当前位置： SCI文献检索 > NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY期刊下所有文献 > Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy.

Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy.

Abstract：

:In a stereological study of the human substantia nigra (SN), the total number of melanin-positive and melanin-negative neurones from 28 male subjects aged 19-92 years was estimated using a uniform sampling design and optical disectors. There was a significant decrease in the total number of melanin-positive neurones as a function of age (r(2)=0.18, residual-CV=0.35, 2P=0.032). Using the rotator method, the size distribution of the melanin-positive neurones was estimated and showed a significant difference in mean cell volume of melanin-positive neurones between the seven youngest (21,077 microm(3)) and the seven oldest individuals (32,011 microm(3)), 2P=0.022. Using a combination of the total number of melanin-positive neurones and their size distribution, the total perikaryon volume of melanin-positive neurones could be estimated and showed no decrease with increasing age (r(2)=0.01, residual-CV=0.41, 2P=0.62). Age-related decline in dopamine-transporter neurones within the SN might explain the occurrence of extrapyramidal symptoms in many elderly individuals. Although age-related cell hypertrophy is usually considered to be an indication of cell degeneration or necrosis, this might not always be the case. The fact that motor symptoms, although present in many of the elderly, are of a limited nature despite the high percentage of lost neurones could be due to a compensatory increase in the cell body of dopamine-producing SN neurones. Thus, the total amount of cell substance capable of producing the essential transmitters might not be reduced to a critically low level as a result of ageing.

journal_name

Neuropathol Appl Neurobiol

journal_title

Neuropathology and applied neurobiology

authors

Cabello CR,Thune JJ,Pakkenberg H,Pakkenberg B

doi

10.1046/j.1365-2990.2002.00393.x

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

283-91

issue

4

eissn

0305-1846

issn

1365-2990

pii

393

journal_volume

28

pub_type

杂志文章

相关文献

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY文献大全
  • Immunohistochemical expression of trk receptor proteins in focal cortical dysplasia with intractable epilepsy.

    abstract：:Focal cortical dysplasia (FCD), which is often associated with intractable epilepsy, is a form of abnormal structure of the cerebral cortex caused by a disorder of normal neocortical development. In such cerebral lesions obtained from four patients (two male, two female; average age 32.3 years at operation), the immun...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2990.1999.00180.x

    authors： Nishio S,Morioka T,Hamada Y,Hisada K,Fukui M

    更新日期：1999-06-01 00:00:00

  • Review: Mechanistic target of rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy.

    abstract：:Over the last decade, there has been increasing evidence that hyperactivation of the mechanistic target of rapamycin (mTOR) pathway is a hallmark of malformations of cortical development such as focal cortical dysplasia (FCD) or hemimegalencephaly. The mTOR pathway governs protein and lipid synthesis, cell growth and ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/nan.12463

    authors： Marsan E,Baulac S

    更新日期：2018-02-01 00:00:00

  • Congenital amaurotic idiocy--a pathological, histochemical, biochemical and ultrastructural study.

    abstract：:A case of congenital amaurotic idiocy, a subgroup of the neurovisceral lipidoses, is described. This is a rare condition of which only five cases have been reported previously. The brain was small and firm with marked neuronal loss and gliosis. Granular material with histochemical properties of the ceroid-lipofuscin g...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1985.tb00041.x

    authors： Humphreys S,Lake BD,Scholtz CL

    更新日期：1985-11-01 00:00:00

  • Lrrk2 R1441 substitution and progressive supranuclear palsy.

    abstract：:Mutation of the LRRK2 gene has been associated with autosomal dominant parkinsonism. An R1441C pathogenic substitution was identified in Family D, a large Western Nebraskan kindred, with four members demonstrating pleomorphic pathology at autopsy. One member of this family displayed tau pathology suggestive of progres...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2006.00693.x

    authors： Ross OA,Whittle AJ,Cobb SA,Hulihan MM,Lincoln SJ,Toft M,Farrer MJ,Dickson DW

    更新日期：2006-02-01 00:00:00

  • Secreted protein, acidic and rich in cysteine (SPARC) expression in astrocytic tumour cells negatively correlates with proliferation, while vascular SPARC expression is associated with patient survival.

    abstract：AIMS:Secreted protein, acidic and rich in cysteine (SPARC) is a regulator of cell-matrix interaction and has been associated with tumour stage and patient survival in various malignancies. As no large-scale study has yet been undertaken, we investigated human brain and astrocytomas for SPARC expression and associations...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2010.01072.x

    authors： Capper D,Mittelbronn M,Goeppert B,Meyermann R,Schittenhelm J

    更新日期：2010-04-01 00:00:00

  • Subependymal cells provide a faster response to ependymal injury than astrocytes in the hydrocephalic brain.

