Autoreactive T cells to citrullinated HSP90 are associated with interstitial lung disease in rheumatoid arthritis.

Abstract:

AIM:Previous analysis of comparative anti-citrullinated heat shock protein 90 (citHSP90) antibody profiles between bronchoalveolar lavage fluid and serum indicates that the lung plays a direct role in shaping the immune repertoire of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). METHODS:To address the contribution of citHSP90β-specific T cells in this process, we evaluated in vitro cytokine responses to citHSP90β in RA patients with different stages of ILD as well as in controls with non-RA connective tissue disease-associated ILD (CTD-ILD). Cultures derived from whole blood were individually stimulated with HSP90β, citHSP90β, citrullinated BSA, or no antigen. The concentrations of 13 cytokines and chemokines in the plasma supernatant were then measured using Luminex xMAP technology. RESULTS:CitHSP90β induced significantly higher levels of interferon-γ (IFN-γ) levels in RA-ILD (interstitial lung abnormalities = 2 + 3) groups compared to the RA-no ILD group (P = 0.01), but did not stimulate the production of other cytokines (P > 0.05). Furthermore, citHSP90β did not stimulate the production of IFN-γ or other cytokines in those individuals with non-RA CTD-ILD. CONCLUSION:Overall, the production of IFN-γ by T cells stimulated with citHSP90β demonstrates a bias toward TH1 immune responses that are likely involved in the pathogenesis of RA-ILD.

journal_name

Int J Rheum Dis

authors

Chen J,Song S,Liu Y,Liu D,Lin Y,Ge S,Ascherman DP

doi

10.1111/1756-185X.13316

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

1398-1405

issue

7

eissn

1756-1841

issn

1756-185X

journal_volume

21

pub_type

杂志文章
  • Inflammatory cytokines as predictors of resistance to intravenous immunoglobulin therapy in Kawasaki disease patients.

    abstract:OBJECTIVES:Kawasaki disease (KD) is an acute systemic vasculitis. Activation of the immune system is a central feature of KD. Some KD patients are resistant to initial high-dose intravenous immunoglobulin (IVIG) treatment. The study aimed to determine the predictors of IVIG resistance. METHOD:A single-center, retrospe...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12082

    authors: Sato S,Kawashima H,Kashiwagi Y,Hoshika A

    更新日期:2013-04-01 00:00:00

  • Effects of patient satisfaction and confidence on the success of treatment of combined rheumatic disease and interstitial lung disease in a multidisciplinary outpatient clinic.

    abstract:OBJECTIVES:Multidisciplinary discussions (MDDs) have emphasized improve medical services and outcomes. We used a multidisciplinary approach to explore whether patient emotional satisfaction and confidence affected treatment outcomes in rheumatic disease (RD)-related interstitial lung disease (ILD). METHODS:From Decemb...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13331

    authors: Jeong SO,Uh ST,Park S,Kim HS

    更新日期:2018-08-01 00:00:00

  • Inhibition of P-glycoprotein facilitated glycosaminoglycan accumulation during chondrogenesis of human bone marrow mesenchymal stem cells.

    abstract:AIM:P-glycoprotein (P-gp) is an adenosine-5-triphosphate Binding Cassettes B 1 (ABCB1) transporter that exports various substrates on cellular membrane. Surface expression of P-gp was decreased during chondrogenesis of human bone marrow mesenchymal stem cells (BM-MSCs). We examined the role of P-gp in extracellular mat...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/j.1756-185X.2011.01610.x

    authors: Kim SG,Lee AJ,Lee SJ,Suh HS,Shin IH

    更新日期:2011-05-01 00:00:00

  • Reactivation of hepatitis B virus infection following rituximab treatment in HBsAg-negative, HBcAb-positive rheumatoid arthritis patients: A long-term, real-world observation.

