Targeted disruption of supraspinal motor circuitry reveals a distributed network underlying Restless Legs Syndrome (RLS)-like movements in the rat.

abstract：:Hypoxia-related gene (HRG) expression is associated with survival outcomes of colorectal cancer (CRC). Our aim was developing a nomogram predicting CRC overall survival (OS) with HRGs and clinicopathological factors. The Cancer Genome Atlas (TCGA) database was used as discovery cohort and two Gene Expression Omnibus d...

journal_title：Scientific reports

authors： Lee JH,Jung S,Park WS,Choe EK,Kim E,Shin R,Heo SC,Lee JH,Kim K,Chai YJ

更新日期：2019-02-12 00:00:00

abstract：:The impacts of ecosystem engineers may be expected to vary along environmental gradients. Due to some resources being more limited in arid than in mesic environments, disturbances created by burrowing mammals are expected to have a greater ameliorating effect in arid environments, with larger differences in microhabit...

journal_title：Scientific reports

authors： Louw MA,Haussmann NS,le Roux PC

更新日期：2019-12-18 00:00:00

abstract：:The current study aimed to formulate Selenium-Chitosan-Mupirocin (M-SeNPs-CCH) complex. The nanohybrid system was prepared using chitosan-cetyltrimethylammonium bromide (CTAB)-based hydrogel (CCH) that entrapped mupirocin (M) and selenium nanoparticles (SeNPs). The in vitro studies were performed by evaluation of the ...

journal_title：Scientific reports

authors： Golmohammadi R,Najar-Peerayeh S,Tohidi Moghadam T,Hosseini SMJ

更新日期：2020-02-18 00:00:00

abstract：:The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endangered list of threat...

journal_title：Scientific reports

authors： Smedley CJ,Stanley PA,Qazzaz ME,Prota AE,Olieric N,Collins H,Eastman H,Barrow AS,Lim KH,Kam TS,Smith BJ,Duivenvoorden HM,Parker BS,Bradshaw TD,Steinmetz MO,Moses JE

更新日期：2018-07-13 00:00:00

abstract：:Bacillus Calmette-Guérin (BCG) is the only licensed vaccine for tuberculosis (TB) and induces highly variable protection against pulmonary disease in different countries. We hypothesised that DNA methylation is one of the molecular mechanisms driving variability in BCG-induced immune responses. DNA methylation in peri...

journal_title：Scientific reports

authors： Hasso-Agopsowicz M,Scriba TJ,Hanekom WA,Dockrell HM,Smith SG

更新日期：2018-08-30 00:00:00

abstract：:Upper urinary tract urothelial carcinomas are usually managed by radical nephroureterectomy (RNU), often followed by intravesical chemotherapy to minimize recurrence. Open surgery is the gold standard procedure for RNU, but it associates with high morbidity, and it has been increasingly replaced by minimally invasive ...

journal_title：Scientific reports

authors： Oliveira C,Barros AA,Reis RL,Correia-Pinto J,Lima E

更新日期：2019-12-10 00:00:00

abstract：:Lipopolysaccharide (LPS) is a major component of the outer wall of gram negative bacteria. In high doses LPS contributes to the inflammation in gram negative sepsis, and in low doses contributes to the low grade inflammation characteristic of the metabolic syndrome. We wanted to assess the role of beta2-glycoprotein I...

journal_title：Scientific reports

authors： Zhou S,Chen G,Qi M,El-Assaad F,Wang Y,Dong S,Chen L,Yu D,Weaver JC,Beretov J,Krilis SA,Giannakopoulos B

更新日期：2016-09-27 00:00:00

abstract：:One of the famous results of network science states that networks with heterogeneous connectivity are more susceptible to epidemic spreading than their more homogeneous counterparts. In particular, in networks of identical nodes it has been shown that network heterogeneity, i.e. a broad degree distribution, can lower ...

journal_title：Scientific reports

authors： Yang H,Tang M,Gross T

更新日期：2015-08-21 00:00:00

abstract：:Diagnostic test accuracy of the loop-mediated isothermal amplification (LAMP) assay for culture proven tuberculosis is unclear. We searched electronic databases for both cohort and case-control studies that provided data to calculate sensitivity and specificity. The index test was any LAMP assay including both commerc...

journal_title：Scientific reports

authors： Nagai K,Horita N,Yamamoto M,Tsukahara T,Nagakura H,Tashiro K,Shibata Y,Watanabe H,Nakashima K,Ushio R,Ikeda M,Narita A,Kanai A,Sato T,Kaneko T

更新日期：2016-12-13 00:00:00

abstract：:We investigate the behaviour of the recently proposed Quantum PageRank algorithm, in large complex networks. We find that the algorithm is able to univocally reveal the underlying topology of the network and to identify and order the most relevant nodes. Furthermore, it is capable to clearly highlight the structure of...

