Abstract：
AIM:Systemic lupus erythematosus (SLE) presents as the abnormal activation and over-proliferation of immune competent cells. Few studies have characterized the role of natural killer (NK) and NK T (NKT) cells in the pathogenesis of SLE, and therefore a consensus has not been reached as yet. METHOD:Thirty-two patients with new-onset SLE and 15 healthy controls were recruited. Activated and inhibitory NK and NKT cells in peripheral blood were quantified by flow cytometry. The proportions of spontaneous and stimulated interferon (IFN)-γ(+) NK and NKT cells and CD107a(+) NK cells was examined. Finally, the potential relationship between the cell subsets and clinical indexes was analyzed. RESULTS:The proportions of NK and NKT cells (P = 0.002 and 0.004, respectively) as well as the proportions of NKG2C(+) NK cells, inhibitory NK and NKT cell subsets (P = 0.016, P = 0.019, P = 0.049, and P = 0.028, respectively) in SLE patients were significantly lower than those in controls. In contrast, the proportions of activated NK cells and NKT cell subsets were significantly higher (P = 0.036, P = 0.034, P = 0.005, and P = 0.007, respectively). Moreover, the proportions of stimulated IFN-γ(+) NKT cells were significantly higher than in the controls, and the proportions of stimulated CD107a(+) NKT cells in SLE patients were significantly lower than in the controls (P = 0.032 and P = 0.02, respectively). CONCLUSION:Lower proportions of NK and NKT cells, higher proportions of activated NK cells and activated NKT cells, lower proportions of inhibitory NK and NKT cells, higher NKT cell activity, and lower NKT cell degranulation may induce the autoimmune reaction involved in the pathogenesis of SLE.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Ye Z,Ma N,Zhao L,Jiang ZY,Jiang YFdoi
10.1111/1756-185X.12289subject
Has Abstractpub_date
2016-06-01 00:00:00pages
613-21issue
6eissn
1756-1841issn
1756-185Xjournal_volume
19pub_type
杂志文章abstract：AIM:To examine the prevalence of sicca symptoms and secondary Sjögren's syndrome (sSS) in rheumatoid arthritis (RA) patients, and the impact of sSS on disease activity and treatment profile in RA patients. METHODS:Three hundred and seven RA patients responding positive to at least one of the questions in a questionnai...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2012.01717.x
更新日期：2012-06-01 00:00:00
abstract：AIM:The main objective of this study is to elucidate the clinical significance of the SLC2A9/GLUT9 rs11722228 polymorphism among male gout patients. METHOD:We consecutively recruited all newly diagnosed male gout patients who were treatment-naive from the rheumatology outpatient clinics of two Malaysian hospitals. Age...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,多中心研究
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abstract：AIM:This study evaluated the anti-inflammatory properties of a species of Sorghum bicolor leaf (SBL) grown in West Africa. METHOD:Cyclo-oxygenase (COX)-2:COX-1 selectivity assay was carried out by plating isolated peripheral blood mononuclear cells in culture medium with specific SBL fractions: crude extract (J), ethy...
journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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doi：10.1111/1756-185X.13103
更新日期：2017-04-01 00:00:00
abstract：AIM:To assess the psychometric properties of the Japanese version of the Revised Fibromyalgia Impact Questionnaire (JFIQR) in fibromyalgia (FM) patients. METHOD:The reliability and validity of the JFIQR were assessed using online data collected from Japanese FM patients. Reliability was evaluated based on test-retest ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12574
更新日期：2017-09-01 00:00:00
abstract：AIM:This study was designed to examine the effect of Burdock root tea on inflammatory markers and oxidative stress indicators in patients with knee osteoarthritis (OA). METHODS:Thirty-six patients (10 men and 26 women) aged 50-70 years old with knee osteoarthritis referred to the Physical Medicine and Rehabilitation D...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,随机对照试验
doi：10.1111/1756-185X.12477
更新日期：2016-03-01 00:00:00
abstract：AIM:To elucidate the pathophysiology of rheumatoid arthritis (RA) as well as osteoarthritis (OA), we analyzed protein profiles of bone marrow-derived adherent cells (BMACs) from patients with these diseases. METHODS:Proteins, extracted from BMACs from three RA and three OA patients, were comprehensively analyzed by 2-...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2012.01702.x
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To assess parental stress levels of mothers of children with juvenile idiopathic arthritis (JIA) aged between 2-12 years and compare with those reported for other chronic childhood illnesses. METHODOLOGY:Mothers of children aged between 2-12 years with JIA were recruited from hospital-based outpatient clinic...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,多中心研究
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更新日期：2014-06-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13891
更新日期：2020-07-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12522
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1756-185X.13265
更新日期：2018-04-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12637
更新日期：2016-12-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2009.01430.x
更新日期：2009-12-01 00:00:00
abstract：AIM:Nonspecific chronic synovitis of the knee joint was reported by Pollard in 1962 and its pathogenesis is considered to be a physiological reaction to intra-articular disease. In this study, we evaluated the pathological findings of the synovium of early osteoarthritis (OA)-affected knee joints with hydrarthrosis in ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,meta分析,评审
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
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journal_title：International journal of rheumatic diseases
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pub_type： 杂志文章,多中心研究
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更新日期：2019-07-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12824
更新日期：2016-09-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13632
更新日期：2019-08-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
