当前位置： SCI文献检索 > NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY期刊下所有文献 > Spongiform encephalopathy: a neurocytologist's viewpoint with a note on Alzheimer's disease.

Spongiform encephalopathy: a neurocytologist's viewpoint with a note on Alzheimer's disease.

Abstract：

:Ultrastructural studies of spongiform encephalopathy (SE) reveal no very early pathological changes in kuru where membrane lamellation has been reported. This observation is challenged. In the later stages of SE, two main theories are examined--the spiroplasma theory and the prion (6 nm filament) theory. Neither are sufficiently convincing at present. In my own ultrastudies of Creutzfeldt-Jakob disease brain, extensive dismantling of the dendritic microtubule cytoskeleton has been observed. Loss of dendritic cytoskeleton implies loss of dendritic cytotransport with abolition of postsynaptic events. This would explain neurological symptoms and death where other causes, pneumonia etc. are not involved. My experimental model, involving depletion or loss of dendritic microtubules, indicates that spongy vacuoles may be fixation artifacts. In a brief consideration of Alzheimer's disease, loss of dendritic microtubules has also been observed, with the implications mentioned above. Finally, the neuritic plaque will be considered.

journal_name

Neuropathol Appl Neurobiol

journal_title

Neuropathology and applied neurobiology

authors

Gray EG

doi

10.1111/j.1365-2990.1986.tb00047.x

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

149-72

issue

2

eissn

0305-1846

issn

1365-2990

journal_volume

12

pub_type

杂志文章

相关文献

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY文献大全
  • Toll-like receptor-4-mediated autophagy contributes to microglial activation and inflammatory injury in mouse models of intracerebral haemorrhage.

    abstract：AIMS:Much evidence demonstrates that Toll-like receptor-4 (TLR4)-mediated microglial activation is an important contributor to the inflammatory injury in intracerebral haemorrhage (ICH). However, the exact mechanism of TLR4-mediated microglial activation induced by ICH is not clear. In addition, microglial autophagy is...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12177

    authors： Yang Z,Liu B,Zhong L,Shen H,Lin C,Lin L,Zhang N,Yuan B

    更新日期：2015-06-01 00:00:00

  • The effects of the growth factor-antagonist, trapidil, on remyelination in the CNS.

    abstract：:In this study we describe the effects of trapidil, a putative platelet-derived growth factor-antagonist, on spontaneously occurring remyelination in rat spinal cord. Demyelination was created in the dorsal funiculus of 6- and 11-week-old female rats by the direct injection of 1.0 microliter of 1% lysolecithin. The ani...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：

    authors： McKay JS,Blakemore WF,Franklin RJ

    更新日期：1997-02-01 00:00:00

  • Regional pattern of microgliosis in sporadic Creutzfeldt-Jakob disease in relation to phenotypic variants and disease progression.

    abstract：AIMS:The aim of this study was to describe the regional profiles of microglial activation in sporadic Creutzfeldt-Jakob disease (sCJD) subtypes and analyse the influence of prion strain, disease duration and codon 129 genotype. METHODS:We studied the amount/severity and distribution of activated microglia, protease-re...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12461

    authors： Franceschini A,Strammiello R,Capellari S,Giese A,Parchi P

    更新日期：2018-10-01 00:00:00

  • Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress.

    abstract：:Dysfunction of the ubiquitin-dependent proteolytic pathway contributes to progressive accumulation of ubiquitinated protein inclusions in neurodegenerative disorders, such as Parkinson's disease (PD). Ubiquitin C-terminal hydrolase-L1 (UCH-L1), alternatively designated protein gene product 9.5 (PGP9.5), is a neural de...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2001.00313.x

    authors： Satoh JI,Kuroda Y

    更新日期：2001-04-01 00:00:00

  • Selective excitotoxic pathology in the rat hippocampus.

    abstract：:The pattern of cell loss and neuronal degeneration resulting from multiple microinjections of N-methyl-D-aspartate (NMDA), ibotenate (IBO), quisqualate (QUIS), and kainate (KA) into hippocampus was studied, together with the protection provided by the NMDA antagonist 3-(+/-)-2-carboxypiperazin-4-yl-propyl-1-phosphonat...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1993.tb00458.x

    authors： Jarrard LE,Meldrum BS

    更新日期：1993-10-01 00:00:00

  • HDAC2 dysregulation in the nucleus basalis of Meynert during the progression of Alzheimer's disease.

