Abstract:
PURPOSE:Concomitant use of anti-dementia drugs with psychotropic drugs is potentially problematic in patients with dementia. The aim of this study was to investigate how frequently patients in Norway use anti-dementia drugs concomitantly with psychotropic drugs. METHODS:Analyses are based on data from the Norwegian Prescription Database. All patients who had an anti-dementia drug (ATC-code N06D) dispensed from a Norwegian pharmacy between January 2004 and July 2009 were included. RESULTS:A total of 33,816 individuals received anti-dementia drugs at some time during this period. The total concomitant use of anti-dementia drugs with psychotropic drugs was 57.4% in men and 65.8% in women. Compared with men, a significantly higher percentage of women used antidepressants (35.8% versus 27.2%), mild hypnotics (28.8% versus 23.6%), benzodiazepines (25.4% versus 20.8%) and opioids (22.8% versus 17.4%) concomitantly with anti-dementia drugs. Concomitant use of antipsychotics with anti-dementia drugs was about 16% for both male and female patients. Of the total sample, 11.9% of the women and 11.7% of the men used acetylcholinesterase inhibitor (AChEI) anti-dementia drugs concomitantly with an interacting psychotropic drug. CONCLUSION:The concomitant use of psychotropic drugs with anti-dementia drugs was extensive, especially among women. Co-medication with potentially interacting drugs occurred at a rate of one in 10. The concomitant use of anti-dementia drugs with psychotropic drugs identified in this study may inform the ongoing clinical debate about drug use in this patient group.
journal_name
Pharmacoepidemiol Drug Safjournal_title
Pharmacoepidemiology and drug safetyauthors
Langballe EM,Engdahl B,Selbaek G,Nordeng Hdoi
10.1002/pds.2211subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1319-26issue
12eissn
1053-8569issn
1099-1557journal_volume
20pub_type
杂志文章abstract:PURPOSE:A case-control study is the most powerful design to test the risk of specific congenital malformations associated with a specific drug. However, malformation registries often lack non-malformed controls. For the Dutch EUROCAT, we collected a non-malformed control group: the 'Healthy Pregnant'. The aim of this s...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.2254
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria (BIFAP) is a population based database administered by the AEMPS (Spanish Agency for Medicines) of longitudinal electronic medical records (EMR) of patients attended in primary care. Its main purpose is to serve as source of informat...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
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journal_title:Pharmacoepidemiology and drug safety
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更新日期:2019-02-01 00:00:00
abstract:PURPOSE:We use simulations and an empirical example to evaluate the performance of disease risk score (DRS) matching compared with propensity score (PS) matching when controlling large numbers of covariates in settings involving newly introduced treatments. METHODS:We simulated a dichotomous treatment, a dichotomous o...
journal_title:Pharmacoepidemiology and drug safety
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doi:10.1002/pds.3810
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To investigate the association between socioeconomic position and use of lipid-lowering drugs and ACE-inhibitors after an acute myocardial infarction (AMI) when simultaneously considering participation in the national quality register RIKS-HIA (Register of Information and Knowledge about Swedish Heart Intensive...
journal_title:Pharmacoepidemiology and drug safety
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更新日期:2010-04-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
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更新日期:2013-05-01 00:00:00
abstract:PURPOSE:UK primary care databases are frequently used in observational studies with cancer outcomes. We aimed to systematically review methods used by such studies to identify and validate incident cancers of the breast, colorectum, and prostate. METHODS:Medline and Embase (1980-2013) were searched for UK primary care...
