Quantitation and in vitro analysis of the inflammatory cells in experimental allergic encephalomyelitis in the guinea-pig.

abstract：BACKGROUND:Juvenile neuronal ceroid lipofuscinoses (JNCL) or juvenile Batten disease is a recessively inherited childhood neurodegenerative disorder resulting from a mutation in CLN3, which encodes a putative lysosomal protein of unknown function. AIM:Recent evidence suggests that a disruption in CLN3 function results...

journal_title：Neuropathology and applied neurobiology

authors： Chan CH,Ramirez-Montealegre D,Pearce DA

更新日期：2009-04-01 00:00:00

abstract：:The pattern of cell loss and neuronal degeneration resulting from multiple microinjections of N-methyl-D-aspartate (NMDA), ibotenate (IBO), quisqualate (QUIS), and kainate (KA) into hippocampus was studied, together with the protection provided by the NMDA antagonist 3-(+/-)-2-carboxypiperazin-4-yl-propyl-1-phosphonat...

journal_title：Neuropathology and applied neurobiology

authors： Jarrard LE,Meldrum BS

更新日期：1993-10-01 00:00:00

abstract：:Mutations in the tau gene cause familial frontotemporal dementia with parkinsonism linked to chromosome 17 characterized by filamentous tau protein deposits. Here we describe the clinical and neuropathological features of a case from a newly identified family with an intron 10+3-splice site mutation in the tau gene. T...

journal_title：Neuropathology and applied neurobiology

authors： Neumann M,Mittelbronn M,Simon P,Vanmassenhove B,de Silva R,Lees A,Klapp J,Meyermann R,Kretzschmar HA

更新日期：2005-08-01 00:00:00

abstract：AIMS:Transition metals, oxidative stress and neuroinflammation have been proposed as part of a vicious cycle in central nervous system neurodegeneration. Our aim was to study the anti-inflammatory effect of pioglitazone, a peroxisome proliferative activated receptor-γ agonist, on iron-induced oxidative injury in rat br...

journal_title：Neuropathology and applied neurobiology

authors： Yu HC,Feng SF,Chao PL,Lin AM

更新日期：2010-12-01 00:00:00

abstract：:A single dose (19 mg kg-1) of triethyllead given to weanling rats produces necrosis in a small number of hippocampal pyramidal (CA3) and hilar neurons with reversible changes in the remaining neurons of this region. The sequence of events has been studied by light and electron microscopy over a period from 12 h to 14 ...

journal_title：Neuropathology and applied neurobiology

authors： Nolan CC,Brown AW

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:In definite Creutzfeldt-Jakob disease (CJD), morphological and immunohistochemical patterns are useful to identify molecular subtypes. Severe cerebellar pathology and hippocampal involvement helps to identify VV subtypes. The rare VV1 variant (<1%), more frequent in young individuals, is additionally charact...

journal_title：Neuropathology and applied neurobiology

authors： Martinez-Saez E,Gelpi E,Rey MJ,Ferrer I,Ribalta T,Botta-Orfila T,Nos C,Yagüe J,Sanchez-Valle R

更新日期：2012-04-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is characterized by the deposition of granular osmiophilic material in association with vascular smooth muscle cells in many different organs. However, the cause of the subsequent destruction of smooth muscle cells tha...

journal_title：Neuropathology and applied neurobiology

authors： Ruchoux MM,Maurage CA

更新日期：1998-02-01 00:00:00

abstract：AIMS:Brain mural cells (BMC), smooth muscle cells and pericytes, interact closely with endothelial cells and modulate numerous cerebrovascular functions. A loss of BMC function is suspected to play a role in the pathophysiology of Alzheimer's Disease (AD). METHODS:BMC markers, namely smooth muscle alpha actin (α-SMA) ...

journal_title：Neuropathology and applied neurobiology

authors： Bourassa P,Tremblay C,Schneider JA,Bennett DA,Calon F

更新日期：2020-08-01 00:00:00

abstract：:Over the past few years, the traditional view of brain tumorigenesis has been revolutionized by advances in genomic medicine, molecular biology, stem cell biology and genetically engineered small-animal modelling. We now appreciate that paediatric brain tumours arise following specific genetic mutations in specialized...

journal_title：Neuropathology and applied neurobiology

authors： Thangarajh M,Gutmann DH

更新日期：2012-06-01 00:00:00

abstract：:The anatomical arrangement of the pia mater suggests that it may act as a regulatory interface between cerebrospinal fluid and the surface of the brain and between arterioles within the brain and the surrounding neural tissue. However, the functional aspects of such a barrier are difficult to evaluate in vivo. In the ...

journal_title：Neuropathology and applied neurobiology

authors： Feurer DJ,Weller RO

更新日期：1991-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an angiogenic factor essential for the formation of new blood vessels during embryogenesis and in many pathological conditions. A new role for VEGF as a neurotrophic factor has recently emerged. In the developing nervous system, VEGF plays a pivotal role not only in vascula...

