Abstract:
:The secretory pathway along which newly synthesized secretory and membrane proteins traffic through the cell was revealed in two articles published 50 years ago. This discovery was the culmination of decades of effort to unite the power of biochemical and morphological methodologies in order to elucidate the dynamic nature of the cell's biosynthetic machinery. The secretory pathway remains a central paradigm of modern cell biology. Its elucidation 50 years ago inspired tremendous multidisciplinary and on-going efforts to understand the machinery that makes it run, the adaptations that permit it to serve the needs of specialized cell types, and the pathological consequences that arise when it is perturbed.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Matlin KS,Caplan MJdoi
10.1091/mbc.E16-07-0508subject
Has Abstractpub_date
2017-01-15 00:00:00pages
229-232issue
2eissn
1059-1524issn
1939-4586pii
28/2/229journal_volume
28pub_type
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