Tetralogy of Fallot: epidemiology meets real-world management: lessons from the Baltimore-Washington Infant Study.

Abstract:

:Decades ago, mass-scale epidemiologic studies were undertaken to accurately describe the prevalence of congenital heart disease and associated malformations, and to identify inheritance patterns, teratogenic influence and aetiologic underpinnings. Despite phenomenal breakthroughs in molecular diagnosis of congenital heart disease, original population-based studies for detailed knowledge of prevalence, associated malformations, and appropriate patient and family counselling remain invaluable to the armamentarium and knowledge base of paediatric cardiologists. No modern-era studies have supplanted the importance of the Baltimore-Washington Infant Study undertaken from 1981 to 1989. In this article, we reprise the findings of the Baltimore-Washington Infant Study in tetralogy of Fallot, as well as to review current molecular diagnosis.

journal_name

Cardiol Young

journal_title

Cardiology in the young

authors

Nies M,Brenner JI

doi

10.1017/S1047951113001698

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

867-70

issue

6

eissn

1047-9511

issn

1467-1107

pii

S1047951113001698

journal_volume

23

pub_type

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