    abstract:AIM:Longitudinal data of the reactivation of hepatitis B virus (rHBV) and serial serological markers or HBV-DNA has been limited. This study aimed to investigate the temporal course of rHBV development in rheumatoid arthritis (RA) patients undergoing long-term rituximab therapy. METHODS:The occurrence of rHBV was exam...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13582

    authors: Chen YM,Chen HH,Huang WN,Chen YH,Hsieh TY,Yang SS,Lan JL,Chen DY

    更新日期:2019-06-01 00:00:00

  • Effect of anti-interleukin-1 treatment on quality of life in children with colchicine-resistant familial Mediterranean fever: A single-center experience.

    abstract:AIM:The aim of this study is to evaluate the clinical parameters, acute-phase reactants, side effects, genetic mutations among colchicine-resistant Familial Mediterranean fever (FMF) patients who received anti-interleukin-1 (anti-IL-1) treatment. We also evaluate the quality of life and school attendance among colchici...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13891

    authors: Kurt T,Aydın F,Nilüfer Tekgöz P,Sezer M,Uncu N,Çelikel Acar B

    更新日期:2020-07-01 00:00:00

  • Effect of omega-3 fatty acids on disease severity in patients with psoriasis: A systematic review.

    abstract:AIM:Many randomized controlled trials have been performed on the efficacy and mechanism of action of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on psoriasis. However, contradictory results have been obtained. This study wants to assess the effects of n-3 PUFAs on the severity of psoriasis. METHODS:The Cochrane Ce...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1756-185X.13051

    authors: Upala S,Yong WC,Theparee T,Sanguankeo A

    更新日期:2017-04-01 00:00:00

  • Klinefelter's syndrome and rheumatoid arthritis: report of a case and review of the literature.

    abstract::Kilnefelter's syndrome (KFS) tends to be associated with autoimmune diseases. Although several reports describe association of KFS with different autoimmune diseases, association with rheumatoid arthritis is very rare. We report a case of (KFS) who had seropositive erosive rheumatoid arthritis, and discuss the role of...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1756-185X.2009.01452.x

    authors: Al-Arfaj HF

    更新日期:2010-02-01 00:00:00

  • Measuring bone density in axial spondyloarthropathy: Time to turn things on their side?

    abstract:AIM:Osteoporosis in axial spondyloarthropathy (axSpA) is difficult to accurately diagnose due to osteoproliferation of the spine interfering with conventional (anteroposterior, AP) dual-energy X-ray absorptiometry (DXA). This study compares AP and lateral projections of DXA when assessing bone mineral density (BMD) of ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1111/1756-185X.13765

    authors: Fitzgerald G,Anachebe T,McCarroll K,O'Shea F

    更新日期:2020-03-01 00:00:00

  • Differentiation of patented crystalline glucosamine sulfate from other glucosamine preparations will optimize osteoarthritis treatment.

    abstract::Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and delay joint structural changes. Among SYSADOAs, evidence is greatest for the patented crystalline glucosamine sulf...

    journal_title:International journal of rheumatic diseases

    pub_type: 社论,评审

    doi:10.1111/1756-185X.13068

    authors: Saengnipanthkul S,Waikakul S,Rojanasthien S,Totemchokchyakarn K,Srinkapaibulaya A,Cheh Chin T,Mai Hong N,Bruyère O,Cooper C,Reginster JY,Lwin M

    更新日期:2019-03-01 00:00:00

  • LncRNA GAS5 activates the AMPK pathway in peripheral blood mononuclear cells derived from rheumatoid arthritis patients.

    abstract:BACKGROUND:Rheumatoid arthritis (RA) is an inflammatory disease, which seriously affects human joints. This study aimed to detect the changes in the expression of long non-coding RNA growth arrest-specific transcript 5 (GAS5) in peripheral blood mononuclear cells (PBMCs) derived from patients with RA and healthy contro...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13930

    authors: Cao J,Lv X,Zhang Y,Xu A,Jiang T

    更新日期:2020-08-04 00:00:00

  • A systematic review of the epidemiology, disease characteristics and management of systemic sclerosis in Australian adults.

