Treatment of familial hypercholesterolaemia in children and adolescents in the last three decades.

Abstract:

BACKGROUND:This study evaluated the effectiveness of long-term intensive lipid-lowering therapy in children and adolescents with familial hypercholesterolaemia. METHODS:The charts of 89 children and adolescents with heterozygous familial hypercholesterolaemia among ∼1000 patients treated from 1974 to 2008 were reviewed. Familial hypercholesterolaemia was defined as low-density lipoprotein cholesterol level >90th percentile in individuals with a history of familial hypercholesterolaemia. RESULTS:Of the 89 patients, 51% were male; the mean age at diagnosis was 8 ± 4 years, and the mean follow-up was 13 ± 8 years. Baseline and most recent low-density lipoprotein cholesterol levels (mg/dl) under treatment were 250 ± 50 and 142 ± 49, respectively, reduced 43% from baseline (p < 0.0001). At the most recent visit, 39 patients received statin monotherapy, mainly atorvastatin or rosuvastatin, and 50 (56%) patients received combination therapy, mainly vytorin or rosuvastain/ezetimibe, 15 patients were >30 years of age, and none developed symptomatic cardiovascular disease or needed revascularisation. CONCLUSIONS:Long-term statin-based therapy can reduce low-density lipoprotein cholesterol levels in most children and adolescents with heterozygous familial hypercholesterolaemia and decrease cardiovascular risk significantly.

journal_name

Cardiol Young

journal_title

Cardiology in the young

authors

Elis A,Zhou R,Stein EA

doi

10.1017/S1047951113000528

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

437-41

issue

3

eissn

1047-9511

issn

1467-1107

pii

S1047951113000528

journal_volume

24

pub_type

杂志文章
  • d-Transposition of the great arteries in a 12-year-old child: is arterial switch still an option?

    abstract::Arterial switch surgery for d-transposition of great arteries is usually performed in the first 2 weeks of life before the left ventricle regresses. The arterial switch surgery that helps achieve anatomic and physiologic correction of this condition has better long-term outcomes than other surgical approaches. The pro...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951111001004

    authors: Mahima J,Shivanna DN,Subramanian A

    更新日期:2012-02-01 00:00:00

  • Subtle bacterial endocarditis due to Kingella kingae in an infant: a case report.

    abstract::A 9-month-old infant presented with fever, dyspnoea, and a murmur. Echocardiography showed a mitral vegetation with significant regurgitation. Mitral valve plasty was performed on day 6, and was polymerase chain reaction positive for Kingella kingae. The cardiac outcome was favourable. This case illustrates a subtle p...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951110000351

    authors: Youssef D,Henaine R,Di Filippo S

    更新日期:2010-08-01 00:00:00

  • Hybrid closure of a large atrial septal defect using Occlutech Flex II septal occluder in a patient with interrupted inferior caval vein.

    abstract::We present a case of a 31-year-old male with a large atrial septal defect, who was found to have interrupted inferior caval vein with azygous continuation to the superior caval vein, which precluded transcutaneous closure by device. The defect was successfully closed with a 33 mm Occlutech Figula septal occluder using...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S104795112000092X

    authors: Bani Hani A,Abdullattif M,Al-Ammouri I

    更新日期:2020-06-01 00:00:00

  • Out of many, one: integrating data in the paediatric cardiovascular environment.

    abstract::Large volumes of data and multiple computing platforms are now universal components of paediatric cardiovascular medicine, but are in a constant state of evolution. Often, multiple sets of related data reside in disconnected "silos", resulting in clinical, administrative, and research activities that may be duplicativ...

    journal_title:Cardiology in the young

    pub_type: 杂志文章,评审

    doi:10.1017/S1047951116001268

    authors: Bradley DJ,Wu DTY,Goldberg CS,Serwer GS,Lowery RE,Donohue JE,Hirsch-Romano JC,Zheng K,Pasquali SK

    更新日期:2017-05-01 00:00:00

  • Levoatriocardinal vein in D-transposition of the great arteries.

    abstract::The levoatriocardinal vein is the embryological remnant of the connection between the pulmonary and systemic venous systems. It is a rare lesion that usually occurs in the presence of left-sided obstruction, developing as a pathway for decompression of the pulmonary veins. We report the first case of a levoatriocardin...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951116000652

    authors: Moodley S,Duncan W,Gandhi S

    更新日期:2016-08-01 00:00:00

  • Different haemodynamic patterns in head-up tilt test on 400 paediatric cases with unexplained syncope.

