miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice.

abstract：:Cigarette smoking is one of the most important and preventable risk factors for atherosclerosis. However, because of the complex composition of cigarette smoke, the detailed pathophysiological mechanisms are not fully understood. Based on controversial reports on the pro-atherogenic activity of cigarette smoke condens...

journal_title：Cell death & disease

authors： Messner B,Frotschnig S,Steinacher-Nigisch A,Winter B,Eichmair E,Gebetsberger J,Schwaiger S,Ploner C,Laufer G,Bernhard D

更新日期：2012-11-15 00:00:00

abstract：:MicroRNAs are key regulators of many biological processes, including cell differentiation. These small RNAs exert their function assembled in the RNA-induced silencing complexes (RISCs), where members of Argonaute (Ago) family of proteins provide a unique platform for target recognition and gene silencing. Here, by us...

journal_title：Cell death & disease

authors： Iosue I,Quaranta R,Masciarelli S,Fontemaggi G,Batassa EM,Bertolami C,Ottone T,Divona M,Salvatori B,Padula F,Fatica A,Lo-Coco F,Nervi C,Fazi F

更新日期：2013-11-21 00:00:00

abstract：:Following publication of this article, it was brought to our attention that there was a typo in the References (reference number 43) whereby the first author's name was misspelled. The correct citation is provided below. We apologize for the inconvenience. ...

journal_title：Cell death & disease

authors： Wang LH,Baker NE

更新日期：2019-10-22 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Han X,Shi H,Sun Y,Shang C,Luan T,Wang D,Ba X,Zeng X

更新日期：2019-09-05 00:00:00

abstract：:Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis. The smoothened (Smo) receptor is one of the main upstream transducers of the ...

journal_title：Cell death & disease

authors： Infante P,Alfonsi R,Ingallina C,Quaglio D,Ghirga F,D'Acquarica I,Bernardi F,Di Magno L,Canettieri G,Screpanti I,Gulino A,Botta B,Mori M,Di Marcotullio L

更新日期：2016-09-22 00:00:00

abstract：:DNA damage regulated autophagy modulator 1 (DRAM1) is a stress-inducible regulator of autophagy and cell death. DRAM1 has been implicated in cancer, myocardial infarction, and infectious diseases, but the molecular and cellular functions of this transmembrane protein remain poorly understood. Previously, we have propo...

journal_title：Cell death & disease

authors： Zhang R,Varela M,Forn-Cuní G,Torraca V,van der Vaart M,Meijer AH

更新日期：2020-04-24 00:00:00

abstract：:Chronic hyperglycemia causes a progressive decrease of β-cell function and mass in type 2 diabetic patients. Growing evidence suggests that augment of autophagy may be an effective approach to protect β cells against various extra-/intracellular stimuli. In this study, we thus investigated whether bone marrow-derived ...

journal_title：Cell death & disease

authors： Zhao K,Hao H,Liu J,Tong C,Cheng Y,Xie Z,Zang L,Mu Y,Han W

更新日期：2015-09-17 00:00:00

abstract：:The biological clock is an endogenous biological timing system, which controls metabolic functions in almost all organs. Nutrient metabolism, substrate processing, and detoxification are circadian controlled in livers. However, how the clock genes respond to toxins and influence toxicity keeps unclear. We identified t...

journal_title：Cell death & disease

authors： Ge W,Wang T,Zhao Y,Yang Y,Sun Q,Yang X,Gao Y,Xu X,Zhang J

更新日期：2021-01-12 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gastric cancer (GC) patients. Here, we have identified a novel subset of CD45+CD33lowCD11bdim MDSCs in the periphe...

journal_title：Cell death & disease

authors： Mao FY,Zhao YL,Lv YP,Teng YS,Kong H,Liu YG,Wu XL,Hao CJ,Chen W,Duan MB,Han B,Ma Q,Wang TT,Peng LS,Zhang JY,Cheng P,Su CY,Fu XL,Zou QM,Guo G,Guo XL,Zhuang Y

更新日期：2018-07-09 00:00:00

abstract：:Adenanthin, a natural diterpenoid isolated from the leaves of Isodon adenanthus, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On the other hand, increasing lines of evidence propose that these Prx proteins would become potential targets to screen drugs ...

journal_title：Cell death & disease

authors： Hou JK,Huang Y,He W,Yan ZW,Fan L,Liu MH,Xiao WL,Sun HD,Chen GQ

更新日期：2014-09-04 00:00:00

abstract：:Histological inspection of visually normal tissue adjacent to neoplastic lesions often reveals multiple foci of cellular abnormalities. This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic reactive oxygen speci...