    abstract:OBJECTIVE:Australia has one of the highest prevalence rates of systemic sclerosis (SSc) worldwide. In order to highlight management deficiencies and key areas for further research, it is essential to understand its local epidemiological patterns, natural history, prognosis and mortality trends over time. METHODS:To id...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1756-185X.13203

    authors: Morrisroe K,Stevens W,Proudman S,Nikpour M

    更新日期:2017-11-01 00:00:00

  • Gout: an Asia-Pacific update.

    abstract::Even though, Hippocrates recognized gout as an affection of older men and a product of high living long back in 5th century BC, this painful condition promises to accompany humanity to the 21st century. The incidence is progressively rising and females are also affected in the modern era. There are also regional and e...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1756-185X.13103

    authors: Paul BJ,James R

    更新日期:2017-04-01 00:00:00

  • Usual interstitial pneumonia following resolution of cavitated pulmonary masses in a patient with ANCA-associated vasculitis.

    abstract::A 72-year-old woman with slight pulmonary interstitial reticular markings was initially diagnosed with microscopic polyangiitis (MPA). Two years later, cavitated pulmonary masses appeared, and a biopsy specimen revealed granulomas. Granulomatosis with polyangiitis (GPA) was diagnosed. The masses resolved with treatmen...

    journal_title:International journal of rheumatic diseases

    pub_type:

    doi:10.1111/1756-185X.12430

    authors: Fukui S,Kobayashi S,Kamei S,Takizawa Y,Setoguchi K,Hishima T

    更新日期:2018-04-01 00:00:00

  • Assessing the construct validity of clinical tests to identify sacroiliac joint inflammation in patients with non-radiographic axial spondyloarthritis.

    abstract:AIM:Magnetic resonance imaging (MRI) can be used to identify sacroiliac joint (SIJ) inflammation and provide an earlier diagnosis of nonradiographic axial spondyloarthritis (nrAxSpA). However, MRI is frequently a resource-limited examination. Our aim was to assess if a set of physical clinical tests can identify SIJ in...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13606

    authors: Castro MP,Stebbings SM,Milosavljevic S,Pedersen SJ,Bussey MD

    更新日期:2019-08-01 00:00:00

  • Insights into osteoarthritis from MRI.

    abstract::Magnetic resonance imaging (MRI) has added a new dimension to the study of osteoarthritis, a long-known degenerative joint disease with limited therapeutic options. It has advanced our understanding of joint pathophysiology and identifying that osteoarthritis as a simple 'wear and tear' process of the articular cartil...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1756-185X.2011.01677.x

    authors: Tan YK,Conaghan PG

    更新日期:2012-02-01 00:00:00

  • A multi-center, observational study shows high proportion of Australian rheumatoid arthritis patients have inadequate disease control.

    abstract:OBJECTIVES:To evaluate the disease activity and current pharmacological interventions used to achieve remission in rheumatoid arthritis (RA) patients in Australia. METHODS:Rheumatoid arthritis patients treated in participating Australian clinics were included in the study. Patient demographics, disease onset, medicati...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1111/1756-185X.12163

    authors: Littlejohn G,Roberts L,Arnold M,Bird P,Burnet S,de Jager J,Griffiths H,Nicholls D,Scott J,Zochling J,Tymms KE

    更新日期:2013-10-01 00:00:00

  • Dry eye in vitamin D deficiency: more than an incidental association.

    abstract:AIM:The aim of this article is two-fold: (i) to demonstrate the relation between vitamin D deficiency and dry eye and impaired tear function; and (ii) to investigate the possible associations among clinical parameters of hypovitaminosis D with dry eye parameters. METHOD:Fifty premenopausal women with vitamin D deficie...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12727

    authors: Yildirim P,Garip Y,Karci AA,Guler T

    更新日期:2016-01-01 00:00:00

  • Apigenin and apigeninidin isolates from the Sorghum bicolor leaf targets inflammation via cyclo-oxygenase-2 and prostaglandin-E2 blockade.