    abstract:OBJECTIVE:To assess haemodynamic patterns in head-up tilt testing on 400 paediatric cases with unexplained syncope. METHODS:Medical records of 520 children who underwent head-up tilt testing in the preceding year were retrospectively evaluated, and 400 children, 264 (66%) girls and 136 (34%) boys, aged 12.6±2.6 years ...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951114001176

    authors: Yozgat Y,Karadeniz C,Ozdemir R,Doksoz O,Kucuk M,Karaarslan U,Mese T,Unal N

    更新日期:2015-06-01 00:00:00

  • Aortic arch augmentation using a pulmonary artery autograft patch and a reversed left subclavian artery flap for an interrupted aortic arch type B complex.

    abstract::Adequate arch augmentation for interrupted aortic arch repair is quite important to avoid post-operative recoarctation and bronchial compression. We describe here two successful cases of aortic arch reconstruction using autologous materials such as a pulmonary artery patch and a reversed left subclavian artery flap in...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951113000899

    authors: Hasegawa T,Oshima Y,Kadowaki T

    更新日期:2014-06-01 00:00:00

  • Unusual cases of right-sided and left-sided May-Thurner syndrome.

    abstract::May-Thurner syndrome is a rare clinical entity involving venous obstruction of the left lower extremity. The May-Thurner syndrome is a phenomenon commonly described as an acquired stenosis of the left common iliac vein secondary to compression of the left common iliac vein between the right common iliac artery and the...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951114001115

    authors: Vijayalakshmi IB,Setty HS,Narasimhan C

    更新日期:2015-04-01 00:00:00

  • Is the burden of late hypertension and cardiovascular target organ damage in children and adolescents with coarctation of the aorta after early successful repair different to healthy controls?

    abstract:OBJECTIVE:Cardiovascular morbidity is high in patients with coarctation of aorta even after successful repair. This study aimed to assess the frequency of late hypertension and the relationship between ambulatory hypertension and cardiovascular target organ damage in children and adolescents after early and successful ...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S104795112000205X

    authors: Ağbaş A,Gökalp S,Canpolat N,Çalışkan S,Öztunç F

    更新日期:2020-09-01 00:00:00

  • Prevalence of ophthalmological abnormalities in children and adolescents with CHD: systematic review and meta-analysis of observational studies.

    abstract:BACKGROUND:CHDs form a complex and heterogeneous group of clinical entities, with high morbidity and mortality. With the advancement of surgical and invasive techniques and clinical treatment, the survival of these patients has increased significantly, and there are reports of a high prevalence of ocular abnormalities ...

    journal_title:Cardiology in the young

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S104795111500044X

    authors: Vilela MA,Sbruzzi G,Pellanda LC

    更新日期:2016-03-01 00:00:00

  • Dexmedetomidine utilisation and outcomes of children with trisomy 21 undergoing congenital heart disease surgery.

    abstract:INTRODUCTION:The diagnosis of trisomy 21 in children has been associated with failed extubation after CHD surgery. Dexmedetomidine may be a useful agent to improve postoperative outcomes in these patients, such as ventilator time, ICU length of stay, or hospital length of stay. MATERIALS AND METHODS:The Pediatric Heal...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951114001462

    authors: Moffett BS,Mossad EB,Tobias JD,Cabrera AG

    更新日期:2015-06-01 00:00:00

  • The diagnostic evaluation of patients with complete transposition.

    abstract::SummaryThe vast majority of patients with complete transposition present during either the neonatal period or early infancy. Almost always the diagnosis and the categorization of associated lesions can be established by cross-sectional echocardiography. Doppler techniques usually provide enough information about flows...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S104795110000007X

    authors: Rigby ML,Chan KY

    更新日期:1991-01-01 00:00:00

  • The efficacy of echocardiographic criterions for the diagnosis of carditis in acute rheumatic fever.

    abstract:BACKGROUND:There is a great need for echocardiographic criterions for accurate diagnosis of carditis in acute rheumatic fever. AIM:To test the efficacy of proposed echocardiographic criterions for the diagnosis of carditis. MATERIALS AND METHODS:We studied 333 patients suspected of having acute rheumatic fever, under...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951108003107

    authors: Vijayalakshmi IB,Vishnuprabhu RO,Chitra N,Rajasri R,Anuradha TV

    更新日期:2008-12-01 00:00:00

  • Involvement of patients and parents in research undertaken by the Australian and New Zealand Fontan Registry.

    abstract::Research that is closely connected with the population it is studying and in which the translational value to healthcare is high is a laudable goal, but it is not often achieved. The Australian and New Zealand Fontan Registry has developed a model for involving patients and parents of children with a Fontan circulatio...

