Abstract:
OBJECTIVE:To determine serum levels and histopathological characteristics of fatty acid binding protein 3 (FABP3) in patients with polymyositis (PM) and dermatomyositis (DM), and to evaluate the correlation between the FABP3 and muscle strength. METHODS:The study population included 24 subjects with PM/DM, 12 subjects with asymptomatic or minimally symptomatic hyper-creatine kinase-emia (AMSH), and 10 healthy control subjects. Muscle strength was measured by using the Manual Muscle Test (MMT8). Serum CK, myoglobin and FABP3 levels were tested. Correlations between variables were studied by using Spearman's rank and partial correlation analysis methods. Immunohistochemical and double immunofluorescent stainings of FABP3 were performed to investigate its distribution in skeletal muscle. RESULTS:PM/DM patients had significantly higher (P < 0.05) serum FABP3 levels (35.46 ± 38.45 ng/mL) than did AMSH patients (3.77 ± 1.21 ng/mL) and healthy control subjects (4.30 ± 3.18 ng/mL). MMT8 scores correlated negatively with CK, myoglobin and FABP3 levels. Partial correlation analysis was performed and showed that the correlation coefficients between MMT8 score and serum CK, myoglobin and FABP3 levels were -0.276 (P > 0.05), -0.228 (P > 0.05) and -0.927 (P < 0.001), respectively. Immunohistochemical and double immunofluorescent staining showed that FABP3 expression increased in the skeletal muscle of PM/DM patients and was mainly distributed in slow twitch muscle fibers. CONCLUSION:Serum levels of FABP3 in PM/DM patients were significantly increased and were mainly distributed in slow twitch muscle fibers, displaying a closer association with muscle weakness than did serum levels of CK and myoglobin. FABP3 is likely to be a useful serum biomarker in PM/DM patients.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Zhang L,Zhou H,Peng Q,Jiang W,Qiao W,Wang Gdoi
10.1111/1756-185X.12838subject
Has Abstractpub_date
2017-02-01 00:00:00pages
252-260issue
2eissn
1756-1841issn
1756-185Xjournal_volume
20pub_type
杂志文章abstract:OBJECTIVE:To investigate the association of core stability with physical function and functional performance in patients with systemic sclerosis (SSc). METHODS:Forty patients who met the American College of Rheumatology / European League Against Rheumatism 2013 classification criteria for SSc were included in the cros...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.14067
更新日期:2021-01-19 00:00:00
abstract:AIM:Idiopathic granulomatous mastitis (IGM) is an enigmatic inflammatory breast disorder. IGM responds to immunomodulatory treatment and may be associated with systemic manifestations such as arthritis and erythema nodosum. These patients are increasingly referred to rheumatologists for management, but IGM is rarely di...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.14065
更新日期:2021-02-01 00:00:00
abstract:AIM:It is generally accepted that hyperuricemia is commonly associated with psoriatic arthritis (PsA). However, variations in ethnicity, diet and habitat may contribute to differences in prevalence and risk factors for hyperuricemia in PsA patients. Moreover, Asian specific data is deficient. The primary objective of t...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.13265
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Idiopathic inflammatory myopathies (IIM) are immune-mediated conditions that affect striated muscle, and are frequently associated with dysphagia. Dysphagia in these cases can be due to weakness of the muscles involved in swallowing or the presence of restrictive pharyngeal defects, such as cricopharyngeal b...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.14006
更新日期:2021-01-01 00:00:00
abstract::Although treatment with intravenous immunoglobulin (IVIg) with aspirin is the standard of care for children with Kawasaki disease (KD), 15-20% of patients fail to respond and experience persistent or recurrent fever after completion of IVIg administration. These IVIg non-responders are at high risk for coronary artery...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.13209
更新日期:2018-01-01 00:00:00
abstract:AIM:Eosinophilic fasciitis (EF) is a rare, fibrosing disorder of skin and subcutaneous tissue. This study was undertaken to describe its clinical and laboratory features and identify prognostic factors associated with outcome. METHODS:We conducted a retrospective review of all EF patients evaluated at our institution ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13770
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:As for the association between vitamin D receptor (VDR) gene polymorphisms and osteoporosis, the current results have yielded conflicts. Therefore, we performed a pooled analysis based on Chinese individuals to provide comprehensive data on the association between VDR BsmI, ApaI, Tru9I polymorphisms and oste...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1756-185X.13282
更新日期:2018-05-01 00:00:00
abstract:AIM:This study aimed to evaluate the relationship between circulating adiponectin and visfatin levels and rheumatoid arthritis (RA) and to establish a correlation between serum adipokine levels and RA activity. METHODS:We conducted meta-analyses on serum/plasma adiponectin or visfatin levels in patients with RA and co...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1756-185X.13038
更新日期:2018-03-01 00:00:00
abstract:AIM:The aim of this study is to evaluate the clinical parameters, acute-phase reactants, side effects, genetic mutations among colchicine-resistant Familial Mediterranean fever (FMF) patients who received anti-interleukin-1 (anti-IL-1) treatment. We also evaluate the quality of life and school attendance among colchici...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13891
更新日期:2020-07-01 00:00:00
abstract:AIM:An elevated serum uric acid level is associated with various diseases, such as gout, hypertension, renal impairment, and diabetes. Heavy metals, including lead and cadmium, are suspected to increase serum uric acid levels, but evidence regarding this is not sufficient, particularly in the Asian population. Therefor...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13632
更新日期:2019-08-01 00:00:00
abstract::The classification of the systemic vasculitides has been controversial for several decades. The Chapel Hill consensus Conference definitions originally developed in 1994, but revised and extended in 2012 are now widely accepted. The American College of Rheumatology (ACR) criteria were first published in 1990, are now ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.13303
更新日期:2019-01-01 00:00:00
abstract:AIM:To present the prevalence of tonsillitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) patients, to compare the clinical characteristics and disease activities between SAPHO patients with and without tonsillitis and to preliminarily explore the efficacy of tonsillectomy in SAPHO syndrome. METHO...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.14064