    abstract:AIM:This study evaluated the anti-inflammatory properties of a species of Sorghum bicolor leaf (SBL) grown in West Africa. METHOD:Cyclo-oxygenase (COX)-2:COX-1 selectivity assay was carried out by plating isolated peripheral blood mononuclear cells in culture medium with specific SBL fractions: crude extract (J), ethy...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13355

    authors: Makanjuola SBL,Ogundaini AO,Ajonuma LC,Dosunmu A

    更新日期:2018-08-01 00:00:00

  • Taiwan Rheumatology Association consensus recommendations for the management of axial spondyloarthritis.

    abstract:AIM:To establish guidelines for the clinical management of axial spondyloarthritis that take into account local issues and clinical practice concerns for Taiwan. METHOD:Overarching principles and recommendations were established by consensus among a panel of rheumatology and rehabilitation experts, based on analysis o...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1756-185X.13752

    authors: Wei JC,Liu CH,Tseng JC,Hsieh LF,Chen CH,Chen HH,Chen HA,Chen YC,Chou CT,Liao HT,Lin YC,Luo SF,Yang DH,Yeo KJ,Tsai WC,Taiwan Rheumatology Association (TRA).

    更新日期:2020-01-01 00:00:00

  • The incidence of extra-articular manifestations in southern Chinese patients with inflammatory joint diseases.

    abstract:AIM:Inflammatory joint diseases (IJDs) are chronic arthritis, but frequently present with co-morbidities of other organs and systems, which is known as extra-articular manifestations (EAMs). It is still unclear which clinical characteristics or bio-markers can predict the development of EAMs. The aim of this study was ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13657

    authors: Yan S,Cui Y,Zhang X,Zhang G,Dong G,Feng Y,Song Y

    更新日期:2019-09-01 00:00:00

  • Evaluation of sleep quality in patients with ankylosing spondylitis and efficacy of anti-TNF-α therapy on sleep problems: A polisomnographic study.

    abstract:INTRODUCTION:This study was conducted to investigate the relationship between sleep quality (SQ) and disease activity (DA) in patients with ankylosing spondylitis (AS) and to evaluate the response to anti-tumor necrosis factor α (anti-TNF-α) therapy on sleep disorders. MATERIALS AND METHODS:A total of 34 patients who ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13102

    authors: Karatas G,Bal A,Yuceege M,Firat H,Gurcay E,Ardic S,Cakci FA

    更新日期:2018-06-01 00:00:00

  • Serum soluble toll-like receptor 2: a novel biomarker for systemic lupus erythematosus disease activity and lupus-related cardiovascular dysfunction.

    abstract:AIM:To assess the serum levels of soluble toll-like receptor (sTLR2) as an endogenous negative regulator of TLR2 signaling in systemic lupus erythematosus (SLE) patients, to investigate the correlation between sTLR2 and SLE disease activity index (SELDAI), SLE-related cardiovascular risk factors and ventricular dysfunc...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12452

    authors: Houssen ME,El-Mahdy RH,Shahin DA

    更新日期:2016-07-01 00:00:00

  • The Gouty Joseph in Giulio Romano's 'Holy Family'.

    abstract::Joint diseases in antiquity and the Renaissance were generally known by the all-encompassing term, gout (podagra or gotta). Only in later centuries was there a differentiation in the types of joint diseases, distinguishing gout in the modern sense from other arthritic and rheumatic disorders. The present article illus...

    journal_title:International journal of rheumatic diseases

    pub_type: 传,历史文章,杂志文章

    doi:10.1111/j.1756-185X.2011.01622.x

    authors: Weisz GM,Albury WR,Lippi D,Matucci-Cerinic M

    更新日期:2011-08-01 00:00:00

  • FCGR3B copy number loss rather than gain is a risk factor for systemic lupus erythematous and lupus nephritis: a meta-analysis.