journal_title：Scientific reports

authors： Paparo GD,Müller M,Comellas F,Martin-Delgado MA

更新日期：2013-10-04 00:00:00

abstract：:With the development of next generation sequencing, more and more common inherited diseases have been reported. However, accurate and convenient molecular diagnosis cannot be achieved easily because of the enormous size of disease causing mutations. In this study, we introduced a new single-step method for the genetic...

journal_title：Scientific reports

authors： Sun Y,Man J,Wan Y,Pan G,Du L,Li L,Yang Y,Qiu L,Gao Q,Dan H,Mao L,Cheng Z,Fan C,Yu J,Lin M,Kristiansen K,Shen Y,Wei X

更新日期：2018-08-03 00:00:00

abstract：:Mitochondrial dysfunction and significant changes in metabolic pathways accompany cancer development and are responsible for maintaining the tumor microenvironment. Normal mitochondria can trigger intrinsic apoptosis by releasing cytochrome c into the cytosol. The survival of malignant cells highly depends on the supp...

journal_title：Scientific reports

authors： Bencze G,Bencze S,Rivera KD,Watson JD,Hidvegi M,Orfi L,Tonks NK,Pappin DJ

更新日期：2020-08-25 00:00:00

abstract：:In order to screen out an effective bone loss protectant from natural plant polyphenol and to elucidate the mechanism of the plant polyphenols that alleviate bone loss under simulated microgravity, the proliferation activities of 9 total polyphenol extracts from natural product (TPENP) on osteoblasts were measured. Po...

journal_title：Scientific reports

authors： Diao Y,Chen B,Wei L,Wang Z

更新日期：2018-08-24 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Mikel P,Vasickova P,Kralik P

更新日期：2019-04-17 00:00:00

abstract：:The association of cabbage white butterflies (Pieris spec., Lepidoptera: Pieridae) with their glucosinolate-containing host plants represents a well-investigated example of the sequential evolution of plant defenses and insect herbivore counteradaptations. The defensive potential of glucosinolates, a group of amino ac...

journal_title：Scientific reports

authors： Steiner AM,Busching C,Vogel H,Wittstock U

更新日期：2018-07-17 00:00:00

abstract：:Due to distinct biological behavior of mucinous adenocarcinoma (MAC) and signet ring cell cancer (SRC), the efficacy of radiotherapy on long-term outcome for rectal cancer (RC) patients with mucinous tumors is still unclear. Here, we identified 1808 RC patients with MAC/SRC from Surveillance, Epidemiology, and End-Res...

journal_title：Scientific reports

authors： Guan X,Jia S,Chen W,Jiang Z,Liu Z,Chen Y,Wang G,Wang X

更新日期：2017-03-08 00:00:00

abstract：:Stylosanthes guianensis (Aubl.) Sw. is an economically important pasture and forage legume in tropical regions of the world. Genetic improvement of the crop can be enhanced through marker-assisted breeding. However, neither single nucleotide polymorphism (SNP) markers nor SNP-based genetic linkage map has been previou...

journal_title：Scientific reports

authors： Tang YQ,Xia ZQ,Ding ZT,Ding YC,Liu Z,Ma X,Liu JP

更新日期：2019-03-07 00:00:00

abstract：:The D40 gene encodes a kinetochore protein that plays an essential role in kinetochore formation during mitosis. Short inhibitory RNA against D40, D40 siRNA, has been shown to deplete the D40 protein in the human cancer cell line HeLa, which harbors wild-type p53, and this activity was followed by the significant inhi...

journal_title：Scientific reports

authors： Urata YN,Takeshita F,Tanaka H,Ochiya T,Takimoto M

更新日期：2015-09-08 00:00:00

abstract：:During ice-free periods, the Northern Sea Route (NSR) could be an attractive shipping route. The decline in Arctic sea-ice extent, however, could be associated with an increase in the frequency of the causes of severe weather phenomena, and high wind-driven waves and the advection of sea ice could make ship navigation...

journal_title：Scientific reports

authors： Inoue J,Yamazaki A,Ono J,Dethloff K,Maturilli M,Neuber R,Edwards P,Yamaguchi H

更新日期：2015-11-20 00:00:00

abstract：:Spheroid cultures derived from explanted cancer specimens are an increasingly utilized resource for studying complex biological processes like tumor cell invasion and metastasis, representing an important bridge between the simplicity and practicality of 2-dimensional monolayer cultures and the complexity and realism ...