    abstract：:Obstructive hydrocephalus was induced in 12-day-old rats by the infusion of kaolin into the cisterna magna. After 7 days, cortical and ependymal lesions were made with thin wire in non-hydrocephalic brains and in hydrocephalic brains. The wounds were allowed to heal for times ranging from 1 day to 10 days post-lesion,...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1992.tb00800.x

    authors： Collins P,Goulding DA

    更新日期：1992-08-01 00:00:00

  • Immunoreactivity for Bcl-2 and C-Jun/AP1 in hippocampal corpora amylacea after ischaemia in humans.

    abstract：:Corpora amylacea (CAm) are regarded as a hallmark of brain ageing, but little is known about their role in normal and pathological circumstances. CAm contain, in addition to glucose polymers, ageing-, stress- and proinflammatory proteins. In view of their almost universal occurrence and their cumulation with time, for...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2001.00362.x

    authors： Botez G,Rami A

    更新日期：2001-12-01 00:00:00

  • Changes of 5'-nucleotidase activity in cultured glioma cells.

    abstract：:Changes of 5'-nucleotidase (5'-N) activity during subcultivation of C6 clonal rat glioma cells were studied histochemically, cytochemically and biochemically. Two different cell populations were seeded with high or low cell density respectively. 5'-N activity in cultured cells increased continuously in both population...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1985.tb00014.x

    authors： Amano S,Sasahara M,Yamada E,Kataoka H,Hazama F

    更新日期：1985-05-01 00:00:00

  • Age-related changes of intracellular Abeta in cynomolgus monkey brains.

    abstract：:To confirm the intracellular accumulation of amyloid beta-protein (Abeta), we carefully performed immunohistochemistry using brains of cynomolgus monkeys of various ages. Cortical neurones and their large neurites were immunostained with antibodies against Abeta in young monkey brains. In aged monkey brains, intracell...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2004.00624.x

    authors： Kimura N,Yanagisawa K,Terao K,Ono F,Sakakibara I,Ishii Y,Kyuwa S,Yoshikawa Y

    更新日期：2005-04-01 00:00:00

  • The fine structure of the CNS in multiple sclerosis. I. Interpretation of cytoplasmic papovavirus-like and paramyxovirus-like inclusions.

    abstract：:During an electron microscopic study of the white matter in multiple sclerosis (MS), spheroidal reticular particles were found both in MS and in control brains. These particles have previously been described in the brain in MS and in brain-derived cell cultures in subacute sclerosing panencephalitis. In both cases the...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1978.tb01347.x

    authors： Kirk J,Hutchinson WM

    更新日期：1978-09-01 00:00:00

  • Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.

    abstract：AIMS:Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for some of the cognitive impairment not fully explained by Alzheimer-type pathology. METHODS:Fr...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12252

    authors： Simpson JE,Ince PG,Minett T,Matthews FE,Heath PR,Shaw PJ,Goodall E,Garwood CJ,Ratcliffe LE,Brayne C,Rattray M,Wharton SB,MRC Cognitive Function and Ageing Neuropathology Study Group.

    更新日期：2016-02-01 00:00:00

  • Endothelial changes in muscle and skin biopsies in patients with CADASIL.

    abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is characterized by the deposition of granular osmiophilic material in association with vascular smooth muscle cells in many different organs. However, the cause of the subsequent destruction of smooth muscle cells tha...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.1998.00087.x

    authors： Ruchoux MM,Maurage CA

    更新日期：1998-02-01 00:00:00

  • Correlations between cortical and subcortical tau pathology.

    abstract：AIM:Recent studies indicate that tau pathology in Alzheimer's disease (AD) does not initially manifest in the cerebral cortex but in selected subcortical nuclei, in particular the locus ceruleus (LC). In this study we correlate both olfactory and brainstem tau pathology with neuritic Braak stages. METHODS:We examined ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2011.01244.x

    authors： Attems J,Thomas A,Jellinger K

    更新日期：2012-10-01 00:00:00

  • Loss of axonal contact causes down-regulation of the PLP gene in oligodendrocytes: evidence from partial lesions of the optic nerve.

