Abstract：
:Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory. Although LSD1 phosphorylation by PKCα was implicated in circadian rhythmicity, the importance of LSD1 phosphorylation in learning and memory is unknown. In this study, we examined the roles of LSD1 in synaptic plasticity and memory using Lsd1 SA/SA knock-in (KI) mice, in which a PKCα phosphorylation site is mutated. Interestingly, short-term and long-term contextual fear memory as well as spatial memory were impaired in Lsd1 KI mice. In addition, short-term synaptic plasticity, such as paired pulse ratio and post-tetanic potentiation was impaired, whereas long-term synaptic plasticity, including long-term potentiation and long-term depression, was normal. Moreover, the frequency of miniature excitatory postsynaptic current was significantly increased, suggesting presynaptic dysfunction in Lsd1 KI mice. Consistent with this, RNA-seq analysis using the hippocampus of Lsd1 KI mice showed significant alterations in the expressions of presynaptic function-related genes. Intriguingly, LSD1n-SA mutant showed diminished binding to histone deacetylase 1 (HDAC1) compared to LSD1n-WT in SH-SY5Y cells. These results suggest that LSD1 is involved in the regulation of presynaptic gene expression and subsequently regulates the hippocampus-dependent memory in phosphorylation-dependent manner.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lim CS,Nam HJ,Lee J,Kim D,Choi JE,Kang SJ,Kim S,Kim H,Kwak C,Shim KW,Kim S,Ko HG,Lee RU,Jang EH,Yoo J,Shim J,Islam MA,Lee YS,Lee JH,Baek SH,Kaang BKdoi
10.1038/s41598-017-05239-7subject
Has Abstractpub_date
2017-07-07 00:00:00pages
4912issue
1issn
2045-2322pii
10.1038/s41598-017-05239-7journal_volume
7pub_type
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