Local steroid injection versus wrist splinting for carpal tunnel syndrome: A randomized clinical trial.


AIM:We conducted a prospective randomized parallel clinical trial comparing the efficacy of local steroid injection and nocturnal wrist splinting in patients with carpal tunnel syndrome (CTS). METHODS:The well-validated and disease-specific Boston Carpal Tunnel Questionnaire (BCTQ) was employed and its score at 4 weeks after treatment was used as the primary outcome measure. Important secondary outcomes included patient satisfaction, the change of an objective finger dexterity test and the side effects. RESULTS:Twenty-five patients in the local steroid group and 25 patients in the wrist splinting group completed the study procedures. At 4 weeks after treatment, there was significant improvement of the BTCQ scores in both the steroid group and splinting group. There was improvement of the finger dexterity test only in the steroid group but not in the splinting group. However, there was no statistically significant difference in the changes of BTCQ scores between the two groups after treatment. Patient satisfaction score was higher in the steroid group. Patients in the steroid group took fewer painkillers after treatment. Four patients developed side effects after splinting and three after local steroid injection, which was not statistically significant. CONCLUSION:Although local steroid injection and nocturnal wrist splinting were equally effective in the treatment of patients with CTS, only the former improved objective hand function. Local steroid injection also resulted in better patient satisfaction and less painkiller use without causing more side effects.


Int J Rheum Dis


So H,Chung VCH,Cheng JCK,Yip RML




Has Abstract


2018-01-01 00:00:00












  • Periodontal disease in Thai patients with rheumatoid arthritis.

    abstract:AIM:To evaluate the prevalence and severity of periodontal disease in patients with rheumatoid arthritis (RA) who attended a rheumatology clinic in a university hospital. METHODS:All consecutive patients with RA who attended the rheumatology clinic between June 2009 and January 2010 were asked to enroll in this study....

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Khantisopon N,Louthrenoo W,Kasitanon N,Sivasomboon C,Wangkaew S,Sang-In S,Jotikasthira N,Bandhaya P

    更新日期:2014-06-01 00:00:00

  • Intracellular tubulo-reticular structures of peripheral blood mononuclear cells as an ultra-structural marker of disease activity in systemic lupus erythematosus: a pilot study.

    abstract:OBJECTIVE:Under physiological stress, the membranes of organelles undergo conformational change to tubulo-reticular structures (TRS) for gaining survival advantage. We aim to explore whether TRS formation in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE) correlates wi...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Mak A,Almsherqi ZA,Lai YW,Cheak AA,Deng Y

    更新日期:2013-12-01 00:00:00

  • Prognosis, complications and treatment response in systemic juvenile idiopathic arthritis patients: A single-center experience.

    abstract:AIM:Systemic juvenile idiopathic arthritis (sJIA) is a distinctive subtype of JIA characterized by systemic features and poor outcome. We aimed to investigate demographic and clinical features, long-term treatment response and disease complications in a large sJIA cohort. METHODS:Patients diagnosed with sJIA followed ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Barut K,Adrovic A,Sahin S,Tarcin G,Tahaoglu G,Koker O,Yildiz M,Kasapcopur O

    更新日期:2019-09-01 00:00:00

  • Measuring bone density in axial spondyloarthropathy: Time to turn things on their side?

    abstract:AIM:Osteoporosis in axial spondyloarthropathy (axSpA) is difficult to accurately diagnose due to osteoproliferation of the spine interfering with conventional (anteroposterior, AP) dual-energy X-ray absorptiometry (DXA). This study compares AP and lateral projections of DXA when assessing bone mineral density (BMD) of ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Fitzgerald G,Anachebe T,McCarroll K,O'Shea F

    更新日期:2020-03-01 00:00:00

  • Risk factors for herpes zoster infection among Filipinos with systemic lupus erythematosus.

    abstract:AIM:To identify clinical risk factors associated with herpes zoster (HZ) infections in systemic lupus erythematosus (SLE). METHODS:A case-control study of HZ infection was performed in SLE patients seen at the University of Santo Tomas Lupus Clinics from 2009-2014. Cases were matched 1:2 to SLE controls without HZ inf...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Zamora LD,Collante MTM,Navarra SV

    更新日期:2020-02-01 00:00:00

  • Cadmium, one of the villains behind the curtain: has exposure to cadmium helped to pull the strings of seropositive rheumatoid arthritis pathogenesis all along?

