当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Formulation and characterization of chitosan encapsulated phytoconstituents of curcumin and rutin nanoparticles.

Formulation and characterization of chitosan encapsulated phytoconstituents of curcumin and rutin nanoparticles.

Abstract：

:Curcumin and Rutin are natural polyphenolic molecules exhibits several pharmacological actives like antibacterial, anticancer, antioxidant, chemo-preventive and anti-inflammatory properties. However till date, no studies have been reported on their combination efficacy, especially in treating multi-drug resistance of cancers because of their poor solubility and bioavailability. Hence in the present study, an attempt has been made to load both these drugs into a single nanoparticlulate system to enhance their bioavailability and efficacy. This novel formulation was prepared by solvent evaporation technique and was evaluated for particle size and shape using Zeta Sizer, Scanning Electron Microscopy (SEM) and Fourier Transform Infra Red (FT-IR) Spectroscopy. The optimized formulation was further subjected to in vitro and in vivo evaluations. The prepared nanoparticles were in the size range of 25-100nm and the release profile was found to be Non -Fickian transport. In-vivo pharmacokinetic studies were carried in rabbits and the pharmacokinetic profile was studied. The results indicate that oral bioavailability of Curcumin and Rutin has been increased to 3.06 and 4.24 folds respectively when compared to their pure drugs. This data suggest that the present novel nanoparticles loaded with these combinational drugs may have better therapeutic potential in treating drug resistant cancers.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Ramaswamy S,Dwarampudi LP,Kadiyala M,Kuppuswamy G,Veera Venkata Satyanarayana Reddy K,Kumar CKA,Paranjothy M

doi

10.1016/j.ijbiomac.2017.06.112

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1807-1812

issue

Pt B

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)32596-X

journal_volume

104

pub_type

杂志文章

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