当前位置： SCI文献检索 > NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY期刊下所有文献 > The neurotoxicity of alpha-chlorohydrin in rats and mice: I. Evolution of the cellular changes.

The neurotoxicity of alpha-chlorohydrin in rats and mice: I. Evolution of the cellular changes.

Abstract：

:Mice and rats are found to be equally susceptible to developing symmetrical brain stem lesions on exposure to alpha-chlorohydrin and in both species the earliest neurotoxic changes are strictly confined to glial cells, particularly astrocytes; haemorrhages are not found in either species. Minimal evidence of increased vascular leakage of horse-radish peroxidase (HRP) in rats is shown by increased HRP content of perivascular cells within the lesions. Later macrophage invasion and capillary proliferation is accompanied by rare focal leakiness of HRP. Gross astrocytic damage, therefore, does not necessarily impair integrity of the blood-brain barrier. While early in intoxication, astrocytes are severely distended with fluid and their organelles seriously disorganized, they do not die but rapidly regenerate their processes. They thus appear to undergo a process of 'clasmatodendrosis' from which they recover. Comparisons are made with the genesis of symmetrical brain stem lesions in other acute energy deprivation syndromes, including Wernicke's encephalopathy.

journal_name

Neuropathol Appl Neurobiol

journal_title

Neuropathology and applied neurobiology

authors

Cavanagh JB,Nolan CC,Seville MP

doi

10.1111/j.1365-2990.1993.tb00434.x

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

240-52

issue

3

eissn

0305-1846

issn

1365-2990

journal_volume

19

pub_type

杂志文章

相关文献

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY文献大全
  • The cellular origin of lysosomal enzymes in the plaque in multiple sclerosis: a combined histological and biochemical study.

    abstract：:Using a combined biochemical and histological approach certain conclusions can be drawn as to the origin of the increase in lysosomal enzymes in white matter from MS brains. Firstly, there is a gradient of lysosomal enzyme activity, plaque greater than periplaque greater than macroscopically normal white matter, which...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1978.tb01357.x

    authors： McKeown SR,Allen IV

    更新日期：1978-11-01 00:00:00

  • Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress.

    abstract：:Dysfunction of the ubiquitin-dependent proteolytic pathway contributes to progressive accumulation of ubiquitinated protein inclusions in neurodegenerative disorders, such as Parkinson's disease (PD). Ubiquitin C-terminal hydrolase-L1 (UCH-L1), alternatively designated protein gene product 9.5 (PGP9.5), is a neural de...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2001.00313.x

    authors： Satoh JI,Kuroda Y

    更新日期：2001-04-01 00:00:00

  • Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.

    abstract：AIMS:Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for some of the cognitive impairment not fully explained by Alzheimer-type pathology. METHODS:Fr...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12252

    authors： Simpson JE,Ince PG,Minett T,Matthews FE,Heath PR,Shaw PJ,Goodall E,Garwood CJ,Ratcliffe LE,Brayne C,Rattray M,Wharton SB,MRC Cognitive Function and Ageing Neuropathology Study Group.

    更新日期：2016-02-01 00:00:00

  • Cytoplasmic intermediate filaments in cultured glial cells.

    abstract：:Monolayer cultures of rat glial cells derived from 12 to 14 day fetal spinal cords and rat C6 glioma cells were examined for immunofluorescent reactivity with human or rabbit autoantibodies to intermediate filaments and with rabbit antibody to GFAP. The embryonic glial cells and C6 glima cells reacted identically with...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1980.tb00213.x

    authors： Sotelo J,Toh BH,Lolait SJ,Yildiz A,Osung O,Holborow EJ

    更新日期：1980-07-01 00:00:00

  • Viliuisk encephalomyelitis--review of the spectrum of pathological changes.

    abstract：:Viliuisk encephalomyelitis (VE) is an unique neurological disease occurring in the Iakut (Sakha) people of Siberia. Evolution of the disease follows one of three broad clinical forms: subacute, slowly progressive or chronic. Death occurs within 3 to 6 months in subacute cases and within 6 years in the slowly progressi...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：

    authors： McLean CA,Masters CL,Vladimirtsev VA,Prokhorova IA,Goldfarb LG,Asher DM,Vladimirtsev AI,Alekseev VP,Gajdusek DC

    更新日期：1997-06-01 00:00:00

  • The effects of pre-natal exposure to methylazoxymethanol acetate on microglia.

