Abstract：
:Several lines of research indicate that osteoarthritis (OA) is not only a joint disorder associated with mechanical stress and aging but also a 'metabolic syndrome' in which several risk factors work together to contribute to disease initiation and/or development. One such metabolic risk factor could be high cholesterol levels in the body. Even though high cholesterol level is a well-known risk factor for cardiovascular disorders, its possible role in musculoskeletal diseases, particularly OA, is not clear. The authors discuss the fundamental viewpoints on cholesterol involvement in the pathogenesis of OA, stressing the need for understanding the molecular mechanisms behind this association. This is the area of research needed to provide knowledge on how one should live to prevent OA development as well as to suggest new targets for drug therapy.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Farnaghi S,Crawford R,Xiao Y,Prasadam Idoi
10.1111/1756-185X.13061subject
Has Abstractpub_date
2017-02-01 00:00:00pages
131-140issue
2eissn
1756-1841issn
1756-185Xjournal_volume
20pub_type
杂志文章,评审abstract：BACKGROUND/OBJECTIVE:Peripheral neuropathies (PN) are heterogeneous nerve disorders; frequently rheumatic patients have neuropathic symptoms. In some rheumatic diseases (RD) PN are secondary to nerve compression while others are related to metabolic abnormalities, inflammation or vasculitis. Our aim was to explore the ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13755
更新日期：2020-02-01 00:00:00
abstract：:Loss of B-cell tolerance is a hallmark feature of the pathogenesis in systemic lupus erythematosus (SLE), an autoimmune disease that is characterized by hypergammaglobulinemia and autoantibody production. These autoantibodies lead to formation of immune-complex deposition in internal organs causing inflammation and da...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/j.1756-185X.2009.01458.x
更新日期：2010-02-01 00:00:00
abstract：:Intravenous immunoglobulin (IVIg) is a purified plasma product that is used for many immune-deficient conditions and autoimmune conditions. Use of IVIg for treatment for Kawasaki disease (KD) is critical for control of inflammation. The American Heart Association (AHA) recommends a single infusion of 2 g/kg preferably...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/1756-185X.13220
更新日期：2018-01-01 00:00:00
abstract：AIM:Current rheumatoid arthritis (RA) guidelines have incorporated a treat-to-target (T2T) approach and require that it be implemented through shared decision making (SDM). Current discourse has questioned whether collaborative T2T is feasible in RA, in part because of discrepancies in the way that patients and practit...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13664
更新日期：2019-09-01 00:00:00
abstract：:Magnetic resonance imaging (MRI) has added a new dimension to the study of osteoarthritis, a long-known degenerative joint disease with limited therapeutic options. It has advanced our understanding of joint pathophysiology and identifying that osteoarthritis as a simple 'wear and tear' process of the articular cartil...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,评审
doi：10.1111/j.1756-185X.2011.01677.x
更新日期：2012-02-01 00:00:00
abstract：:We report a rare case of antisynthase syndrome (ASS) complicated with Kaposi sarcoma, analyze its clinical characteristics, and review the literature on the topic. An 80-year-old male patient developed fever, cough, and shortness of breath. Lung high-resolution computed tomography showed nonspecific interstitial pneum...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13861
更新日期：2020-06-01 00:00:00
abstract：AIM:Vitamin K is an essential factor for carboxylation of bone matrix protein. Low vitamin K may be associated with reduced bone mineral density (BMD). The issue of whether long-term sodium warfarin therapy as oral anticoagulant that antagonizes vitamin K, results in decreased bone density, is controversial. Our purpos...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2009.01395.x
更新日期：2009-07-01 00:00:00
abstract：:Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae with predominant involvement of skin and nerves. We present a 70-year-old man with leprosy whose initial presentation resembled rheumatologic disease, due to leprae reaction. He presented with an 8-week history of worsening neuropathic pain in...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12916
更新日期：2016-10-01 00:00:00
abstract：AIM:To study the profile of autoantibodies on long-term follow-up of children with Kawasaki disease (KD). PATIENTS AND METHODS:In this single-center observational cohort study, 50 children who had been diagnosed and treated for KD with a minimum follow-up period of 3 years were enrolled. The organ-specific autoantibod...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13372
更新日期：2018-11-01 00:00:00
abstract：AIM:Systemic juvenile idiopathic arthritis (sJIA) is a distinctive subtype of JIA characterized by systemic features and poor outcome. We aimed to investigate demographic and clinical features, long-term treatment response and disease complications in a large sJIA cohort. METHODS:Patients diagnosed with sJIA followed ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13649
更新日期：2019-09-01 00:00:00
abstract：AIM:P-glycoprotein (P-gp) is an adenosine-5-triphosphate Binding Cassettes B 1 (ABCB1) transporter that exports various substrates on cellular membrane. Surface expression of P-gp was decreased during chondrogenesis of human bone marrow mesenchymal stem cells (BM-MSCs). We examined the role of P-gp in extracellular mat...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2011.01610.x
更新日期：2011-05-01 00:00:00
abstract：AIM:The objective of this study was to assess arthritis of the whole body before and after total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA) using positron emission tomography (PET). METHOD:Seventeen knees of 17 RA patients (median age 68 years) who underwent TKA were included in this study. Cli...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12855
更新日期：2017-06-01 00:00:00
abstract：AIM:In this study we aimed at identifying the bone mineral density (BMD) reference values of hands, according to age, measured by dual-energy X-ray absorptiometry (DEXA) and assessing the correlation of these values with lumbar and femoral BMD values. METHOD:A total of 403 healthy women aged between 20 and 70 particip...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12159
更新日期：2017-12-01 00:00:00
abstract：AIM:To assess the serum levels of soluble toll-like receptor (sTLR2) as an endogenous negative regulator of TLR2 signaling in systemic lupus erythematosus (SLE) patients, to investigate the correlation between sTLR2 and SLE disease activity index (SELDAI), SLE-related cardiovascular risk factors and ventricular dysfunc...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12452
