Abstract:
AIMS:To investigate the utility of fluorine-18-labelled deoxyglucose positron emission tomography (FDG-PET) in routine clinical practice to diagnose and monitor disease activity and treatment response in large vessel vasculitis in a South Australian cohort. METHODS:We performed a retrospective clinical audit of adult patients who received a FDG-PET at a tertiary referral center between August 2010 and August 2015, where the term "vasculitis" appeared in either the request or report. RESULTS:A total of 45 patients met the inclusion criteria. Nine patients (20%) had a positive FDG-PET for large vessel vasculitis. FDG-PET was positive in 3/6 (50%) patients who met the American College of Rheumatology (ACR) criteria for giant cell arteritis or Takayasu's arteritis (TA) on retrospective review. A positive FDG-PET for large vessel inflammation assisted the primary clinician in making the diagnosis of unclassified large vessel vasculitis in six patients. Four of the seven patients who had more than one scan for large vessel vasculitis demonstrated normalized FDG uptake on subsequent scans after a period on glucocorticoid treatment. The remaining three patients persisted in having increased FDG uptake on FDG-PET imaging while on active treatment. CONCLUSION:Fluorine-18-labelled deoxyglucose positron emission tomography has a role in the diagnosis of large vessel vasculitis, particularly in patients with a high suspicion of active large vessel vasculitis who do not meet the ACR criteria. FDG-PET may have a role in monitoring disease activity in selected patients with large vessel vasculitis especially in identifying occult sites of large vessel inflammation or to titrate prednisolone therapy.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Nguyen AD,Crowhurst T,Lester S,Dobson R,Bartholomeusz D,Hill Cdoi
10.1111/1756-185X.13617subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1378-1382issue
8eissn
1756-1841issn
1756-185Xjournal_volume
22pub_type
杂志文章abstract:OBJECTIVES:To measure serial interleukin (IL)-6 levels in newly diagnosed patients with giant cell arteritis (GCA), treated in a randomized controlled trial of modified-release prednisone (MR) vs immediate-release prednisolone (IR) used in a tapering regimen conforming to British Society for Rheumatology GCA guidelines...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/1756-185X.13702
更新日期:2019-10-01 00:00:00
abstract::Intravenous immunoglobulin (IVIg) is a purified plasma product that is used for many immune-deficient conditions and autoimmune conditions. Use of IVIg for treatment for Kawasaki disease (KD) is critical for control of inflammation. The American Heart Association (AHA) recommends a single infusion of 2 g/kg preferably...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.13220
更新日期:2018-01-01 00:00:00
abstract:AIM:To elucidate the pathophysiology of rheumatoid arthritis (RA) as well as osteoarthritis (OA), we analyzed protein profiles of bone marrow-derived adherent cells (BMACs) from patients with these diseases. METHODS:Proteins, extracted from BMACs from three RA and three OA patients, were comprehensively analyzed by 2-...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2012.01702.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the association between chest computed tomography (CT) findings and incidence of respiratory adverse events (RAEs), and to detect risk factors for RAEs, in RA patients treated with long-term biological therapy. METHODS:Clinical and radiological data of 332 RA patients who were trea...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13434
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Rheumatoid arthritis (RA) is an inflammatory disease, which seriously affects human joints. This study aimed to detect the changes in the expression of long non-coding RNA growth arrest-specific transcript 5 (GAS5) in peripheral blood mononuclear cells (PBMCs) derived from patients with RA and healthy contro...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13930
更新日期:2020-08-04 00:00:00
abstract:OBJECTIVE:Under physiological stress, the membranes of organelles undergo conformational change to tubulo-reticular structures (TRS) for gaining survival advantage. We aim to explore whether TRS formation in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE) correlates wi...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12195
更新日期:2013-12-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the therapeutic effect of a traditional Chinese medicine (TCM), Bushen-Jianpi-Huoxue decoction (BJHD), on diabetic osteoporosis (DOP) and the action mechanisms likely mediated by nuclear factor-kappa B (NF-κB) and Wnt signaling pathways. METHODS:Fifty-five male Wistar rats wer...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13050
更新日期:2017-08-01 00:00:00
abstract:AIM:To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's disease (BD) and the goal...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.12369
更新日期:2017-05-01 00:00:00
abstract:AIM:Knee osteoarthritis (OA), is the most common degenerative joint disease. Several non-pharmacological interventions have been used for this purpose such as insoles. There are contradictory data about the superiority and effectiveness of laterally wedged compared with neutrally wedged insoles. This study was designed...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/1756-185X.12036
更新日期:2014-01-01 00:00:00
abstract:AIM:The objective of this study was to assess arthritis of the whole body before and after total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA) using positron emission tomography (PET). METHOD:Seventeen knees of 17 RA patients (median age 68 years) who underwent TKA were included in this study. Cli...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12855
更新日期:2017-06-01 00:00:00
abstract:AIM:The aim of this study is to evaluate the clinical parameters, acute-phase reactants, side effects, genetic mutations among colchicine-resistant Familial Mediterranean fever (FMF) patients who received anti-interleukin-1 (anti-IL-1) treatment. We also evaluate the quality of life and school attendance among colchici...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13891
更新日期:2020-07-01 00:00:00
abstract:AIMS:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Prostaglandins E2 (PGE2), the product of the cyclo-oxygenase 2 (COX-2) enzyme, has critical roles in the etiology of autoimmune diseases. PGE2 level is controlled by a balance between its synthesis mediator (COX-2 enzyme) and its cata...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13808
更新日期:2020-05-01 00:00:00
abstract:AIM:Procalcitonin is a marker of bacterial and fungal infection and sepsis. The present study evaluated the relationship between serum procalcitonin levels and disease activity in patients with ankylosing spondylitis (AS). METHOD:A total of 61 patients who met the 1984 New York criteria for AS were studied. Twenty-fou...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12386
更新日期:2016-05-01 00:00:00
abstract::Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and delay joint structural changes. Among SYSADOAs, evidence is greatest for the patented crystalline glucosamine sulf...