    journal_title:Cardiology in the young

    pub_type: 杂志文章,评审

    doi:10.1017/S1047951117001494

    authors: d'Udekem Y,Forsdick V,du Plessis K

    更新日期:2018-04-01 00:00:00

  • The evaluation of developmental enamel defects and dental treatment conditions in a group of Turkish children with congenital heart disease.

    abstract:OBJECTIVE:The aim of this study was to determine developmental enamel defects and dental treatment conditions in children with congenital heart disease by comparing them with a control group of healthy children. METHODS:Children included in the study were referred to a paediatric dentistry for dental examination and t...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951113002308

    authors: Cantekin K,Gumus H,Torun YA,Sahin H

    更新日期:2015-02-01 00:00:00

  • Closure of a secundum atrial septal defect in two infants with chronic lung disease using the Gore HELEX Septal Occluder.

    abstract::Children with a secundum atrial septal defect are usually asymptomatic and are referred for elective closure after 3-4 years of age; however, in premature infants with chronic lung disease, bronchopulmonary dysplasia, or pulmonary hypertension, increased pulmonary blood flow secondary to a left-to-right atrial shunt, ...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951114002650

    authors: Zussman ME,Freire G,Cupp SD,Stapleton GE

    更新日期:2016-01-01 00:00:00

  • Holt-Oram syndrome: novel TBX5 mutation and associated anomalous right coronary artery.

    abstract::The Holt-Oram syndrome was confirmed in an asymptomatic 36-year-old man by a novel TBX5-gene mutation (exon 8 acceptor splicing site, c.663-1G greater than A). Computed tomography showed an atrial septal defect and an anomalous right coronary artery crossing between the aorta and pulmonary arteries. Surgery corrected ...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951111000072

    authors: Vianna CB,Miura N,Pereira AC,Jatene MB

    更新日期:2011-06-01 00:00:00

  • Reoperation after isolated subaortic membrane resection.

    abstract:BACKGROUND:The resection of a subaortic membrane remains far from a curative operation. We sought to examine factors associated with reoperation and the degree of aortic valve regurgitation as a potential long-term source for reoperation. METHODS:All patients who underwent resection of an isolated subaortic membrane b...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951119002336

    authors: Binsalamah ZM,Spigel ZA,Zhu H,Kim MB,Chacon-Portillo MA,Adachi I,Imamura M,Mery CM,Mckenzie ED,Fraser CD,Heinle JS

    更新日期:2019-11-01 00:00:00

  • Evaluation of long-term cardiac side effects of anthracycline chemotherapy by conventional and non-conventional echocardiographic methods in childhood cancer survivors.

    abstract:OBJECTIVE:Anthracycline chemotherapeutic agents carry the well-recognised risk of cardiac toxicity. The aim of this study was to determine the long-term effect of anthracycline chemotherapy on the biventricular function in childhood cancer survivors using tissue Doppler imaging and two-dimensional speckle tracking echo...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951119001094

    authors: Yoldaş T,Yeşil Ş,Karademir S,Şahin G,Arman Örün U,Doğan V,Özgür S

    更新日期:2019-07-01 00:00:00

  • Positional cyanosis in infants: an unusual presentation of right-sided cardiac masses.

    abstract::Positional cyanosis is an uncommon finding in young patients. We report three infants who presented with positional cyanosis due to a pedunculated tumour in the right heart. Arterial desaturation was the result of right-to-left shunting at the level of the oval foramen caused by obstruction and/or insufficiency of the...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/s1047951104001088

    authors: Levitas A,Gross G,Zucker N,Zalzstein E

    更新日期:2004-02-01 00:00:00

  • Biomarkers detect involvement of acute myocardial injury in a paediatric haemolytic-uraemic syndrome patient.

    abstract::Although extrarenal manifestations of haemolytic-uraemic syndrome are not frequent, myocardial dysfunction should be given special consideration because of the importance of proper early haemodynamic management and potential complications. We report the case of a 21-month-old child with haemolytic-uraemic syndrome who...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951115002759

    authors: Palanca Arias D,López Ramón M,Jiménez Montañés L

    更新日期:2016-06-01 00:00:00

  • Not just vegetations: focal myocardial changes in patients with fungal infections.