    abstract:AIM:Some studies have been performed to elucidate the association between Fc gamma receptor 3B (FCGR3B) copy number (CN) and the risk of systemic lupus erythematosus (SLE) and/or lupus nephritis (LN), yet the results remain conflicting. Therefore, we have undertaken a systematic review of all the studies published and ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/1756-185X.12342

    authors: Yuan J,Zhao D,Wu L,Xu X,Pang Y,Zhang J,Ma Y,Liu J,Wang J

    更新日期:2015-05-01 00:00:00

  • Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis.

    abstract:AIM:In rheumatoid arthritis (RA) hands, we applied high-resolution peripheral quantitative computed tomography (HR-pQCT) and 3 Tesla (3 T) magnetic resonance imaging (MRI), which are new methods for erosion detection and bone marrow edema (BME) quantification. We compared the erosion measurements between these techniqu...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12495

    authors: Lee CH,Srikhum W,Burghardt AJ,Virayavanich W,Imboden JB,Link TM,Li X

    更新日期:2015-07-01 00:00:00

  • Differences in clinical presentation and incidence of cardiopulmonary involvement in late-onset versus early-onset systemic sclerosis: inception cohort study.

    abstract:INTRODUCTION:Data regarding the incidence rate (IR) of cardiopulmonary involvement in comparison between late-onset SSc and early-onset SSc are limited. OBJECTIVE:To compare the prevalence of clinical manifestations and the IR of cardiopulmonary involvement compared between the two subgroups. METHODS:An inception coh...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13307

    authors: Wangkaew S,Phiriyakrit P,Sawangduan V,Prasertwittayakij N,Euathrongchit J

    更新日期:2018-05-01 00:00:00

  • Increased frequency of class I and II anti-human leukocyte antigen antibodies in systemic lupus erythematosus and scleroderma and associated factors: a comparative study.

    abstract:AIM:There is significant autoantibody production in systemic lupus erythematosus (SLE) and scleroderma (SSc); microchimerism is also thought to play a role in pathogenesis. We determined the frequency of anti-HLA antibodies in SLE and SSc patients and evaluated associated clinical factors. METHODS:We included 77 SLE p...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12484

    authors: Tozkir H,Pamuk ON,Duymaz J,Gurkan H,Yazar M,Sari G,Tanrikulu H,Pamuk GE

    更新日期:2016-12-01 00:00:00

  • Assessment of the relationship between aortic stiffness and left ventricular functions with echocardiography in patients with Sjögren's syndrome.

    abstract:BACKGROUND AND AIM:Capable of multi-organ involvement in Sjogren's syndrome (SS), cardiac findings of pulmonary effusion, left ventricular diastolic dysfunction and pulmonary hypertension are seen in patients with SS. Aortic stiffness (AS) reflects the mechanical tension and elasticity of the aorta. In this study, our ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12258

    authors: Ciçek OF,Bayram NA,Ayhan H,Erten S,Aslan AN,Sarı C,Ozen MB,Bİlen E,Bastuğ S,Durmaz T,Keleş T,Bozkurt E

    更新日期:2014-07-01 00:00:00

  • Maintenance of Remission in antineutrophil cytoplasm antibody-associated vasculitides.

    abstract::The classification of the systemic vasculitides has been controversial for several decades. The Chapel Hill consensus Conference definitions originally developed in 1994, but revised and extended in 2012 are now widely accepted. The American College of Rheumatology (ACR) criteria were first published in 1990, are now ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1756-185X.13303

    authors: Guillevin L,Terrier B

    更新日期:2019-01-01 00:00:00

  • IgG4-related retroperitoneal fibrosis: a newly characterized disease.

    abstract::Retroperitoneal fibrosis (RPF) is a rare disease characterized by chronic, nonspecific inflammatory and sclerotic or fibrotic tissue in the periaortic or periiliac retroperitoneum that encases adjacent structures. There will be a series of clinical manifestations once the proliferated fibrous tissues encase the abdomi...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1756-185X.12863

    authors: Lian L,Wang C,Tian JL

    更新日期:2016-11-01 00:00:00