    abstract::Exposure to cadmium links smoking, the most import antetiological factor in the development of seropositive RA, and many of the other known contemporary risk factors. Epidemiological studies investigating the link between smoking, occupations, social class, region of residency and RA should consider cadmium exposure a...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Hutchinson D

    更新日期:2015-06-01 00:00:00

  • Vasculitis research: Current trends and future perspectives.

    abstract::We discuss recent and prospective research in small and large vessel vasculitis. Large cohorts of Takayasu arteritis (TA) have been recently published from across the world, clarifying our understanding of this uncommon disease. Novel open-ended approaches like large-scale genotyping, proteomics and metabolomics have ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Misra DP,Naidu GSRSNK,Agarwal V,Sharma A

    更新日期:2019-01-01 00:00:00

  • The frequency of metabolic syndrome in women with rheumatoid arthritis and in controls.

    abstract:AIM:To compare the frequency of the metabolic syndrome and its components in a sample of patients with rheumatoid arthritis (RA) and controls. METHODS:This case control study was performed on 188 women over 18 years old: 92 RA patients and 96 healthy controls, from 2006 to 2008. Blood pressure, height, weight and wais...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Karimi M,Mazloomzadeh S,Kafan S,Amirmoghadami H

    更新日期:2011-08-01 00:00:00

  • Taiwan Rheumatology Association consensus recommendations for the management of axial spondyloarthritis.

    abstract:AIM:To establish guidelines for the clinical management of axial spondyloarthritis that take into account local issues and clinical practice concerns for Taiwan. METHOD:Overarching principles and recommendations were established by consensus among a panel of rheumatology and rehabilitation experts, based on analysis o...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Wei JC,Liu CH,Tseng JC,Hsieh LF,Chen CH,Chen HH,Chen HA,Chen YC,Chou CT,Liao HT,Lin YC,Luo SF,Yang DH,Yeo KJ,Tsai WC,Taiwan Rheumatology Association (TRA).

    更新日期:2020-01-01 00:00:00

  • Leflunomide in clinical practice. A retrospective observational study on use of leflunomide in New Zealand.

    abstract:AIM:The aim was to study the side-effect profile and the survival characteristics of leflunomide used in a regional patient population in New Zealand (NZ). METHOD:  Patients were identified using special authority forms (SAFs) that had been prospectively filed from January 2001 to June 2007. Statistical analysis of su...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Jagoda JS,Rajapakse CN

    更新日期:2011-10-01 00:00:00

  • Elevation of cytomegalovirus antigenemia predicts serious infection and death in patients receiving immunosuppressive therapies for autoimmune diseases.

    abstract:AIM:We examined the relationship between cytomegalovirus (CMV) reactivation and serious infections. METHOD:We conducted a single-center retrospective chart review study with 43 autoimmune disease patients experiencing CMV reactivation. We investigated the risk factors for serious infections among the patients using lo...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Yoshihara R,Komai T,Shoda H,Fujio K

    更新日期:2020-11-01 00:00:00

  • Clinical features and long-term outcomes of 105 granulomatosis with polyangiitis patients: A single center experience from north India.

    abstract:AIM:To describe the clinical features, treatment and long-term outcomes in north Indian patients with granulomatosis with polyangiitis (GPA). METHODS:Clinical details, Birmingham Vasculitis Activity Score (BVAS-v3), laboratory data, histopathology findings, treatment details and outcomes of all consecutive patients di...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Sharma A,Naidu GSRSNK,Rathi M,Verma R,Modi M,Pinto B,Sharma K,Dhir V,Singhal M,Prakash M,Nada R,Panda NK,Minz RW

    更新日期:2018-01-01 00:00:00

  • Hyperuricemia in Asian psoriatic arthritis patients.

    abstract:AIM:It is generally accepted that hyperuricemia is commonly associated with psoriatic arthritis (PsA). However, variations in ethnicity, diet and habitat may contribute to differences in prevalence and risk factors for hyperuricemia in PsA patients. Moreover, Asian specific data is deficient. The primary objective of t...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Lai TL,Yim CW,Wong PY,Leung MC,Ng WL

    更新日期:2018-04-01 00:00:00

  • Lipid peroxidation, glutathione, vitamin E, and antioxidant enzymes in synovial fluid from patients with osteoarthritis.

