Abstract:
OBJECTIVE:This study aimed to assess the association between chest computed tomography (CT) findings and incidence of respiratory adverse events (RAEs), and to detect risk factors for RAEs, in RA patients treated with long-term biological therapy. METHODS:Clinical and radiological data of 332 RA patients who were treated with biological disease-modifying antirheumatic drugs were collected. CT data were assessed by an experienced radiologist. Patients were categorized into the interstitial lung disease (ILD) group (n = 29), airway disease (AD) group (n = 76), co-existing ILD and AD (Co-existing) group (n = 6), and the group without detectable change (WDC, n = 221) based on CT findings and scores. The incidence of RAEs was calculated for each group, and risk factors for RAEs from CT findings were explored. RESULTS:We identified 41 RAEs, including acute onset or exacerbation of ILD (ILD events, n = 15), respiratory tract infection events (infection events, n = 21), and other events (n = 6). Cumulative incidences of ILD events were 20.2, 3.75, 47.2, and 1.94 (/1000 patient-years: PY) in the ILD, AD, Co-existing, and WDC groups, respectively, and those of infection events were 11.3, 17.6, 23.6, and 2.39 (/1000PY), respectively. Severity, as assessed by CT scores, was correlated with the incidence of RAEs. Risk factors for ILD events were reticular and honeycomb changes, and those for infection events were consolidation, bronchial wall thickening, bronchiectasis, bronchiolitis, air trapping, and atelectasis after adjusting for background factors. CONCLUSION:Our findings highlight particular CT findings that are associated with RAEs in RA patients undergoing long-term biological therapy.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Matsumoto T,Iwano S,Takahashi N,Asai S,Watanabe T,Asai N,Sobue Y,Ito S,Ishiguro N,Kojima Tdoi
10.1111/1756-185X.13434subject
Has Abstractpub_date
2019-04-01 00:00:00pages
626-635issue
4eissn
1756-1841issn
1756-185Xjournal_volume
22pub_type
杂志文章abstract:AIM:Inflammatory joint diseases (IJDs) are chronic arthritis, but frequently present with co-morbidities of other organs and systems, which is known as extra-articular manifestations (EAMs). It is still unclear which clinical characteristics or bio-markers can predict the development of EAMs. The aim of this study was ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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