Abstract:
AIM:To determine the appropriate size of risk windows in both exposed and unexposed sub-cohorts. METHOD:Data was taken from a previous study of upper gastrointestinal haemorrhage and perforation. The length of each prescription for NSAIDs was estimated. The risk was calculated for the duration of a prescription plus increments of -30, -25,..., +115, +120 (i.e. 31 increments). Ten unexposed groups were re-sampled for each increment (stratified for age and sex), using the same lengths of risk window as the exposed group. Mean risks and rate-ratios were calculated (per thousand person-years). RESULTS:The NSAID risk rose from 3.52 at -30 days to a peak of 5.82 at -15 days, and then decreased gradually to 2.83 at +120 days. Unexposed risk was variable for the negative increments, and decreased gradually from 2.16 at +0 days to 1.54 at +120 days. The rate-ratio rose from 1.55 at -30 days to a peak of 2.85 at -5 days, and then decreased to 1.85 at +120 days. CONCLUSION:Risk windows should be the same as (or slightly less than) the calculated length of a prescription. Lengthy windows should not be used for unexposed comparator groups (the exposed windows may be randomly allocated).
journal_name
Pharmacoepidemiol Drug Safjournal_title
Pharmacoepidemiology and drug safetyauthors
McMahon AD,Evans JM,McGilchrist MM,McDevitt DG,MacDonald TMdoi
10.1002/(SICI)1099-1557(199807/08)7:4<275::AID-PDSkeywords:
subject
Has Abstractpub_date
1998-07-01 00:00:00pages
275-80issue
4eissn
1053-8569issn
1099-1557journal_volume
7pub_type
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