    abstract：:The effects of exposure to a cytotoxic agent, methylazoxymethanol acetate (MAM Ac), on the distribution, density and quantitative morphology of microglia in the rat forebrain have been examined with the aid of a peroxidase-conjugated lectin derived from Griffonia simplicifolia. Following exposure to MAM Ac (25 mg/kg m...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1992.tb00832.x

    authors： Ashwell KW

    更新日期：1992-12-01 00:00:00

  • Granule cells and the development of synapses with mossy fibres in the cerebellum of the jaundiced Gunn rat.

    abstract：:The development of granule cells and the formation of synapses with mossy fibres were investigated in cerebella from jaundiced (j/j) Gunn rats with hereditary hyperbilirubinemia. The external granular layer was thinner than that in cerebella from heterozygous (+/j) Gunn rats without hyperbilirubinemia on days 12 and 1...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1993.tb00445.x

    authors： Takagishi Y,Yamamura H

    更新日期：1993-08-01 00:00:00

  • Reversible neuronal damage in hippocampal pyramidal cells with triethyllead: the role of astrocytes.

    abstract：:A single dose (19 mg kg-1) of triethyllead given to weanling rats produces necrosis in a small number of hippocampal pyramidal (CA3) and hilar neurons with reversible changes in the remaining neurons of this region. The sequence of events has been studied by light and electron microscopy over a period from 12 h to 14 ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1989.tb01245.x

    authors： Nolan CC,Brown AW

    更新日期：1989-09-01 00:00:00

  • Tumour-associated microglia/macrophages predict poor prognosis in high-grade gliomas and correlate with an aggressive tumour subtype.

    abstract：AIMS:Glioblastomas are highly aggressive and treatment resistant. Increasing evidence suggests that tumour-associated macrophages/microglia (TAMs) facilitate tumour progression by acquiring a M2-like phenotype. Our objective was to investigate the prognostic value of TAMs in gliomas using automated quantitative double ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12428

    authors： Sørensen MD,Dahlrot RH,Boldt HB,Hansen S,Kristensen BW

    更新日期：2018-02-01 00:00:00

  • Spinal manifestations of CLN1 disease start during the early postnatal period.

    abstract：AIM:To understand the progression of CLN1 disease and develop effective therapies we need to characterize early sites of pathology. Therefore, we performed a comprehensive evaluation of the nature and timing of early CLN1 disease pathology in the spinal cord, which appears especially vulnerable, and how this may affect...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12658

    authors： Nelvagal HR,Dearborn JT,Ostergaard JR,Sands MS,Cooper JD

    更新日期：2020-08-25 00:00:00

  • Congenital amaurotic idiocy--a pathological, histochemical, biochemical and ultrastructural study.

    abstract：:A case of congenital amaurotic idiocy, a subgroup of the neurovisceral lipidoses, is described. This is a rare condition of which only five cases have been reported previously. The brain was small and firm with marked neuronal loss and gliosis. Granular material with histochemical properties of the ceroid-lipofuscin g...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1985.tb00041.x

    authors： Humphreys S,Lake BD,Scholtz CL

    更新日期：1985-11-01 00:00:00

  • Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease.

    abstract：:The pathological findings in Alzheimer's disease (AD) are partly attributed to alterations in calcium-binding protein (CBP) functions. We showed previously that immunoreactivity of secretagogin, a recently cloned CBP, in the human hippocampus is restricted to pyramidal neurones and that the amount of immunoreactive ne...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2007.00854.x

    authors： Attems J,Preusser M,Grosinger-Quass M,Wagner L,Lintner F,Jellinger K

    更新日期：2008-02-01 00:00:00

  • Hirano body-rich subtypes of Creutzfeldt-Jakob disease.

    abstract：BACKGROUND:In definite Creutzfeldt-Jakob disease (CJD), morphological and immunohistochemical patterns are useful to identify molecular subtypes. Severe cerebellar pathology and hippocampal involvement helps to identify VV subtypes. The rare VV1 variant (<1%), more frequent in young individuals, is additionally charact...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2011.01208.x

    authors： Martinez-Saez E,Gelpi E,Rey MJ,Ferrer I,Ribalta T,Botta-Orfila T,Nos C,Yagüe J,Sanchez-Valle R

    更新日期：2012-04-01 00:00:00

  • A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort.

    abstract：AIMS:Population-based studies have shown that approximately 20% of the ageing population (aged 65 years and over) with dementia have little or no classical Alzheimer-type neuropathology. Cumulative DNA damage and a reduced capacity of DNA repair may result in neuronal dysfunction and contribute to cognitive impairment ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12202

    authors： Simpson JE,Ince PG,Matthews FE,Shaw PJ,Heath PR,Brayne C,Garwood C,Higginbottom A,Wharton SB,MRC Cognitive Function and Ageing Neuropathology Study Group.