    abstract:BACKGROUND:Fungal endocarditis classically involves dense heterogenous vegetations. However, several patients with fungal infections were noted to have myocardial changes ranging from focal brightening to nodular thickening of chordae or papillary muscles. This study evaluates whether these findings are associated with...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951120003674

    authors: Cresalia NM,Owens ST,Stillwell TL,Norris MD,Yu S,Retzloff L,Ensing GJ

    更新日期:2020-11-13 00:00:00

  • Normal limits for heart rate as established using 24-hour ambulatory electrocardiography in children and adolescents.

    abstract:BACKGROUND:To the best of our knowledge, normal limits of heart rate with respect to gender, and as established using 24-hour ambulatory Holter electrocardiography, have yet to be published for the entire age range of children and adolescents. OBJECTIVES:To establish the normal limits for heart rate in newborns, infan...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951108002539

    authors: Salameh A,Gebauer RA,Grollmuss O,Vít P,Reich O,Janousek J

    更新日期:2008-10-01 00:00:00

  • A rare association of major aorto-pulmonary collaterals with right isomerism and totally anomalous pulmonary venous drainage.

    abstract::A female neonate, born at term, presented with complex cardiac anatomy dominated by right isomerism and infra-diaphragmatic totally anomalous pulmonary venous connection. Surgical repair was performed using circulatory arrest under deep hypothermia. In the postoperative period, the patient could not be weaned off mech...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951105001836

    authors: Kumar S,Ansari J,Weerasena N

    更新日期:2005-12-01 00:00:00

  • Chaotic atrial tachycardia-related ventricular fibrillation in a 2-month-old baby with Wolff-Parkinson-White syndrome.

    abstract::A 2-month-old baby was resuscitated from ventricular fibrillation attributed to a concurrent chaotic atrial tachycardia with Wolff-Parkinson-White syndrome. He underwent successful radiofrequency catheter ablation of an accessory pathway. Throughout the 4-year follow-up after the procedure, the boy remained free of an...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951109992034

    authors: Ko JK,Kim YH,Park IS

    更新日期:2010-04-01 00:00:00

  • Thymidylate synthase gene variation is associated with the risk for conotruncal heart defects in Chinese population.

    abstract::Conotruncal heart defects are considered to be one of the most common types of birth defect worldwide. Genetic disturbances in folate metabolism such as Thymidylate synthase may increase risk for conotruncal heart defects. We evaluated two common Thymidylate synthase polymorphisms, including the 28 bp tandem repeat in...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951118002184

    authors: Wang X,Wei H,Wu Y,Tian Y,Luo L

    更新日期:2018-12-21 00:00:00

  • Ventricular tachycardia recorded in a competitive swimmer using Confirm Rx™ loop recorder.

    abstract::Conventional ambulatory heart rhythm monitoring is limited in its ability to provide rapid diagnosis of arrhythmias in athletes participating in water or high-intensity sports. This case report is of a 17-year-old female competitive swimmer who underwent loop recorder implantation with Confirm Rx™ ICM 3500 (Abbott, Mi...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951120000232

    authors: Yoon JG,Snyder CS,Hoyt WJ

    更新日期:2020-03-01 00:00:00

  • Atrial fibrillation in a child with COVID-19 infection.

    abstract::The SARS-CoV-2 (COVID-19) pandemic has challenged our initial predictions of its ramifications, both short and long term. Cardiovascular manifestations of COVID-19 in children remain a topic of investigation as literature is lacking. We describe new onset atrial fibrillation in a child with a history of COVID-19 infec...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951120003893

    authors: Santi AD,Aquino P,Dorfman M

    更新日期:2020-10-19 00:00:00

  • Myocardial infarction in infancy caused by compression of an anomalous left coronary artery arising from the right coronary artery.

    abstract::A 5-week-old child presented with a cardiac arrest secondary to myocardial ischaemia. Echocardiography demonstrated a single coronary artery arising from the right sinus of Valsalva. The coronary artery branched into left and right arteries, with the left artery then coursing anomalously in the tissue plane between th...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/S1047951104006092

    authors: Duke C,Rosenthal E,Simpson JM

    更新日期:2004-12-01 00:00:00

  • Amiodarone-induced pulmonary toxicity in an adolescent.

    abstract::We report amiodarone-induced pulmonary toxicity in an 18-year-old boy who had undergone corrective surgery for tetralogy of Fallot 4 years earlier, and was treated with amiodarone because of recurrent malignant postoperative ventricular tachyarrhythmias. Toxicity was recognized on the basis of clinical features, chest...

    journal_title:Cardiology in the young

    pub_type: 杂志文章

    doi:10.1017/s1047951100008441

    authors: Kothari SS,Balijepally S,Taneja K

    更新日期:1999-03-01 00:00:00