    abstract：:We have examined the influence that axons may have on the expression of proteolipid protein (PLP), the major myelin protein of the CNS. Partial transections were made of the optic nerve of adult rats to produce approximately a 50% loss of axons. Twenty-eight days after lesioning, sections of the distal nerves were imm...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1991.tb00725.x

    authors： McPhilemy K,Griffiths IR,Mitchell LS,Kennedy PG

    更新日期：1991-08-01 00:00:00

  • Myopathology in congenital myopathies.

    abstract：:Congenital myopathies are clinically and genetically a heterogeneous group of early onset neuromuscular disorders, characterized by hypotonia and muscle weakness. Clinical severity and age of onset are variable. Many patients are severely affected at birth while others have a milder, moderately progressive or nonprogr...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/nan.12369

    authors： Sewry CA,Wallgren-Pettersson C

    更新日期：2017-02-01 00:00:00

  • Histochemical fibre typing and ultrastructure of the small fibres in Duchenne muscular dystrophy.

    abstract：:Fibre type differentiation was carried out on 20 biopsies from Duchenne Muscular Dystrophy (DMD) sufferers using the acid-preincubated reaction for myofibrillar ATPase. Fibres, classified as either type 1, type 2 or 2C, were counted and their minimum diameters (least fibre axis) measured. Particular attention was paid...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1985.tb00039.x

    authors： Watkins SC,Cullen MJ

    更新日期：1985-11-01 00:00:00

  • Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.

    abstract：INTRODUCTION:Magnetic resonance imaging (MRI) cerebral microbleeds (CMB) arise from ferromagnetic haemosiderin iron assumed to derive from extravasation of erythrocytes. Light microscopy of ageing brain frequently reveals foci of haemosiderin from single crystalloids to larger, predominantly perivascular, aggregates. T...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12062

    authors： Janaway BM,Simpson JE,Hoggard N,Highley JR,Forster G,Drew D,Gebril OH,Matthews FE,Brayne C,Wharton SB,Ince PG,MRC Cognitive Function and Ageing Neuropathology Study.

    更新日期：2014-04-01 00:00:00

  • Role of axon-deprived Schwann cells in perineurial regeneration in the rat sciatic nerve.

    abstract：:The role of Schwann cells (SC) in perineurial regeneration after nerve injury has not yet been resolved. It was hypothesized that SC alone are able to induce at least partial morphological restoration of the destroyed orthotopic perineureum (PN). To test the hypothesis, a permanently denervated segment of the rat scia...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2000.00238.x

    authors： Popović M,Bresjanac M,Sketelj J

    更新日期：2000-06-01 00:00:00

  • Antisense epidermal growth factor receptor RNA transfection in human malignant glioma cells leads to inhibition of proliferation and induction of differentiation.

    abstract：:The epidermal growth factor receptor (EGFR) is a protooncogene that is frequently observed with alterations in late stage gliomas, suggesting an important role of this gene in glial tumorigenesis and progression. In this study we evaluated an antisense EGFR approach as an alternative therapeutic modality for glioblast...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.1998.00128.x

    authors： Tian XX,Lam PY,Chen J,Pang JC,To SS,Di-Tomaso E,Ng HK

    更新日期：1998-10-01 00:00:00

  • Immunolocalization of cathepsin D in the human central nervous system and central nervous system neoplasms.

    abstract：:The cellular distribution of the lysosomal proteinase cathepsin D was studied in a series of 76 neoplasms and 18 non-neoplastic tissues from the human central nervous system, using a well-characterized polyclonal antibody in a peroxidase-antiperoxidase technique. In the normal and developing brain, cathepsin D is conf...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1990.tb00930.x

    authors： Robson DK,Ironside JW,Reid WA,Bogue PR

    更新日期：1990-02-01 00:00:00

  • A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles.

    abstract：:Serial sections of the brains of two cases with Alzheimer's disease were stained with the standard Bodian, modified Bielschowsky (reformed Gros-Schultze's modification) and thioflavin S methods. The numbers of demonstrated Alzheimer's neurofibrillary tangles (NFTs) were different between the two silver stains: from 15...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1986.tb00677.x

    authors： Yamamoto T,Hirano A

    更新日期：1986-01-01 00:00:00

  • Reversible neuronal damage in hippocampal pyramidal cells with triethyllead: the role of astrocytes.

    abstract：:A single dose (19 mg kg-1) of triethyllead given to weanling rats produces necrosis in a small number of hippocampal pyramidal (CA3) and hilar neurons with reversible changes in the remaining neurons of this region. The sequence of events has been studied by light and electron microscopy over a period from 12 h to 14 ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1989.tb01245.x

    authors： Nolan CC,Brown AW

    更新日期：1989-09-01 00:00:00

  • STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.