    更新日期：2015-06-01 00:00:00

  • The effects of the growth factor-antagonist, trapidil, on remyelination in the CNS.

    abstract：:In this study we describe the effects of trapidil, a putative platelet-derived growth factor-antagonist, on spontaneously occurring remyelination in rat spinal cord. Demyelination was created in the dorsal funiculus of 6- and 11-week-old female rats by the direct injection of 1.0 microliter of 1% lysolecithin. The ani...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：

    authors： McKay JS,Blakemore WF,Franklin RJ

    更新日期：1997-02-01 00:00:00

  • Cryopreservation of viable human glioblastoma xenografts.

    abstract：:Human tumour xenografts maintained in nude mice are a valuable research tool. The passaging and maintenance of human tumour xenografts in immune-deficient animals are expensive and labour-intensive. This study presents a protocol that permits long-term cryopreservation of viable glioblastoma xenograft tissue pieces in...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2000.026002172.x

    authors： Goike HM,Asplund AC,Pettersson EH,Liu L,Ichimura K,Collins VP

    更新日期：2000-04-01 00:00:00

  • Endothelial changes in muscle and skin biopsies in patients with CADASIL.

    abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is characterized by the deposition of granular osmiophilic material in association with vascular smooth muscle cells in many different organs. However, the cause of the subsequent destruction of smooth muscle cells tha...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.1998.00087.x

    authors： Ruchoux MM,Maurage CA

    更新日期：1998-02-01 00:00:00

  • Childhood spinal muscular atrophy induces alterations in contractile and regulatory protein isoform expressions.

    abstract：AIMS:Although modifications of the survival motor neurone gene are responsible for most spinal muscular atrophy (SMA) cases, the molecular pathophysiology and the muscular target proteins involved are still unknown. The aim of this study was to compare the expression of contractile and regulatory protein isoforms in qu...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2008.00950.x

    authors： Stevens L,Bastide B,Maurage CA,Dupont E,Montel V,Cieniewski-Bernard C,Cuisset JM,Vallée L,Mounier Y

    更新日期：2008-12-01 00:00:00

  • Altered arginine metabolism in the central nervous system (CNS) of the Cln3-/- mouse model of juvenile Batten disease.

    abstract：BACKGROUND:Juvenile neuronal ceroid lipofuscinoses (JNCL) or juvenile Batten disease is a recessively inherited childhood neurodegenerative disorder resulting from a mutation in CLN3, which encodes a putative lysosomal protein of unknown function. AIM:Recent evidence suggests that a disruption in CLN3 function results...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2008.00984.x

    authors： Chan CH,Ramirez-Montealegre D,Pearce DA

    更新日期：2009-04-01 00:00:00

  • A cortical microvascular structure in vascular dementia, Alzheimer's disease, frontotemporal lobar degeneration and nondemented controls: a sign of angiogenesis due to brain ischaemia?

    abstract：AIMS:We observed a microvascular structure in the cerebral cortex that has not, to our knowledge, been previously described. We have termed the structure a 'raspberry', referring to its appearance under a bright-field microscope. We hypothesized that raspberries form through angiogenesis due to some form of brain ischa...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12552

    authors： Ek Olofsson H,Englund E

    更新日期：2019-10-01 00:00:00

  • Age-related changes of intracellular Abeta in cynomolgus monkey brains.

    abstract：:To confirm the intracellular accumulation of amyloid beta-protein (Abeta), we carefully performed immunohistochemistry using brains of cynomolgus monkeys of various ages. Cortical neurones and their large neurites were immunostained with antibodies against Abeta in young monkey brains. In aged monkey brains, intracell...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2004.00624.x

    authors： Kimura N,Yanagisawa K,Terao K,Ono F,Sakakibara I,Ishii Y,Kyuwa S,Yoshikawa Y

    更新日期：2005-04-01 00:00:00

  • Changes of 5'-nucleotidase activity in cultured glioma cells.