journal_title:International journal of rheumatic diseases
pub_type: 社论,评审
doi:10.1111/1756-185X.13068
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND AND AIM:Women with Sjögren's syndrome (SS) may have sexual dysfunctions due to vaginal dryness and may also have pelvic floor problems. The aim of this study was to examine the pelvic floor distress of women with SS with a self-reported questionnaire, to compare this group with healthy individuals, and to ex...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13998
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). The survival rates and mortality-predictive factors of a nationwide registry of Korean patients with CTD-PH measured by echocardiography were determined. METHODS:Patients with CTD-PH were enrolled between...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12645
更新日期:2017-09-01 00:00:00
abstract:AIM:Eosinophilic fasciitis (EF) is a rare, fibrosing disorder of skin and subcutaneous tissue. This study was undertaken to describe its clinical and laboratory features and identify prognostic factors associated with outcome. METHODS:We conducted a retrospective review of all EF patients evaluated at our institution ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13770
更新日期:2020-02-01 00:00:00
abstract:AIM:To evaluate the prevalence and severity of periodontal disease in patients with rheumatoid arthritis (RA) who attended a rheumatology clinic in a university hospital. METHODS:All consecutive patients with RA who attended the rheumatology clinic between June 2009 and January 2010 were asked to enroll in this study....
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12315
更新日期:2014-06-01 00:00:00
abstract::Joint diseases in antiquity and the Renaissance were generally known by the all-encompassing term, gout (podagra or gotta). Only in later centuries was there a differentiation in the types of joint diseases, distinguishing gout in the modern sense from other arthritic and rheumatic disorders. The present article illus...
journal_title:International journal of rheumatic diseases
pub_type: 传,历史文章,杂志文章
doi:10.1111/j.1756-185X.2011.01622.x
更新日期:2011-08-01 00:00:00
abstract:AIM:There is growing evidence that cold-inducible RNA-binding protein (CIRP) promotes inflammatory responses. This study investigated the relationship between CIRP and rheumatoid arthritis (RA). METHODS:Peripheral blood and synovial fluid were collected from 15 patients with RA and from 16 patients with osteoarthritis...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12892
更新日期:2018-01-01 00:00:00
abstract::Although treatment with intravenous immunoglobulin (IVIg) with aspirin is the standard of care for children with Kawasaki disease (KD), 15-20% of patients fail to respond and experience persistent or recurrent fever after completion of IVIg administration. These IVIg non-responders are at high risk for coronary artery...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.13209
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To make a rheumatology-specific electronic medical record (EMR) application for easy clinical data entry, automated display of outcome measures in real-time that generates well laid-out print-outs; and provides an easily retrievable database for clinical analysis and research. METHODS:Highly labour-intensiv...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2010.01551.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease with multifactorial etiology. Several studies show that genetic factors have an important part in the incidence of SLE. The C1QTNF4 gene is involved in the regulation of the inflammatory pathways by pro-inflammatory function. In the present study, w...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13981
更新日期:2020-11-01 00:00:00
abstract:AIM:To present the prevalence of tonsillitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) patients, to compare the clinical characteristics and disease activities between SAPHO patients with and without tonsillitis and to preliminarily explore the efficacy of tonsillectomy in SAPHO syndrome. METHO...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.14064
更新日期:2021-01-27 00:00:00
abstract::Vemurafenib is an inhibitor of the BRAF V600E mutation which is associated with tumor responses in patients with metastatic melanoma. Although it is generally well tolerated, common side effects of vemurafenib have been reported. Arthralgia is one of the more common adverse event associated with vemurafenib. We herein...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12396
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:To conduct a systematic review and meta-analysis assessing the prevalence of metabolic syndrome (MetS) in patients with systemic lupus erythematosus (SLE) and the association between SLE and MetS. METHOD:A database search of PubMed, the Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1756-185X.13153
更新日期:2017-08-01 00:00:00
abstract:AIM:Systemic lupus erythematosus (SLE) presents as the abnormal activation and over-proliferation of immune competent cells. Few studies have characterized the role of natural killer (NK) and NK T (NKT) cells in the pathogenesis of SLE, and therefore a consensus has not been reached as yet. METHOD:Thirty-two patients ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12289
更新日期:2016-06-01 00:00:00
abstract:AIM:Osteoporosis in axial spondyloarthropathy (axSpA) is difficult to accurately diagnose due to osteoproliferation of the spine interfering with conventional (anteroposterior, AP) dual-energy X-ray absorptiometry (DXA). This study compares AP and lateral projections of DXA when assessing bone mineral density (BMD) of ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.13765
更新日期:2020-03-01 00:00:00
abstract:AIM:To test whether treatment with celecoxib reduces the incidence of gastroduodenal ulcers compared to diclofenac in Asian patients with osteoarthritis (OA) or rheumatoid arthritis (RA) with minimal significant risk factors. METHODS:Patients with a clinical diagnosis of OA or RA of at least 3 months were randomized t...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1756-185X.2010.01463.x
更新日期:2010-05-01 00:00:00
abstract::Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae with predominant involvement of skin and nerves. We present a 70-year-old man with leprosy whose initial presentation resembled rheumatologic disease, due to leprae reaction. He presented with an 8-week history of worsening neuropathic pain in...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12916
更新日期:2016-10-01 00:00:00