更新日期:2021-01-27 00:00:00
abstract:INTRODUCTION:Maintenance of temperature during collection and transport of blood is an important pre-requisite for cryoglobulin assays. In this manuscript, we describe 'cryodevice', a low-cost device for transportation and/or incubation of vials of whole blood at 37°C. Such a device would reduce false negatives in cryo...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13161
更新日期:2018-01-01 00:00:00
abstract::Loss of B-cell tolerance is a hallmark feature of the pathogenesis in systemic lupus erythematosus (SLE), an autoimmune disease that is characterized by hypergammaglobulinemia and autoantibody production. These autoantibodies lead to formation of immune-complex deposition in internal organs causing inflammation and da...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1756-185X.2009.01458.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To study the prevalence of musculoskeletal (MSK) symptoms and disorders among garment workers in Bangladesh, to look for possible relationships between pain location and type of work performed and to estimate the prevalence of rheumatological diagnoses. METHODS:A cross-sectional pilot study among 350 garment...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13423
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:To measure serial interleukin (IL)-6 levels in newly diagnosed patients with giant cell arteritis (GCA), treated in a randomized controlled trial of modified-release prednisone (MR) vs immediate-release prednisolone (IR) used in a tapering regimen conforming to British Society for Rheumatology GCA guidelines...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/1756-185X.13702
更新日期:2019-10-01 00:00:00
abstract:AIM:The objective of this study was to compare the efficacy and safety of dexamethasone and methylprednisolone for pulse therapy of rheumatoid arthritis flare-up. METHODS:This randomized double-blind controlled study was performed in the Emam Reza Educational Hospital of Tabriz University of Medical Sciences, Tabriz, ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/1756-185X.12278
更新日期:2014-05-01 00:00:00
abstract:AIM:This study investigated the use of fat fraction (FF) measurements in the sacroiliac (SI) joint to determine radiologic progression in patients with spondyloarthritis (SpA). METHOD:A total of 138 patients who underwent pelvic magnetic resonance imaging (MRI) between September 2014 and March 2015 were retrospectivel...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13485
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine the effect of active immunization of interleukin (IL)-17A to inhibit B cell functions and monitor the risk of infection in a pristane-induced lupus mice model. METHODS:Female Balb/c mice were given a single intraperitoneal injection of 0.5 mL pristane. IL-17A was coupled ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13325
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine hepatitis B virus (HBV) screening rates in patients receiving anti-tumor necrosis factor (TNF)-α therapy and the frequency of HBV reactivation in patients with resolved hepatitis B virus infection (hepatitis B surface antigen [HBsAg] negative, hepatitis B core antibo...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.14034
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:To determine the level of agreement among patients with rheumatoid arthritis (RA) with the principles and recommendations of the treat-to-target (T2T) initiative in New Zealand (NZ) and to further explore specific patient opinions via online iterative surveys. METHODS:Participants with RA were recruited fro...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13514
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of vitamin D inadequacy in a group of Filipino post-menopausal women with osteoporosis. METHODS:Seventy otherwise healthy post-menopausal Filipino women seen at the University of Santo Tomas Hospital, Section of Rheumatology, were diagnosed with osteoporosis by central dual-energy...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2009.01414.x
更新日期:2009-09-01 00:00:00
abstract:AIM:P-glycoprotein (P-gp) is an adenosine-5-triphosphate Binding Cassettes B 1 (ABCB1) transporter that exports various substrates on cellular membrane. Surface expression of P-gp was decreased during chondrogenesis of human bone marrow mesenchymal stem cells (BM-MSCs). We examined the role of P-gp in extracellular mat...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2011.01610.x
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To conduct a systematic review and meta-analysis assessing the prevalence of metabolic syndrome (MetS) in patients with systemic lupus erythematosus (SLE) and the association between SLE and MetS. METHOD:A database search of PubMed, the Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1756-185X.13153
更新日期:2017-08-01 00:00:00
abstract:AIM:To review the clinical features of brachial synovial cyst. METHOD:A case of bilateral brachial synovial cysts is described in a child suffering from systemic juvenile idiopathic arthritis during a relapse. Magnetic resonance imaging and ultrasonography were conducted to further evaluate the nature of the cysts. Th...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.13618
更新日期:2019-08-01 00:00:00
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12258
更新日期:2014-07-01 00:00:00
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12495
更新日期:2015-07-01 00:00:00
abstract:AIM:To evaluate the prevalence and severity of periodontal disease in patients with rheumatoid arthritis (RA) who attended a rheumatology clinic in a university hospital. METHODS:All consecutive patients with RA who attended the rheumatology clinic between June 2009 and January 2010 were asked to enroll in this study....
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12315
更新日期:2014-06-01 00:00:00
abstract::Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic condition characterized by reversible vasogenic edema on neuroimaging. It is associated with various neurological manifestations, including headaches, vomiting, seizures, visual loss, altered mental status and focal neurological deficits. PRES mainly ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2010.01545.x
更新日期:2010-10-01 00:00:00
abstract:AIM:To develop a translated and culturally adapted Bengali version of the WHO Fracture Risk Assessment Tool (FRAX(®) ) and to test its feasibility, content validity and reliability. METHOD:The English FRAX was translated and culturally adapted for use in Bangladeshi populations following established forward-backward t...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12425
更新日期:2015-03-01 00:00:00