    abstract：AIMS:Alzheimer's disease (AD) is characterized by degeneration of cholinergic basal forebrain (CBF) neurons in the nucleus basalis of Meynert (nbM), which provides the major cholinergic input to the cortical mantle and is related to cognitive decline in patients with AD. Cortical histone deacetylase (HDAC) dysregulatio...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12518

    authors： Mahady L,Nadeem M,Malek-Ahmadi M,Chen K,Perez SE,Mufson EJ

    更新日期：2019-06-01 00:00:00

  • Reactive microglia in Creutzfeldt-Jakob disease.

    abstract：:Creutzfeldt-Jakob disease (CJD) is characterized by a loss of neurons accompanied by astrogliosis and spongiform changes in the neuropil. It has been recognized that reactive microglia occur in CJD but little is known about the regional distribution and extent of the microglial activation. We have, therefore, examined...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1995.tb01097.x

    authors： Mühleisen H,Gehrmann J,Meyermann R

    更新日期：1995-12-01 00:00:00

  • Optineurin is potentially associated with TDP-43 and involved in the pathogenesis of inclusion body myositis.

    abstract：AIMS:Increasing evidences suggest a similarity in the pathophysiological mechanisms of neuronal cell death in amyotrophic lateral sclerosis (ALS) and myofibre degeneration in sporadic inclusion body myositis (sIBM). The aim of this study is to elucidate the involvement of ALS-causing proteins in the pathophysiological ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2012.01297.x

    authors： Yamashita S,Kimura E,Tawara N,Sakaguchi H,Nakama T,Maeda Y,Hirano T,Uchino M,Ando Y

    更新日期：2013-06-01 00:00:00

  • Regional neurone damage after cerebral ischaemia in the normo- and hypoglycaemic rat.

    abstract：:Ten minutes of total cerebral ischaemia was produced in normo- and hypoglycaemic rats. The most conspicuous findings were loss of hippocampal (CA-1) pyramidal cells and Purkinje cells, which were most pronounced in the normoglycaemic rats. While pre-ischaemic hypoglycaemia to some extent protected these cells, it led ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1981.tb00091.x

    authors： Diemer NH,Siemkowicz E

    更新日期：1981-05-01 00:00:00

  • Quantitation and in vitro analysis of the inflammatory cells in experimental allergic encephalomyelitis in the guinea-pig.

    abstract：:Inflammatory cells from the meninges of guinea-pigs with acute EAE have been isolated and quantitated. A mean of 7.5 x 10(6) cells were recovered from the brains of animals showing clinical signs of disease in contrast to only 1.5 x 10(6) cells in the controls. The immunological specificity of the meningeal inflammato...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1981.tb00082.x

    authors： Allsopp G,Parker D,Hinrichs DJ,Turk JL

    更新日期：1981-03-01 00:00:00

  • Immunohistochemical analysis of cyclin A in astrocytic tumours.

    abstract：:Cyclins are important regulators of the cell cycle; there is increasing evidence that some cyclins are positively involved in carcinogenesis. Amplification and translocation of the cyclin genes and overexpression of their mRNAs and proteins have been observed in a variety of tumours. We studied cyclin A protein in ast...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.1998.00114.x

    authors： Chakrabarty A,Bridges LR

    更新日期：1998-06-01 00:00:00

  • Region-specific regulation of the serotonin 2A receptor expression in development and ageing in post mortem human brain.

    abstract：AIMS:The serotonin 2A receptor (HTR2A) is widely expressed in the brain and involved in the modulation of fear, mood, anxiety and other symptoms. HTR2A and HTR2A gene variations are implicated in depression, schizophrenia, anxiety and obsessive-compulsive disorder. To understand HTR2A signalling changes in psychiatric ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12167

    authors： Marinova Z,Monoranu CM,Fetz S,Walitza S,Grünblatt E

    更新日期：2015-06-01 00:00:00

  • Review: the long-term consequences of microglial activation following acute traumatic brain injury.

    abstract：:The brain is vulnerable to a number of acute insults, with traumatic brain injury being among the commonest. Neuroinflammation is a common response to acute injury and microglial activation is a key component of the inflammatory response. In the acute and subacute phase it is likely that this response is protective an...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/nan.12006

    authors： Smith C

    更新日期：2013-02-01 00:00:00

  • Synaptic protein levels altered in vascular dementia.

    abstract：INTRODUCTION:Cerebral ischaemia is the defining pathophysiological abnormality in most forms of vascular dementia (VAD), but the pathogenesis of the dementia remains poorly understood. In Alzheimer's disease (AD), there is early loss of synaptic proteins, but these have been little studied in VAD. MATERIALS AND METHOD...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12215

    authors： Sinclair LI,Tayler HM,Love S

    更新日期：2015-06-01 00:00:00

  • Lrrk2 R1441 substitution and progressive supranuclear palsy.