journal_title：Cell death & disease

authors： Chan JS,Tan MJ,Sng MK,Teo Z,Phua T,Choo CC,Li L,Zhu P,Tan NS

更新日期：2017-01-19 00:00:00

abstract：:Autophagy (macroautophagy) is an evolutionarily conserved lysosomal degradation process, in which a cell degrades long-lived proteins and damaged organelles. Recently, accumulating evidence has revealed the core molecular machinery of autophagy in carcinogenesis; however, the intricate relationship between autophagy a...

journal_title：Cell death & disease

authors： Liu B,Wen X,Cheng Y

更新日期：2013-10-31 00:00:00

abstract：:Previously, we confirmed that sphingosine kinase 1 (SphK1) inhibition improves sepsis-associated liver injury. High-mobility group box 1 (HMGB1) translocation participates in the development of acute liver failure. However, little information is available on the association between SphK1 and HMGB1 translocation during...

journal_title：Cell death & disease

authors： Tian T,Yao D,Zheng L,Zhou Z,Duan Y,Liu B,Wang P,Li Y

更新日期：2020-12-06 00:00:00

abstract：:Little is known about the function of Keratin 80 (KRT80), an epithelial keratin, in cancer. This study investigated the role of KRT80 in the prognosis of colorectal carcinoma (CRC) and the underlying mechanisms involved in CRC migration and invasion. We analyzed the expression of KRT80 using The Cancer Genome Atlas an...

journal_title：Cell death & disease

authors： Li C,Liu X,Liu Y,Liu X,Wang R,Liao J,Wu S,Fan J,Peng Z,Li B,Wang Z

更新日期：2018-09-27 00:00:00

abstract：:Inactivation of the retinoblastoma protein (Rb) has a key role in tumorigenesis. It is well established that Rb function is largely regulated by a dynamic balance of phosphorylation and dephosphorylation. Although much research has been done to understand the mechanisms and function of RB phosphorylation, the regulati...

journal_title：Cell death & disease

authors： Tong Y,Ying H,Liu R,Li L,Bergholz J,Xiao ZX

更新日期：2015-02-12 00:00:00

abstract：:Recent cases of successful control of human immunodeficiency virus (HIV) by bone marrow transplant in combination with suppressive antiretroviral therapy (ART) and very early initiation of ART have provided proof of concept that HIV infection might now be cured. Current efforts focusing on gene therapy, boosting HIV-s...

journal_title：Cell death & disease

authors： Badley AD,Sainski A,Wightman F,Lewin SR

更新日期：2013-07-11 00:00:00

abstract：:Mitochondrial membrane potential provides a valuable indicator of cells' health and functional status. Cytometry- and microscopy-based analyses, in combination with fluorescent probes, are widely used to study mitochondrial behavior related to cellular pathways, most notably - apoptosis. The cyanine dye JC-1 (5,5',6,6...

journal_title：Cell death & disease

authors： Perelman A,Wachtel C,Cohen M,Haupt S,Shapiro H,Tzur A

更新日期：2012-11-22 00:00:00

abstract：:Glucocorticoids (GCs) represent an important component of modern treatment regimens for fludarabine-refractory or TP53-defective chronic lymphocytic leukemia (CLL). However, GC therapy is not effective in all patients. The molecular mechanisms responsible for GC-induced apoptosis and resistance were therefore investig...

journal_title：Cell death & disease

authors： Melarangi T,Zhuang J,Lin K,Rockliffe N,Bosanquet AG,Oates M,Slupsky JR,Pettitt AR

更新日期：2012-08-16 00:00:00

abstract：:Calcium ions play a critical role in neuronal cell death. Pigment epithelium-derived factor (PEDF) is a promising neuroprotective protein for photoreceptor cells but the mechanisms mediating its effects against retinal degeneration are still not well characterized. We addressed this question in the rd1 degenerating mo...

journal_title：Cell death & disease

authors： Comitato A,Subramanian P,Turchiano G,Montanari M,Becerra SP,Marigo V

更新日期：2018-05-01 00:00:00

abstract：:Mesothelin (MSLN) is an attractive antigen for chimeric antigen receptor (CAR) T therapy and the epitope selection within MSLN is essential. In this study, we constructed two types of CARs targeting either region I of MSLN (meso1 CAR, also known as a membrane-distal region) or region III of MSLN (meso3 CAR, also known...

journal_title：Cell death & disease

authors： Zhang Z,Jiang D,Yang H,He Z,Liu X,Qin W,Li L,Wang C,Li Y,Li H,Xu H,Jin H,Qian Q