    abstract：AIMS:Insufficient oligodendroglial differentiation of oligodendroglial progenitor cells (OPCs) is suggested to be responsible for remyelination failure and astroglial scar formation in Theiler's murine encephalomyelitis (TME). The aim of the present study is to identify molecular key regulators of OPC differentiation i...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12133

    authors： Sun Y,Lehmbecker A,Kalkuhl A,Deschl U,Sun W,Rohn K,Tzvetanova ID,Nave KA,Baumgärtner W,Ulrich R

    更新日期：2015-04-01 00:00:00

  • Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies.

    abstract：AIM:The insular cortex consists of a heterogenous cytoarchitecture and diverse connections and is thought to integrate autonomic, cognitive, emotional and interoceptive functions to guide behaviour. In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), it reveals α-synuclein pathology in advanced stages. The...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12501

    authors： Fathy YY,Jonker AJ,Oudejans E,de Jong FJJ,van Dam AW,Rozemuller AJM,van de Berg WDJ

    更新日期：2019-04-01 00:00:00

  • Expression of late myogenic differentiation markers in sarcoplasmic masses of patients with myotonic dystrophy.

    abstract：:Sarcoplasmic masses contain disorganized myofibrillar material and are a striking feature of myotonic dystrophy. However their significance is still unclear. Using immunocytochemistry we studied the expression of cytoskeletal proteins (desmin and vimentin), dystrophin, markers of myogenic differentiation (foetal myosi...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2004.00602.x

    authors： Vattemi G,Tomelleri G,Filosto M,Savio C,Rizzuto N,Tonin P

    更新日期：2005-02-01 00:00:00

  • MHC class II expression by microglia in tetanus toxin-induced experimental epilepsy in the rat.

    abstract：:Minute amounts of tetanus toxin injected into the hippocampus of rats results in an epileptiform syndrome. When the toxin injection is made unilaterally or bilaterally into the ventral hippocampus, about one-third of animals with seizures show bilateral neuronal loss in dorsal CA1 of the hippocampus after 1 week. In a...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1994.tb00985.x

    authors： Shaw JA,Perry VH,Mellanby J

    更新日期：1994-08-01 00:00:00

  • Spinal manifestations of CLN1 disease start during the early postnatal period.

    abstract：AIM:To understand the progression of CLN1 disease and develop effective therapies we need to characterize early sites of pathology. Therefore, we performed a comprehensive evaluation of the nature and timing of early CLN1 disease pathology in the spinal cord, which appears especially vulnerable, and how this may affect...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12658

    authors： Nelvagal HR,Dearborn JT,Ostergaard JR,Sands MS,Cooper JD

    更新日期：2020-08-25 00:00:00

  • Tumour-associated microglia/macrophages predict poor prognosis in high-grade gliomas and correlate with an aggressive tumour subtype.

    abstract：AIMS:Glioblastomas are highly aggressive and treatment resistant. Increasing evidence suggests that tumour-associated macrophages/microglia (TAMs) facilitate tumour progression by acquiring a M2-like phenotype. Our objective was to investigate the prognostic value of TAMs in gliomas using automated quantitative double ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12428

    authors： Sørensen MD,Dahlrot RH,Boldt HB,Hansen S,Kristensen BW

    更新日期：2018-02-01 00:00:00

  • Aspergillosis of the nervous system. Report of two cases.

    abstract：:Two cases of Aspergillus infection of the nervous system are reported. In the first case it occurred in a healthy individual and presented as a space occupying lesion mimicking a tuberculous granuloma. In the second case it was an opportunistic infection in a patient with predisposing conditions and manifested as chro...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1983.tb00131.x

    authors： Diengdoh JV,Barnard RO,Thomas DG

    更新日期：1983-11-01 00:00:00

  • Telomeric alterations in the default mode network during the progression of Alzheimer's disease: Selective vulnerability of the precuneus.

    abstract：AIMS:Although telomere length (TL) and telomere maintenance proteins (shelterins) are markers of cellular senescence and peripheral blood biomarkers of Alzheimer's disease (AD), little information is available on telomeric alterations during the prodromal stage (MCI) of AD. We investigated TL in the default mode networ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12672

    authors： Mahady LJ,He B,Malek-Ahmadi M,Mufson EJ

    更新日期：2020-10-26 00:00:00