Abstract:
OBJECTIVE:Anthracycline chemotherapeutic agents carry the well-recognised risk of cardiac toxicity. The aim of this study was to determine the long-term effect of anthracycline chemotherapy on the biventricular function in childhood cancer survivors using tissue Doppler imaging and two-dimensional speckle tracking echocardiography. PATIENTS AND METHODS:The study included 45 survivors of childhood cancers and 50 healthy age-matched control patients. Cardiac function was prospectively studied with conventional echocardiography, tissue Doppler imaging, and speckle tracking echocardiography after completion of treatment. The same analysis was performed on matched controls. RESULTS:There was no difference in age, gender, height, and weight between the study and control groups. The mean anthracycline dose was 240 ± 106 mg/m2 and the mean remission duration was 8.2 ± 5 years (1-20 years) in the study group. Conventional echocardiography showed similar ejection fraction, shortening fraction, and left ventricle end-diastolic diameter in both groups. Mitral lateral and septal tissue Doppler imaging showed normal but according to control group relatively sub-normal systolic and diastolic function in patient group. The global longitudinal and circumferential strain and strain rates were significantly lower in the patient group compared to control group. Correlation analysis revealed a negative and significant correlation between total anthracycline dose and global longitudinal and circumferential strain and strain rates. CONCLUSION:Sub-clinical systolic and diastolic dysfunction may not be detected by conventional echocardiographic methods which are frequently used in daily practice. Sub-clinical systolic and diastolic dysfunction may be detected more sensitively by echocardiographic method such as speckle tracking echocardiography in childhood cancer survivors.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Yoldaş T,Yeşil Ş,Karademir S,Şahin G,Arman Örün U,Doğan V,Özgür Sdoi
10.1017/S1047951119001094subject
Has Abstractpub_date
2019-07-01 00:00:00pages
904-909issue
7eissn
1047-9511issn
1467-1107pii
S1047951119001094journal_volume
29pub_type
杂志文章abstract::We occluded a large arterial duct in a patient with atrial fibrillation, using an Amplatzer duct occluder, with no residual shunt at the end of the procedure. Follow-up revealed recanalization, which was successfully treated with a 4 mm Amplatzer ASD occluder. It is speculated the reopening of the initially occluded d...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951104003142
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:We previously reported four heterozygous missense mutations of MYH7, KCNQ1, MYLK2, and TMEM70 in a single three-generation Chinese family with dual Long QT and hypertrophic cardiomyopathy phenotypes for the first time. However, the clinical course among the family members was various, and the potential myoca...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951118000860
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:The aim of this study is to investigate the prevalence of subclinical rheumatic heart disease in schoolchildren aged 5-18 by using portable echocardiography in Ankara, Turkey. METHODS:The portable echocardiography screening was performed by a paediatric cardiologist for all of the cases. The mean age of 255...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951119002075
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease is a leading cause of morbidity and mortality in childhood cancer survivors. Cardiologists must be aware of risk factors and long-term follow-up guidelines, which have historically been the purview of oncologists. Little is known about paediatric cardiologists' knowledge regarding the ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111900088X
更新日期:2019-06-01 00:00:00
abstract::Many, if not most, of the controversies regarding the description of the congenitally malformed heart have been resolved over the turn of the 20th century. A group of lesions that remains contentious is the situation in which both arterial trunks, in their greater part, are supported by the morphologically right ventr...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951116001190
更新日期:2017-01-01 00:00:00
abstract::We present a case of circumferential fracture of aortic coarctation stent with severe re-stentosis presenting 16 years after initial stent implantation with end-stage renal disease. The patient was treated with a covered stent using the stent-in-stent technique. The use of an ultra-high-pressure balloon was proved nec...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001079
更新日期:2016-02-01 00:00:00
abstract::Oxidative stress may contribute to the pathogenesis of congenital heart defects, but the role of dynamic thiol/disulphide homeostasis has not been evaluated. The objective of this study was to assess whether there are changes in thiol/disulphide homeostasis and nitric oxide levels in children with tetralogy of Fallot ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111900012X
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:Our aim was to investigate the change in diameter of holes within the oval fossa, and the role of aneurismal formation in reducing the size of the hole, in patients diagnosed during infancy with isolated defects in the floor of the fossa. PATIENTS:In a retrospective study, we included 100 patients diagnosed ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951107001692
更新日期:2008-02-01 00:00:00
abstract::Aim We aimed to study the dimensions, systolic and diastolic functions of the left ventricle; dimensions and elasticity of the aorta; and carotid intima-media thickness and flow-mediated dilatation of the brachial artery in mitral valve prolapse. METHODS:The study group consisted of 43 patients (mean age=13.3±3.9) an...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117001950
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Although some prior studies have provided evidence to question the historical belief that pulmonary vascular resistance index ⩾6 Wood Units×m2 should be a contraindication to heart transplantation in children, no national analyses specific to the modern area have addressed this question. METHODS:Data were a...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001796
更新日期:2015-08-01 00:00:00
abstract::Herein, we present the first case of dilated cardiomyopathy due to premature constriction of the ductus arteriosus. A fetal echocardiography showed narrowing in the ductus arteriosus, and colour Doppler flow mapping could not identify blood flow through the ductus. Neonatal echocardiography revealed a left ventricular...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951118001002
更新日期:2018-09-01 00:00:00
abstract::Following the sudden death of a friend in 1966, Dr Michel Mirowski began pioneering work on the first implantable cardioverter-defibrillator. By 1969 he had developed an experimental model and performed the first transvenous defibrillation. In 1970 he reported on the use of a "standby automatic defibrillator" that was...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951116002353
更新日期:2017-01-01 00:00:00
abstract::D is an 8-year-old boy brought to his paediatrician for evaluation. His mother is concerned as his teacher has been frequently complaining that he is very restless and often disturbs the rest of the class by getting up on some pretext or the other. He is unable to concentrate on his work and gets distracted very easil...
