Abstract:
BACKGROUND:The relationship between sildenafil dosing, exposure, and systemic hypotension in infants is incompletely understood. OBJECTIVES:The aim of this study was to characterise the relationship between predicted sildenafil exposure and hypotension in hospitalised infants. METHODS:We extracted information on sildenafil dosing and clinical characteristics from electronic health records of 348 neonatal ICUs from 1997 to 2013, and we predicted drug exposure using a population pharmacokinetic model. RESULTS:We identified 232 infants receiving sildenafil at a median dose of 3.2 mg/kg/day (2.0, 6.0). The median steady-state area under the concentration-time curve over 24 hours (AUC24,SS) and maximum concentration of sildenafil (Cmax,SS,SIL) were 712 ng×hour/ml (401, 1561) and 129 ng/ml (69, 293), respectively. Systemic hypotension occurred in 9% of the cohort. In multivariable analysis, neither dosing nor exposure were associated with systemic hypotension: odds ratio=0.96 (95% confidence interval: 0.81, 1.14) for sildenafil dose; 0.87 (0.59, 1.28) for AUC24,SS; 1.19 (0.78, 1.82) for Cmax,SS,SIL. CONCLUSIONS:We found no association between sildenafil dosing or exposure with systemic hypotension. Continued assessment of sildenafil's safety profile in infants is warranted.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Hornik CP,Onufrak NJ,Smith PB,Cohen-Wolkowiez M,Laughon MM,Clark RH,Gonzalez Ddoi
10.1017/S1047951117001639subject
Has Abstractpub_date
2018-01-01 00:00:00pages
85-92issue
1eissn
1047-9511issn
1467-1107pii
S1047951117001639journal_volume
28pub_type
杂志文章abstract:OBJECTIVES:To evaluate the rate of hospitalization for acute respiratory tract infection in children less than 24 months with haemodynamically significant congenital cardiac disease, and to describe associated risk factors, preventive measures, aetiology, and clinical course. MATERIALS AND METHODS:We followed 760 subj...
journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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journal_title:Cardiology in the young
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doi:10.1017/S1047951117000944
更新日期:2017-11-01 00:00:00
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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doi:10.1017/S1047951113001698
更新日期:2013-12-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951109990497
更新日期:2009-09-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951113000176
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
pub_type: 信件
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更新日期:2019-11-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951119001525
更新日期:2019-09-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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