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更新日期:2015-01-01 00:00:00
abstract:PURPOSE:This study was performed to evaluate the change of prescribing patterns after the regulatory action regarding fluoroquinolones in pediatric patients. METHODS:We conducted a time series analysis using the Korea Health Insurance Review and Assessment Service National Patients Sample database. Study subjects cons...
journal_title:Pharmacoepidemiology and drug safety
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更新日期:2014-12-01 00:00:00
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更新日期:2003-07-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章,meta分析
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更新日期:2013-04-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
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更新日期:2009-12-01 00:00:00
abstract:PURPOSE:To provide an up-to-date account of drug prescription during pregnancy in France from 2011 to 2014 using the permanent sample of the French national computerized healthcare database and with a focus on recommended supplementations, fetotoxic drugs and teratogenic drugs. METHODS:All pregnancies identified by th...
journal_title:Pharmacoepidemiology and drug safety
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doi:10.1002/pds.4265
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:The objective of this study was to evaluate the validity and completeness of the General Practice Research Database (GPRD) as a tool for research into inflammatory bowel disease epidemiology. METHODS:Patients diagnosed with inflammatory bowel disease were identified from GPRD. Mailed surveys were sent to the g...
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更新日期:2002-04-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
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doi:10.1002/pds.4781
更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/pds.682
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:The changes in each year in influenza vaccine antigenic components as well as vaccine administration patterns may pose new risks of adverse events following immunization (AEs). To evaluate the safety of influenza vaccines annually administered to people ≥ 6 months, we conducted weekly post licensure surveillanc...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.3996
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:Outcome misclassification may occur in observational studies using administrative databases. We evaluated a two-step multiple imputation approach based on complementary internal validation data obtained from two subsamples of study participants to reduce bias in hazard ratio (HR) estimates in Cox regressions....
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.4223
更新日期:2017-08-01 00:00:00
abstract::When a biological hypothesis of causal effect can be inferred, the hypothesis can sometimes be tested in the selfsame database that gave rise to the study data from which the hypothesis grew. Valid testing happens when the inferred biological hypothesis has scientific implications that predict new relations between ob...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.1929
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:Several studies indicate that the medical burden of fatal adverse drug reactions (FADRs) is significant, but the preventability of FADRs in the general population is largely unknown. The aim of this study was to determine the proportion of preventable FADRs and preventable fatal drug poisonings (FDPs) in a Swed...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.1890
更新日期:2010-02-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章,评审
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更新日期:2006-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.1701
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:This study evaluated the safety of oseltamivir during the 2009 influenza pandemic. METHODS:Case reports were obtained from the Roche safety database. The incidence of adverse events (AEs) during the pandemic (1 May 2009 to 31 December 2009) was compared with that beforehand (during previous influenza seasons) ...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.2136
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To study the association between antibiotic use in early pregnancy and the risk of isolated orofacial clefts. METHODS:We conducted a cohort study of 806,011 live births in Denmark from 1996 through September 2008. Individual-level information on prescribed antibiotics during pregnancy, orofacial cleft diagnosi...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.2179
更新日期:2012-03-01 00:00:00
abstract:AIM:To determine the contribution of patients' adverse drug reaction (ADR) reports to signals detection, through a study of the signals sent by Lareb to the Dutch Medicines Evaluation Board. METHODS:The percentage of patient's ADR reports contributing to generate signals of adverse drug reactions was determined. A cas...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.2092
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:Our objective was to examine the numbers and characteristics of US pediatric adverse events (AEs) reported to the Food and Drug Administration (FDA)'s adverse event reporting system (AERS) for 5 years following implementation of the Best Pharmaceuticals for Children Act (BPCA) in 2002. METHODS:We analyzed repo...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.1679
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:To describe published validation studies of administrative health care claims data in the Asia-Pacific region. METHODS:A comprehensive literature search was conducted in PubMed for English language articles published through 31-Oct-2017 in humans from 10 Asian-Pacific countries or regions (Japan, Australia, Ne...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章,评审
doi:10.1002/pds.4616
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To compare the frequency of adverse drug reactions (ADRs) recorded by doctors with perceived ADRs reported by patients during hospitalization and post-discharge and to compare both to formal reporting in Thailand. SETTING:Tertiary teaching hospital, North-East Thailand. METHODS:Over a 6-month period doctors w...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.1708
更新日期:2009-03-01 00:00:00