A method for data-driven exploration to pinpoint key features in medical data and facilitate expert review.

abstract：PURPOSE:Pentaerythrityl tetranitrate (PETN) was the most commonly prescribed long-acting nitrate in Germany. We aimed to assess whether the discontinuation of PETN reimbursability in 2011 resulted in alternative prescriptions of anti-anginal medications or in a discontinuation of anti-anginal therapy. METHODS:This is ...

journal_title：Pharmacoepidemiology and drug safety

authors： Grimmsmann T,Chenot JF,Angelow A

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Observational pharmacoepidemiological studies can provide valuable information on the effectiveness or safety of interventions in the real world, but one major challenge is the existence of unmeasured confounder(s). While many analytical methods have been developed for dealing with this challenge, they appear u...

journal_title：Pharmacoepidemiology and drug safety

authors： Zhang X,Faries DE,Li H,Stamey JD,Imbens GW

更新日期：2018-04-01 00:00:00

abstract：:This paper addresses strategies for selecting variables for adjustment in non-experimental comparative effectiveness research and uses causal graphs to illustrate the causal network that relates treatment to outcome. Variables in the causal network take on multiple structural forms. Adjustment for a common cause pathw...

journal_title：Pharmacoepidemiology and drug safety

authors： Sauer BC,Brookhart MA,Roy J,VanderWeele T

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:Most epidemiologic studies have detected no association between prior use of antidepressant medications and breast cancer risk. Despite the uniform conclusion, there is a continuous rise in the proportion of women using antidepressants, lending support to further monitoring of disease effects. METHODS:We condu...

journal_title：Pharmacoepidemiology and drug safety

authors： Wernli KJ,Hampton JM,Trentham-Dietz A,Newcomb PA

更新日期：2009-04-01 00:00:00

abstract：:The ability to manage risk depends critically on an understanding of the degree to which a known risk is balanced by the probability of a clinical benefit. Despite the massive emphasis on risk and risk management in the past few years and the long-term focus on defining benefit in the regulatory system, considerable u...

journal_title：Pharmacoepidemiology and drug safety

authors： Califf RM,CERTs Benefit Assessment Workshop Participants.

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To enhance automated methods for accurately identifying opioid-related overdoses and classifying types of overdose using electronic health record (EHR) databases. METHODS:We developed a natural language processing (NLP) software application to code clinical text documentation of overdose, including identificat...

journal_title：Pharmacoepidemiology and drug safety

authors： Hazlehurst B,Green CA,Perrin NA,Brandes J,Carrell DS,Baer A,DeVeaugh-Geiss A,Coplan PM

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Bias analysis methods are developed for application to 2 x 2 tables, which may be crude or stratified data. Methods for application to associations adjusted for multiple covariates, such as associations from regression modeling, are rarely seen. We have developed probabilistic methods to evaluate bias from dise...

journal_title：Pharmacoepidemiology and drug safety

authors： Lash TL,Schmidt M,Jensen AØ,Engebjerg MC

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Because health insurance claims lack clinical information, comparative effectiveness research studies that rely on these data may be challenging to interpret and may result in biased inference. We conducted an exploratory study to determine if medical information contained in patient charts could offer clinical...

journal_title：Pharmacoepidemiology and drug safety

authors： Croghan TW,Esposito D,Daniel G,Wahl P,Stoto MA

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:During the past two decades, many novel immunosuppressive drugs have been approved for transplant recipients. Trends in the use of maintenance immunosuppressants after liver transplantation in Asia are unclear. Thus, we aimed to analyze the prescription trends in maintenance immunosuppressive drugs among liver ...

journal_title：Pharmacoepidemiology and drug safety

authors： Huang YY,Hsu CC,Chou CL,Loong CC,Wu MS,Chou YC

更新日期：2016-06-01 00:00:00

abstract：:The current medical care environment has created expectations that exceed its capabilities, one effect of which has been an increasing awareness of lapses in the quality of healthcare, including medical errors. As more new therapies reach clinical application, the expectations on the part of the public are unlikely to...

journal_title：Pharmacoepidemiology and drug safety

authors： Califf RM

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:We aimed to investigate the association between psychotropic treatment and risk of burn injury in individuals with mental illness. METHODS:A nested case-control study was conducted by using the National Health Insurance Research Database in Taiwan. A total of 3187 cases with burn injury under International Cla...

