Elevation of cytomegalovirus antigenemia predicts serious infection and death in patients receiving immunosuppressive therapies for autoimmune diseases.

Abstract:

AIM:We examined the relationship between cytomegalovirus (CMV) reactivation and serious infections. METHOD:We conducted a single-center retrospective chart review study with 43 autoimmune disease patients experiencing CMV reactivation. We investigated the risk factors for serious infections among the patients using logistic regression analysis. RESULTS:We identified that the maximum count of CMV antigenemia during the course of infection (CMV Ag MAX) was significantly associated with serious infection by multivariate analysis (adjusted odds ratio: 1.509; 95% confidence interval: 1.071-2.125). The receiver operating characteristic curve of CMV Ag MAX count showed a predictive value for serious infections (76.9% in sensitivity and 93.3% in specificity) and death (83.3% in sensitivity and 91.9% in specificity), and the cut-off count of serious infections and death was 6 and 10 per 105 white blood cell count, respectively. CONCLUSION:We suggest that the counts of CMV Ag MAX can reflect the extent of compromise in the immune system, and can be a predictive marker for serious infections and death.

journal_name

Int J Rheum Dis

authors

Yoshihara R,Komai T,Shoda H,Fujio K

doi

10.1111/1756-185X.13990

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1534-1540

issue

11

eissn

1756-1841

issn

1756-185X

journal_volume

23

pub_type

杂志文章
  • A low perfusion-metabolic mismatch in 99m Tl and 123 I-BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement.

    abstract:AIM:This study investigated the prognostic factors of cardiac death or cardiac failure using cardiac scintigraphy, echocardiography (UCG), and magnetic resonance imaging (MRI) in asymptomatic systemic sclerosis (SSc) patients. METHODS:We retrospectively evaluated SSc patients who had undergone cardiac scintigraphy usi...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13508

    authors: Iida H,Hanaoka H,Okada Y,Kiyokawa T,Takakuwa Y,Yamada H,Okazaki T,Ozaki S,Yamaguchi K,Nakajima Y,Kawahata K

    更新日期:2019-06-01 00:00:00

  • Health-related quality of life in rheumatoid arthritis: Systematic review and meta-analysis of EuroQoL (EQ-5D) utility scores from Asia.

    abstract:INTRODUCTION:Region-specific health-related quality of life (HRQoL) scores or utility values are representative and pivotal for economic evaluations as they are influenced by the value judgment of the local population. This study systematically reviewed and pooled EuroQoL-5 Dimension (EQ-5D) utility scores of rheumatoi...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.14066

    authors: Haridoss M,Bagepally BS,Natarajan M

    更新日期:2021-01-23 00:00:00

  • Serum soluble toll-like receptor 2: a novel biomarker for systemic lupus erythematosus disease activity and lupus-related cardiovascular dysfunction.

    abstract:AIM:To assess the serum levels of soluble toll-like receptor (sTLR2) as an endogenous negative regulator of TLR2 signaling in systemic lupus erythematosus (SLE) patients, to investigate the correlation between sTLR2 and SLE disease activity index (SELDAI), SLE-related cardiovascular risk factors and ventricular dysfunc...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12452

    authors: Houssen ME,El-Mahdy RH,Shahin DA

    更新日期:2016-07-01 00:00:00

  • FCGR3B copy number loss rather than gain is a risk factor for systemic lupus erythematous and lupus nephritis: a meta-analysis.

    abstract:AIM:Some studies have been performed to elucidate the association between Fc gamma receptor 3B (FCGR3B) copy number (CN) and the risk of systemic lupus erythematosus (SLE) and/or lupus nephritis (LN), yet the results remain conflicting. Therefore, we have undertaken a systematic review of all the studies published and ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/1756-185X.12342

    authors: Yuan J,Zhao D,Wu L,Xu X,Pang Y,Zhang J,Ma Y,Liu J,Wang J

    更新日期:2015-05-01 00:00:00

  • Psoriatic arthritis: A systematic review of non-HLA genetic studies and important signaling pathways.

    abstract::Psoriatic arthritis (PsA) is a common, chronic inflammatory disease with complex pathogenesis. In recent years, a number of susceptibility non-human leukocyte antigen (HLA) genes of PsA have been revealed, which also act as important factors in the pathogenesis of PsA as well as HLA genes. By searching the databases N...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1756-185X.13879

    authors: Chen J,Yuan F,Fan X,Wang Y

    更新日期:2020-08-06 00:00:00

  • Insights into osteoarthritis from MRI.

