Catastrophic subarachnoid hemorrhage in eosinophilic granulomatosis with polyangiitis without asthma.

Abstract:

:Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by eosinophilic vasculitis. Patients rarely present without asthma. Cases developing subarachnoid hemorrhage from central nervous system vasculitis are rarely reported. We report a 48-year-old woman with rapidly evolving and progressive multi-system eosinophilic vasculitis in the absence of asthma. Tissue eosinophilia was apparent in a breast lump biopsy. Prior otitis media and prominent lymphoid tissue in the postnasal spaces hinted at otolaryngological disease. She had rapid disease progression with mononeuritis multiplex and eventually succumbed to complications of intracranial hemorrhage secondary to central nervous system vasculitis. This case demonstrates the diagnostic dilemma and treatment considerations in EGPA without asthma. It also raises the question if a reliable biomarker can aid diagnosis in atypical presentations of disease.

journal_name

Int J Rheum Dis

authors

Lee MXW,Teng GG,Raju GC,Lim AYN

doi

10.1111/1756-185X.12594

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

2127-2131

issue

12

eissn

1756-1841

issn

1756-185X

journal_volume

20

pub_type

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