journal_title：Pharmacoepidemiology and drug safety

authors： Chang CM,Wu KY,Chiu YW,Wu HT,Tsai YT,Chau YL,Tsai HJ

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To evaluate the internet way of feedback to prescribing physicians, providing data on antimicrobial use and to assess the applicability of the DU90% (i.e. Drug Utilisation 90%--the number of drugs accounting for 90% of the volume of usage in defined daily doses, (DDDs)) methodology in the hospital setting. MET...

journal_title：Pharmacoepidemiology and drug safety

authors： Bergman U,Risinggård H,Vlahović-Palcevski V,Ericsson O

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:Administration of pegylated interferon-alpha (IFN-alpha) and ribavirin in adults with chronic hepatitis C (CHC) is a recommended therapeutic standard. Nevertheless, this therapeutic regimen rises numerous controversies. The aim of this study was to analyze adverse effects during the treatment with pegylated IFN...

journal_title：Pharmacoepidemiology and drug safety

authors： Kowala-Piaskowska A,Mozer-Lisewska I,Figlerowicz M,Słuzewski W

更新日期：2007-10-01 00:00:00

abstract：:In 1978, a systematic collection of adverse drug reactions (ADRs) was set up in a hospital including several departments and continued for more than 18 years. Quarterly meetings were organized gathering clinicians, students, nurses and pharmacologists to discuss the clinical cases collected each quarter. Approximately...

journal_title：Pharmacoepidemiology and drug safety

authors： Zenut M,Fialip J,Lavarenne J

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Antiepileptic drugs (AEDs) are also prescribed for therapeutic indications other than epilepsy (EPI), namely, psychiatric disorders (PSY). Our aim was to develop an algorithm able to distinguish between EPI and PSY among childbearing age women based on differences in AED exposure in these patient groups. ME...

journal_title：Pharmacoepidemiology and drug safety

authors： Naldi I,Piccinni C,Mostacci B,Renzini J,Accetta G,Bisulli F,Tappatà M,Piazza A,Pagano P,Bianchi S,D'Alessandro R,Tinuper P,Poluzzi E,ESPEA (Emilia-Romagna Study on Pregnancy and Exposure to Antiepileptic drugs) Group.

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Our aim was to describe and assess the medicinal products and doses used for euthanasia in a series of cases, identified within an epidemiological death certificate study in Belgium, where euthanasia was until recently legally forbidden and where guidelines for euthanasia are not available. METHODS:In a random...

journal_title：Pharmacoepidemiology and drug safety

authors： Vander Stichele RH,Bilsen JJ,Bernheim JL,Mortier F,Deliens L

更新日期：2004-02-01 00:00:00

abstract：:Rosiglitazone has previously been widely used to treat patients with type 2 diabetes mellitus, but its safety in terms of cardiovascular morbidity and mortality had been called into question. Recently, there have been doubts raised about the meta-analytic evidence with the regulatory authorities relaxing its restricti...

journal_title：Pharmacoepidemiology and drug safety

authors： Stone JC,Furuya-Kanamori L,Barendregt JJ,Doi SA

更新日期：2015-03-01 00:00:00

abstract：UNLABELLED:Computerized hospital databases are used for clinical and economic research. In France, the hospital administrative database, Programme de médicalisation des systèmes d'information (PMSI), could be an interesting means for identifying cases of abuse and dependence in hospitals. PURPOSE:To assess the capabil...

journal_title：Pharmacoepidemiology and drug safety

authors： Daveluy A,Miremont-Salamé G,Kostrzewa A,Couret A,Lacoin L,Lecomte C,Moore N,Gilleron V,Haramburu F

更新日期：2012-12-01 00:00:00

abstract：AIM:To determine the appropriate size of risk windows in both exposed and unexposed sub-cohorts. METHOD:Data was taken from a previous study of upper gastrointestinal haemorrhage and perforation. The length of each prescription for NSAIDs was estimated. The risk was calculated for the duration of a prescription plus i...

journal_title：Pharmacoepidemiology and drug safety

authors： McMahon AD,Evans JM,McGilchrist MM,McDevitt DG,MacDonald TM

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:Adverse drug events (ADEs) are an important cause of preventable hospitalizations among elderly individuals taking high-risk medications. The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin. METHODS:We conducted a prospectiv...

journal_title：Pharmacoepidemiology and drug safety

authors： Haynes K,Hennessy S,Localio AR,Cohen A,Leonard CE,Kimmel SE,Feldman HI,Strom BL,Metlay JP

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:We use simulations and an empirical example to evaluate the performance of disease risk score (DRS) matching compared with propensity score (PS) matching when controlling large numbers of covariates in settings involving newly introduced treatments. METHODS:We simulated a dichotomous treatment, a dichotomous o...