    abstract：:Mutation of the LRRK2 gene has been associated with autosomal dominant parkinsonism. An R1441C pathogenic substitution was identified in Family D, a large Western Nebraskan kindred, with four members demonstrating pleomorphic pathology at autopsy. One member of this family displayed tau pathology suggestive of progres...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2006.00693.x

    authors： Ross OA,Whittle AJ,Cobb SA,Hulihan MM,Lincoln SJ,Toft M,Farrer MJ,Dickson DW

    更新日期：2006-02-01 00:00:00

  • Accumulation of dipeptide repeat proteins predates that of TDP-43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene.

    abstract：AIMS:Frontotemporal lobar degeneration (FTLD) and motor neurone disease are linked by the possession of a hexanucleotide repeat expansion in C9ORF72, and both show neuronal cytoplasmic inclusions within cerebellar and hippocampal neurones which are TDP-43 negative but immunoreactive for p62 and dipeptide repeat protein...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12178

    authors： Baborie A,Griffiths TD,Jaros E,Perry R,McKeith IG,Burn DJ,Masuda-Suzukake M,Hasegawa M,Rollinson S,Pickering-Brown S,Robinson AC,Davidson YS,Mann DM

    更新日期：2015-08-01 00:00:00

  • Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies.

    abstract：AIM:The insular cortex consists of a heterogenous cytoarchitecture and diverse connections and is thought to integrate autonomic, cognitive, emotional and interoceptive functions to guide behaviour. In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), it reveals α-synuclein pathology in advanced stages. The...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12501

    authors： Fathy YY,Jonker AJ,Oudejans E,de Jong FJJ,van Dam AW,Rozemuller AJM,van de Berg WDJ

    更新日期：2019-04-01 00:00:00

  • Hirano body-rich subtypes of Creutzfeldt-Jakob disease.

    abstract：BACKGROUND:In definite Creutzfeldt-Jakob disease (CJD), morphological and immunohistochemical patterns are useful to identify molecular subtypes. Severe cerebellar pathology and hippocampal involvement helps to identify VV subtypes. The rare VV1 variant (<1%), more frequent in young individuals, is additionally charact...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2011.01208.x

    authors： Martinez-Saez E,Gelpi E,Rey MJ,Ferrer I,Ribalta T,Botta-Orfila T,Nos C,Yagüe J,Sanchez-Valle R

    更新日期：2012-04-01 00:00:00

  • Ultrastructural localization of adhalin, alpha-dystroglycan and merosin in normal and dystrophic muscle.

    abstract：:Adhalin and alpha-dystroglycan are two components of a complex of proteins that, in conjunction with dystrophin, provide a link between the subsarcolemmal cytoskeleton and the basal lamina of the extracellular matrix of skeletal muscle. In the absence of dystrophin, in Duchenne muscular dystrophy (DMD) and the mdx mou...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：

    authors： Cullen MJ,Walsh J,Roberds SL,Campbell KP

    更新日期：1996-02-01 00:00:00

  • Telomeric alterations in the default mode network during the progression of Alzheimer's disease: Selective vulnerability of the precuneus.

    abstract：AIMS:Although telomere length (TL) and telomere maintenance proteins (shelterins) are markers of cellular senescence and peripheral blood biomarkers of Alzheimer's disease (AD), little information is available on telomeric alterations during the prodromal stage (MCI) of AD. We investigated TL in the default mode networ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12672

    authors： Mahady LJ,He B,Malek-Ahmadi M,Mufson EJ

    更新日期：2020-10-26 00:00:00

  • A case of Pelizaeus-Merzbacher disease showing increased dosage of the proteolipid protein gene.

    abstract：:Clinical, neuropathological and molecular genetic studies in a 9 month old boy with Pelizaeus-Merzbacher disease are described. The principal clinical features were developmental delay, nystagmus, stridor and seizures. Both brain and spinal cord showed almost complete absence of stainable central myelin, while cranial...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1995.tb01036.x

    authors： Harding B,Ellis D,Malcolm S

    更新日期：1995-04-01 00:00:00

  • Neonatal rat model of intraventricular haemorrhage and post-haemorrhagic ventricular dilatation with long-term survival into adulthood.

    abstract：AIMS:post-haemorrhagic ventricular dilatation (PHVD) is a significant problem in neonatal care, with sequelae extending beyond childhood. Its management is important in determining outcome. Although rodent hydrocephalus models have been developed, PHVD, as a specific entity with a distinct pathophysiology, has not been...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2010.01118.x

    authors： Aquilina K,Chakkarapani E,Love S,Thoresen M

    更新日期：2011-02-01 00:00:00

  • Cryopreservation of viable human glioblastoma xenografts.