journal_title:Cardiology in the young
pub_type: 信件
doi:10.1017/S1047951115001274
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Tricuspid regurgitation as a manifestation of an isolated congenital anomaly of the tricuspid valve is rare. Cross-sectional and color Doppler echocardiography allow improved evaluation of tricuspid valvar function. As a result, the heterogeneous category of congenital tricuspid valvar dysplasia may be bette...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100004972
更新日期:1999-05-01 00:00:00
abstract:INTRODUCTION:Dilatation of the ascending aorta is described in Turner's syndrome with variable prevalence (6.8-32%). Reported series typically include patients with associated cardiac anomalies. OBJECTIVE:To characterise the prevalence, age of onset, and the progress of dilatation of the ascending aorta in Turner's sy...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115000682
更新日期:2016-03-01 00:00:00
abstract::Endothelial dysfunction has been reported in hypoxaemic patients with the Eisenmenger syndrome, but a direct correlation between levels of endothelial markers and the severity of hypoxaemia has not been explored. With this in mind, we compared the levels in the plasma of tissue-type plasminogen activator, thrombomodul...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105001381
更新日期:2005-10-01 00:00:00
abstract::Heart failure in children is a complex clinical syndrome with multiple aetiologies. The underlying disorders that lead to heart failure in children differ significantly from those in adults. Some clinical biomarkers for heart failure status and prognosis appear to be useful in both age groups. This review outlines the...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951115000839
更新日期:2015-08-01 00:00:00
abstract::We report a left atrial appendage diverticulum in close proximity to the left coronary artery, thereby mimicking a fistulous connection between the two structures. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111400211X
更新日期:2015-03-01 00:00:00
abstract:UNLABELLED:Real-time three-dimensional echocardiography can surpass simple cross-sectional echocardiography in providing precise details of cardiac lesions. For the purpose of optimising treatment, we describe our findings with real-time three-dimensional echocardiography when interrogating different types of communica...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111001107
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the relations between the P-wave dispersion and diastolic functions in type 1 diabetic children. PATIENTS:A total of 33 diabetic patients without any cardiovascular disease, with a mean age of 12.3 plus or minus 4.2 years, and 29 healthy controls, with a mean age of 1...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795110999031X
更新日期:2010-04-01 00:00:00
abstract::This review includes a brief discussion, from the perspective of cardiac surgeons, of the rationale for creation and maintenance of multi-institutional databases of outcomes of congenital heart surgery, together with a history of the evolution of such databases, a description of the current state of the art, and a dis...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951108002813
更新日期:2008-12-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120002139
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to demonstrate the safety and feasibility of using the new Cardia Ultrasept II™ device with interposed Goretex patch referring to the perforation of polyvinyl alcohol membrane. BACKGROUND:Great advances have been made in the development of devices for closure of atrial septal...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951118000100
更新日期:2018-05-01 00:00:00
abstract::We describe a three-year-old boy who presented with recurrent expectoration of bronchial casts six months following creation of a fenestrated lateral tunnel Fontan circulation for pulmonary atresia with intact ventricular septum. Cardiac catheterization demonstrated elevated central venous pressure with two areas of s...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951101000385
更新日期:2001-05-01 00:00:00
abstract::Congenital anomalies of the coronary arteries are present in 0.2-1.4% of the general population. These anomalies represent one of the most confusing issues in the field of cardiology and challenges for interventional cardiologists and cardiac surgeons if the anomalies are unrecognised. Double right coronary artery is ...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951113000176
更新日期:2014-02-01 00:00:00
abstract::Femoral vein access is the first choice for percutaneous atrial septal defect closure, and when it cannot be used due to anatomic reasons, the alternative sites should be considered, frequently increasing the complexity of the procedure. Here we report the case of a 3-year-old boy, with situs inversus and dextrocardia...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951119002099
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Neonates and infants with congenital and acquired cardiac disease often require placement of central venous lines for extended intravenous therapy. It may be advantageous to avoid the larger venous vessels of the head and neck and lower extremities in order to preserve these for future interventions and ther...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110000090
更新日期:2010-06-01 00:00:00
abstract::Severe cyanosis due to pulmonary arteriovenous fistulas occurs often after a bidirectional superior cavopulmonary anastomosis (Glenn operation) and also in some congenital anomalies in which hepatic venous blood bypasses the lungs in the first passage. Relocation of hepatic flow into the lungs usually causes these fis...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951113000140
更新日期:2013-10-01 00:00:00
abstract::Congenitally corrected transposition is a rare congenital anomaly, with only a few cases diagnosed and reported prenatally even in the largest fetal series. To determine the morphologic features and outcome for the lesion as recognized during fetal life, we reviewed the fetal and postnatal echocardiograms and medical ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795110400304X
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:Murmurs are abnormal audible heart sounds produced by turbulent blood flow. Therefore, murmurs in a child may be a source of anxiety for family members. Families often use online materials to explore possible reasons for these murmurs, given the accessibility of information on the Internet. In this study, we ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111900307X
更新日期:2020-03-01 00:00:00