Abstract:
AIMS:In order to investigate the histological change in effect attenuation cases of etanercept compared with methotrexate (MTX), we performed immunohistochemical examination by seven different molecules. METHODS:We histologically assessed synovial tissue from five MTX-treated rheumatoid arthritis (RA) patients as control and six etanercept and MTX-treated RA patients after synovectomy by arthroscopy. The synovium of both groups were assessed by hematoxylin and eosin (HE) and we also analysed the expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), matrix metalloproteinase-3 (MMP-3), B-cell precursors and mature B-cell transmembrane protein, CD20, macrophage marker, CD68, bromodeoxyuridine (BrdU) and vascular endothelial growth factor (VEGF) by immunohistochemistry. RESULTS:HE staining showed vascular and cell proliferations of the synovium of the RA patients who received etanercept compared with the control MTX group. TNF-alpha and IL-6 were expressed in both groups.MMP-3 and CD68 expressed less significantly in the etanercept group compared with the control (P < 0.05). CD20 strongly expressed in the etanercept group significantly (P < 0.05). BrdU expressed in the synovium in the etanercept group significantly (P < 0.05). VEGF was not found overall in both group. CONCLUSION:Based on the histological change of synovium, treatment by etanercept may be involved in vascular and cell proliferations with inhibition of the expression of CD68 and MMP-3 in synovium of RA patients. These findings indicate immunohistochemical change of synovium with etanercept is one of the mechanism of efficacy of etanercept.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Suzuki Y,Inoue K,Chiba J,Inoue Y,Kanbe Kdoi
10.1111/j.1756-185X.2009.01372.xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
7-13issue
1eissn
1756-1841issn
1756-185Xpii
APL1372journal_volume
12pub_type
杂志文章abstract:AIM:Current rheumatoid arthritis (RA) guidelines have incorporated a treat-to-target (T2T) approach and require that it be implemented through shared decision making (SDM). Current discourse has questioned whether collaborative T2T is feasible in RA, in part because of discrepancies in the way that patients and practit...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13664
更新日期:2019-09-01 00:00:00
abstract:AIM:We examined the relationship between cytomegalovirus (CMV) reactivation and serious infections. METHOD:We conducted a single-center retrospective chart review study with 43 autoimmune disease patients experiencing CMV reactivation. We investigated the risk factors for serious infections among the patients using lo...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13990
更新日期:2020-11-01 00:00:00
abstract:AIM:To develop a translated and culturally adapted Bengali version of the WHO Fracture Risk Assessment Tool (FRAX(®) ) and to test its feasibility, content validity and reliability. METHOD:The English FRAX was translated and culturally adapted for use in Bangladeshi populations following established forward-backward t...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12425
更新日期:2015-03-01 00:00:00
abstract::Loss of B-cell tolerance is a hallmark feature of the pathogenesis in systemic lupus erythematosus (SLE), an autoimmune disease that is characterized by hypergammaglobulinemia and autoantibody production. These autoantibodies lead to formation of immune-complex deposition in internal organs causing inflammation and da...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1756-185X.2009.01458.x
更新日期:2010-02-01 00:00:00
abstract:AIM:Knee osteoarthritis (OA), is the most common degenerative joint disease. Several non-pharmacological interventions have been used for this purpose such as insoles. There are contradictory data about the superiority and effectiveness of laterally wedged compared with neutrally wedged insoles. This study was designed...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/1756-185X.12036
更新日期:2014-01-01 00:00:00
abstract:AIM:Genetic factors have a substantial contribution to the pathogenesis of rheumatoid arthritis (RA). Single nucleotide polymorphisms of NLRP3 p.Q705K and CARD8 p.C10X are two gene mutations that have been linked to many diseases. Here we carried out a meta-analysis to identify their association with susceptibility to ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1756-185X.13016