    abstract：:Changes of 5'-nucleotidase (5'-N) activity during subcultivation of C6 clonal rat glioma cells were studied histochemically, cytochemically and biochemically. Two different cell populations were seeded with high or low cell density respectively. 5'-N activity in cultured cells increased continuously in both population...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1985.tb00014.x

    authors： Amano S,Sasahara M,Yamada E,Kataoka H,Hazama F

    更新日期：1985-05-01 00:00:00

  • Early unsuspected neuron and axon terminal loss in scrapie-infected mice revealed by morphometry and immunocytochemistry.

    abstract：:Neuronal loss is often quoted as an element of the pathology of the transmissible spongiform encephalopathies, but few data are published. To determine whether neuronal loss is a salient feature of murine scrapie, and whether there is a relationship with the other hallmark lesions of scrapie we compared the numbers of...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1995.tb01027.x

    authors： Jeffrey M,Fraser JR,Halliday WG,Fowler N,Goodsir CM,Brown DA

    更新日期：1995-02-01 00:00:00

  • Expression of late myogenic differentiation markers in sarcoplasmic masses of patients with myotonic dystrophy.

    abstract：:Sarcoplasmic masses contain disorganized myofibrillar material and are a striking feature of myotonic dystrophy. However their significance is still unclear. Using immunocytochemistry we studied the expression of cytoskeletal proteins (desmin and vimentin), dystrophin, markers of myogenic differentiation (foetal myosi...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2004.00602.x

    authors： Vattemi G,Tomelleri G,Filosto M,Savio C,Rizzuto N,Tonin P

    更新日期：2005-02-01 00:00:00

  • The early evolution of neurofilamentous accumulations due to 2,5-hexanediol in the optic pathways of the rat.

    abstract：:Rats were given 2,5-hexanediol in their water for more than 5 weeks. The changes in the optic pathways were studied both qualitatively and quantitatively. Increase in 10-nm filaments within axons was noticeable from 10 days onwards in the superior colliculus and in the brachium of the superior colliculus. From then on...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1982.tb00298.x

    authors： Jones HB,Cavanagh JB

    更新日期：1982-07-01 00:00:00

  • Hemiparkinsonism with infarction of the ipsilateral substantia nigra.

    abstract：:An elderly man suffering from dementia associated with hypertension developed right-sided parkinsonism marked by rigidity and flexion. At autopsy the brain showed generalized vascular changes chiefly in the white matter, diffuse plaque and neurofibrillary tangle formation in the temporal cortex, and a discrete gliotic...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1978.tb00548.x

    authors： Hunter R,Smith J,Thomson T,Dayan AD

    更新日期：1978-07-01 00:00:00

  • CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia.

    abstract：AIMS:Microglial cells have been originally identified as a target for the CXC chemokine, SDF-1, by their expression of CXCR4. More recently, it has been recognized that SDF-1 additionally binds to CXCR7, which depending on the cell type acts as either a nonclassical, a classical or a scavenger chemokine receptor. Here,...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12015

    authors： Lipfert J,Ödemis V,Wagner DC,Boltze J,Engele J

    更新日期：2013-10-01 00:00:00

  • Sequential studies of a childhood myopathy: a clinical, histochemical and morphometric investigation.

    abstract：:An unusual inherited progressive distal myopathy of early childhood onset is described in two sisters from a consanguineous Asian family. Motor milestones were normal but gait deteriorated slowly thereafter with development of generalized hypotonia and muscle weakness particularly in the wrist extensors and hand muscl...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1989.tb01145.x

    authors： Mahon M,Kristmundsdottir F,Cumming WJ,Noronha MJ

    更新日期：1989-01-01 00:00:00

  • A double three-step theory of brain metastasis in mice: the role of the pia mater and matrix metalloproteinases.

    abstract：:The brain is frequently affected by the spread of lung cancer, and haematogenous metastasis is a common route to brain metastasis. We therefore developed an isogenic brain metastasis model of lung cancer to use the Lewis lung carcinoma cell line and analysed dynamics of neoplastic cells after extravasation. Histologic...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2007.00799.x

    authors： Saito N,Hatori T,Murata N,Zhang ZA,Ishikawa F,Nonaka H,Iwabuchi S,Samejima H

    更新日期：2007-06-01 00:00:00

  • An immunohistological study of macrophages in the human fetal brain.

    abstract：:Brains from human fetuses of 13 to 27 weeks gestation have been examined immunohistologically for the presence of macrophages using the marker alpha-1-anti-chymotrypsin. A preliminary study demonstrated this to be a satisfactory marker of brain macrophages, although macrophages were also weakly positive for the more s...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1991.tb00738.x

    authors： Gould SJ,Howard S

    更新日期：1991-10-01 00:00:00