    abstract::Magnetic resonance imaging (MRI) has added a new dimension to the study of osteoarthritis, a long-known degenerative joint disease with limited therapeutic options. It has advanced our understanding of joint pathophysiology and identifying that osteoarthritis as a simple 'wear and tear' process of the articular cartil...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1756-185X.2011.01677.x

    authors: Tan YK,Conaghan PG

    更新日期:2012-02-01 00:00:00

  • Good response to infliximab in rheumatoid arthritis following failure of interleukin-1 receptor antagonist.

    abstract:AIM:To evaluate the efficacy of tumor necrosis factor inhibitor infliximab in patients with rheumatoid arthritis (RA) who were disease-resistant to recombinant human interleukin-1 receptor antagonist (IL-1Ra). METHODS:A total of 104 patients with active RA despite methotrexate (MTX) treatment were enrolled in the open...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1756-185X.12387

    authors: Bao J,Yue T,Li T,He DY,Bao YX

    更新日期:2016-04-01 00:00:00

  • C1QTNF4 gene p.His198Gln mutation is correlated with early-onset systemic lupus erythematosus in Iranian patients.

    abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease with multifactorial etiology. Several studies show that genetic factors have an important part in the incidence of SLE. The C1QTNF4 gene is involved in the regulation of the inflammatory pathways by pro-inflammatory function. In the present study, w...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13981

    authors: Pakzad B,Shirpour R,Mousavi M,Karimzadeh H,Salehi A,Kazemi M,Amini G,Akbari M,Salehi R

    更新日期:2020-11-01 00:00:00

  • Impact of subclinical synovitis in ankles and feet detected by ultrasonography in patients with rheumatoid arthritis.

    abstract:OBJECTIVE:To investigate the impact of subclinical synovitis detected by ultrasonography (US) on the ankles and feet of patients with rheumatoid arthritis. METHODS:We retrospectively reviewed the data of patients (n = 59) who underwent US. RESULTS:The functional ability and quality of life (QoL) of patients in the su...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13399

    authors: Inamo J,Kaneko Y,Sakata K,Takeuchi T

    更新日期:2019-01-01 00:00:00

  • Effect of active immunization with IL-17A on B cell function and infection risk in pristane-induced lupus model.

    abstract:PURPOSE:The aim of this study was to determine the effect of active immunization of interleukin (IL)-17A to inhibit B cell functions and monitor the risk of infection in a pristane-induced lupus mice model. METHODS:Female Balb/c mice were given a single intraperitoneal injection of 0.5 mL pristane. IL-17A was coupled ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13325

    authors: Handono K,Pratama MZ,Sari DK,Hermawan HO,Agdana HM,Kawuningan KB,Nur'aini N,Hasanah D,Kalim H

    更新日期:2018-06-01 00:00:00

  • Clinical profile of Filipino patients with osteoarthritis seen at two arthritis clinics.

    abstract:AIM:To describe a cohort of Filipinos with primary osteoarthritis (OA). METHOD:Charts with diagnosis of OA from two arthritis clinics (Philippine General Hospital and a private clinic) from January 2008 to May 2011, were reviewed for demographics, clinical presentation, risk factors and management. Descriptive statist...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/j.1756-185X.2012.01758.x

    authors: Racaza GZ,Salido EO,Penserga EG

    更新日期:2012-08-01 00:00:00

  • Cadmium, one of the villains behind the curtain: has exposure to cadmium helped to pull the strings of seropositive rheumatoid arthritis pathogenesis all along?

    abstract::Exposure to cadmium links smoking, the most import antetiological factor in the development of seropositive RA, and many of the other known contemporary risk factors. Epidemiological studies investigating the link between smoking, occupations, social class, region of residency and RA should consider cadmium exposure a...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12673

    authors: Hutchinson D

    更新日期:2015-06-01 00:00:00

  • A rheumatologic approach to granulomatous mastitis: A case series and review of the literature.

    abstract:AIM:Idiopathic granulomatous mastitis (IGM) is an enigmatic inflammatory breast disorder. IGM responds to immunomodulatory treatment and may be associated with systemic manifestations such as arthritis and erythema nodosum. These patients are increasingly referred to rheumatologists for management, but IGM is rarely di...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.14065

    authors: Ringsted S,Friedman M

    更新日期:2021-02-01 00:00:00

  • Bilateral brachial synovial cysts in systemic juvenile idiopathic arthritis: Case report and literature review.

    abstract:AIM:To review the clinical features of brachial synovial cyst. METHOD:A case of bilateral brachial synovial cysts is described in a child suffering from systemic juvenile idiopathic arthritis during a relapse. Magnetic resonance imaging and ultrasonography were conducted to further evaluate the nature of the cysts. Th...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1756-185X.13618

    authors: Zheng Q,Lu M

    更新日期:2019-08-01 00:00:00

  • The association between P selectin glycoprotein ligand 1 gene variable number of tandem repeats polymorphism and risk of thrombosis in Behçet's disease.