journal_title：Pharmacoepidemiology and drug safety

authors： Wyss R,Ellis AR,Brookhart MA,Jonsson Funk M,Girman CJ,Simpson RJ Jr,Stürmer T

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:PCORnet, the National Patient-Centered Clinical Research Network, represents an innovative system for the conduct of observational and pragmatic studies. We describe the identification and validation of a retrospective cohort of patients with type 2 diabetes (T2DM) from four PCORnet sites. METHODS:We adapted e...

journal_title：Pharmacoepidemiology and drug safety

authors： Wiese AD,Roumie CL,Buse JB,Guzman H,Bradford R,Zalimeni E,Knoepp P,Morris HL,Donahoo WT,Fanous N,Epstein BF,Katalenich BL,Ayala SG,Cook MM,Worley KJ,Bachmann KN,Grijalva CG,Rothman RL,Chakkalakal RJ

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Little is known about opioid use after bariatric surgery among patients who did not use opioids chronically before surgery. Our purpose was to determine opioid use the year after bariatric surgery among patients who did not use opioids chronically pre-surgery and to identify pre-surgery characteristics associat...

journal_title：Pharmacoepidemiology and drug safety

authors： Raebel MA,Newcomer SR,Bayliss EA,Boudreau D,DeBar L,Elliott TE,Ahmed AT,Pawloski PA,Fisher D,Toh S,Donahoo WT

更新日期：2014-12-01 00:00:00

abstract：:Erythromycin is commonly used to treat simple community-acquired pneumonia. We measured the prolongation in QT(c) intervals in EKGs associated with intravenous erythromycin administration among patients hospitalized for simple pneumonia (DRGs 89 and 90). We reviewed the medical records of 50 patients who received at l...

journal_title：Pharmacoepidemiology and drug safety

authors： Freeman J,Platt R

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:We aimed to describe time-trends in the use of NOACs among a group of ambulatory patients with nonvalvular atrial fibrillation (NVAF) in Colombia and to describe treatment patterns and user characteristics. METHODS:Using the Audifarma S.A administrative healthcare database in Colombia, we identified 10 528 pat...

journal_title：Pharmacoepidemiology and drug safety

authors： Machado-Alba JE,Gaviria-Mendoza A,Machado-Duque ME,Tovar-Yepes C,Ruigómez A,García Rodríguez LA

更新日期：2020-10-15 00:00:00

abstract：PURPOSE:Economic factors, market dynamics, and safety issues are largely responsible for decisions to withdraw pharmaceutical products from the market. In this study, new molecular entities (NMEs) approved by the Food and Drug Administration (FDA) were examined in the USA from 1980 to 2009. METHODS:Data were obtained ...

journal_title：Pharmacoepidemiology and drug safety

authors： Qureshi ZP,Seoane-Vazquez E,Rodriguez-Monguio R,Stevenson KB,Szeinbach SL

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Poor-quality patient drug information has been identified as a major cause of preventable medication errors in the United States. The US Food and Drug Administration (FDA) has the authority to require marketing authorization holders of medicinal products to implement risk evaluation and mitigation strategies...

journal_title：Pharmacoepidemiology and drug safety

authors： Chan HW,Russell AM,Smith MY

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Three recent observational studies reported that the risk of fatal overdose is greater with venlafaxine than SSRI use. It is not clear whether patient factors could account for this finding. We evaluated whether risk factors for suicide are more prevalent among patients prescribed venlafaxine than patients pres...

journal_title：Pharmacoepidemiology and drug safety

authors： Mines D,Hill D,Yu H,Novelli L

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:This study mainly aimed at describing the prevalence of psychotropic medication consumption in the Spanish elderly population between the years 1993 and 2003. METHODS:Descriptive, cross-sectional study covering the Spanish population aged 65 years and over, using data drawn from the 1993 and 2003 Spanish Natio...

journal_title：Pharmacoepidemiology and drug safety

authors： Carrasco-Garrido P,Jiménez-García R,Astasio-Arbiza P,Ortega-Molina P,de Miguel AG

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:The success of an epidemiological study for drug safety surveillance or comparative effectiveness depends largely on design and analysis strategies besides data quality. The Observational Medical Outcomes Partnership (OMOP) methods community implemented a collection of statistical methods with extensive paramet...

journal_title：Pharmacoepidemiology and drug safety

authors： Li X,Hui S,Ryan P,Rosenman M,Overhage M

更新日期：2013-05-01 00:00:00