Abstract：
AIM:To elucidate the pathophysiology of rheumatoid arthritis (RA) as well as osteoarthritis (OA), we analyzed protein profiles of bone marrow-derived adherent cells (BMACs) from patients with these diseases. METHODS:Proteins, extracted from BMACs from three RA and three OA patients, were comprehensively analyzed by 2-dimensional differential image gel electrophoresis (2D-DIGE). Then a part of the detected proteins, differently expressed between the two diseases, were identified by mass spectrometric analysis. RESULTS:2D-DIGE analysis detected more than 1600 protein spots in both RA and OA BMACs. Out of these, expression of 340 spots was significantly altered between the diseases (more than 1.5-fold: RA > OA, 26 spots; OA > RA, 314 spots; P < 0.05). Eleven protein spots the intensity of which were significantly altered by more than 2.0-fold were identified, which included vimentin and annexin A5 as increased proteins in RA rather than in OA. As increased proteins in OA compared to RA, alpha chain of collagen VI, a membrane anchor for acetylcholine esterase, heat shock protein 27, caldesmon and cytoskeletal proteins, such as beta actin and alpha tubulin, were identified. CONCLUSIONS:We here report different protein profiles of BMACs between RA and OA for the first time. BMACs possessing differently expressed proteins may be involved in the pathophysiology of the two diseases.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Kamada T,Kurokawa MS,Kato T,Takenouchi K,Takahashi K,Yoshioka T,Uchida T,Mitsui H,Suematsu N,Okamoto K,Yudo K,Katayama Y,Nakamura Hdoi
10.1111/j.1756-185X.2012.01702.xsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
169-78issue
2eissn
1756-1841issn
1756-185Xjournal_volume
15pub_type
杂志文章abstract：:The classification of the systemic vasculitides has been controversial for several decades. The Chapel Hill consensus Conference definitions originally developed in 1994, but revised and extended in 2012 are now widely accepted. The American College of Rheumatology (ACR) criteria were first published in 1990, are now ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/1756-185X.13303
更新日期：2019-01-01 00:00:00
abstract：AIM:To describe baseline characteristics of patients with primary Sjögren's syndrome (pSS) with right heart catheterization (RHC)-confirmed pulmonary arterial hypertension (PAH) and explore risk factors for PAH in pSS. METHODS:This case-control study included consecutive patients hospitalized with pSS-PAH from 2007 to...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13290
更新日期：2018-05-01 00:00:00
abstract：AIM:Genetic factors have a substantial contribution to the pathogenesis of rheumatoid arthritis (RA). Single nucleotide polymorphisms of NLRP3 p.Q705K and CARD8 p.C10X are two gene mutations that have been linked to many diseases. Here we carried out a meta-analysis to identify their association with susceptibility to ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,meta分析,评审
doi：10.1111/1756-185X.13016
更新日期：2017-10-01 00:00:00
abstract：AIM:Colchicine prophylaxis is the single most important factor in ameliorating familial Mediterranean fever (FMF) for the prevention of both attacks and secondary amyloidosis. The aim of the present study was to evaluate the exact proportion of those patients who do not respond to colchicine and to characterize their d...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12374
更新日期：2017-12-01 00:00:00
abstract：AIM:To prospectively evaluate the long-term efficacy and safety of repeated sodium hyaluronate injections for the treatment of knee pain due to Kashin-Beck disease (KBD). METHODS:A total of 85 patients with KBD-based knee pain were treated with two cycles of a 5-week course of sodium hyaluronate and received clinical ...
journal_title：International journal of rheumatic diseases
pub_type： 临床试验,杂志文章
doi：10.1111/1756-185X.13435
更新日期：2019-03-01 00:00:00
abstract：AIM:To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's disease (BD) and the goal...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1756-185X.12369
更新日期：2017-05-01 00:00:00
abstract：:A 72-year-old woman with slight pulmonary interstitial reticular markings was initially diagnosed with microscopic polyangiitis (MPA). Two years later, cavitated pulmonary masses appeared, and a biopsy specimen revealed granulomas. Granulomatosis with polyangiitis (GPA) was diagnosed. The masses resolved with treatmen...