    abstract:OBJECTIVES:Behçet's disease (BD) has been recognized as an unclassified type of vasculitis with an accompanying tendency to thrombosis. No disease-specific pathology has been demonstrated so far to explain the prothrombotic state, and this predisposition is considered to be associated with endothelial activation/dysfun...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13151

    authors: Cosan F,Oku B,Gedar Totuk OM,Abaci N,Ustek D,Diz Kucukkaya R,Gul A

    更新日期:2018-12-01 00:00:00

  • Association of FcγRIIIa-158V/F with systemic lupus erythematosus in a Chinese population.

    abstract:AIM:It has long been a controversy that polymorphisms in FcγRIIIa (CD16A) receptors are associated with systemic lupus erythematosus (SLE). We aimed to verify the association of FcγRIIIa polymorphisms with SLE in a large Chinese population. METHODS:We genotyped FcγRIIIa-158V/F (rs396991) using a pyro-sequencing assay ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,meta分析

    doi:10.1111/1756-185X.12176

    authors: Dai M,Zhou Z,Wang X,Qian X,Huang X

    更新日期:2013-12-01 00:00:00

  • Superiority of laterally elevated wedged insoles to neutrally wedged insoles in medial knee osteoarthritis symptom relief.

    abstract:AIM:Knee osteoarthritis (OA), is the most common degenerative joint disease. Several non-pharmacological interventions have been used for this purpose such as insoles. There are contradictory data about the superiority and effectiveness of laterally wedged compared with neutrally wedged insoles. This study was designed...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1756-185X.12036

    authors: Hatef MR,Mirfeizi Z,Sahebari M,Jokar MH,Mirheydari M

    更新日期:2014-01-01 00:00:00

  • A multi-center, observational study shows high proportion of Australian rheumatoid arthritis patients have inadequate disease control.

    abstract:OBJECTIVES:To evaluate the disease activity and current pharmacological interventions used to achieve remission in rheumatoid arthritis (RA) patients in Australia. METHODS:Rheumatoid arthritis patients treated in participating Australian clinics were included in the study. Patient demographics, disease onset, medicati...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1111/1756-185X.12163

    authors: Littlejohn G,Roberts L,Arnold M,Bird P,Burnet S,de Jager J,Griffiths H,Nicholls D,Scott J,Zochling J,Tymms KE

    更新日期:2013-10-01 00:00:00

  • Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee.

    abstract:AIM:To prospectively evaluate the long-term efficacy and safety of repeated sodium hyaluronate injections for the treatment of knee pain due to Kashin-Beck disease (KBD). METHODS:A total of 85 patients with KBD-based knee pain were treated with two cycles of a 5-week course of sodium hyaluronate and received clinical ...

    journal_title:International journal of rheumatic diseases

    pub_type: 临床试验,杂志文章

    doi:10.1111/1756-185X.13435

    authors: Tang X,Zhou ZK,Shen B,Kang PD,Pei FX,Li J

    更新日期:2019-03-01 00:00:00

  • Association between clinical and sonographic synovitis in patients with painful knee osteoarthritis.

    abstract:AIM AND OBJECTIVE:To evaluate the association between ultrasonographic findings of inflammation (effusion, synovitis) and clinical findings in patients with primary painful knee osteoarthritis. METHOD:This cross-sectional study was performed on 142 patients with primary painful knee osteoarthritis (American College of...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12834

    authors: Abbasi B,Pezeshki-Rad M,Akhavan R,Sahebari M

    更新日期:2017-05-01 00:00:00

  • Serum levels of anti-streptolysin O antibodies: their role in evaluating rheumatic diseases.

    abstract:BACKGROUND:Family physicians measure serum levels of anti-streptolysin O antibodies (ASO) in the routine evaluation of patients with rheumatic conditions. AIM:To evaluate the significance of elevated serum ASO titer in hospitalized patients with various clinical conditions. PATIENTS AND METHODS:We retrieved the names...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/j.1756-185X.2011.01668.x

    authors: Ben-Chetrit E,Moses AE,Agmon-Levin N,Block C,Ben-Chetrit E

    更新日期:2012-02-01 00:00:00

  • Lest we forget Hansen's disease (leprosy): an unusual presentation with an acute onset of inflammatory polyarthritis and the rheumatology experience.

    abstract::Several forms of arthritis and rheumatism can sometimes complicate leprosy. However, its presentation as an acute onset arthritis is unusual. We report two adult male naïve patients who presented to our rheumatology outpatient clinic with acute onset inflammatory polyarthritis, skin rash and mild sensory neurodeficit....

