Abstract：
AIM:The aim of this article is two-fold: (i) to demonstrate the relation between vitamin D deficiency and dry eye and impaired tear function; and (ii) to investigate the possible associations among clinical parameters of hypovitaminosis D with dry eye parameters. METHOD:Fifty premenopausal women with vitamin D deficiency (serum vitamin D levels < 20 ng/mL) and 48 controls were included. Participants were assessed by Schirmer's test, tear break-up time test (TBUT), ocular surface disease index (OSDI), Stanford Health Assessment Questionnaire (HAQ), fatigue severity scale (FSS), and visual analogue scale-pain (VAS-pain). RESULTS:Lower scores in Schirmer's test and TBUT, and higher in OSDI were detected in patients with vitamin D deficiency than in controls (P < 0.05). FSS was negatively correlated with Schirmer's test (r = -0,29; P = 0.038) and TBUT scores (r = -0,43; P = 0.002); VAS-pain was negatively correlated with TBUT scores (r = -0.32; P = 0.023). HAQ scores showed no significant correlation with dry eye parameters (P > 0.05). Vitamin D level was negatively correlated with OSDI (r = -0.49; P < 0.001), and positively with Schirmer's test (r = 0.45; P = 0.001) and TBUT scores (r = 0.30; P = 0.029). CONCLUSION:Dry eye and impaired tear function in patients with vitamin D deficiency may indicate a protective role of vitamin D in the development of dry eye, probably by enhancing tear film parameters and reducing ocular surface inflammation. Patients with vitamin D deficiency should be evaluated for dry eye syndromes.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Yildirim P,Garip Y,Karci AA,Guler Tdoi
10.1111/1756-185X.12727subject
Has Abstractpub_date
2016-01-01 00:00:00pages
49-54issue
1eissn
1756-1841issn
1756-185Xjournal_volume
19pub_type
杂志文章abstract：:Even though, Hippocrates recognized gout as an affection of older men and a product of high living long back in 5th century BC, this painful condition promises to accompany humanity to the 21st century. The incidence is progressively rising and females are also affected in the modern era. There are also regional and e...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/1756-185X.13103
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abstract：INTRODUCTION:Data regarding the incidence rate (IR) of cardiopulmonary involvement in comparison between late-onset SSc and early-onset SSc are limited. OBJECTIVE:To compare the prevalence of clinical manifestations and the IR of cardiopulmonary involvement compared between the two subgroups. METHODS:An inception coh...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13307
更新日期：2018-05-01 00:00:00
abstract：:Psoriatic arthritis (PsA) is a common, chronic inflammatory disease with complex pathogenesis. In recent years, a number of susceptibility non-human leukocyte antigen (HLA) genes of PsA have been revealed, which also act as important factors in the pathogenesis of PsA as well as HLA genes. By searching the databases N...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/1756-185X.13879
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abstract：:Multiple myeloma (MM) is a malignant plasma cell disorder. Musculoskeletal and skin manifestations of this disorder are rare. Here we report a case of a young male patient presenting with polyarthritis and skin rash resembling vasculitis. Detailed investigations revealed that he was suffering from multiple myeloma in ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2010.01526.x
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease with multifactorial etiology. Several studies show that genetic factors have an important part in the incidence of SLE. The C1QTNF4 gene is involved in the regulation of the inflammatory pathways by pro-inflammatory function. In the present study, w...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13981
更新日期：2020-11-01 00:00:00
abstract：AIM:The aim was to study the side-effect profile and the survival characteristics of leflunomide used in a regional patient population in New Zealand (NZ). METHOD: Patients were identified using special authority forms (SAFs) that had been prospectively filed from January 2001 to June 2007. Statistical analysis of su...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2011.01637.x
更新日期：2011-10-01 00:00:00
abstract：AIM:Recent studies highlight the importance of the interleukin (IL)-17A cytokine in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). There are also reports of associations between some single nucleotide polymorphisms (SNPs) in IL-17A and RA but not SLE. Notably, these findings have not been replicated ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13426
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVES:To measure serial interleukin (IL)-6 levels in newly diagnosed patients with giant cell arteritis (GCA), treated in a randomized controlled trial of modified-release prednisone (MR) vs immediate-release prednisolone (IR) used in a tapering regimen conforming to British Society for Rheumatology GCA guidelines...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,随机对照试验
doi：10.1111/1756-185X.13702
更新日期：2019-10-01 00:00:00
abstract：INTRODUCTION:This study was conducted to investigate the relationship between sleep quality (SQ) and disease activity (DA) in patients with ankylosing spondylitis (AS) and to evaluate the response to anti-tumor necrosis factor α (anti-TNF-α) therapy on sleep disorders. MATERIALS AND METHODS:A total of 34 patients who ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13102
更新日期：2018-06-01 00:00:00