    abstract:AIM:To compare levels of lipid peroxidation and antioxidants in synovial fluid from primary knee osteoarthritis (OA) patients with severe cartilage damage undergoing total knee replacement with those in the synovial fluid from injured knee joint patients with intact cartilage undergoing knee arthroscopy. METHODS:Thirt...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Sutipornpalangkul W,Morales NP,Charoencholvanich K,Harnroongroj T

    更新日期:2009-12-01 00:00:00

  • LncRNA GAS5 activates the AMPK pathway in peripheral blood mononuclear cells derived from rheumatoid arthritis patients.

    abstract:BACKGROUND:Rheumatoid arthritis (RA) is an inflammatory disease, which seriously affects human joints. This study aimed to detect the changes in the expression of long non-coding RNA growth arrest-specific transcript 5 (GAS5) in peripheral blood mononuclear cells (PBMCs) derived from patients with RA and healthy contro...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Cao J,Lv X,Zhang Y,Xu A,Jiang T

    更新日期:2020-08-04 00:00:00

  • Dry eye in vitamin D deficiency: more than an incidental association.

    abstract:AIM:The aim of this article is two-fold: (i) to demonstrate the relation between vitamin D deficiency and dry eye and impaired tear function; and (ii) to investigate the possible associations among clinical parameters of hypovitaminosis D with dry eye parameters. METHOD:Fifty premenopausal women with vitamin D deficie...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Yildirim P,Garip Y,Karci AA,Guler T

    更新日期:2016-01-01 00:00:00

  • Development, implementation and benefits of a rheumatology-specific electronic medical record application with automated display of outcome measures.

    abstract:OBJECTIVES:To make a rheumatology-specific electronic medical record (EMR) application for easy clinical data entry, automated display of outcome measures in real-time that generates well laid-out print-outs; and provides an easily retrievable database for clinical analysis and research. METHODS:Highly labour-intensiv...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Malaviya AN,Gogia SB

    更新日期:2010-10-01 00:00:00

  • Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee.

    abstract:AIM:To prospectively evaluate the long-term efficacy and safety of repeated sodium hyaluronate injections for the treatment of knee pain due to Kashin-Beck disease (KBD). METHODS:A total of 85 patients with KBD-based knee pain were treated with two cycles of a 5-week course of sodium hyaluronate and received clinical ...

    journal_title:International journal of rheumatic diseases

    pub_type: 临床试验,杂志文章


    authors: Tang X,Zhou ZK,Shen B,Kang PD,Pei FX,Li J

    更新日期:2019-03-01 00:00:00

  • Validity and reliability of the unsupported upper-limb exercise test in individuals with rheumatoid arthritis.

    abstract:BACKGROUND:Rheumatoid arthritis (RA) is a chronic disease which affects the performance of the upper extremities. There is no method to evaluate the specific upper extremity endurance of individuals with this disease. The unsupported upper-limb exercise test (UULEX) is a performance test that evaluates upper extremity ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Cetin SY,Basakci Calik B,Ayan A,Cavlak U

    更新日期:2019-11-01 00:00:00

  • Psychometric assessment of the Japanese version of the Revised Fibromyalgia Impact Questionnaire: reliability and validity.

    abstract:AIM:To assess the psychometric properties of the Japanese version of the Revised Fibromyalgia Impact Questionnaire (JFIQR) in fibromyalgia (FM) patients. METHOD:The reliability and validity of the JFIQR were assessed using online data collected from Japanese FM patients. Reliability was evaluated based on test-retest ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Isomura T,Nakamura I,Kawaguchi M,Sato E,Inuzuka K,Osada K,Nishioka K,Hayakawa K

    更新日期:2017-09-01 00:00:00

  • Hand bone mineral density reference values in a Turkish healthy female population.

    abstract:AIM:In this study we aimed at identifying the bone mineral density (BMD) reference values of hands, according to age, measured by dual-energy X-ray absorptiometry (DEXA) and assessing the correlation of these values with lumbar and femoral BMD values. METHOD:A total of 403 healthy women aged between 20 and 70 particip...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Alioglu K,Dogu B,Sirzai H,Yilmaz F,Kuran B

    更新日期:2017-12-01 00:00:00

  • The Role of 18F Fluorodeoxyglucose Positron Emission Tomography Scanning in the Diagnosis and Management of Systemic Vasculitis.

    abstract::Primary systemic vasculitis is a group of heterogeneous disorders, characterized by inflammation of blood vessels causing end organ damage from ischemia, aneurysm formation or dissection. Delay in the early diagnosis owing to non-specific symptoms, lack of definitive serological tests, limited availability of biopsy a...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Danve A,O'Dell J

