Abstract:
AIM:The results of previous studies regarding the role of adiponectin in the pathogenesis of osteoarthritis (OA) are controversial. The aim of this study is to investigate the relation of plasma adiponectin levels with clinical and radiological disease severity in knee OA patients. METHOD:Sixty patients with knee OA and 25 healthy controls were included in the study. Patients were divided into two subgroups: lean (Group 1, n = 30) and obese (Group 2, n = 30). Healthy controls were accepted as Group 3 (n = 25). Pain intensity was measured with a visual analogue scale (VAS), functional disability with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Quality of Life (QoL) with Short Form-36 (SF-36). Also all patients were radiologically evaluated and graded according to Kellgren-Lawrence (KL) scale. Plasma concentrations of adiponectin levels were measured by enzyme-linked immune-sorbent assay (ELISA). RESULTS:Serum adiponectin levels were higher in OA patient subgroups than those in the control group but the difference did not reach a significant level after adjustments for age, gender and body mass index (P = 0.078). There was a positive correlation between adiponectin concentration and KL grading scores. Additionally, there was a positive correlation between adiponectin levels and clinical variables (VAS and WOMAC total scores) in patient subgroups (r = 0.326 P = 0.012, r = 0.583 P < 0.001, respectively). SF-36 scores were inversely associated with adiponectin levels. CONCLUSION:Plasma adiponectin concentrations were associated with both clinical and radiological disease severity in knee OA patients. Thus, adiponectin hormone might be a potential clinically useful biomarker while assessing disease severity in the future.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Cuzdan Coskun N,Ay S,Evcik FD,Oztuna Ddoi
10.1111/1756-185X.12790subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1942-1949issue
12eissn
1756-1841issn
1756-185Xjournal_volume
20pub_type
杂志文章abstract:AIM:Osteoporosis in axial spondyloarthropathy (axSpA) is difficult to accurately diagnose due to osteoproliferation of the spine interfering with conventional (anteroposterior, AP) dual-energy X-ray absorptiometry (DXA). This study compares AP and lateral projections of DXA when assessing bone mineral density (BMD) of ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.13765
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND AIM:Women with Sjögren's syndrome (SS) may have sexual dysfunctions due to vaginal dryness and may also have pelvic floor problems. The aim of this study was to examine the pelvic floor distress of women with SS with a self-reported questionnaire, to compare this group with healthy individuals, and to ex...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
abstract:AIM:To review the clinical features of brachial synovial cyst. METHOD:A case of bilateral brachial synovial cysts is described in a child suffering from systemic juvenile idiopathic arthritis during a relapse. Magnetic resonance imaging and ultrasonography were conducted to further evaluate the nature of the cysts. Th...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.13618
更新日期:2019-08-01 00:00:00
abstract:AIMS:In order to investigate the histological change in effect attenuation cases of etanercept compared with methotrexate (MTX), we performed immunohistochemical examination by seven different molecules. METHODS:We histologically assessed synovial tissue from five MTX-treated rheumatoid arthritis (RA) patients as cont...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2009.01372.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Under physiological stress, the membranes of organelles undergo conformational change to tubulo-reticular structures (TRS) for gaining survival advantage. We aim to explore whether TRS formation in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE) correlates wi...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12195
更新日期:2013-12-01 00:00:00
abstract:AIM:Medication non-adherence influences outcomes of therapies for chronic diseases. Allopurinol is a cornerstone therapy for patients with gout; however, non-adherence to allopurinol is prevalent in Singapore and limits its effectiveness. Between 2008-2010, an adherence-enhancing program was implemented at the rheumato...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13446
更新日期:2019-04-01 00:00:00
abstract:AIM AND OBJECTIVE:To evaluate the association between ultrasonographic findings of inflammation (effusion, synovitis) and clinical findings in patients with primary painful knee osteoarthritis. METHOD:This cross-sectional study was performed on 142 patients with primary painful knee osteoarthritis (American College of...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12834
更新日期:2017-05-01 00:00:00
abstract:AIM:Idiopathic granulomatous mastitis (IGM) is an enigmatic inflammatory breast disorder. IGM responds to immunomodulatory treatment and may be associated with systemic manifestations such as arthritis and erythema nodosum. These patients are increasingly referred to rheumatologists for management, but IGM is rarely di...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.14065
更新日期:2021-02-01 00:00:00
abstract::Intravenous immunoglobulin (IVIg) is a purified plasma product that is used for many immune-deficient conditions and autoimmune conditions. Use of IVIg for treatment for Kawasaki disease (KD) is critical for control of inflammation. The American Heart Association (AHA) recommends a single infusion of 2 g/kg preferably...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.13220
更新日期:2018-01-01 00:00:00
abstract:AIM:Colchicine prophylaxis is the single most important factor in ameliorating familial Mediterranean fever (FMF) for the prevention of both attacks and secondary amyloidosis. The aim of the present study was to evaluate the exact proportion of those patients who do not respond to colchicine and to characterize their d...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12374
更新日期:2017-12-01 00:00:00
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12855
更新日期:2017-06-01 00:00:00
abstract:INTRODUCTION:Rheumatoid arthritis (RA) is associated with chronic periodontitis (CP) due to shared risk factors, immuno-genetics and tissue destruction pathways. Human cathelicidin LL-37 has been suggested as a possible mechanistic link for these diseases. This study investigated the levels of salivary and serum LL-37 ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13919