abstract：AIM:Longitudinal data of the reactivation of hepatitis B virus (rHBV) and serial serological markers or HBV-DNA has been limited. This study aimed to investigate the temporal course of rHBV development in rheumatoid arthritis (RA) patients undergoing long-term rituximab therapy. METHODS:The occurrence of rHBV was exam...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13582
更新日期：2019-06-01 00:00:00
abstract：:We report a rare case of antisynthase syndrome (ASS) complicated with Kaposi sarcoma, analyze its clinical characteristics, and review the literature on the topic. An 80-year-old male patient developed fever, cough, and shortness of breath. Lung high-resolution computed tomography showed nonspecific interstitial pneum...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13861
更新日期：2020-06-01 00:00:00
abstract：:Exposure to cadmium links smoking, the most import antetiological factor in the development of seropositive RA, and many of the other known contemporary risk factors. Epidemiological studies investigating the link between smoking, occupations, social class, region of residency and RA should consider cadmium exposure a...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12673
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:Remission is an ideal target in the management of rheumatoid arthritis (RA). We compared American College of Rheumatology (ACR) 1981 preliminary definition of remission, European League Against Rheumatism (EULAR) disease activity score of 28 joints - C-reactive protein (DAS28 (3)-CRP) and DAS28 (3)-ESR (eryth...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12091
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:Complex regional pain syndrome (CRPS) type I is one of the most important problems with regard to physical medicine and rehabilitation. CRPS may cause not only higher therapeutic costs but also greater work time loss. The mechanism and pathogenesis of CRPS still remains unknown. Some findings indicating oxida...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12140
更新日期：2014-02-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13446
更新日期：2019-04-01 00:00:00
abstract：AIM:To describe a cohort of Filipinos with primary osteoarthritis (OA). METHOD:Charts with diagnosis of OA from two arthritis clinics (Philippine General Hospital and a private clinic) from January 2008 to May 2011, were reviewed for demographics, clinical presentation, risk factors and management. Descriptive statist...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2012.01758.x
更新日期：2012-08-01 00:00:00
abstract：AIM:The objective of this study was to assess arthritis of the whole body before and after total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA) using positron emission tomography (PET). METHOD:Seventeen knees of 17 RA patients (median age 68 years) who underwent TKA were included in this study. Cli...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12855
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Rheumatoid arthritis (RA) is a chronic disease which affects the performance of the upper extremities. There is no method to evaluate the specific upper extremity endurance of individuals with this disease. The unsupported upper-limb exercise test (UULEX) is a performance test that evaluates upper extremity ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13720
更新日期：2019-11-01 00:00:00
abstract：AIM:This Clinical Guidance is aimed to help practitioners assess, diagnose and manage their patients with osteoporosis (OP), using the best available evidence. METHODS:A literature search using PubMed (MEDLINE) and The Cochrane Library identified all relevant articles on OP and its assessment, diagnosis and treatment,...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/1756-185x.12037
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abstract：AIM:To describe the clinical features, treatment and long-term outcomes in north Indian patients with granulomatosis with polyangiitis (GPA). METHODS:Clinical details, Birmingham Vasculitis Activity Score (BVAS-v3), laboratory data, histopathology findings, treatment details and outcomes of all consecutive patients di...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13071
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abstract：AIM:Pulmonary arterial hypertension (PAH) is a complex and devastating complication of systemic lupus erythematosus (SLE). We sought to describe the baseline characteristics of right heart catheterization (RHC)-confirmed SLE-associated PAH and identify risk factors for PAH in SLE patients. METHODS:A multicenter, cross...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,多中心研究
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更新日期：2019-05-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/1756-185X.13618
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abstract：AIM:Vitamin K is an essential factor for carboxylation of bone matrix protein. Low vitamin K may be associated with reduced bone mineral density (BMD). The issue of whether long-term sodium warfarin therapy as oral anticoagulant that antagonizes vitamin K, results in decreased bone density, is controversial. Our purpos...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2009.01395.x
更新日期：2009-07-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12484
更新日期：2016-12-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12495
更新日期：2015-07-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2009.01430.x
更新日期：2009-12-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
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更新日期：2009-04-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13638
更新日期：2019-09-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12824
更新日期：2016-09-01 00:00:00
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journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13372
更新日期：2018-11-01 00:00:00