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To assess parental stress levels of mothers of children with juvenile idiopathic arthritis (JIA) aged between 2-12 years and compare with those reported for other chronic childhood illnesses. METHODOLOGY:Mothers of children aged between 2-12 years with JIA were recruited from hospital-based outpatient clinic...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.12394
更新日期:2014-06-01 00:00:00
abstract:AIM:To assess the psychometric properties of the Japanese version of the Revised Fibromyalgia Impact Questionnaire (JFIQR) in fibromyalgia (FM) patients. METHOD:The reliability and validity of the JFIQR were assessed using online data collected from Japanese FM patients. Reliability was evaluated based on test-retest ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12574
更新日期:2017-09-01 00:00:00
abstract:AIM:Procalcitonin is a marker of bacterial and fungal infection and sepsis. The present study evaluated the relationship between serum procalcitonin levels and disease activity in patients with ankylosing spondylitis (AS). METHOD:A total of 61 patients who met the 1984 New York criteria for AS were studied. Twenty-fou...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12386
更新日期:2016-05-01 00:00:00
abstract:AIM:Some studies have been performed to elucidate the association between Fc gamma receptor 3B (FCGR3B) copy number (CN) and the risk of systemic lupus erythematosus (SLE) and/or lupus nephritis (LN), yet the results remain conflicting. Therefore, we have undertaken a systematic review of all the studies published and ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1756-185X.12342
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety of tumor necrosis factor-α (TNF-α) monoclonal antibody (infliximab) therapy in patients with rheumatoid arthritis (RA) and previous exposure to hepatitis B virus (HBV) who had normal liver function. METHODS:This is a retrospective study from a 26-week, prospective, multicenter trial in...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.12125
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To determine if showing patients with rheumatoid arthritis (RA) ultrasound (US) images of their inflamed joints: (i) increased belief in the necessity of medication; (ii) encouraged patient activation, that is, confidence and understanding in managing their health; and (iii) facilitated medication adherence. ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12402
更新日期:2016-07-01 00:00:00
abstract:AIM:To compare the Disease Activity Score with 28 joint (DAS28) using erythrocyte sedimentation rate (ESR) (DAS28-ESR) and DAS28 using C-reactive protein (CRP) (DAS28-CRP) with thresholds validated for DAS28-ESR in Turkish patients with rheumatoid arthritis. METHOD:The DAS28 data of 112 patients with rheumatoid arthri...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12695
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVES:To investigate the causes and risk of death in a large cohort of Korean patients with rheumatoid arthritis (RA). METHODS:Patients in the Hanyang BAE (Bae registry of Autoimmune diseases for Epidemiology) RA cohort who fulfilled the American College of Rheumatology criteria were analyzed. A total of 2355 pat...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.14058
更新日期:2021-01-19 00:00:00
abstract:INTRODUCTION:Maintenance of temperature during collection and transport of blood is an important pre-requisite for cryoglobulin assays. In this manuscript, we describe 'cryodevice', a low-cost device for transportation and/or incubation of vials of whole blood at 37°C. Such a device would reduce false negatives in cryo...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13161
更新日期:2018-01-01 00:00:00
abstract::The classification of the systemic vasculitides has been controversial for several decades. The Chapel Hill consensus Conference definitions originally developed in 1994, but revised and extended in 2012 are now widely accepted. The American College of Rheumatology (ACR) criteria were first published in 1990, are now ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.13303
更新日期:2019-01-01 00:00:00
abstract::Biologics have emerged as an important modality of treatment in rheumatic diseases and have allowed the rheumatologist to explore varied therapeutic uses of these drugs. Rituximab, a monoclonal antibody against CD20 receptor is an important member of the biologic armamentarium for the treatment of various refractory a...
