Neonatal lupus erythematosus: a review of 123 cases in China.

Abstract:

AIM:To analyze the clinical features, outcomes and prognosis of neonatal lupus erythematosus (NLE) in China. METHOD:We reviewed 12 NLE cases at the Peking Union Medical College Hospital and compared the data with 111 cases reported in China between 1990 and 2014. The Chinese medical journal search engines used in this study were Wanfang.data and Science China. RESULTS:No gender dominance in NLE incidence was found. Cutaneous lesions were present in more than 96% of patients, while cardiac, hematological and hepatobiliary manifestations were seen in 12.61%, 45.53% and 17.89% of cases, respectively. Congenital heart block (CHB) tended to be more persistent, with two cases showing CHB for 1 year and three cases persisting for 7-10 years. In this study more than 90% of mothers were anti-Sjögren's syndrome A positive, and 65.04% were asymptomatic prior to the pregnancy. CONCLUSION:These results indicate that clinicians, especially dermatologists, in China should improve their recognition of this disease to avoid misdiagnosis, and more attention should be paid to the follow-up of NLE patients and their asymptomatic mothers.

journal_name

Int J Rheum Dis

authors

Li YQ,Wang Q,Luo Y,Zhao Y

doi

10.1111/1756-185X.12652

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

761-7

issue

7

eissn

1756-1841

issn

1756-185X

journal_volume

18

pub_type

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