Abstract:
AIM:The aim of this study was to evaluate the therapeutic effect of a traditional Chinese medicine (TCM), Bushen-Jianpi-Huoxue decoction (BJHD), on diabetic osteoporosis (DOP) and the action mechanisms likely mediated by nuclear factor-kappa B (NF-κB) and Wnt signaling pathways. METHODS:Fifty-five male Wistar rats were used in this study; they were divided into normal control (n = 10) and established DOP model (n = 45) groups. The DOP model was induced using a combination high carbohydrate - high fat diet and intraperitoneal injections of streptozotocin (STZ). The successfully induced animals were randomized to the model, Western medicine, TCM and control groups. Levels of fasting blood glucose; insulin; serum Ca, P and alkaline phosphatase, and the femoral bone mineral density (BMD) were measured. Furthermore, messenger RNA (mRNA) levels of cytokines in the Wnt and NF-κB signaling pathways were measured using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS:Thirty rats were successfully established as the DOP model (10/group). After treatment, the levels of fasting blood glucose, insulin resistance and alkaline phosphatase in the TCM group rats were lower, while P and BMD were higher than those in the model groups. The mRNA levels of cytokines in the Wnt signaling pathway were higher in the TCM group than those in the model group. Moreover, the expressions of factors in the NF-κB pathway were markedly lower in the TCM group than they were in the model group. CONCLUSION:Bushen-Jianpi-Huoxue decoction relieved DOP by activating the Wnt signaling pathway while inhibiting NF-κB signaling.
journal_name
Int J Rheum Disjournal_title
International journal of rheumatic diseasesauthors
Zhang Y,Liu M,Li H,Chen Z,Liang N,Xu J,Zhang X,Zhang Ydoi
10.1111/1756-185X.13050subject
Has Abstractpub_date
2017-08-01 00:00:00pages
941-948issue
8eissn
1756-1841issn
1756-185Xjournal_volume
20pub_type
杂志文章abstract::Retroperitoneal fibrosis (RPF) is a rare disease characterized by chronic, nonspecific inflammatory and sclerotic or fibrotic tissue in the periaortic or periiliac retroperitoneum that encases adjacent structures. There will be a series of clinical manifestations once the proliferated fibrous tissues encase the abdomi...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1111/1756-185X.12863
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abstract:AIM:The use of healthcare resources by rheumatoid arthritis (RA) patients can be related to the presence of disease, comorbid conditions, use of steroids, and the combined use of immunosuppressants. This study evaluated the risk factors associated with infection and hospitalization in RA. METHODS:This multicenter, cro...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
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abstract:OBJECTIVE:To assess parental stress levels of mothers of children with juvenile idiopathic arthritis (JIA) aged between 2-12 years and compare with those reported for other chronic childhood illnesses. METHODOLOGY:Mothers of children aged between 2-12 years with JIA were recruited from hospital-based outpatient clinic...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
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abstract:AIM:It has long been a controversy that polymorphisms in FcγRIIIa (CD16A) receptors are associated with systemic lupus erythematosus (SLE). We aimed to verify the association of FcγRIIIa polymorphisms with SLE in a large Chinese population. METHODS:We genotyped FcγRIIIa-158V/F (rs396991) using a pyro-sequencing assay ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
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journal_title:International journal of rheumatic diseases
pub_type: 传,历史文章,杂志文章
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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abstract:AIM:To compare the Disease Activity Score with 28 joint (DAS28) using erythrocyte sedimentation rate (ESR) (DAS28-ESR) and DAS28 using C-reactive protein (CRP) (DAS28-CRP) with thresholds validated for DAS28-ESR in Turkish patients with rheumatoid arthritis. METHOD:The DAS28 data of 112 patients with rheumatoid arthri...
journal_title:International journal of rheumatic diseases
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更新日期:2018-08-01 00:00:00
abstract:AIM:Systemic lupus erythematosus (SLE) is an autoimmune disease that is associated with genetic and environmental factors and microbial infection. With respect to microbial infection, the Epstein-Barr virus (EBV) has been a widely discussed issue in recent decades. Human herpesvirus 8 (HHV-8) belongs to the same γ-herp...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12193
更新日期:2013-12-01 00:00:00
abstract::Exposure to cadmium links smoking, the most import antetiological factor in the development of seropositive RA, and many of the other known contemporary risk factors. Epidemiological studies investigating the link between smoking, occupations, social class, region of residency and RA should consider cadmium exposure a...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.12673
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章
doi:10.1111/1756-185X.13426
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,实务指引,评审
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journal_title:International journal of rheumatic diseases
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journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,多中心研究
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abstract::We discuss recent and prospective research in small and large vessel vasculitis. Large cohorts of Takayasu arteritis (TA) have been recently published from across the world, clarifying our understanding of this uncommon disease. Novel open-ended approaches like large-scale genotyping, proteomics and metabolomics have ...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
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abstract::Even though, Hippocrates recognized gout as an affection of older men and a product of high living long back in 5th century BC, this painful condition promises to accompany humanity to the 21st century. The incidence is progressively rising and females are also affected in the modern era. There are also regional and e...
journal_title:International journal of rheumatic diseases
pub_type: 杂志文章,评审
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