Systemic lupus erythematosus complicated with posterior reversible encephalopathy syndrome and intracranial vasculopathy.

Abstract:

:Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic condition characterized by reversible vasogenic edema on neuroimaging. It is associated with various neurological manifestations, including headaches, vomiting, seizures, visual loss, altered mental status and focal neurological deficits. PRES mainly occurs in the setting of eclampsia, hypertension, uremia, malignancy, transplantation, autoimmune diseases and/or use of immunosuppressive drugs. This syndrome has been described in patients with systemic lupus erythematosus (SLE). PRES is a potentially reversible clinical-radiological entity; however, it can be complicated with vasculopathy, infarction or hemorrhage. Vasculopathy has been demonstrated to be a common finding in patients with SLE. We report the case of a woman with lupus nephritis and PRES whose diffuse vasculopathy was present on initial neuroimaging. Subsequent brain computed tomography scan demonstrated interval development of intraparenchymal hemorrhage and subarachnoid hemorrhage. To our knowledge, this unique brain image pattern has not been reported in SLE patients.

journal_name

Int J Rheum Dis

authors

Chen HA,Lin YJ,Chen PC,Chen TY,Lin KC,Cheng HH

doi

10.1111/j.1756-185X.2010.01545.x

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

e79-82

issue

4

eissn

1756-1841

issn

1756-185X

journal_volume

13

pub_type

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