journal_title：Neuropathology and applied neurobiology

authors： Brockington A,Lewis C,Wharton S,Shaw PJ

更新日期：2004-10-01 00:00:00

abstract：AIMS:Although modifications of the survival motor neurone gene are responsible for most spinal muscular atrophy (SMA) cases, the molecular pathophysiology and the muscular target proteins involved are still unknown. The aim of this study was to compare the expression of contractile and regulatory protein isoforms in qu...

journal_title：Neuropathology and applied neurobiology

authors： Stevens L,Bastide B,Maurage CA,Dupont E,Montel V,Cieniewski-Bernard C,Cuisset JM,Vallée L,Mounier Y

更新日期：2008-12-01 00:00:00

abstract：:The relative amounts of amyloid beta-protein (A beta) in cerebral blood vessels and parenchyma vary considerably amongst patients with Alzheimer's disease (AD). Although several mechanisms have been proposed to explain this variability, the underlying genetic and environmental determinants are still unclear, as are th...

journal_title：Neuropathology and applied neurobiology

authors： Chalmers K,Wilcock GK,Love S

更新日期：2003-06-01 00:00:00

abstract：:Irradiation of a rat hind limb at 15 days of age caused marked shortening of the limb, with a consequent reduction in nerve length. The tibial nerves of the irradiated limbs were examined qualitatively and quantitatively, and compared with the unirradiated nerve. There was no evidence of fibre degeneration and only ve...

journal_title：Neuropathology and applied neurobiology

authors： Jacobs JM,Myers R

更新日期：1993-02-01 00:00:00

abstract：:The cellular distribution of the lysosomal proteinase cathepsin D was studied in a series of 76 neoplasms and 18 non-neoplastic tissues from the human central nervous system, using a well-characterized polyclonal antibody in a peroxidase-antiperoxidase technique. In the normal and developing brain, cathepsin D is conf...

journal_title：Neuropathology and applied neurobiology

authors： Robson DK,Ironside JW,Reid WA,Bogue PR

更新日期：1990-02-01 00:00:00

abstract：:Dystrophic (D) and normal (N) chicken pectoral muscle was analysed for histopathological differences from the embryo (day 20) through to the mature adult stage. A variety of indices of structural changes were used, to express the progression quantitatively. At the embryonic stage, fibroblast numbers (but not satellite...

journal_title：Neuropathology and applied neurobiology

authors： Pizzey JA,Barnard EA

更新日期：1983-03-01 00:00:00

abstract：:Dysfunction of the ubiquitin-dependent proteolytic pathway contributes to progressive accumulation of ubiquitinated protein inclusions in neurodegenerative disorders, such as Parkinson's disease (PD). Ubiquitin C-terminal hydrolase-L1 (UCH-L1), alternatively designated protein gene product 9.5 (PGP9.5), is a neural de...

journal_title：Neuropathology and applied neurobiology

authors： Satoh JI,Kuroda Y

更新日期：2001-04-01 00:00:00

abstract：:Two cases are described, one with a multifocal cranial and limb neuropathy of adult onset associated with optic neuropathy, and the other with a diffuse demyelinating neuropathy characterized by congenital cataract, mental retardation and progressive lower limb paresis with an onset in childhood. Extensive investigati...

journal_title：Neuropathology and applied neurobiology

authors： Thomas PK,King RH,Workman JM,Schröder JM

更新日期：2000-12-01 00:00:00

abstract：:The relationships between the degree of cortical prion protein (PrP) deposition, tissue vacuolation and astrocytosis were studied in the frontal cortex of 27 cases of human spongiform encephalopathy, encompassing 13 cases of sporadic Creutzfeldt-Jakob disease (sCJD), four cases of familial CJD (fCJD) (one owing to E20...

journal_title：Neuropathology and applied neurobiology

authors： Fraser E,McDonagh AM,Head M,Bishop M,Ironside JW,Mann DM

更新日期：2003-10-01 00:00:00

abstract：AIMS:Frontotemporal lobar degeneration (FTLD) is clinically and pathologically heterogeneous. Although associated with variations in MAPT, GRN and C9ORF72, the pathogenesis of these, and of other nongenetic, forms of FTLD, remains unknown. Epigenetic factors such as histone regulation by histone deacetylases (HDAC) may...

journal_title：Neuropathology and applied neurobiology

authors： Whitehouse A,Doherty K,Yeh HH,Robinson AC,Rollinson S,Pickering-Brown S,Snowden J,Thompson JC,Davidson YS,Mann DM

