalic brains and in hydrocephalic brains. The wounds were allowed to heal for times ranging from 1 day to 10 days post-lesion,...

journal_title：Neuropathology and applied neurobiology

authors： Collins P,Goulding DA

更新日期：1992-08-01 00:00:00

abstract：:A quantitative assessment was made of the myogenic capability in vitro of muscle cells from dystrophic (129 Rej dy/dy) and normal mice from birth to 5 months old. Seeding efficiency was increased in dystrophic cells from neonatal and 1-week-old mice compared to age-matched controls. The extent of myogenesis in culture...

journal_title：Neuropathology and applied neurobiology

authors： Summers PJ,Parsons R

更新日期：1981-07-01 00:00:00

abstract：AIM:To understand the progression of CLN1 disease and develop effective therapies we need to characterize early sites of pathology. Therefore, we performed a comprehensive evaluation of the nature and timing of early CLN1 disease pathology in the spinal cord, which appears especially vulnerable, and how this may affect...

journal_title：Neuropathology and applied neurobiology

authors： Nelvagal HR,Dearborn JT,Ostergaard JR,Sands MS,Cooper JD

更新日期：2020-08-25 00:00:00

abstract：AIMS:Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease recurrence. Our aim was to shed light on the biology of pLGG...

journal_title：Neuropathology and applied neurobiology

authors： Catanzaro G,Besharat ZM,Miele E,Chiacchiarini M,Po A,Carai A,Marras CE,Antonelli M,Badiali M,Raso A,Mascelli S,Schrimpf D,Stichel D,Tartaglia M,Capper D,von Deimling A,Giangaspero F,Mastronuzzi A,Locatelli F,Ferrett

更新日期：2018-12-01 00:00:00

abstract：:Serial sections of the brains of two cases with Alzheimer's disease were stained with the standard Bodian, modified Bielschowsky (reformed Gros-Schultze's modification) and thioflavin S methods. The numbers of demonstrated Alzheimer's neurofibrillary tangles (NFTs) were different between the two silver stains: from 15...

journal_title：Neuropathology and applied neurobiology

authors： Yamamoto T,Hirano A

更新日期：1986-01-01 00:00:00

abstract：:Ten minutes of total cerebral ischaemia was produced in normo- and hypoglycaemic rats. The most conspicuous findings were loss of hippocampal (CA-1) pyramidal cells and Purkinje cells, which were most pronounced in the normoglycaemic rats. While pre-ischaemic hypoglycaemia to some extent protected these cells, it led ...

journal_title：Neuropathology and applied neurobiology

authors： Diemer NH,Siemkowicz E

更新日期：1981-05-01 00:00:00

abstract：:Existing techniques have been adapted and it has been possible to demonstrate acid phosphatase (APP) and myelin, lipid or astrocytic fibres in the same histological section. In normal controls APP was demonstrated in neurons, astrocytes, ependyma including choroid plexus epithelium and in pericytes, but not in oligode...

journal_title：Neuropathology and applied neurobiology

authors： Allen IV,Glover G,McKeown SR,McCormick D

更新日期：1979-05-01 00:00:00

abstract：:Professional boxers and other contact sport athletes are exposed to repetitive brain trauma that may affect motor functions, cognitive performance, emotional regulation and social awareness. The term of chronic traumatic encephalopathy (CTE) was recently introduced to regroup a wide spectrum of symptoms such as cerebe...

journal_title：Neuropathology and applied neurobiology

authors： Costanza A,Weber K,Gandy S,Bouras C,Hof PR,Giannakopoulos P,Canuto A

更新日期：2011-10-01 00:00:00

abstract：:An unusual inherited progressive distal myopathy of early childhood onset is described in two sisters from a consanguineous Asian family. Motor milestones were normal but gait deteriorated slowly thereafter with development of generalized hypotonia and muscle weakness particularly in the wrist extensors and hand muscl...

journal_title：Neuropathology and applied neurobiology

authors： Mahon M,Kristmundsdottir F,Cumming WJ,Noronha MJ

更新日期：1989-01-01 00:00:00

abstract：AIMS:Insufficient oligodendroglial differentiation of oligodendroglial progenitor cells (OPCs) is suggested to be responsible for remyelination failure and astroglial scar formation in Theiler's murine encephalomyelitis (TME). The aim of the present study is to identify molecular key regulators of OPC differentiation i...

journal_title：Neuropathology and applied neurobiology

authors： Sun Y,Lehmbecker A,Kalkuhl A,Deschl U,Sun W,Rohn K,Tzvetanova ID,Nave KA,Baumgärtner W,Ulrich R

