Abstract：
AIM:To prospectively evaluate the long-term efficacy and safety of repeated sodium hyaluronate injections for the treatment of knee pain due to Kashin-Beck disease (KBD). METHODS:A total of 85 patients with KBD-based knee pain were treated with two cycles of a 5-week course of sodium hyaluronate and received clinical assessments with a follow-up period of 24 months after the first cycle. The primary efficacy measure was the visual analogue scale (VAS) pain score. The second efficacy measure included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores; and the patients' and physicians' global assessments. Tolerability was evaluated based on adverse events (AEs). RESULTS:Seventy-one patients (83.5%) completed the final study. The VAS was significantly reduced from 65.06 ± 12.21 mm (mean ± standard deviation [SD]) at baseline to 30.17 ± 11.92 mm at 6 months and was maintained for 24 months (35.79 ± 7.92 mm, P < 0.01 vs baseline). This finding was supported by the secondary variables (the WOMAC A, B and C scores; the total WOMAC scores; and the global assessments of the patients and their physicians at months 6, 12, 18 and 24). The overall incidence of AEs during the first and second cycles was 8 (9.4%) and 7 patients (8.2%), respectively. No serious AEs were reported. CONCLUSIONS:Repeated once yearly cycles of intra-articular sodium hyaluronate injections may improve knee KBD symptoms during the inbetween cycle period as well as exert a significant carry-over effect for at least 1 year after the repeated cycle. Other randomized double-blind studies are needed to confirm the findings from our study.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Tang X,Zhou ZK,Shen B,Kang PD,Pei FX,Li Jdoi
10.1111/1756-185X.13435subject
Has Abstractpub_date
2019-03-01 00:00:00pages
392-398issue
3eissn
1756-1841issn
1756-185Xjournal_volume
22pub_type
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,随机对照试验
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,随机对照试验
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abstract：AIM:Gastrodia elata and Radix aconiti lateralis preparrata are respectively named as Tian-Ma and Fu-Zi (TF) in Chinese. We explored the active components against rheumatoid arthritis (RA) from an extensively used couplet of Chinese herbs, Gastrodia elata and Radix aconiti lateralis preparata (TF) via untargeted metabol...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13779
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
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journal_title：International journal of rheumatic diseases
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pub_type： 杂志文章,meta分析
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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journal_title：International journal of rheumatic diseases
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