Abstract:
AIM:To evaluate the efficacy of tumor necrosis factor inhibitor infliximab in patients with rheumatoid arthritis (RA) who were disease-resistant to recombinant human interleukin-1 receptor antagonist (IL-1Ra). METHODS:A total of 104 patients with active RA despite methotrexate (MTX) treatment were enrolled in the open trial. Among them, 27 IL-1Ra nonresponders 'Switchers' and 51 biologic-naive patients 'Naivers' received an infusion of 3 mg/kg infliximab at weeks 0, 2, 6 and 14, combined with concurrent MTX therapy, while the other 26 patients who had never received any biologics 'Controls' continued MTX monotherapy. Clinical outcomes and safety were assessed at weeks 0, 2 and every 4 weeks thereafter for 18 weeks with the American College of Rheumatology (ACR) core set criteria, the Disease Activity Score in 28 joints, and records of adverse events (AEs) and abnormal laboratory findings. RESULTS:At week 18, an ACR20 response was achieved in 56% of Switchers and 61% of Naivers, compared with 23% of Controls (P = 0.0013 and 0.0126, respectively). Compared with Controls, both Switchers and Naivers achieved a significant improvement in tender-joint count, swollen-joint count, patient's assessment of pain, patient's and physician's global assessment of disease activity, erythrocyte sedimentation rate and C-reactive protein. Switchers even achieved a greater benefit from health assessment questionnaire (HAQ) scores than Naivers. Infliximab was well tolerated, with a similar incidence of AEs across all study groups. CONCLUSION:Switching from IL-1Ra to infliximab is effective in improving disease activity and maintaining joint function.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Bao J,Yue T,Li T,He DY,Bao YXdoi
10.1111/1756-185X.12387subject
Has Abstractpub_date
2016-04-01 00:00:00pages
370-6issue
4eissn
1756-1841issn
1756-185Xjournal_volume
19pub_type
杂志文章,随机对照试验abstract:AIM:This study investigated the prognostic factors of cardiac death or cardiac failure using cardiac scintigraphy, echocardiography (UCG), and magnetic resonance imaging (MRI) in asymptomatic systemic sclerosis (SSc) patients. METHODS:We retrospectively evaluated SSc patients who had undergone cardiac scintigraphy usi...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13508
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12082
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abstract:BACKGROUND:Rheumatoid arthritis (RA) is an inflammatory disease, which seriously affects human joints. This study aimed to detect the changes in the expression of long non-coding RNA growth arrest-specific transcript 5 (GAS5) in peripheral blood mononuclear cells (PBMCs) derived from patients with RA and healthy contro...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/j.1756-185X.2011.01595.x
更新日期:2011-08-01 00:00:00
abstract:AIM:To assess the serum levels of soluble toll-like receptor (sTLR2) as an endogenous negative regulator of TLR2 signaling in systemic lupus erythematosus (SLE) patients, to investigate the correlation between sTLR2 and SLE disease activity index (SELDAI), SLE-related cardiovascular risk factors and ventricular dysfunc...
journal_title:International journal of rheumatic diseases
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doi:10.1111/1756-185X.12452
更新日期:2016-07-01 00:00:00
abstract:AIM:Systemic sclerosis (SSc) is characterized by immune abnormalities, progressive fibrosis of the skin and internal organs, and microvascular injury and damage. Interleukin-21 receptor (IL-21R) is expressed in the epidermis from patients with SSc. However, information describing the role of IL-21 in SSc is limited. M...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12522
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abstract::Although treatment with intravenous immunoglobulin (IVIg) with aspirin is the standard of care for children with Kawasaki disease (KD), 15-20% of patients fail to respond and experience persistent or recurrent fever after completion of IVIg administration. These IVIg non-responders are at high risk for coronary artery...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
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abstract:AIM:Previous analysis of comparative anti-citrullinated heat shock protein 90 (citHSP90) antibody profiles between bronchoalveolar lavage fluid and serum indicates that the lung plays a direct role in shaping the immune repertoire of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). METHODS:To addres...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13316
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Under physiological stress, the membranes of organelles undergo conformational change to tubulo-reticular structures (TRS) for gaining survival advantage. We aim to explore whether TRS formation in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE) correlates wi...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12195
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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abstract::Exposure to cadmium links smoking, the most import antetiological factor in the development of seropositive RA, and many of the other known contemporary risk factors. Epidemiological studies investigating the link between smoking, occupations, social class, region of residency and RA should consider cadmium exposure a...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12673
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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doi:10.1111/1756-185X.13051
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
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