更新日期:2020-08-02 00:00:00
abstract:AIM:Systemic lupus erythematosus (SLE) presents as the abnormal activation and over-proliferation of immune competent cells. Few studies have characterized the role of natural killer (NK) and NK T (NKT) cells in the pathogenesis of SLE, and therefore a consensus has not been reached as yet. METHOD:Thirty-two patients ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12289
更新日期:2016-06-01 00:00:00
abstract:AIM:In June 2015, the Thai Rheumatism Association (TRA) approved an update of its recommendation for the use of biologic disease-modifying anti-rheumatic drugs (bDMARDs) and targeted synthetic (tsDMARD) in the treatment of rheumatoid arthritis (RA) to cover those currently available in Thailand (etanercept, infliximab,...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,实务指引,评审
doi:10.1111/1756-185X.13130
更新日期:2017-09-01 00:00:00
abstract:AIM:Knee osteoarthritis (OA), is the most common degenerative joint disease. Several non-pharmacological interventions have been used for this purpose such as insoles. There are contradictory data about the superiority and effectiveness of laterally wedged compared with neutrally wedged insoles. This study was designed...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/1756-185X.12036
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To make a rheumatology-specific electronic medical record (EMR) application for easy clinical data entry, automated display of outcome measures in real-time that generates well laid-out print-outs; and provides an easily retrievable database for clinical analysis and research. METHODS:Highly labour-intensiv...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2010.01551.x
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). The survival rates and mortality-predictive factors of a nationwide registry of Korean patients with CTD-PH measured by echocardiography were determined. METHODS:Patients with CTD-PH were enrolled between...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12645
更新日期:2017-09-01 00:00:00
abstract:AIM:The aim of this article is two-fold: (i) to demonstrate the relation between vitamin D deficiency and dry eye and impaired tear function; and (ii) to investigate the possible associations among clinical parameters of hypovitaminosis D with dry eye parameters. METHOD:Fifty premenopausal women with vitamin D deficie...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12727
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Systemic sclerosis (SSc) has increased risk of morbidity and mortality due to pulmonary fibrosis, pulmonary arterial hypertension, renal crisis, infections and malignancies. Chemical exposure, smoking and cytotoxic drugs increase the malignancy risk in rheumatic diseases including SSc. We aim to evaluate cha...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13311
更新日期:2018-05-01 00:00:00
abstract::We report a rare case of antisynthase syndrome (ASS) complicated with Kaposi sarcoma, analyze its clinical characteristics, and review the literature on the topic. An 80-year-old male patient developed fever, cough, and shortness of breath. Lung high-resolution computed tomography showed nonspecific interstitial pneum...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13861
更新日期:2020-06-01 00:00:00
abstract:AIM:It has long been a controversy that polymorphisms in FcγRIIIa (CD16A) receptors are associated with systemic lupus erythematosus (SLE). We aimed to verify the association of FcγRIIIa polymorphisms with SLE in a large Chinese population. METHODS:We genotyped FcγRIIIa-158V/F (rs396991) using a pyro-sequencing assay ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析
doi:10.1111/1756-185X.12176
更新日期:2013-12-01 00:00:00
abstract::Primary systemic vasculitis is a group of heterogeneous disorders, characterized by inflammation of blood vessels causing end organ damage from ischemia, aneurysm formation or dissection. Delay in the early diagnosis owing to non-specific symptoms, lack of definitive serological tests, limited availability of biopsy a...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.12713
更新日期:2015-09-01 00:00:00
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2011.01595.x
更新日期:2011-08-01 00:00:00
abstract::Joint diseases in antiquity and the Renaissance were generally known by the all-encompassing term, gout (podagra or gotta). Only in later centuries was there a differentiation in the types of joint diseases, distinguishing gout in the modern sense from other arthritic and rheumatic disorders. The present article illus...
journal_title:International journal of rheumatic diseases
pub_type: 传,历史文章,杂志文章
doi:10.1111/j.1756-185X.2011.01622.x
更新日期:2011-08-01 00:00:00
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2011.01668.x
更新日期:2012-02-01 00:00:00
abstract::Retroperitoneal fibrosis (RPF) is a rare disease characterized by chronic, nonspecific inflammatory and sclerotic or fibrotic tissue in the periaortic or periiliac retroperitoneum that encases adjacent structures. There will be a series of clinical manifestations once the proliferated fibrous tissues encase the abdomi...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.12863
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Laboratory and immunological abnormalities seen in overt macrophage activation syndrome (MAS) may be observed in patients with untreated new onset systemic onset juvenile idiopathic arthritis (SoJIA). We investigated the prevalence of clinical and traditional laboratory markers of MAS as well as soluble CD163...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12196
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To investigate the association of core stability with physical function and functional performance in patients with systemic sclerosis (SSc). METHODS:Forty patients who met the American College of Rheumatology / European League Against Rheumatism 2013 classification criteria for SSc were included in the cros...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.14067
更新日期:2021-01-19 00:00:00
abstract:OBJECTIVE:It is controversial whether the use of biological disease-modifying antirheumatic drugs (DMARDs) increases the risk of herpes zoster (HZ). We aimed to evaluate the risks of HZ in tumor necrosis factor inhibitor (TNFI) and non-TNFI users with rheumatoid arthritis (RA) over 3 years in Japan. METHOD:Using the J...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13300
更新日期:2018-09-01 00:00:00