journal_title：International journal of rheumatic diseases
pub_type：
doi：10.1111/1756-185X.12430
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To investigate the association of core stability with physical function and functional performance in patients with systemic sclerosis (SSc). METHODS:Forty patients who met the American College of Rheumatology / European League Against Rheumatism 2013 classification criteria for SSc were included in the cros...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.14067
更新日期：2021-01-19 00:00:00
abstract：AIM:Systemic lupus erythematosus (SLE) is an autoimmune disease that is associated with genetic and environmental factors and microbial infection. With respect to microbial infection, the Epstein-Barr virus (EBV) has been a widely discussed issue in recent decades. Human herpesvirus 8 (HHV-8) belongs to the same γ-herp...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12193
更新日期：2013-12-01 00:00:00
abstract：AIM:Nonspecific chronic synovitis of the knee joint was reported by Pollard in 1962 and its pathogenesis is considered to be a physiological reaction to intra-articular disease. In this study, we evaluated the pathological findings of the synovium of early osteoarthritis (OA)-affected knee joints with hydrarthrosis in ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12404
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:This study aimed to assess the association between chest computed tomography (CT) findings and incidence of respiratory adverse events (RAEs), and to detect risk factors for RAEs, in RA patients treated with long-term biological therapy. METHODS:Clinical and radiological data of 332 RA patients who were trea...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13434
更新日期：2019-04-01 00:00:00
abstract：AIM:Axial spondyloarthritis (axSpA) affects patients in the prime of their economic productivity. We aim to identify factors associated with poor work productivity in patients with axSpA in Singapore. METHODS:A cross-sectional study was performed in two tertiary centers in Singapore. Consecutive adult patients ≥21 yea...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1756-185X.13696
更新日期：2019-11-01 00:00:00
abstract：AIM:To assess the serum levels of soluble toll-like receptor (sTLR2) as an endogenous negative regulator of TLR2 signaling in systemic lupus erythematosus (SLE) patients, to investigate the correlation between sTLR2 and SLE disease activity index (SELDAI), SLE-related cardiovascular risk factors and ventricular dysfunc...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12452
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND AND AIM:Capable of multi-organ involvement in Sjogren's syndrome (SS), cardiac findings of pulmonary effusion, left ventricular diastolic dysfunction and pulmonary hypertension are seen in patients with SS. Aortic stiffness (AS) reflects the mechanical tension and elasticity of the aorta. In this study, our ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12258
更新日期：2014-07-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12159
更新日期：2017-12-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13426
更新日期：2019-03-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12386
更新日期：2016-05-01 00:00:00
abstract：:Retroperitoneal fibrosis (RPF) is a rare disease characterized by chronic, nonspecific inflammatory and sclerotic or fibrotic tissue in the periaortic or periiliac retroperitoneum that encases adjacent structures. There will be a series of clinical manifestations once the proliferated fibrous tissues encase the abdomi...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/1756-185X.12863
更新日期：2016-11-01 00:00:00
abstract：INTRODUCTION:Maintenance of temperature during collection and transport of blood is an important pre-requisite for cryoglobulin assays. In this manuscript, we describe 'cryodevice', a low-cost device for transportation and/or incubation of vials of whole blood at 37°C. Such a device would reduce false negatives in cryo...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13161
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,随机对照试验
doi：10.1111/1756-185X.13162
更新日期：2018-01-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13423
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12289
更新日期：2016-06-01 00:00:00
abstract：AIM:An elevated serum uric acid level is associated with various diseases, such as gout, hypertension, renal impairment, and diabetes. Heavy metals, including lead and cadmium, are suspected to increase serum uric acid levels, but evidence regarding this is not sufficient, particularly in the Asian population. Therefor...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13632
更新日期：2019-08-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,随机对照试验
doi：10.1111/1756-185X.12036
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease with multifactorial etiology. Several studies show that genetic factors have an important part in the incidence of SLE. The C1QTNF4 gene is involved in the regulation of the inflammatory pathways by pro-inflammatory function. In the present study, w...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13981
更新日期：2020-11-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12091
更新日期：2013-06-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2010.01526.x
更新日期：2010-08-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13649
更新日期：2019-09-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12140
更新日期：2014-02-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/1756-185X.13618
更新日期：2019-08-01 00:00:00