更新日期：2015-04-01 00:00:00

abstract：:Multiple system atrophy (MSA) is an unrelenting, sporadic, adult-onset, neurodegenerative disease of unknown aetiology. Its clinically progressive course is characterized by a variable combination of parkinsonism, cerebellar ataxia and/or autonomic dysfunction. Neuropathological examination often reveals gross abnorma...

journal_title：Neuropathology and applied neurobiology

authors： Ahmed Z,Asi YT,Sailer A,Lees AJ,Houlden H,Revesz T,Holton JL

更新日期：2012-02-01 00:00:00

abstract：:The four GPI-anchored cell adhesion molecules that exemplify the IgLON family are most highly expressed in the nervous system and associate to form up to six different heterodimeric 'Diglons' that can modify cell adhesion and inhibit axon migration. Recently, two members, OPCML and LSAMP, were identified as putative t...

journal_title：Neuropathology and applied neurobiology

authors： Reed JE,Dunn JR,du Plessis DG,Shaw EJ,Reeves P,Gee AL,Warnke PC,Sellar GC,Moss DJ,Walker C

更新日期：2007-02-01 00:00:00

abstract：AIMS:The aim of this study was to describe the regional profiles of microglial activation in sporadic Creutzfeldt-Jakob disease (sCJD) subtypes and analyse the influence of prion strain, disease duration and codon 129 genotype. METHODS:We studied the amount/severity and distribution of activated microglia, protease-re...

journal_title：Neuropathology and applied neurobiology

authors： Franceschini A,Strammiello R,Capellari S,Giese A,Parchi P

更新日期：2018-10-01 00:00:00

abstract：:The brain is frequently affected by the spread of lung cancer, and haematogenous metastasis is a common route to brain metastasis. We therefore developed an isogenic brain metastasis model of lung cancer to use the Lewis lung carcinoma cell line and analysed dynamics of neoplastic cells after extravasation. Histologic...

journal_title：Neuropathology and applied neurobiology

authors： Saito N,Hatori T,Murata N,Zhang ZA,Ishikawa F,Nonaka H,Iwabuchi S,Samejima H

更新日期：2007-06-01 00:00:00

abstract：:Clinical, neuropathological and molecular genetic studies in a 9 month old boy with Pelizaeus-Merzbacher disease are described. The principal clinical features were developmental delay, nystagmus, stridor and seizures. Both brain and spinal cord showed almost complete absence of stainable central myelin, while cranial...

journal_title：Neuropathology and applied neurobiology

authors： Harding B,Ellis D,Malcolm S

更新日期：1995-04-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) was taken from strain 13 guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis, the spinal cords removed for histological examination and meningeal stretch preparations made. CSF cells were counted and characterized by morphological studies, anti-IgG and a...

journal_title：Neuropathology and applied neurobiology

authors： Suckling AJ,Wilson NR,Kirby JA,Rumsby MG

更新日期：1983-05-01 00:00:00

abstract：:The presence of histological variants of haemangioblastoma is well established, but data on the prognostic implications of histological subtyping are missing. We thus characterized clinical factors associated with histological subtypes, that is, of the cellular and reticular variant of haemangioblastoma, in a series o...

journal_title：Neuropathology and applied neurobiology

authors： Hasselblatt M,Jeibmann A,Gerss J,Behrens C,Rama B,Wassmann H,Paulus W

更新日期：2005-12-01 00:00:00

abstract：:Paediatric diffuse high-grade gliomas (pHGG) are rare, but deadly tumours. The discovery of recurrent mutations in the tail of histone H3, changing lysine 27 to methionine, or glycine 34 to arginine or valine, has illuminated a critical role for epigenetic dysregulation in the aetiology of childhood gliomas and opened...

journal_title：Neuropathology and applied neurobiology

authors： Kasper LH,Baker SJ

更新日期：2020-02-01 00:00:00

abstract：:Unless treated with effective antiretroviral therapy many AIDS patients develop a characteristic vacuolar myelopathy of the spinal cord associated with moderate clinical disability. Opinion is divided as to whether vacuolar myelopathy is causally linked to HIV myelitis. To investigate this further, spinal cord patholo...

journal_title：Neuropathology and applied neurobiology

authors： Shepherd EJ,Brettle RP,Liberski PP,Aguzzi A,Ironside JW,Simmonds P,Bell JE

更新日期：1999-02-01 00:00:00

abstract：:Transparent Golgi preparations counterstained for Alzheimer's neurofibrillary changes rendered possible the demonstration of neuropil threads in defined cellular processes. Only dendrites of tangle-bearing cortical nerve cells were found to contain neuropil threads. Processes of glial cells as well as axons present in...