journal_title：Scientific reports

authors： Hou Y,Konen J,Brat DJ,Marcus AI,Cooper LAD

更新日期：2018-05-08 00:00:00

abstract：:Biomimetic scaffolds are of great interest to tissue engineering (TE) and tissue repair as they support important cell functions. Scaffold coating with soluble collagen-I has been used to achieve better tissue integration in orthopaedy, however, as collagen persistence was only temporary such efforts were limited. Ade...

journal_title：Scientific reports

authors： Vielreicher M,Kralisch D,Völkl S,Sternal F,Arkudas A,Friedrich O

更新日期：2018-06-20 00:00:00

abstract：:Generation of multiple mRNAs by alternative splicing is well known in the group of cytokines and has recently been reported for the human erythropoietin (EPO) gene. Here, we focus on the alternatively spliced EPO transcript characterized by deletion of exon 3 (hEPOΔ3). We show co-regulation of EPO and hEPOΔ3 in human ...

journal_title：Scientific reports

authors： Bonnas C,Wüstefeld L,Winkler D,Kronstein-Wiedemann R,Dere E,Specht K,Boxberg M,Tonn T,Ehrenreich H,Stadler H,Sillaber I

更新日期：2017-06-16 00:00:00

abstract：:Curvature components derived from satellite gravity gradients provide new global views of Earth's structure. The satellite gravity gradients are based on the GOCE satellite mission and we illustrate by curvature images how the Earth is seen differently compared to seismic imaging. Tectonic domains with similar seismic...

journal_title：Scientific reports

authors： Ebbing J,Haas P,Ferraccioli F,Pappa F,Szwillus W,Bouman J

更新日期：2018-11-05 00:00:00

abstract：:Abnormalities in actin cytoskeleton have been linked to Friedreich's ataxia (FRDA), an inherited peripheral neuropathy characterised by an early loss of neurons in dorsal root ganglia (DRG) among other clinical symptoms. Despite all efforts to date, we still do not fully understand the molecular events that contribute...

journal_title：Scientific reports

authors： Muñoz-Lasso DC,Mollá B,Calap-Quintana P,García-Giménez JL,Pallardo FV,Palau F,Gonzalez-Cabo P

更新日期：2020-03-23 00:00:00

abstract：:Influenza virus remains an emerging virus and causes pandemics with high levels of fatality. After screening different plant extracts with potential anti-influenza activity, a water extract of Taxodium distichum stems (TDSWex) showed excellent activity against influenza viruses. The EC50 of TDSWex was 0.051 ± 0.024 mg...

journal_title：Scientific reports

authors： Hsieh CF,Chen YL,Lin CF,Ho JY,Huang CH,Chiu CH,Hsieh PW,Horng JT

更新日期：2016-10-31 00:00:00

abstract：:In this paper, the periodic double-layer graphene ribbon arrays placed near a metallic ground plate coated by a dielectric layer are proposed and analyzed by the coupled-mode theory (CMT) to predict the perfect absorption response in the mid-infrared region. Numerical simulations of the finite-difference time-domain (...

journal_title：Scientific reports

authors： Li H,Wang L,Zhai X

更新日期：2016-11-15 00:00:00

abstract：:The extent to which the details of past experiences are retained or forgotten remains controversial. Some studies suggest massive storage while others describe memories as fallible summary recreations of original events. The discrepancy can be ascribed to the content of memories and how memories are evaluated. Many st...

journal_title：Scientific reports

authors： Misra P,Marconi A,Peterson M,Kreiman G

更新日期：2018-11-12 00:00:00

abstract：:Flavonoids and lignans are polyphenol classes with anticarcinogenic activities against colorectal cancer (CRC). However, very limited epidemiological evidence exists on their effects on CRC prognosis. This study aimed to evaluate the association between flavonoid and lignan intakes with the risk of CRC recurrence and ...

journal_title：Scientific reports

authors： Zamora-Ros R,Guinó E,Alonso MH,Vidal C,Barenys M,Soriano A,Moreno V

更新日期：2015-09-15 00:00:00

abstract：:Climate influences vegetation directly and through climate-mediated disturbance processes, such as wildfire. Temperature and area burned are positively associated, conditional on availability of vegetation to burn. Fire is a self-limiting process that is influenced by productivity. Yet, many fire projections assume su...

journal_title：Scientific reports

authors： Hurteau MD,Liang S,Westerling AL,Wiedinmyer C

更新日期：2019-02-26 00:00:00

abstract：:Brain diseases including neurological disorders and tumors remain under treated due to the challenge to access the brain, and blood-brain barrier (BBB) restricting drug delivery which, also profoundly limits the development of pharmacological treatment. Focused ultrasound (FUS) with microbubbles is the sole method to ...

journal_title：Scientific reports

authors： Wu SY,Aurup C,Sanchez CS,Grondin J,Zheng W,Kamimura H,Ferrera VP,Konofagou EE

更新日期：2018-05-22 00:00:00