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/j.1756-185X.2009.01382.x

    authors: Sheetal S,Arvind C

    更新日期:2009-04-01 00:00:00

  • Baseline characteristics and long-term outcomes of eosinophilic fasciitis in 89 patients seen at a single center over 20 years.

    abstract:AIM:Eosinophilic fasciitis (EF) is a rare, fibrosing disorder of skin and subcutaneous tissue. This study was undertaken to describe its clinical and laboratory features and identify prognostic factors associated with outcome. METHODS:We conducted a retrospective review of all EF patients evaluated at our institution ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13770

    authors: Mango RL,Bugdayli K,Crowson CS,Drage LA,Wetter DA,Lehman JS,Peters MS,Davis MD,Chowdhary VR

    更新日期:2020-02-01 00:00:00

  • Association between core stability and physical function, functional performance in patients with systemic sclerosis.

    abstract:OBJECTIVE:To investigate the association of core stability with physical function and functional performance in patients with systemic sclerosis (SSc). METHODS:Forty patients who met the American College of Rheumatology / European League Against Rheumatism 2013 classification criteria for SSc were included in the cros...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.14067

    authors: Yakut H,Özalevli S,Birlik AM

    更新日期:2021-01-19 00:00:00

  • Local steroid injection versus wrist splinting for carpal tunnel syndrome: A randomized clinical trial.

    abstract:AIM:We conducted a prospective randomized parallel clinical trial comparing the efficacy of local steroid injection and nocturnal wrist splinting in patients with carpal tunnel syndrome (CTS). METHODS:The well-validated and disease-specific Boston Carpal Tunnel Questionnaire (BCTQ) was employed and its score at 4 week...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1756-185X.13162

    authors: So H,Chung VCH,Cheng JCK,Yip RML

    更新日期:2018-01-01 00:00:00

  • Lipid peroxidation, glutathione, vitamin E, and antioxidant enzymes in synovial fluid from patients with osteoarthritis.

    abstract:AIM:To compare levels of lipid peroxidation and antioxidants in synovial fluid from primary knee osteoarthritis (OA) patients with severe cartilage damage undergoing total knee replacement with those in the synovial fluid from injured knee joint patients with intact cartilage undergoing knee arthroscopy. METHODS:Thirt...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/j.1756-185X.2009.01430.x

    authors: Sutipornpalangkul W,Morales NP,Charoencholvanich K,Harnroongroj T

    更新日期:2009-12-01 00:00:00

  • IL-17A haplotype confers susceptibility to systemic lupus erythematosus but not to rheumatoid arthritis in Mexican patients.

    abstract:AIM:Recent studies highlight the importance of the interleukin (IL)-17A cytokine in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). There are also reports of associations between some single nucleotide polymorphisms (SNPs) in IL-17A and RA but not SLE. Notably, these findings have not been replicated ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13426

    authors: Montúfar-Robles I,Barbosa-Cobos RE,Alemán-Ávila I,Ramírez-Bello J

    更新日期:2019-03-01 00:00:00

  • Pathological findings from synovium of early osteoarthritic knee joints with persistent hydrarthrosis.

    abstract:AIM:Nonspecific chronic synovitis of the knee joint was reported by Pollard in 1962 and its pathogenesis is considered to be a physiological reaction to intra-articular disease. In this study, we evaluated the pathological findings of the synovium of early osteoarthritis (OA)-affected knee joints with hydrarthrosis in ...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.12404

    authors: Kurose R,Kakizaki H,Akimoto H,Yagihashi N,Sawai T

    更新日期:2016-05-01 00:00:00

  • Traditional Chinese medicine Bushen-Jianpi-Huoxue decoction prevents diabetic osteoporosis in rats via Wnt and nuclear factor-kappa B signaling pathways.

    abstract:AIM:The aim of this study was to evaluate the therapeutic effect of a traditional Chinese medicine (TCM), Bushen-Jianpi-Huoxue decoction (BJHD), on diabetic osteoporosis (DOP) and the action mechanisms likely mediated by nuclear factor-kappa B (NF-κB) and Wnt signaling pathways. METHODS:Fifty-five male Wistar rats wer...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13050

    authors: Zhang Y,Liu M,Li H,Chen Z,Liang N,Xu J,Zhang X,Zhang Y

    更新日期:2017-08-01 00:00:00

  • Risk factors for herpes zoster infection among Filipinos with systemic lupus erythematosus.

    abstract:AIM:To identify clinical risk factors associated with herpes zoster (HZ) infections in systemic lupus erythematosus (SLE). METHODS:A case-control study of HZ infection was performed in SLE patients seen at the University of Santo Tomas Lupus Clinics from 2009-2014. Cases were matched 1:2 to SLE controls without HZ inf...

    journal_title:International journal of rheumatic diseases

    pub_type: 杂志文章

    doi:10.1111/1756-185X.13725

    authors: Zamora LD,Collante MTM,Navarra SV

    更新日期:2020-02-01 00:00:00