journal_title：Neuropathology and applied neurobiology

authors： Braak H,Braak E

更新日期：1988-01-01 00:00:00

abstract：:To characterize the distribution of apoptotic neurons and their relationships with the stage of disease, a history of HIV-dementia, and the degree of productive HIV infection, microglial activation and axonal damage, we examined the brains of 40 patients. Samples of frontal and temporal cortex, basal ganglia and brain...

journal_title：Neuropathology and applied neurobiology

authors： Adle-Biassette H,Chrétien F,Wingertsmann L,Héry C,Ereau T,Scaravilli F,Tardieu M,Gray F

更新日期：1999-04-01 00:00:00

abstract：AIM:The insular cortex consists of a heterogenous cytoarchitecture and diverse connections and is thought to integrate autonomic, cognitive, emotional and interoceptive functions to guide behaviour. In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), it reveals α-synuclein pathology in advanced stages. The...

journal_title：Neuropathology and applied neurobiology

authors： Fathy YY,Jonker AJ,Oudejans E,de Jong FJJ,van Dam AW,Rozemuller AJM,van de Berg WDJ

更新日期：2019-04-01 00:00:00

abstract：:Flow through the vasculature of an experimental rat glioma has been investigated during in situ perfusion of the brain, via the ascending aorta, with a simple saline solution. Using such a system, it has been shown previously that the blood-brain barrier will remain intact with an adequate cerebral perfusate flow rate...

journal_title：Neuropathology and applied neurobiology

authors： Luthert PJ,Greenwood J

更新日期：1994-10-01 00:00:00

abstract：:The organization of astrocytes in myelinated culture of mouse spinal cord tissue was analysed ultrastructurally and compared with the pattern in vivo. Astrocyte cell bodies and their processes, connected by punctate adhesions and gap junctions, formed a continuous layer around the entire explant. Throughout the parenc...

journal_title：Neuropathology and applied neurobiology

authors： Kusaka H,Hirano A,Bornstein MB,Raine CS

更新日期：1984-11-01 00:00:00

abstract：AIMS:Amyloid-β (Aβ) oligomers trigger synaptic degeneration that precedes plaque and tangle pathology. However, the signalling molecules that link Aβ oligomers to synaptic pathology remain unclear. Here, we addressed the potential role of RAPGEF2 as a novel signalling molecule in Aβ oligomer-induced synaptic and cognit...

journal_title：Neuropathology and applied neurobiology

authors： Jang YN,Jang H,Kim GH,Noh JE,Chang KA,Lee KJ

更新日期：2020-12-20 00:00:00

abstract：:Mitochondrial dysfunction leads to oxygen free radical (ROS) generation with consequent oxidative stress and cellular damage. Recently, activation of the cellular antioxidant system and apoptosis were demonstrated in skeletal muscle fibres from patients with mitochondrial diseases, but the underlying mechanisms remain...

journal_title：Neuropathology and applied neurobiology

authors： Filosto M,Tonin P,Vattemi G,Savio C,Rizzuto N,Tomelleri G

更新日期：2003-02-01 00:00:00

abstract：:Pathologists have been establishing archives of human organs and tissue for research use for many years now. Controversy has arisen recently over these collections, particularly with regard to the right of patients or relatives to consent to removal and retention of tissue, genetic research using stored tissue samples...

journal_title：Neuropathology and applied neurobiology

authors： Ashcroft R

更新日期：2000-10-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF)-1alpha is a transcription factor that promotes ischaemia-driven angiogenesis. The aim of this study was to determine the relation of HIF-1alpha to vascular endothelial growth factor (VEGF; an important angiogenic molecule in brain tumours), p53 expression, angiogenesis, proliferative pot...

journal_title：Neuropathology and applied neurobiology

authors： Korkolopoulou P,Patsouris E,Konstantinidou AE,Pavlopoulos PM,Kavantzas N,Boviatsis E,Thymara I,Perdiki M,Thomas-Tsagli E,Angelidakis D,Rologis D,Sakkas D

更新日期：2004-06-01 00:00:00

abstract：:Patients infected with the malaria parasite Plasmodium falciparum may develop a diffuse reversible encephalopathy, termed cerebral malaria. It is unclear how the intraerythrocytic parasite, which sequesters in the cerebral microvasculature but does not enter the brain parenchyma, induces this neurological syndrome. Ad...

journal_title：Neuropathology and applied neurobiology

authors： Brown H,Hien TT,Day N,Mai NT,Chuong LV,Chau TT,Loc PP,Phu NH,Bethell D,Farrar J,Gatter K,White N,Turner G

更新日期：1999-08-01 00:00:00