Abstract：
AIM:The aim was to study the side-effect profile and the survival characteristics of leflunomide used in a regional patient population in New Zealand (NZ). METHOD: Patients were identified using special authority forms (SAFs) that had been prospectively filed from January 2001 to June 2007. Statistical analysis of survival data was done using the Kaplan-Meier (KM) method. RESULTS:Of 110 patients identified on SAFs, only 90 were suitable for analysis. The percentage of women and men were 74% and 26%, respectively. Their mean age was 55.58 years ± 13.44. Their diagnoses were rheumatoid arthritis 75%, psoriatic arthritis 15%, others 10%. Their mean disease duration was 11.31 years ± 8.93. The mean number of concomitant disease-modifying antirheumatic drugs used was 1.95. These were methotrexate (MTX) in 48, hydroxychloroquine in 29, prednisone in 30 and sulfasalazine in 27. Thirty-two of 90 (35.5%) discontinued treatment, 12 (13.3%) of these were in the first 6 months. The mean time to discontinuation was 14.2 months. Twenty-three of 32 discontinuations were for side-effects. The incidence of side-effects were similar to those of an earlier 2-year NZ study, and better than other earlier studies. Leflunomide survival using the KM method at 5 years was 57%, higher than suggested by previous leflunomide studies and this compares well with MTX studies. CONCLUSIONS:Our study suggests a better side-effect profile and a better drug survival for leflunomide than suggested by previous studies with survival comparable to that of MTX.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Jagoda JS,Rajapakse CNdoi
10.1111/j.1756-185X.2011.01637.xsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
340-4issue
4eissn
1756-1841issn
1756-185Xjournal_volume
14pub_type
杂志文章abstract：:Several lines of research indicate that osteoarthritis (OA) is not only a joint disorder associated with mechanical stress and aging but also a 'metabolic syndrome' in which several risk factors work together to contribute to disease initiation and/or development. One such metabolic risk factor could be high cholester...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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更新日期：2010-08-01 00:00:00
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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pub_type： 杂志文章,meta分析,评审
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,多中心研究
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更新日期：2014-06-01 00:00:00
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journal_title：International journal of rheumatic diseases
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doi：10.1111/1756-185X.13649
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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更新日期：2021-01-19 00:00:00