更新日期：2015-02-01 00:00:00

abstract：:In a stereological study of the human substantia nigra (SN), the total number of melanin-positive and melanin-negative neurones from 28 male subjects aged 19-92 years was estimated using a uniform sampling design and optical disectors. There was a significant decrease in the total number of melanin-positive neurones a...

journal_title：Neuropathology and applied neurobiology

authors： Cabello CR,Thune JJ,Pakkenberg H,Pakkenberg B

更新日期：2002-08-01 00:00:00

abstract：:Two HIV-positive male patients presented with a variety of symptoms including hemiparesis, unsteadiness, progressive loss of vision and poor memory. There were multiple non-enhancing lesions shown by CT scan in the white matter of the cerebral hemispheres. Specimens obtained by burr-hole biopsy showed the features of ...

journal_title：Neuropathology and applied neurobiology

authors： Scaravilli F,Ellis DS,Tovey G,Harcourt-Webster JN,Guiloff RJ,Sinclair E

更新日期：1989-09-01 00:00:00

abstract：:Sclerosing meningioma is a rare morphologic subtype of meningioma and may be mistaken for atypical or malignant meningioma and astrocytoma or schwannoma because of marked collagen deposits and a sparse population of cells with little resemblance to meningothelial cells. Authors describe the histopathologic and immunop...

journal_title：Neuropathology and applied neurobiology

authors： Kim NR,Im SH,Chung CK,Suh YL,Choe G,Chi JG

更新日期：2004-04-01 00:00:00

abstract：:Multiple system atrophy (MSA) is an unrelenting, sporadic, adult-onset, neurodegenerative disease of unknown aetiology. Its clinically progressive course is characterized by a variable combination of parkinsonism, cerebellar ataxia and/or autonomic dysfunction. Neuropathological examination often reveals gross abnorma...

journal_title：Neuropathology and applied neurobiology

authors： Ahmed Z,Asi YT,Sailer A,Lees AJ,Houlden H,Revesz T,Holton JL

更新日期：2012-02-01 00:00:00

abstract：AIMS:In Alzheimer's disease (AD), microglial activation prompted by the presence of amyloid has been proposed as an important contributor to the neurodegenerative process. Conversely following Aβ immunization, phagocytic microglia have been implicated in plaque removal, potentially a beneficial effect. We have investig...

journal_title：Neuropathology and applied neurobiology

authors： Zotova E,Holmes C,Johnston D,Neal JW,Nicoll JA,Boche D

更新日期：2011-08-01 00:00:00

abstract：:Flow through the vasculature of an experimental rat glioma has been investigated during in situ perfusion of the brain, via the ascending aorta, with a simple saline solution. Using such a system, it has been shown previously that the blood-brain barrier will remain intact with an adequate cerebral perfusate flow rate...

journal_title：Neuropathology and applied neurobiology

authors： Luthert PJ,Greenwood J

更新日期：1994-10-01 00:00:00

abstract：AIMS:Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory autoimmune diseases that affect the central nervous system. Several genome-wide and candidate gene studies have identified genetic polymorphisms associated with the risk of MS or NMO. In particular, two recently published studies of meta-analy...

journal_title：Neuropathology and applied neurobiology

authors： Park TJ,Kim HJ,Kim JH,Bae JS,Cheong HS,Park BL,Shin HD

更新日期：2013-08-01 00:00:00

abstract：AIMS:Much evidence demonstrates that Toll-like receptor-4 (TLR4)-mediated microglial activation is an important contributor to the inflammatory injury in intracerebral haemorrhage (ICH). However, the exact mechanism of TLR4-mediated microglial activation induced by ICH is not clear. In addition, microglial autophagy is...

journal_title：Neuropathology and applied neurobiology

authors： Yang Z,Liu B,Zhong L,Shen H,Lin C,Lin L,Zhang N,Yuan B

更新日期：2015-06-01 00:00:00

abstract：:This report deals with a comparative study on the expression of alpha B crystallin, ubiquitin, stress-response protein 27 (srp 27), srp 72 and phosphorylated neurofilament protein (pNFP) by ballooned neurons in Pick's disease, Creutzfeldt-Jakob disease (CJD), amyotrophic lateral sclerosis (ALS), leptomeningeal carcino...

journal_title：Neuropathology and applied neurobiology

authors： Kato S,Hirano A,Umahara T,Kato M,Herz F,Ohama E

更新日期：1992-08-01 00:00:00

abstract：AIMS:To explore alterations in the expression of genes encoding enzymes involved in purine metabolism in Parkinson's disease (PD) brains as purines are the core of the DNA, RNA, nucleosides and nucleotides which participate in a wide variety of crucial metabolic pathways. METHODS:Analysis of mRNA using real-time quant...

journal_title：Neuropathology and applied neurobiology

authors： Garcia-Esparcia P,Hernández-Ortega K,Ansoleaga B,Carmona M,Ferrer I

更新日期：2015-12-01 00:00:00