更新日期：2019-06-17 00:00:00

abstract：:Abdominal Aortic aneurysm (AAA) is associated with chronic inflammation, cells apoptosis, and impairment of autophagy. BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-κB, as well as regulate autophagy. However, its...

journal_title：Cell death & disease

authors： Wu QY,Cheng Z,Zhou YZ,Zhao Y,Li JM,Zhou XM,Peng HL,Zhang GS,Liao XB,Fu XM

更新日期：2020-02-18 00:00:00

abstract：:Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, disease treatment, and organ transplantation. As the ethical issue of human ESCs and similarity of pig in human genome and physiological characteristics, the porcine iPSCs (piPSCs) have become an ideal ...

journal_title：Cell death & disease

authors： Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Wang F,Wang Y,Wang X

更新日期：2019-02-20 00:00:00

abstract：:Pathological retinal neovascularization is the most common cause of vision loss. PKCθ has been shown to play a role in type 2 diabetes, which is linked to retinal neovascularization. Based on these clues, we have studied the role of PKCθ and its downstream target genes JunB and VEGFR3 in retinal neovascularization usi...

journal_title：Cell death & disease

authors： Kumar R,Mani AM,Singh NK,Rao GN

更新日期：2020-05-07 00:00:00

abstract：:Bone metastasis is a severe complication of advanced breast cancer, resulting in osteolysis and increased mortality in patients. Raddeanin A (RA), isolated from traditional Chinese herbs, is an oleanane-type triterpenoid saponin with anticancer potential. In this study, we investigated the effects of RA in breast canc...

journal_title：Cell death & disease

authors： Wang Q,Mo J,Zhao C,Huang K,Feng M,He W,Wang J,Chen S,Xie Z,Ma J,Fan S

更新日期：2018-03-07 00:00:00

abstract：:Histones and their post-translational modifications have key roles in chromatin remodeling and gene transcription. Besides intranuclear functions, histones act as damage-associated molecular pattern molecules when they are released into the extracellular space. Administration of exogenous histones to animals leads to ...

journal_title：Cell death & disease

authors： Chen R,Kang R,Fan XG,Tang D

更新日期：2014-08-14 00:00:00

abstract：:Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage liver diseases as hepatocellular carcinoma and cirrhosis. Sinusoidal endothelial cells contribute to myofibroblast activation and liver fibrosis by undergoing endothelial-mesenchymal transition (EndMT). The...

journal_title：Cell death & disease

authors： Li Z,Chen B,Dong W,Kong M,Fan Z,Yu L,Wu D,Lu J,Xu Y

更新日期：2019-11-27 00:00:00

abstract：:Glycine decarboxylase (GLDC) belongs to the glycine cleavage system and is involved in one-carbon metabolism. We previously reported that GLDC downregulation enhances hepatocellular carcinoma (HCC) progression and intrahepatic metastasis through decreasing ROS-mediated ubiquitination of cofilin. The role of autophagy ...

journal_title：Cell death & disease

authors： Zhuang H,Wu F,Wei W,Dang Y,Yang B,Ma X,Han F,Li Y

更新日期：2019-02-25 00:00:00

abstract：:Activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its in vivo significance in diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-specific Rac1-deficient mouse strain and showed that specific inhibition of Rac1...

journal_title：Cell death & disease

authors： Lv Z,Hu M,Fan M,Li X,Lin J,Zhen J,Wang Z,Jin H,Wang R

更新日期：2018-03-01 00:00:00

abstract：:Diffusely infiltrating gliomas are among the most prognostically discouraging neoplasia in human. Temozolomide (TMZ) in combination with radiotherapy is currently used for the treatment of glioblastoma (GBM) patients, but less than half of the patients respond to therapy and chemoresistance develops rapidly. Epigeneti...

journal_title：Cell death & disease

authors： Haemmig S,Baumgartner U,Glück A,Zbinden S,Tschan MP,Kappeler A,Mariani L,Vajtai I,Vassella E

更新日期：2014-06-05 00:00:00

abstract：:Adipogenesis is a process which induces or represses many genes in a way to drive irreversible changes of cell phenotypes; lipid accumulation, round cell-shape, secreting many adipokines. As a master transcription factor (TF), PPARγ2 induces several target genes to orchestrate these adipogenic changes. Thus induction ...

journal_title：Cell death & disease

authors： Park B,Chang S,Lee GJ,Kang B,Kim JK,Park H

更新日期：2019-01-08 00:00:00