    更新日期:2015-09-01 00:00:00

  • Osteoarthritis of the knees in the COPCORD world.

    abstract::This paper examines and summarizes data on knee osteoarthritis (AO) in Community Oriented Program For Control Of Rheumatic Disorders (COPCORD) publications. A literature search was made through PubMed, Google, Proceedings of Asia-Pacific League of Associations for Rheumatology (APLAR) congresses, and Abstracts from AP...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Haq SA,Davatchi F

    更新日期:2011-05-01 00:00:00

  • IL10 low-frequency variants in Behçet's disease patients.

    abstract:AIM:To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's disease (BD) and the goal...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Matos M,Xavier JM,Abrantes P,Sousa I,Rei N,Davatchi F,Shahram F,Jesus G,Barcelos F,Vedes J,Salgado M,Abdollahi BS,Nadji A,Moraes-Fontes MF,Shafiee NM,Ghaderibarmi F,Vaz Patto J,Crespo J,Oliveira SA

    更新日期:2017-05-01 00:00:00

  • Clinical profile of Filipino patients with osteoarthritis seen at two arthritis clinics.

    abstract:AIM:To describe a cohort of Filipinos with primary osteoarthritis (OA). METHOD:Charts with diagnosis of OA from two arthritis clinics (Philippine General Hospital and a private clinic) from January 2008 to May 2011, were reviewed for demographics, clinical presentation, risk factors and management. Descriptive statist...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Racaza GZ,Salido EO,Penserga EG

    更新日期:2012-08-01 00:00:00

  • C1QTNF4 gene p.His198Gln mutation is correlated with early-onset systemic lupus erythematosus in Iranian patients.

    abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease with multifactorial etiology. Several studies show that genetic factors have an important part in the incidence of SLE. The C1QTNF4 gene is involved in the regulation of the inflammatory pathways by pro-inflammatory function. In the present study, w...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Pakzad B,Shirpour R,Mousavi M,Karimzadeh H,Salehi A,Kazemi M,Amini G,Akbari M,Salehi R

    更新日期:2020-11-01 00:00:00

  • Serum procalcitonin levels in patients with ankylosing spondylitis.

    abstract:AIM:Procalcitonin is a marker of bacterial and fungal infection and sepsis. The present study evaluated the relationship between serum procalcitonin levels and disease activity in patients with ankylosing spondylitis (AS). METHOD:A total of 61 patients who met the 1984 New York criteria for AS were studied. Twenty-fou...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章


    authors: Ozmen M,Oktay E,Tarhan EF,Aslan O,Oflazoglu U,Koseoglu MH

    更新日期:2016-05-01 00:00:00

  • Insights into osteoarthritis from MRI.

    abstract::Magnetic resonance imaging (MRI) has added a new dimension to the study of osteoarthritis, a long-known degenerative joint disease with limited therapeutic options. It has advanced our understanding of joint pathophysiology and identifying that osteoarthritis as a simple 'wear and tear' process of the articular cartil...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Tan YK,Conaghan PG

    更新日期:2012-02-01 00:00:00

  • Differentiation of patented crystalline glucosamine sulfate from other glucosamine preparations will optimize osteoarthritis treatment.

    abstract::Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and delay joint structural changes. Among SYSADOAs, evidence is greatest for the patented crystalline glucosamine sulf...

    journal_title:International journal of rheumatic diseases

    pub_type: 社论,评审


    authors: Saengnipanthkul S,Waikakul S,Rojanasthien S,Totemchokchyakarn K,Srinkapaibulaya A,Cheh Chin T,Mai Hong N,Bruyère O,Cooper C,Reginster JY,Lwin M

    更新日期:2019-03-01 00:00:00

  • Incidence of gastroduodenal ulcers during treatment with celecoxib or diclofenac: pooled results from three 12-week trials in Chinese patients with osteoarthritis or rheumatoid arthritis.

    abstract:AIM:To test whether treatment with celecoxib reduces the incidence of gastroduodenal ulcers compared to diclofenac in Asian patients with osteoarthritis (OA) or rheumatoid arthritis (RA) with minimal significant risk factors. METHODS:Patients with a clinical diagnosis of OA or RA of at least 3 months were randomized t...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,随机对照试验


    authors: Cheung R,Cheng TT,Dong Y,Lin HY,Lai K,Lau CS,Feng H,Parsons B

    更新日期:2010-05-01 00:00:00