Abstract:
:Dynamics of endocytic clathrin-coated structures can be remarkably divergent across different cell types, cells within the same culture, or even distinct surfaces of the same cell. The origin of this astounding heterogeneity remains to be elucidated. Here we show that cellular processes associated with changes in effective plasma membrane tension induce significant spatiotemporal alterations in endocytic clathrin coat dynamics. Spatiotemporal heterogeneity of clathrin coat dynamics is also observed during morphological changes taking place within developing multicellular organisms. These findings suggest that tension gradients can lead to patterning and differentiation of tissues through mechanoregulation of clathrin-mediated endocytosis.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Willy NM,Ferguson JP,Huber SD,Heidotting SP,Aygün E,Wurm SA,Johnston-Halperin E,Poirier MG,Kural Cdoi
10.1091/mbc.E17-05-0282subject
Has Abstractpub_date
2017-11-15 00:00:00pages
3480-3488issue
24eissn
1059-1524issn
1939-4586pii
mbc.E17-05-0282journal_volume
28pub_type
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