更新日期：2016-07-01 00:00:00
abstract：AIM:To determine the outcomes of juvenile idiopathic arthritis (JIA) in Thai children. METHODS:A retrospective cohort study. All JIA patients in a rheumatology clinic, Ramathibodi Hospital, between July 1997 and December 2012 were enrolled. The patient data were reviewed from medical records. At the most recent follow...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12637
更新日期：2016-12-01 00:00:00
abstract：AIM:Eosinophilic fasciitis (EF) is a rare, fibrosing disorder of skin and subcutaneous tissue. This study was undertaken to describe its clinical and laboratory features and identify prognostic factors associated with outcome. METHODS:We conducted a retrospective review of all EF patients evaluated at our institution ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13770
更新日期：2020-02-01 00:00:00
abstract：AIM:To describe the clinical features, treatment and long-term outcomes in north Indian patients with granulomatosis with polyangiitis (GPA). METHODS:Clinical details, Birmingham Vasculitis Activity Score (BVAS-v3), laboratory data, histopathology findings, treatment details and outcomes of all consecutive patients di...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13071
更新日期：2018-01-01 00:00:00
abstract：AIM:An elevated serum uric acid level is associated with various diseases, such as gout, hypertension, renal impairment, and diabetes. Heavy metals, including lead and cadmium, are suspected to increase serum uric acid levels, but evidence regarding this is not sufficient, particularly in the Asian population. Therefor...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13632
更新日期：2019-08-01 00:00:00
abstract：AIM:Some studies have been performed to elucidate the association between Fc gamma receptor 3B (FCGR3B) copy number (CN) and the risk of systemic lupus erythematosus (SLE) and/or lupus nephritis (LN), yet the results remain conflicting. Therefore, we have undertaken a systematic review of all the studies published and ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,meta分析,评审
doi：10.1111/1756-185X.12342
更新日期：2015-05-01 00:00:00
abstract：:Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by eosinophilic vasculitis. Patients rarely present without asthma. Cases developing subarachnoid hemorrhage from central nervous system vasculitis are rarely reported. We report a 48-year-old woman with rapidly evolving and progressive multi-system...
journal_title：International journal of rheumatic diseases
pub_type：
doi：10.1111/1756-185X.12594
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:Patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and ankylosing spondylitis (AS) often require total hip arthroplasties. We present a retrospective review of 32 total hip arthroplasties (THA) performed for patients with SLE, RA or AS from 2003 to 2008 in a tertiary hospital in Singa...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2010.01477.x
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To assess parental stress levels of mothers of children with juvenile idiopathic arthritis (JIA) aged between 2-12 years and compare with those reported for other chronic childhood illnesses. METHODOLOGY:Mothers of children aged between 2-12 years with JIA were recruited from hospital-based outpatient clinic...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1756-185X.12394
更新日期：2014-06-01 00:00:00
abstract：AIM:To assess the psychometric properties of the Japanese version of the Revised Fibromyalgia Impact Questionnaire (JFIQR) in fibromyalgia (FM) patients. METHOD:The reliability and validity of the JFIQR were assessed using online data collected from Japanese FM patients. Reliability was evaluated based on test-retest ...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12574
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). The survival rates and mortality-predictive factors of a nationwide registry of Korean patients with CTD-PH measured by echocardiography were determined. METHODS:Patients with CTD-PH were enrolled between...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12645
更新日期：2017-09-01 00:00:00
abstract：AIM:We conducted a prospective randomized parallel clinical trial comparing the efficacy of local steroid injection and nocturnal wrist splinting in patients with carpal tunnel syndrome (CTS). METHODS:The well-validated and disease-specific Boston Carpal Tunnel Questionnaire (BCTQ) was employed and its score at 4 week...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章,随机对照试验
doi：10.1111/1756-185X.13162
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease with multifactorial etiology. Several studies show that genetic factors have an important part in the incidence of SLE. The C1QTNF4 gene is involved in the regulation of the inflammatory pathways by pro-inflammatory function. In the present study, w...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.13981
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:Kawasaki disease (KD) is an acute systemic vasculitis. Activation of the immune system is a central feature of KD. Some KD patients are resistant to initial high-dose intravenous immunoglobulin (IVIG) treatment. The study aimed to determine the predictors of IVIG resistance. METHOD:A single-center, retrospe...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12082
更新日期：2013-04-01 00:00:00
abstract：AIMS:In order to investigate the histological change in effect attenuation cases of etanercept compared with methotrexate (MTX), we performed immunohistochemical examination by seven different molecules. METHODS:We histologically assessed synovial tissue from five MTX-treated rheumatoid arthritis (RA) patients as cont...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/j.1756-185X.2009.01372.x
更新日期：2009-04-01 00:00:00
abstract：:Biologics have emerged as an important modality of treatment in rheumatic diseases and have allowed the rheumatologist to explore varied therapeutic uses of these drugs. Rituximab, a monoclonal antibody against CD20 receptor is an important member of the biologic armamentarium for the treatment of various refractory a...
journal_title：International journal of rheumatic diseases
pub_type：
doi：10.1111/1756-185X.13365
更新日期：2019-05-01 00:00:00
abstract：AIM:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have anti-inflammatory properties that reduce inflammatory cytokine production in rheumatoid arthritis (RA). Cysteine-rich angiogenic inducer 61 (Cyr61) is associated with diseases related to chronic inflammation. The aim of this study was to investi...
journal_title：International journal of rheumatic diseases
pub_type： 杂志文章
doi：10.1111/1756-185X.12913
更新日期：2017-10-01 00:00:00
