HPV test by Hybrid Capture II for the diagnosis of HR-HPV persistent infection.

Abstract:

INTRODUCTION:Persistent high-risk HPV (HR-HPV) infection is associated with a greater risk of cervical cancer. PATIENTS AND METHODS:Statistical data on the prevalence of HR-HPV infections in the Algerian population is lacking. We conducted a prospective study of 300 women aged between 25 and 50 years, screened for cervical cancer from 2012 to 2015 in Sidi Bel Abbès, a western region of Algeria. We aimed to assess the reliability of the repeated use of the HC II test (three longitudinal HPV tests 9 months apart from each other) in diagnosing the persistence of HR-HPV infection. RESULTS:The prevalence of HR-HPV infection was 7.33% and infected women were aged 37.9±3years. For 90.9% of HR-HPV-positive patients, the infection persisted for a mean of 18.5months [95% CI: 16.9-22.1months]. Among these patients, 55.55% developed CIN1 and 11.11% developed CIN2. The sensitivity of the HC II test was 81.74% [95% CI: 71.3-89.6] and its positive predictive value associated with abnormal cervical biopsy was 27.49% [95% CI: 16.0-33.33]. CONCLUSION:Repeating the HC II test is a good predictor for identifying women at high risk of cervical cancer.

journal_name

Med Mal Infect

authors

Serour Y,Bendahmane M,Abbou Baker F,Medles M,Moueddene B,Kraiba R

doi

10.1016/j.medmal.2017.05.013

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

484-489

issue

7

eissn

0399-077X

issn

1769-6690

pii

S0399-077X(17)30665-0

journal_volume

47

pub_type

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