    abstract：:Human tumour xenografts maintained in nude mice are a valuable research tool. The passaging and maintenance of human tumour xenografts in immune-deficient animals are expensive and labour-intensive. This study presents a protocol that permits long-term cryopreservation of viable glioblastoma xenograft tissue pieces in...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2000.026002172.x

    authors： Goike HM,Asplund AC,Pettersson EH,Liu L,Ichimura K,Collins VP

    更新日期：2000-04-01 00:00:00

  • Arrest of myelination and demyelination in rabbit retina induced by herpes simplex virus infection.

    abstract：:Herpes simplex virus was injected into the vitreous of suckling and adult rabbits. In the suckling rabbits the infection caused an arrested myelination of the strip. Further, the infected strips showed degenerative changes with splitting and distension of myelin sheaths which then disintegrated. Ultrastructurally, her...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1978.tb00530.x

    authors： Kristensson K,Wiśniewski HM

    更新日期：1978-01-01 00:00:00

  • Knockout of apolipoprotein A-I decreases parenchymal and vascular β-amyloid pathology in the Tg2576 mouse model of Alzheimer's disease.

    abstract：AIMS:Apolipoprotein A-I (apoA-I), the principal apolipoprotein associated with high-density lipoproteins in the periphery, is also found at high concentrations in the cerebrospinal fluid. Previous studies have reported either no impact or vascular-specific effects of apoA-I knockout (KO) on β-amyloid (Aβ) pathology. Ho...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12556

    authors： Contu L,Carare RO,Hawkes CA

    更新日期：2019-12-01 00:00:00

  • Effect of ammonia on ciliary neurotrophic factor mRNA and protein expression and its upstream signalling pathway in cultured rat astroglial cells: possible implication of c-fos, Sp1 and p38MAPK.

    abstract：:Ciliary neurotrophic factor (CNTF) may be implicated in the pathogenetic mechanisms of hepatic encephalopathy. We tested this hypothesis by treating confluent primary cultures of rat astroglial cells with ammonium chloride for various periods and analysing the effect of ammonia on the signalling pathway that regulates...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2007.00831.x

    authors： Bodega G,Suárez I,Almonacid L,Ciordia S,Beloso A,López-Fernández LA,Zaballos A,Fernández B

    更新日期：2007-08-01 00:00:00

  • Glycohistochemical characterization of vascular muscle cell destruction in CADASIL subjects by lectins, neoglycoconjugates and galectin-specific antibodies.

    abstract：:CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a type of small-artery stroke and vascular dementia-inducing pathology of the brain. In order to explain the molecular mechanisms behind the alterations to the blood vessels in CADASIL subjects, we scrutinized the e...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2003.00478.x

    authors： Brulin-Fardoux P,Godfrain C,Maurage CA,De Reuck J,Hauw JJ,Kaltner H,Bovin NV,Gabius HJ,Ruchoux MM,Kiss R,Camby I

    更新日期：2003-08-01 00:00:00

  • RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.

    abstract：AIMS:Amyloid-β (Aβ) oligomers trigger synaptic degeneration that precedes plaque and tangle pathology. However, the signalling molecules that link Aβ oligomers to synaptic pathology remain unclear. Here, we addressed the potential role of RAPGEF2 as a novel signalling molecule in Aβ oligomer-induced synaptic and cognit...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12686

    authors： Jang YN,Jang H,Kim GH,Noh JE,Chang KA,Lee KJ

    更新日期：2020-12-20 00:00:00

  • Aluminium maltol-induced neurocytoskeletal changes in fetal rabbit midbrain in matrix culture.

    abstract：:We have developed a neuronal culture system to evaluate the neurotoxic effects of aluminium maltol on fetal rabbit midbrain sections containing the oculomotor nucleus. Cultures were treated with 5, 7, 9, 11, 13 and 15 mumol/l aluminium maltol or 39 and 45 mumol/l maltol (molal equivalents to 13 and 15 mumol/l aluminiu...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1991.tb00693.x

    authors： Hewitt CD,Herman MM,Lopes MB,Savory J,Wills MR

    更新日期：1991-02-01 00:00:00

  • Occludin expression in microvessels of neoplastic and non-neoplastic human brain.

    abstract：:The tight junction protein occludin 'glues' normal, adjacent brain microvessel endothelial cells together. Malignant brain tumours cause cerebral oedema because they have leaky endothelial tight junctions, which allow plasma fluid to enter the brain from the microvessel lumen. In order to identify molecular abnormalit...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.0305-1846.2001.00341.x

    authors： Papadopoulos MC,Saadoun S,Woodrow CJ,Davies DC,Costa-Martins P,Moss RF,Krishna S,Bell BA

    更新日期：2001-10-01 00:00:00