journal_title:International journal of rheumatic diseases
pub_type:
doi:10.1111/1756-185X.13365
更新日期:2019-05-01 00:00:00
abstract::Multiple myeloma (MM) is a malignant plasma cell disorder. Musculoskeletal and skin manifestations of this disorder are rare. Here we report a case of a young male patient presenting with polyarthritis and skin rash resembling vasculitis. Detailed investigations revealed that he was suffering from multiple myeloma in ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2010.01526.x
更新日期:2010-08-01 00:00:00
abstract:AIM:An elevated serum uric acid level is associated with various diseases, such as gout, hypertension, renal impairment, and diabetes. Heavy metals, including lead and cadmium, are suspected to increase serum uric acid levels, but evidence regarding this is not sufficient, particularly in the Asian population. Therefor...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13632
更新日期:2019-08-01 00:00:00
abstract:AIM:Numerous epidemiologic studies have evaluated the association between overweight and hand osteoarthritis; However, the existing results are inconsistent. METHODS:Systematic searches were performed and reference lists from the retrieved trials were searched. This meta-analysis and meta-regression was executed to id...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1756-185X.12895
更新日期:2016-12-01 00:00:00
abstract:AIM:Nonspecific chronic synovitis of the knee joint was reported by Pollard in 1962 and its pathogenesis is considered to be a physiological reaction to intra-articular disease. In this study, we evaluated the pathological findings of the synovium of early osteoarthritis (OA)-affected knee joints with hydrarthrosis in ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12404
更新日期:2016-05-01 00:00:00
abstract:AIM:There is growing evidence that cold-inducible RNA-binding protein (CIRP) promotes inflammatory responses. This study investigated the relationship between CIRP and rheumatoid arthritis (RA). METHODS:Peripheral blood and synovial fluid were collected from 15 patients with RA and from 16 patients with osteoarthritis...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12892
更新日期:2018-01-01 00:00:00
abstract::Primary systemic vasculitis is a group of heterogeneous disorders, characterized by inflammation of blood vessels causing end organ damage from ischemia, aneurysm formation or dissection. Delay in the early diagnosis owing to non-specific symptoms, lack of definitive serological tests, limited availability of biopsy a...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.12713
更新日期:2015-09-01 00:00:00
abstract:AIM:Axial spondyloarthritis (axSpA) affects patients in the prime of their economic productivity. We aim to identify factors associated with poor work productivity in patients with axSpA in Singapore. METHODS:A cross-sectional study was performed in two tertiary centers in Singapore. Consecutive adult patients ≥21 yea...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.13696
更新日期:2019-11-01 00:00:00
abstract:AIM:Recent studies highlight the importance of the interleukin (IL)-17A cytokine in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). There are also reports of associations between some single nucleotide polymorphisms (SNPs) in IL-17A and RA but not SLE. Notably, these findings have not been replicated ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13426
更新日期:2019-03-01 00:00:00
abstract:AIM:To investigate the point prevalence of depression and anxiety in psoriatic arthritis and putative reductions in these comorbidities with the treatment of psoriatic arthritis. METHOD:We performed a systematic review in accordance with PRISMA guidelines examining point prevalence of depression and anxiety in psoriat...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析
doi:10.1111/1756-185X.13553
更新日期:2019-06-01 00:00:00
abstract::Exposure to cadmium links smoking, the most import antetiological factor in the development of seropositive RA, and many of the other known contemporary risk factors. Epidemiological studies investigating the link between smoking, occupations, social class, region of residency and RA should consider cadmium exposure a...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12673
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the disease activity and current pharmacological interventions used to achieve remission in rheumatoid arthritis (RA) patients in Australia. METHODS:Rheumatoid arthritis patients treated in participating Australian clinics were included in the study. Patient demographics, disease onset, medicati...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.12163
更新日期:2013-10-01 00:00:00
abstract:AIM:Magnetic resonance imaging (MRI) can be used to identify sacroiliac joint (SIJ) inflammation and provide an earlier diagnosis of nonradiographic axial spondyloarthritis (nrAxSpA). However, MRI is frequently a resource-limited examination. Our aim was to assess if a set of physical clinical tests can identify SIJ in...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13606
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the association between chest computed tomography (CT) findings and incidence of respiratory adverse events (RAEs), and to detect risk factors for RAEs, in RA patients treated with long-term biological therapy. METHODS:Clinical and radiological data of 332 RA patients who were trea...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13434
更新日期:2019-04-01 00:00:00