Abstract:
AIM:To test whether treatment with celecoxib reduces the incidence of gastroduodenal ulcers compared to diclofenac in Asian patients with osteoarthritis (OA) or rheumatoid arthritis (RA) with minimal significant risk factors. METHODS:Patients with a clinical diagnosis of OA or RA of at least 3 months were randomized to 12 weeks of double-blind treatment with celecoxib 100 mg twice daily (n = 440) or diclofenac 50 mg twice daily (n = 440). The primary outcome was the gastric and/or duodenal ulcer rate at endpoint as determined by upper gastrointestinal endoscopy performed during the screening week, and at endpoint. RESULTS:There was no significant difference in the overall incidence of gastroduodenal ulcers at 12-week endpoint for celecoxib compared to diclofenac (2.8% vs. 5.1%; Cochran-Mantel-Haenszel [CMH] chi(2) P = 0.083). However, there was a significantly lower incidence of gastric ulcers on celecoxib versus diclofenac (0.5% vs. 3.6%; CMH chi(2) P = 0.002). Approximately 59% of patients in both treatment groups had no visible gastric lesions at endpoint; and a similar proportion were found to have one or more erosions on celecoxib (n = 85; 21.4%) and diclofenac (N = 91; 23.3%). A survival analysis of time to ulcer was significant for gastric ulcers (log-rank P = 0.004), but not for duodenal ulcers, or for gastroduodenal ulcers combined. Fewer patients reported at least one adverse event on celecoxib compared to diclofenac (42.4% vs. 50.3%; chi(2), 5.52; P = 0.019). CONCLUSIONS:In Asian patients with minimal significant risk factors, treatment with celecoxib was associated with a modest but significantly reduced incidence of gastric ulcers at the end of 12 weeks.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Cheung R,Cheng TT,Dong Y,Lin HY,Lai K,Lau CS,Feng H,Parsons Bdoi
10.1111/j.1756-185X.2010.01463.xsubject
Has Abstractpub_date
2010-05-01 00:00:00pages
151-7issue
2eissn
1756-1841issn
1756-185Xpii
APL1463journal_volume
13pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:It is controversial whether the use of biological disease-modifying antirheumatic drugs (DMARDs) increases the risk of herpes zoster (HZ). We aimed to evaluate the risks of HZ in tumor necrosis factor inhibitor (TNFI) and non-TNFI users with rheumatoid arthritis (RA) over 3 years in Japan. METHOD:Using the J...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13300
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abstract:AIM:To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's disease (BD) and the goal...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.12369
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journal_title:International journal of rheumatic diseases
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abstract:AIM:To investigate the effects on hypercholesterolemia and hypertriglyceridemia in gouty patients receiving uric acid-lowering therapy (UALT). METHODS:A retrospective study was performed from January 2015 to December 2017 in gouty patients receiving UALT. A total of 124 gouty patients with hypercholesterolemia or hype...
journal_title:International journal of rheumatic diseases
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abstract:OBJECTIVES:To investigate the causes and risk of death in a large cohort of Korean patients with rheumatoid arthritis (RA). METHODS:Patients in the Hanyang BAE (Bae registry of Autoimmune diseases for Epidemiology) RA cohort who fulfilled the American College of Rheumatology criteria were analyzed. A total of 2355 pat...
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abstract:OBJECTIVE:To assess parental stress levels of mothers of children with juvenile idiopathic arthritis (JIA) aged between 2-12 years and compare with those reported for other chronic childhood illnesses. METHODOLOGY:Mothers of children aged between 2-12 years with JIA were recruited from hospital-based outpatient clinic...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1756-185X.12394
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abstract:OBJECTIVE:To evaluate the performance of a line blot (LB) assay for identifying anti-PM-Scl antibody (Ab). METHODS:We screened 56 serum samples from systemic sclerosis patients using a protein immunoprecipitation (IP) assay and an LB assay (Systemic Sclerosis Profile Euroline® Blot test kit) to detect anti-PM-Scl Ab. ...
journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 临床试验,杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,随机对照试验
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,随机对照试验
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00